Antineoplastic Agents

Displaying 1 - 50 of 65CSV
Tannock, I. F., de Vries, E. G. E., Fojo, A., Buyse, M., & Moja, L. (2025). Dose optimisation to improve access to effective cancer medicines. The Lancet Oncology, 26(3), e171–e180. https://doi.org/10.1016/s1470-2045(24)00648-x
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Laothamatas, K., Benvenuto, L., Raval, M., Kim, F., Lemaitre, P. H., Sonett, J. R., & Arcasoy, S. M. (2025). Successful Lung Transplantation in A Patient With Pre-Existing Chronic Myeloid Leukemia Treated With Imatinib: A Case Report. Transplantation Proceedings, 57(3), 491–494. https://doi.org/10.1016/j.transproceed.2025.02.020
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Rafic, E., Ma, C., Shih, B. B., Miller, H., Yuste, R., Palomero, T., & Etchenique, R. (2024). RuBi-Ruxolitinib: A Photoreleasable Antitumor JAK Inhibitor. Journal of the American Chemical Society, 146(19), 13317–13325. https://doi.org/10.1021/jacs.4c01720
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Nadezhdin, K. D., Correia, L., Shalygin, A., Aktolun, M., Neuberger, A., Gudermann, T., Kurnikova, M. G., Chubanov, V., & Sobolevsky, A. I. (2024). Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Cell Reports, 43(4), 114108. https://doi.org/10.1016/j.celrep.2024.114108
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Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z
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Abou-Alfa, G. K., Geyer, S. M., Nixon, A. B., Innocenti, F., Shi, Q., Kumthekar, P., Jacobson, S., El Dika, I., Yaqubie, A., Lopez, J., Huang, B., Tang, Y.-W., Wen, Y., Schwartz, L. H., El-Khoueiry, A. B., Knox, J. J., Rajdev, L., Bertagnolli, M. M., Meyerhardt, J. A., … Venook, A. P. (2024). CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma. Cancer Research Communications, 4(3), 682–690. https://doi.org/10.1158/2767-9764.crc-22-0516
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Wang, K., Du, R., Myall, N. J., Lewis, W. E., Uy, N., Hong, L., Skoulidis, F., Byers, L. A., Tsao, A., Cascone, T., Pozadzides, J., Tu, J., Negrao, M. V., Gibbons, D. L., Park, K., Rinsurongkawong, W., Lee, J. J., Gandara, D., Behl, D., … Le, X. (2024). Real-World Efficacy and Safety of Amivantamab for EGFR-Mutant NSCLC. Journal of Thoracic Oncology, 19(3), 500–506. https://doi.org/10.1016/j.jtho.2023.11.020
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Brivio, E., Pennesi, E., Willemse, M. E., Huitema, A. D. R., Jiang, Y., van Tinteren, H. D. R., van der Velden, V. H. J., Beverloo, B. H., den Boer, M. L., Rammeloo, L. A. J., Hudson, C., Heerema, N., Kowalski, K., Zhao, H., Kuttschreuter, L., Bautista Sirvent, F. J., Bukowinski, A., Rizzari, C., Pollard, J., … Zwaan, C. M. (2024). Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921. Journal of Clinical Oncology, 42(7), 821–831. https://doi.org/10.1200/jco.23.00897
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Yandamuri, S. S., Filipek, B., Lele, N., Cohen, I., Bennett, J. L., Nowak, R. J., Sotirchos, E. S., Longbrake, E. E., Mace, E. M., & O’Connor, K. C. (2024). A Noncanonical CD56dimCD16dim/− NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. The Journal of Immunology, 212(5), 785–800. https://doi.org/10.4049/jimmunol.2300015
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Cao, Q., Hajosch, A., Kast, R. E., Loehmann, C., Hlavac, M., Fischer-Posovszky, P., Strobel, H., Westhoff, M.-A., Siegelin, M. D., Wirtz, C. R., Halatsch, M.-E., & Karpel-Massler, G. (2024). Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro. British Journal of Cancer, 130(8), 1365–1376. https://doi.org/10.1038/s41416-024-02608-8
