Carcinoma, Pancreatic Ductal

Displaying 1 - 39 of 39CSV
Resell, M., Rabben, H.-L., Sharma, A., Hagen, L., Hoang, L., Skogaker, N. T., Aarvik, A., Bjåstad, E. K., Svensson, M. K., Amrutkar, M., Verbeke, C. S., Batra, S. K., Qvigstad, G., Wang, T. C., Rustgi, A., Chen, D., & Zhao, C.-M. (2025). Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma. Scientific Data, 12(1). https://doi.org/10.1038/s41597-025-04522-x
Publication Date
Patel, S. H., Colby, S., Sohal, D., Guthrie, K. A., Kachnic, L. A., Chiorean, E. G., Lowy, A. M., Rocha, F. G., Hochster, H. S., Philip, P. A., & Ahmad, S. A. (2025). Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505. Cancer, 131(4). Portico. https://doi.org/10.1002/cncr.35759
Publication Date
May, M. S., Park, H., Moallem, D. H., Seeram, D., Dajiang, S., Hibshoosh, H., Jamison, J. K., Uhlemann, A.-C., & Manji, G. A. (2024). Low Bacterial Biomass in Human Pancreatic Cancer and Adjacent Normal Tissue. International Journal of Molecular Sciences, 26(1), 140. https://doi.org/10.3390/ijms26010140
Publication Date
Smith, L. M., Mahoney, D. W., Bamlet, W. R., Yu, F., Liu, S., Goggins, M. G., Darabi, S., Majumder, S., Wang, Q.-L., Coté, G. A., Demeure, M. J., Zhang, Z., Srivastava, S., Chawla, A., Izmirlian, G., Olson, J. E., Wolpin, B. M., Genkinger, J. M., Zaret, K. S., … Oberg, A. L. (2024). Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies. Pancreatology, 24(8), 1265–1279. https://doi.org/10.1016/j.pan.2024.10.012
Publication Date
Carpenter, E. S., Vendramini-Costa, D. B., Hasselluhn, M. C., Maitra, A., Olive, K. P., Cukierman, E., Pasca di Magliano, M., & Sherman, M. H. (2024). Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here? Cancer Research, 84(21), 3505–3508. https://doi.org/10.1158/0008-5472.can-24-2860
Publication Date
Huang, C., Hecht, E. M., Soloff, E. V., Tiwari, H. A., Bhosale, P. R., Dasayam, A., Galgano, S. J., Kambadakone, A., Kulkarni, N. M., Le, O., Liau, J., Luk, L., Rosenthal, M. H., Sangster, G. P., & Goenka, A. H. (2024). Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs. American Journal of Roentgenology, 223(2). https://doi.org/10.2214/ajr.24.31151
Publication Date
Blackford, A. L., Canto, M. I., Dbouk, M., Hruban, R. H., Katona, B. W., Chak, A., Brand, R. E., Syngal, S., Farrell, J., Kastrinos, F., Stoffel, E. M., Rustgi, A., Klein, A. P., Kamel, I., Fishman, E. K., He, J., Burkhart, R., Shin, E. J., Lennon, A. M., & Goggins, M. (2024). Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology, 10(8), 1087. https://doi.org/10.1001/jamaoncol.2024.1930
Publication Date
Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z
Publication Date
Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
Publication Date
Ben-Ami, R., Wang, Q.-L., Zhang, J., Supplee, J. G., Fahrmann, J. F., Lehmann-Werman, R., Brais, L. K., Nowak, J., Yuan, C., Loftus, M., Babic, A., Irajizad, E., Davidi, T., Zick, A., Hubert, A., Neiman, D., Piyanzin, S., Gal-Rosenberg, O., Horn, A., … Wolpin, B. M. (2023). Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer. Gut, gutjnl-2023-331074. https://doi.org/10.1136/gutjnl-2023-331074
Publication Date
Hasselluhn, M. C., Decker-Farrell, A. R., Vlahos, L., Thomas, D. H., Curiel-Garcia, A., Maurer, H. C., Wasko, U. N., Tomassoni, L., Sastra, S. A., Palermo, C. F., Dalton, T. C., Ma, A., Li, F., Tolosa, E. J., Hibshoosh, H., Fernandez-Zapico, M. E., Muir, A., Califano, A., & Olive, K. P. (2023). Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression. Cancer Discovery, 14(2), 348–361. https://doi.org/10.1158/2159-8290.cd-23-0240
