Role of Pim Oncogenes in Tumorigenesis

Subject Vocabulary

OpenAlex Topic

Unique ID

https://openalex.org/T13779

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z

Authors:

Urszula N. Wasko

Jingjing Jiang

Tanner C. Dalton

Álvaro Curiel‐García

A. Cole Edwards

Yingyun Wang

Bianca J. Lee

Margo Orlen

Sha Tian

Clint A. Stalnecker

Kristina Drizyte‐Miller

Marie Ménard

Julien Dilly

Stephen A. Sastra

Carmine F. Palermo

Marie C. Hasselluhn

Amanda R. Decker-Farrell

Stephanie Chang

Lingyan Jiang

Wei Xing

Yu Chi Yang

Ciara Helland

Haley Courtney

Yevgeniy Gindin

Karl Muonio

Ruiping Zhao

Samantha B. Kemp

Cynthia Clendenin

Rina Sor

William P. Vostrejs

Priya S. Hibshman

Amber M. Amparo

Connor J. Hennessey

Matthew G. Rees

Melissa M. Ronan

Jennifer A. Roth

Jens Brodbeck

Lorenzo Tomassoni

Basil Bakir

Nicholas D. Socci

Laura E. Herring

Natalie K. Barker

Junning Wang

James M. Cleary

Brian M. Wolpin

John A. Chabot

Michael D. Kluger

Gulam A. Manji

Kenneth Y. Tsai

Miroslav Sekulic

Stephen M. Lagana

Andrea Califano

Elsa Quintana

Zhengping Wang

Jacqueline A.M. Smith

Matthew Holderfield

David Wildes

Scott W. Lowe

Michael A. Badgley

Andrew J. Aguirre

Robert H. Vonderheide

Ben Z. Stanger

Timour Baslan

Channing J. Der

Mallika Singh

Kenneth P. Olive

Affiliated Authors:

Urszula N. Wasko

Tanner C. Dalton

Álvaro Curiel‐García

Stephen A. Sastra

Carmine F. Palermo

Marie C. Hasselluhn

Amanda R. Decker-Farrell

Lorenzo Tomassoni

Basil Bakir

John A. Chabot

Michael D. Kluger

Gulam A. Manji

Miroslav Sekulic

Stephen M. Lagana

Andrea Califano

Michael A. Badgley

Kenneth P. Olive

Columbia Affiliation:

Subjects:

Antineoplastic Agents (MeSH)

Carcinoma, Pancreatic Ductal (MeSH)

Guanosine Triphosphate (MeSH)

Pancreatic Neoplasms (MeSH)

Proto-Oncogene Proteins p21(ras) (MeSH)

Pancreatic Cancer Research and Treatment (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Molecular Mechanisms of Ras Signaling Pathways (OpenAlex Topic)

Grants:

T32CA071341 (NIH – National Cancer Institute)

P30CA016086 (NIH – National Cancer Institute)

R01CA276268 (NIH – National Cancer Institute)

U01CA217858 (NIH – National Cancer Institute)

R01CA266558 (NIH – National Cancer Institute)

T32CA009156 (NIH – National Cancer Institute)

P50CA257911 (NIH – National Cancer Institute)

U01CA274312 (NIH – National Cancer Institute)

P01CA129243 (NIH – National Cancer Institute)

R01CA229803 (NIH – National Cancer Institute)

P30CA008748 (NIH – National Cancer Institute)

R35CA232113 (NIH – National Cancer Institute)

T32CA009140 (NIH – National Cancer Institute)

P30CA013696 (NIH – National Cancer Institute)

F31CA275260 (NIH – National Cancer Institute)

U01CA272610 (NIH – National Cancer Institute)

R01CA215607 (NIH – National Cancer Institute)

F32CA232529 (NIH – National Cancer Institute)

U54CA274506 (NIH – National Cancer Institute)

UL1TR001873 (NIH – National Center for Advancing Translational Sciences)

K08AI106953 (NIH – National Institute of Allergy and Infectious Diseases)

P30DK132710 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK138827 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

T32GM119999 (NIH – National Institute of General Medical Sciences)

S10OD012351 (NIH – Office of the Director, National Institutes of Health)

S10OD021764 (NIH – Office of the Director, National Institutes of Health)

S10OD032433 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1038/s41586-024-07379-z

PMID:

38588697

DOI:

10.1038/s41586-024-07379-z

Journal:

Nature

Publication Date:

2024-04-08

Data Source:

OpenAlex

Source Link:

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Record Created:

