Drug Resistance

Displaying 1 - 6 of 6CSV
Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T., … Winzeler, E. A. (2024). Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science, 386(6725). https://doi.org/10.1126/science.adk9893
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Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627
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Collins, J. E., Jiang, T., Lee, J. W., Wendt, K., Nardella, F., Jeon, J., Paes, R., Santos, N. M., Rocamora, F., Chang, M., Schaefer, S., Cichewicz, R. H., Winzeler, E. A., & Chakrabarti, D. (2024). Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1. ACS Infectious Diseases, 10(6), 2276–2287. https://doi.org/10.1021/acsinfecdis.4c00232
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Small-Saunders, J. L., Sinha, A., Bloxham, T. S., Hagenah, L. M., Sun, G., Preiser, P. R., Dedon, P. C., & Fidock, D. A. (2024). tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature Microbiology, 9(6), 1483–1498. https://doi.org/10.1038/s41564-024-01664-3
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Mihreteab, S., Platon, L., Berhane, A., Stokes, B. H., Warsame, M., Campagne, P., Criscuolo, A., Ma, L., Petiot, N., Doderer-Lang, C., Legrand, E., Ward, K. E., Zehaie Kassahun, A., Ringwald, P., Fidock, D. A., & Ménard, D. (2023). Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea. New England Journal of Medicine, 389(13), 1191–1202. https://doi.org/10.1056/nejmoa2210956
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Kucharski, M., Wirjanata, G., Nayak, S., Boentoro, J., Dziekan, J. M., Assisi, C., van der Pluijm, R. W., Miotto, O., Mok, S., Dondorp, A. M., & Bozdech, Z. (2023). Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum. PLOS Pathogens, 19(1), e1011118. https://doi.org/10.1371/journal.ppat.1011118
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