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Chen, F., Tang, C., Yang, F., Ekpenyong, A., Qin, R., Xie, J., Momen-Heravi, F., Saba, N. F., & Teng, Y. (2024). HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer. Science Advances, 10(8). https://doi.org/10.1126/sciadv.adk3663
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Maués, J., Loeser, A., Cowden, J., Johnson, S., Carlson, M., & Lee, S. (2024). The patient perspective on dose optimization for anticancer treatments: A new era of cancer drug dosing—Challenging the “more is better” dogma. Clinical Trials, 21(3), 358–362. https://doi.org/10.1177/17407745241232428
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Bloomhardt, H., Rubin, M., Xue, Y., Jin, Z., Masino, L., Seidel, D., Hijiya, N., & Beauchemin, M. (2024). Pediatric oncology provider perspectives and patient/family perceptions of chemotherapy‐induced nausea and vomiting management: Experiences at an academic medical center. Pediatric Blood & Cancer, 71(4). Portico. https://doi.org/10.1002/pbc.30883
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Garralda, E., Schram, A. M., Bedard, P. L., Schwartz, G. K., Yuen, E., McNeely, S. C., Ribeiro, S., Cunningham, J., Wang, Y., Urunuela, A., Xu, X., & LoRusso, P. (2023). A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors. The Oncologist, 29(1), e131–e140. https://doi.org/10.1093/oncolo/oyad215
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Hijiya, N., Maschan, A., Rizzari, C., Shimada, H., Dufour, C., Goto, H., Kang, H. J., Guinipero, T., Karakas, Z., Bautista, F., Ducassou, S., Yoo, K. H., Zwaan, C. M., Millot, F., Patterson, B. C., Samis, J., Izquierdo, M., Titorenko, K., Li, S., & Sosothikul, D. (2023). The long-term efficacy and safety of nilotinib in pediatric patients with CML: a 5-year update of the DIALOG study. Blood Advances, 7(23), 7279–7289. https://doi.org/10.1182/bloodadvances.2023010122
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Lichtenstein, M. R. L., Beauchemin, M. P., Raghunathan, R., Lee, S., Doshi, S. D., Law, C., Accordino, M. K., Elkin, E. B., Wright, J. D., & Hershman, D. L. (2024). Association Between Copayment Assistance, Insurance Type, Prior Authorization, and Time to Receipt of Oral Anticancer Drugs. JCO Oncology Practice, 20(1), 85–92. https://doi.org/10.1200/op.23.00205
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Zeng, Y., Arisa, O., Peer, C. J., Fojo, A., & Figg, W. D. (2024). PARP inhibitors: A review of the pharmacology, pharmacokinetics, and pharmacogenetics. Seminars in Oncology, 51(1–2), 19–24. https://doi.org/10.1053/j.seminoncol.2023.09.005
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Chakraborty, R., Milani, P., Palladini, G., & Gertz, M. (2023). Role of autologous haematopoietic cell transplantation in the treatment of systemic light chain amyloidosis in the era of anti-CD38 monoclonal antibodies. The Lancet Haematology, 10(11), e936–e940. https://doi.org/10.1016/s2352-3026(23)00175-8
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Liu, Y., Reiken, S., Dridi, H., Yuan, Q., Mohammad, K. S., Trivedi, T., Miotto, M. C., Wedderburn-Pugh, K., Sittenfeld, L., Kerley, Y., Meyer, J. A., Peters, J. S., Persohn, S. C., Bedwell, A. A., Figueiredo, L. L., Suresh, S., She, Y., Soni, R. K., Territo, P. R., … Guise, T. A. (2023). Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice. Science Translational Medicine, 15(715). https://doi.org/10.1126/scitranslmed.adf8977