Monday, July 29, 2024 - 11:42

Efficacy and Safety of Idecabtagene Vicleucel (ide-cel) in Patients with Clinical High-Risk Newly Diagnosed Multiple Myeloma (NDMM) with an Inadequate Response to Frontline Autologous Stem Cell Transplantation (ASCT): KarMMa-2 Cohort 2c Extended Follow-up

Dhodapkar, M. V., Alsina, M., Berdeja, J. G., Patel, K. K., Richard, S., Vij, R., Leleu, X., Egan, D. N., Bergsagel, P. L., Reshef, R., Usmani, S. Z., Truppel-Hartmann, A., Basudhar, D., Thompson, E., Zheng, X., Eliason, L., Zhong, X., Greggio, C., Tran, S., … Siegel, D. S. (2023). Efficacy and Safety of Idecabtagene Vicleucel (ide-cel) in Patients with Clinical High-Risk Newly Diagnosed Multiple Myeloma (NDMM) with an Inadequate Response to Frontline Autologous Stem Cell Transplantation (ASCT): KarMMa-2 Cohort 2c Extended Follow-up. Blood, 142(Supplement 1), 2101–2101. https://doi.org/10.1182/blood-2023-173970

Authors:

Madhav V. Dhodapkar

Melissa Alsina

Jesús G. Berdeja

Krina K. Patel

Shambavi Richard

Ravi Vij

Xavier Leleu

Daniel Egan

P. Leif Bergsagel

Ran Reshef

Saad Z. Usmani

Anna Truppel-Hartmann

Debashree Basudhar

Ethan Thompson

Xirong Zheng

Laurie Eliason

Xiaobo Zhong

Chiara Greggio

Sinhan Tran

Maria Chaudhry

Marlene J. Carrasco-Alfonso

David S. Siegel

Affiliated Authors:

Ran Reshef

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Hematology/Oncology

Subjects:

Diagnosis and Treatment of Multiple Myeloma (OpenAlex Topic)

Targeted Protein Degradation in Biomedical Research (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Publication Type:

Article

Unique ID:

10.1182/blood-2023-173970

DOI:

10.1182/blood-2023-173970

Journal:

Blood

Publication Date:

2023-11-02

Data Source:

OpenAlex

Source Link:

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Record Created:

Wednesday, July 31, 2024 - 12:14

Patterns of Response to 200 Mg Linvoseltamab in Patients with Relapsed/Refractory Multiple Myeloma: Longer Follow-Up of the Linker-MM1 Study

Jagannath, S., Richter, J., Dhodapkar, M. V., Hoffman, J. E., Lee, H. C., Suvannasankha, A., Shah, M. R., Lentzsch, S., Zonder, J. A., Baz, R., Maly, J. J., Namburi, S., Wu, K. L., Pianko, M., Ye, J. C., Silbermann, R., Min, C.-K., Vekemans, M.-C., Munder, M., … Bumma, N. (2023). Patterns of Response to 200 Mg Linvoseltamab in Patients with Relapsed/Refractory Multiple Myeloma: Longer Follow-Up of the Linker-MM1 Study. Blood, 142(Supplement 1), 4746–4746. https://doi.org/10.1182/blood-2023-177968

Authors:

Sundar Jagannath

Joshua Richter

Madhav V. Dhodapkar

James E. Hoffman

Hans C. Lee

Attaya Suvannasankha

Mansi Shah

Suzanne Lentzsch

Jeffrey A. Zonder

Rachid Baz

Joseph Maly

Swathi Namburi

Ka Lung Wu

Matthew J. Pianko

Jing Christine Ye

Rebecca Silbermann

Chang‐Ki Min

Marie‐Christiane Vekemans

Markus Munder

Ja Min Byun

Joaquín Martínez‐López

Michelle DeVeaux

Dhruti Chokshi

Anita Boyapati

Anasuya Hazra

Karen Rodriguez Lorenc

Glenn Kroog

Yariv Houvras

Naresh Bumma

Affiliated Authors:

Suzanne Lentzsch

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Hematology/Oncology

Subjects:

Diagnosis and Treatment of Multiple Myeloma (OpenAlex Topic)

Therapeutic Antibodies: Development, Engineering, and Applications (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Publication Type:

Article

Unique ID:

10.1182/blood-2023-177968

DOI:

10.1182/blood-2023-177968

Journal:

Blood

Publication Date:

2023-11-02

Data Source:

OpenAlex

Source Link:

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Record Created:

Wednesday, July 31, 2024 - 12:16

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

Fu, J., Li, S., Liu, G., MA, H., Marcireau, C., Mapara, M., & Lentzsch, S. (2023). Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways. Blood, 142(Supplement 1), 6618–6618. https://doi.org/10.1182/blood-2023-190740