Publication Date
Decker-Farrell, A. R., Ma, A., Li, F., Muir, A., & Olive, K. P. (2023). Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants. STAR Protocols, 4(4), 102711. https://doi.org/10.1016/j.xpro.2023.102711
Publication Date
Ferguson, L. P., Gatchalian, J., McDermott, M. L., Nakamura, M., Chambers, K., Rajbhandari, N., Lytle, N. K., Rosenthal, S. B., Hamilton, M., Albini, S., Wartenberg, M., Zlobec, I., Galván, J. A., Karamitopoulou, E., Vavinskaya, V., Wascher, A., Lowy, A. M., Schürch, C. M., Puri, P. L., … Reya, T. (2023). Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-35796-7
Publication Date
Park, J., Lim, F., Prest, M., Ferris, J. S., Aziz, Z., Agyekum, A., Wagner, S., Gulati, R., & Hur, C. (2023). Quantifying the potential benefits of early detection for pancreatic cancer through a counterfactual simulation modeling analysis. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-46751-3
Publication Date
Jung, H.-S., Lee, M., Han, Y., Thomas, A. S., Yun, W.-G., Cho, Y. J., Kluger, M. D., Jang, J.-Y., & Kwon, W. (2024). Inadequacy of the eighth edition of the American Joint Committee on Cancer pancreatic cancer staging system for invasive carcinoma associated with premalignant lesions in the pancreas: an analysis using the National Cancer Database. HPB, 26(3), 400–409. https://doi.org/10.1016/j.hpb.2023.11.015
Publication Date
Boutin, R., Lee, H.-F., Guan, T. L., Nguyen, T. T., Huang, X. F., Waller, D. D., Lu, J., Christine Chio, I. I., Michel, R. P., Sebag, M., & Tsantrizos, Y. S. (2023). Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry, 66(23), 15776–15800. https://doi.org/10.1021/acs.jmedchem.3c01271
Publication Date
Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., Lytle, N. K., McDermott, M., Diaz, E., Pettit, H., Kritzik, M., Han, H., Cridebring, D., Wen, K. W., Tsai, S., Goggins, M. G., Lowy, A. M., … Reya, T. (2023). Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell, 41(11), 1989-2005.e9. https://doi.org/10.1016/j.ccell.2023.09.008
Publication Date
Hasselluhn, M. C., Schlösser, D., Versemann, L., Schmidt, G. E., Ulisse, M., Oschwald, J., Zhang, Z., Hamdan, F., Xiao, H., Kopp, W., Spitalieri, J., Kellner, C., Schneider, C., Reutlinger, K., Nagarajan, S., Steuber, B., Sastra, S. A., Palermo, C. F., Appelhans, J., … Hessmann, E. (2024). An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies. Gastroenterology, 166(2), 298-312.e14. https://doi.org/10.1053/j.gastro.2023.10.026
Publication Date
Lee, M., Thomas, A. S., Lee, S. Y., Cho, Y. J., Jung, H.-S., Yun, W.-G., Han, Y., Jang, J.-Y., Kluger, M. D., & Kwon, W. (2023). Reconsidering the absence of extrapancreatic extension in T staging for pancreatic adenocarcinoma in the AJCC (8th ed) Staging Manual using the National Cancer Database. Journal of Gastrointestinal Surgery, 27(11), 2484–2492. https://doi.org/10.1007/s11605-023-05850-2
Publication Date
Jiang, Z., Wu, F., Laise, P., Takayuki, T., Na, F., Kim, W., Kobayashi, H., Chang, W., Takahashi, R., Valenti, G., Sunagawa, M., White, R. A., Macchini, M., Renz, B. W., Middelhoff, M., Hayakawa, Y., Dubeykovskaya, Z. A., Tan, X., Chu, T. H., … Wang, T. C. (2023). Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis. Cell Stem Cell, 30(8), 1091-1109.e7. https://doi.org/10.1016/j.stem.2023.07.002
Publication Date