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Anderson, A., Rowles, W., Poole, S., Balan, A., Bevan, C., Brandstadter, R., Ciplea, A. I., Cooper, J., Fabian, M., Hale, T. W., Jacobs, D., Kakara, M., Krysko, K. M., Longbrake, E. E., Marcus, J., Repovic, P., Riley, C. S., Romeo, A. R., Rutatangwa, A., … Bove, R. (2023). Anti‐CD20 monoclonal antibody therapy in postpartum women with neurological conditions. Annals of Clinical and Translational Neurology, 10(11), 2053–2064. Portico. https://doi.org/10.1002/acn3.51893
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Tavares, L. M., de Jesus, L. C. L., Batista, V. L., Barroso, F. A. L., dos Santos Freitas, A., Campos, G. M., Américo, M. F., da Silva, T. F., Coelho-Rocha, N. D., Belo, G. A., Drumond, M. M., Mancha-Agresti, P., Vital, K. D., Fernandes, S. O. A., Cardoso, V. N., Birbrair, A., Ferreira, E., Martins, F. S., Laguna, J. G., & Azevedo, V. (2023). Synergistic synbiotic containing fructooligosaccharides and Lactobacillus delbrueckii CIDCA 133 alleviates chemotherapy-induced intestinal mucositis in mice. World Journal of Microbiology and Biotechnology, 39(9). https://doi.org/10.1007/s11274-023-03679-0
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Suzuki, Y., Zhou, S., Ota, Y., Harrington, M., Miyagi, E., Takagi, H., Kuno, T., & Wright, J. D. (2023). Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta-analysis. JNCI Cancer Spectrum, 7(5). https://doi.org/10.1093/jncics/pkad069
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Viragova, S., Aparicio, L., Palmerini, P., Zhao, J., Valencia Salazar, L. E., Schurer, A., Dhuri, A., Sahoo, D., Moskaluk, C. A., Rabadan, R., & Dalerba, P. (2023). Inverse agonists of retinoic acid receptor/retinoid X receptor signaling as lineage-specific antitumor agents against human adenoid cystic carcinoma. JNCI: Journal of the National Cancer Institute, 115(7), 838–852. https://doi.org/10.1093/jnci/djad062
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Mato, A. R., Woyach, J. A., Brown, J. R., Ghia, P., Patel, K., Eyre, T. A., Munir, T., Lech-Maranda, E., Lamanna, N., Tam, C. S., Shah, N. N., Coombs, C. C., Ujjani, C. S., Fakhri, B., Cheah, C. Y., Patel, M. R., Alencar, A. J., Cohen, J. B., Gerson, J. N., … Jurczak, W. (2023). Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia. New England Journal of Medicine, 389(1), 33–44. https://doi.org/10.1056/nejmoa2300696
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Shadman, M., Manzoor, B. S., Sail, K., Tuncer, H. H., Allan, J. N., Ujjani, C., Emechebe, N., Kamalakar, R., Coombs, C. C., Leslie, L., Barr, P. M., Brown, J. R., Eyre, T. A., Rampotas, A., Schuh, A., Lamanna, N., Skarbnik, A., Roeker, L. E., Bannerji, R., … Mato, A. R. (2023). Treatment Discontinuation Patterns for Patients With Chronic Lymphocytic Leukemia in Real-World Settings: Results From a Multi-Center International Study. Clinical Lymphoma Myeloma and Leukemia, 23(7), 515–526. https://doi.org/10.1016/j.clml.2023.03.010
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Ellingson, B. M., Wen, P. Y., Chang, S. M., van den Bent, M., Vogelbaum, M. A., Li, G., Li, S., Kim, J., Youssef, G., Wick, W., Lassman, A. B., Gilbert, M. R., de Groot, J. F., Weller, M., Galanis, E., & Cloughesy, T. F. (2023). Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival. Neuro-Oncology, 25(6), 1017–1028. https://doi.org/10.1093/neuonc/noad002