Authors:

Jing Fu

Shirong Li

Guifen Liu

Huihui Ma

Christophe Marcireau

Markus Y. Mapara

Suzanne Lentzsch

Affiliated Authors:

Jing Fu

Shirong Li

Guifen Liu

Markus Y. Mapara

Suzanne Lentzsch

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Hematology/Oncology

Subjects:

Diagnosis and Treatment of Multiple Myeloma (OpenAlex Topic)

Mammalian MAP Kinase Signaling Pathways (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Publication Type:

Article

Unique ID:

10.1182/blood-2023-190740

DOI:

10.1182/blood-2023-190740

Journal:

Blood

Publication Date:

2023-11-02

Data Source:

OpenAlex

Source Link:

View OpenAlex Record

Record Created:

Wednesday, July 31, 2024 - 12:15

Excellent PFS and OS of Newly Diagnosed Multiple Myeloma Patients Receiving Carfilzomib, Bendamustine, and Dexamethasone (KBD): A 6.5 Year Follow-up

Hughes, M. S., Leng, S., Chakraborty, R., Bhutani, D., Mapara, M., Raza, S., & Lentzsch, S. (2023). Excellent PFS and OS of Newly Diagnosed Multiple Myeloma Patients Receiving Carfilzomib, Bendamustine, and Dexamethasone (KBD): A 6.5 Year Follow-up. Blood, 142(Supplement 1), 6576–6576. https://doi.org/10.1182/blood-2023-182842

Authors:

Michael Sang Hughes

Siyang Leng

Rajshekhar Chakraborty

Divaya Bhutani

Markus Y. Mapara

Shahzad Raza

Suzanne Lentzsch

Affiliated Authors:

Michael Sang Hughes

Rajshekhar Chakraborty

Divaya Bhutani

Markus Y. Mapara

Suzanne Lentzsch

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Hematology/Oncology

Subjects:

Diagnosis and Treatment of Multiple Myeloma (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Publication Type:

Article

Unique ID:

10.1182/blood-2023-182842

DOI:

10.1182/blood-2023-182842

Journal:

Blood

Publication Date:

2023-11-02

Data Source:

OpenAlex

Source Link:

View OpenAlex Record

Record Created:

Wednesday, July 31, 2024 - 12:16

Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

Kim, S., Carvajal, R., Kim, M., & Yang, H. W. (2023). Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma. Cell Reports, 42(6), 112570. https://doi.org/10.1016/j.celrep.2023.112570

Authors:

Sung Soo Kim

Richard D. Carvajal

Minah Kim

Hee Won Yang

Affiliated Authors:

Sung Soo Kim

Richard D. Carvajal

Minah Kim

Hee Won Yang

Columbia Affiliation:

Subjects:

Melanoma (MeSH)

Mitogen-Activated Protein Kinase Kinases (MeSH)

Mammalian MAP Kinase Signaling Pathways (OpenAlex Topic)

Computational Methods in Drug Discovery (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Author Keywords:

braf

cp: cancer

erk

rtk

melanoma

persister cells

signaling dynamics

Grants:

R37CA266270 (NIH – National Cancer Institute)

P30CA013696 (NIH – National Cancer Institute)

R03AG073833 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/j.celrep.2023.112570

PMID:

37252843

DOI:

10.1016/j.celrep.2023.112570

Journal:

Cell Reports

Publication Date:

2023-06-01

Data Source:

OpenAlex

Source Link:

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Record Created:

Monday, August 12, 2024 - 10:47

MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma

Li, S., Fu, J., Yang, J., Ma, H., Mapara, M. Y., Marcireau, C., & Lentzsch, S. (2021). MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma. Blood, 138(Supplement 1), 2662–2662. https://doi.org/10.1182/blood-2021-151844

Authors:

Shirong Li

Jing Fu

Jun Yang

Huihui Ma

Markus Y. Mapara

Christophe Marcireau

Suzanne Lentzsch

Affiliated Authors:

Shirong Li

Jing Fu

Jun Yang

Huihui Ma

Markus Y. Mapara

Suzanne Lentzsch

Columbia Affiliation:

Subjects:

Diagnosis and Treatment of Multiple Myeloma (OpenAlex Topic)

Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)

Targeted Protein Degradation in Biomedical Research (OpenAlex Topic)

Publication Type:

Article

Unique ID:

10.1182/blood-2021-151844

DOI:

10.1182/blood-2021-151844

Journal:

Blood

Publication Date:

2021-11-05

Data Source:

OpenAlex

Source Link:

View OpenAlex Record

Record Created:

Thursday, May 8, 2025 - 11:42