Yun, W., Han, Y., Lee, M., Cho, Y. J., Jung, H., Thomas, A. S., Kluger, M. D., Kwon, W., & Jang, J. (2023). The role of local treatment including pancreatectomy for pancreatic ductal adenocarcinoma patients with isolated synchronous liver metastasis: Propensity score‐matched analyses. Journal of Hepato-Biliary-Pancreatic Sciences, 30(8), 1036–1045. Portico. https://doi.org/10.1002/jhbp.1313
Publication Date
Goel, N., Rhim, A. D., Xi, H., Olive, K. P., Thomas, A. S., Kwon, W., Schwartz, J., Sugahara, K. N., Schrope, B. A., Chabot, J. A., & Kluger, M. D. (2022). Transfusion of salvaged red blood cells during pancreatic ductal adenocarcinoma operations. British Journal of Surgery, 110(8), 917–919. https://doi.org/10.1093/bjs/znac393
Publication Date
Lo, E. K. W., Mears, B. M., Maurer, H. C., Idrizi, A., Hansen, K. D., Thompson, E. D., Hruban, R. H., Olive, K. P., & Feinberg, A. P. (2023). Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis. Cancer Research, 83(11), 1905–1916. https://doi.org/10.1158/0008-5472.can-22-4052
Publication Date
Ko, A. H., Kim, K.-P., Siveke, J. T., Lopez, C. D., Lacy, J., O’Reilly, E. M., Macarulla, T., Manji, G. A., Lee, J., Ajani, J., Alsina Maqueda, M., Rha, S.-Y., Lau, J., Al-Sakaff, N., Allen, S., Lu, D., Shemesh, C. S., Gan, X., Cha, E., & Oh, D.-Y. (2023). Atezolizumab Plus PEGPH20 Versus Chemotherapy in Advanced Pancreatic Ductal Adenocarcinoma and Gastric Cancer: MORPHEUS Phase Ib/II Umbrella Randomized Study Platform. The Oncologist, 28(6), 553-e472. https://doi.org/10.1093/oncolo/oyad022
Publication Date
Katona, B. W., Klute, K., Brand, R. E., Everett, J. N., Farrell, J. J., Hawthorne, K., Kaul, V., Kupfer, S. S., Paiella, S., Simeone, D. M., Sussman, D. A., Zogopoulos, G., Lucas, A. L., Kastrinos, F., Bi, Y., Brentnall, T., Chung, D., Earl, J., … Wadlow, R. (2023). Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance. Cancer Prevention Research, 16(6), 343–352. https://doi.org/10.1158/1940-6207.capr-22-0529
Publication Date
May, M. S., Jamison, J. K., Wong, W., Michel, A., Raufi, A. G., Neugut, A. I., & Manji, G. A. (2023). Smoking is Not Associated with Lung Metastasis in Pancreatic Cancer. Cancer Investigation, 41(5), 487–490. https://doi.org/10.1080/07357907.2023.2203747
Publication Date
Fulop, D. J., Zylberberg, H. M., Wu, Y. L., Aronson, A., Labiner, A. J., Wisnivesky, J., Cohen, D. J., Sigel, K. M., & Lucas, A. L. (2023). Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy. JAMA Network Open, 6(3), e234254. https://doi.org/10.1001/jamanetworkopen.2023.4254
Publication Date
McBrearty, N., Cho, C., Chen, J., Zahedi, F., Peck, A. R., Radaelli, E., Assenmacher, C.-A., Pavlak, C., Devine, A., Yu, P., Lu, Z., Zhang, H., Li, J., Pitarresi, J. R., Astsaturov, I., Cukierman, E., Rustgi, A. K., Stanger, B. Z., Rui, H., & Fuchs, S. Y. (2022). Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. Molecular Cancer Research, 21(3), 228–239. https://doi.org/10.1158/1541-7786.mcr-22-0602
Publication Date
Parejo-Alonso, B., Royo-García, A., Espiau-Romera, P., Courtois, S., Curiel-García, Á., Zagorac, S., Villaoslada, I., Olive, K. P., Heeschen, C., & Sancho, P. (2023). Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma. Biomedicine & Pharmacotherapy, 158, 114162. https://doi.org/10.1016/j.biopha.2022.114162
Publication Date
Kim, H. S., Song, W., Choo, W., Lee, S., Han, Y., Bassi, C., Salvia, R., Marchegiani, G., Wolfgang, C. L., He, J., Blair, A. B., Kluger, M. D., Su, G. H., Kim, S. C., Song, K., Yamamoto, M., Hatori, T., Yang, C., Yamaue, H., … Jang, J. (2021). Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study. Journal of Hepato-Biliary-Pancreatic Sciences, 30(1), 133–143. Portico. https://doi.org/10.1002/jhbp.962