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Mundi, P. S., Dela Cruz, F. S., Grunn, A., Diolaiti, D., Mauguen, A., Rainey, A. R., Guillan, K., Siddiquee, A., You, D., Realubit, R., Karan, C., Ortiz, M. V., Douglass, E. F., Accordino, M., Mistretta, S., Brogan, F., Bruce, J. N., Caescu, C. I., Carvajal, R. D., … Califano, A. (2023). A Transcriptome-Based Precision Oncology Platform for Patient–Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies. Cancer Discovery, 13(6), 1386–1407. https://doi.org/10.1158/2159-8290.cd-22-1020
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Mair, M. J., Bartsch, R., Le Rhun, E., Berghoff, A. S., Brastianos, P. K., Cortes, J., Gan, H. K., Lin, N. U., Lassman, A. B., Wen, P. Y., Weller, M., van den Bent, M., & Preusser, M. (2023). Understanding the activity of antibody–drug conjugates in primary and secondary brain tumours. Nature Reviews Clinical Oncology, 20(6), 372–389. https://doi.org/10.1038/s41571-023-00756-z
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Michel, A., Lee, R. T., Salehi, E., & Accordino, M. K. (2023). Improving Quality of Life During Chemotherapy: Cannabinoids, Cryotherapy, and Scalp Cooling. American Society of Clinical Oncology Educational Book, 43. https://doi.org/10.1200/edbk_390428
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Lim, E. A., Schweizer, M. T., Chi, K. N., Aggarwal, R., Agarwal, N., Gulley, J., Attiyeh, E., Greger, J., Wu, S., Jaiprasart, P., Loffredo, J., Bandyopadhyay, N., Xie, H., & Hansen, A. R. (2023). Phase 1 Study of Safety and Preliminary Clinical Activity of JNJ-63898081, a PSMA and CD3 Bispecific Antibody, for Metastatic Castration-Resistant Prostate Cancer. Clinical Genitourinary Cancer, 21(3), 366–375. https://doi.org/10.1016/j.clgc.2023.02.010
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Kim, D.-W., Kim, S.-W., Camidge, D. R., Shu, C. A., Marrone, K. A., Le, X., Blakely, C. M., Park, K., Chang, G.-C., Patel, S. P., Kar, G., Cooper, Z. A., Samadani, R., Pluta, M., Kumar, R., & Ramalingam, S. (2023). CD73 Inhibitor Oleclumab Plus Osimertinib in Previously Treated Patients With Advanced T790M-Negative EGFR-Mutated NSCLC: A Brief Report. Journal of Thoracic Oncology, 18(5), 650–656. https://doi.org/10.1016/j.jtho.2022.12.021
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Ayaz, P., Lyczek, A., Paung, Y., Mingione, V. R., Iacob, R. E., de Waal, P. W., Engen, J. R., Seeliger, M. A., Shan, Y., & Shaw, D. E. (2023). Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36956-5
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LaRose, M., Connolly, R. M., O’Sullivan, C. C., Velcheti, V., Vilimas, R., Gano, K., Bates, S. E., Pommier, Y., & Thomas, A. (2023). A Phase I Study of a Combination of Liposomal Irinotecan and Veliparib in Solid Tumors. The Oncologist, 28(5), 460-e298. https://doi.org/10.1093/oncolo/oyad023
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Gounder, M. M., Bauer, T. M., Schwartz, G. K., Weise, A. M., LoRusso, P., Kumar, P., Tao, B., Hong, Y., Patel, P., Lu, Y., Lesegretain, A., Tirunagaru, V. G., Xu, F., Doebele, R. C., & Hong, D. S. (2023). A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas. Journal of Clinical Oncology, 41(9), 1714–1724. https://doi.org/10.1200/jco.22.01285
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Fu, S., Yao, S., Yuan, Y., Previs, R. A., Elias, A. D., Carvajal, R. D., George, T. J., Yuan, Y., Yu, L., Westin, S. N., Xing, Y., Dumbrava, E. E., Karp, D. D., Piha-Paul, S. A., Tsimberidou, A. M., Ahnert, J. R., Takebe, N., Lu, K., Keyomarsi, K., & Meric-Bernstam, F. (2023). Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification. Journal of Clinical Oncology, 41(9), 1725–1734. https://doi.org/10.1200/jco.22.00830