Publication Date
Chu, L. C., Wang, Z. J., Kambadakone, A., Hecht, E. M., He, J., Narang, A. K., Laheru, D. A., Arif-Tiwari, H., Bhosale, P., Bolan, C. W., Brook, O. R., Bezuidenhout, A. F., Do, R. K. G., Galgano, S. J., Goenka, A. H., Guimaraes, A. R., Hough, D. M., Kulkarni, N., Le, O., … Zaheer, A. (2022). Postoperative surveillance of pancreatic ductal adenocarcinoma (PDAC) recurrence: practice pattern on standardized imaging and reporting from the society of abdominal radiology disease focus panel on PDAC. Abdominal Radiology, 48(1), 318–339. https://doi.org/10.1007/s00261-022-03693-0
Publication Date
Gartrell, R. D., Enzler, T., Kim, P. S., Fullerton, B. T., Fazlollahi, L., Chen, A. X., Minns, H. E., Perni, S., Weisberg, S. P., Rizk, E. M., Wang, S., Oh, E. J., Guo, X. V., Chiuzan, C., Manji, G. A., Bates, S. E., Chabot, J., Schrope, B., Kluger, M., … Saenger, Y. M. (2022). Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma. OncoImmunology, 11(1). https://doi.org/10.1080/2162402x.2022.2066767
Publication Date
Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., Li, Y., Dozier, S., Nair, A., Filliol, A., Sinchai, N., Rosenthal, S. B., Santini, J., Metallo, C. M., Molina, A., … Karin, M. (2022). Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature, 610(7931), 366–372. https://doi.org/10.1038/s41586-022-05169-z
Publication Date
Dbouk, M., Katona, B. W., Brand, R. E., Chak, A., Syngal, S., Farrell, J. J., Kastrinos, F., Stoffel, E. M., Blackford, A. L., Rustgi, A. K., Dudley, B., Lee, L. S., Chhoda, A., Kwon, R., Ginsberg, G. G., Klein, A. P., Kamel, I., Hruban, R. H., He, J., … Goggins, M. (2022). The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival. Journal of Clinical Oncology, 40(28), 3257–3266. https://doi.org/10.1200/jco.22.00298
Publication Date
Ingram, M. A., Lauren, B. N., Pumpalova, Y., Park, J., Lim, F., Bates, S. E., Kastrinos, F., Manji, G. A., Kong, C. Y., & Hur, C. (2022). Cost‐effectiveness of neoadjuvant FOLFIRINOX versus gemcitabine plus nab‐paclitaxel in borderline resectable/locally advanced pancreatic cancer patients. Cancer Reports, 5(9). Portico. https://doi.org/10.1002/cnr2.1565
Publication Date
Peters, M. L. B., Eckel, A., Lietz, A., Seguin, C., Mueller, P., Hur, C., & Pandharipande, P. V. (2022). Genetic testing to guide screening for pancreatic ductal adenocarcinoma: Results of a microsimulation model. Pancreatology, 22(6), 760–769. https://doi.org/10.1016/j.pan.2022.05.003
Publication Date
He, D., Feng, H., Sundberg, B., Yang, J., Powers, J., Christian, A. H., Wilkinson, J. E., Monnin, C., Avizonis, D., Thomas, C. J., Friedman, R. A., Kluger, M. D., Hollingsworth, M. A., Grandgenett, P. M., Klute, K. A., Toste, F. D., Chang, C. J., & Chio, I. I. C. (2022). Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Molecular Cell, 82(16), 3045-3060.e11. https://doi.org/10.1016/j.molcel.2022.06.005
Publication Date
Kurz, E., Hirsch, C. A., Dalton, T., Shadaloey, S. A., Khodadadi-Jamayran, A., Miller, G., Pareek, S., Rajaei, H., Mohindroo, C., Baydogan, S., Ngo-Huang, A., Parker, N., Katz, M. H. G., Petzel, M., Vucic, E., McAllister, F., Schadler, K., Winograd, R., & Bar-Sagi, D. (2022). Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell, 40(7), 720-737.e5. https://doi.org/10.1016/j.ccell.2022.05.006
Publication Date