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Tsai, C.-Y., Saito, T., Sarangdhar, M., Abu-El-Haija, M., Wen, L., Lee, B., Yu, M., Lipata, D. A., Manohar, M., Barakat, M. T., Contrepois, K., Tran, T. H., Theoret, Y., Bo, N., Ding, Y., Stevenson, K., Ladas, E. J., Silverman, L. B., Quadro, L., … Husain, S. Z. (2023). A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis. Science Translational Medicine, 15(687). https://doi.org/10.1126/scitranslmed.abn2110
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Guo, C., Figueiredo, I., Gurel, B., Neeb, A., Seed, G., Crespo, M., Carreira, S., Rekowski, J., Buroni, L., Welti, J., Bogdan, D., Gallagher, L., Sharp, A., Fenor de la Maza, M. D., Rescigno, P., Westaby, D., Chandran, K., Riisnaes, R., Ferreira, A., … de Bono, J. S. (2023). B7-H3 as a Therapeutic Target in Advanced Prostate Cancer. European Urology, 83(3), 224–238. https://doi.org/10.1016/j.eururo.2022.09.004
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Siddiqui, B. A., Chapin, B. F., Jindal, S., Duan, F., Basu, S., Yadav, S. S., Gu, A.-D., Espejo, A. B., Kinder, M., Pettaway, C. A., Ward, J. F., Tidwell, R. S. S., Troncoso, P., Corn, P. G., Logothetis, C. J., Knoblauch, R., Hutnick, N., Gottardis, M., Drake, C. G., … Subudhi, S. K. (2023). Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor). Journal for ImmunoTherapy of Cancer, 11(3), e006262. https://doi.org/10.1136/jitc-2022-006262
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Beauchemin, M. P., Lichtenstein, M. R. L., Raghunathan, R., Doshi, S. D., Lee, S., Law, C., Accordino, M. K., Elkin, E. B., Wright, J. D., & Hershman, D. L. (2023). Impact of a Hospital-Based Specialty Pharmacy in Partnership With a Care Coordination Organization on Time to Delivery and Receipt of Oral Anticancer Drugs. JCO Oncology Practice, 19(3), e326–e335. https://doi.org/10.1200/op.22.00451
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Brown, J. R., Eichhorst, B., Hillmen, P., Jurczak, W., Kaźmierczak, M., Lamanna, N., O’Brien, S. M., Tam, C. S., Qiu, L., Zhou, K., Simkovic, M., Mayer, J., Gillespie-Twardy, A., Ferrajoli, A., Ganly, P. S., Weinkove, R., Grosicki, S., Mital, A., Robak, T., … Shadman, M. (2023). Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia. New England Journal of Medicine, 388(4), 319–332. https://doi.org/10.1056/nejmoa2211582
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Araujo, D., Greystoke, A., Bates, S., Bayle, A., Calvo, E., Castelo-Branco, L., de Bono, J., Drilon, A., Garralda, E., Ivy, P., Kholmanskikh, O., Melero, I., Pentheroudakis, G., Petrie, J., Plummer, R., Ponce, S., Postel-Vinay, S., Siu, L., Spreafico, A., … Seymour, L. (2023). Oncology phase I trial design and conduct: time for a change - MDICT Guidelines 2022. Annals of Oncology, 34(1), 48–60. https://doi.org/10.1016/j.annonc.2022.09.158
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Lipsky, A. H., & Lamanna, N. (2022). Novel combination approaches with targeted agents in frontline chronic lymphocytic leukemia. Cancer, 129(1), 18–31. Portico. https://doi.org/10.1002/cncr.34510
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Andrillon, A., Chevret, S., Lee, S. M., & Biard, L. (2022). Surv‐CRM‐12: A Bayesian phase I/II survival CRM for right‐censored toxicity endpoints with competing disease progression. Statistics in Medicine, 41(29), 5753–5766. Portico. https://doi.org/10.1002/sim.9591
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Chaudhary, K. R., Kinslow, C. J., Cheng, H., Silva, J. M., Yu, J., Wang, Tony. J., Hei, T. K., Halmos, B., & Cheng, S. K. (2022). Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-14448-8
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