Melanoma

Displaying 1 - 47 of 47CSV
Dimitriou, F., Orloff, M. M., Koch Hein, E. C., Cheng, P. F., Hughes, I. F., Simeone, E., Montazeri, K., Grover, P., Mehmi, I., Gerard, C. L., Gaudy-Marqueste, C., Grob, J.-J., Michielin, O., Hamid, O., Long, G. V., Sullivan, R., Kapiteijn, E., Johnson, D. B., Ascierto, P. A., … Dummer, R. (2025). Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors. European Journal of Cancer, 214, 115161. https://doi.org/10.1016/j.ejca.2024.115161
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Conway, K., Edmiston, S. N., Vondras, A., Reiner, A., Corcoran, D. L., Shen, R., Parrish, E. A., Hao, H., Lin, L., Kenney, J. M., Ilelaboye, G., Kostrzewa, C. E., Kuan, P. F., Busam, K. J., Lezcano, C., Lee, T. K., Hernando, E., Googe, P. B., Ollila, D. W., … Rainka, M. (2024). DNA Methylation Classes of Stage II and III Primary Melanomas and Their Clinical and Prognostic Significance. JCO Precision Oncology, 8. https://doi.org/10.1200/po-24-00375
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Ma, K. L., Mitchell, T. C., Dougher, M., Sharon, C. E., Tortorello, G. N., Elder, D. E., Morgan, E. E., Gimotty, P. A., Huang, A. C., Amaravadi, R. K., Schuchter, L. M., Flowers, A., Miura, J. T., Karakousis, G. C., & Xu, X. (2024). Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival. Clinical Cancer Research, 30(21), 4987–4994. https://doi.org/10.1158/1078-0432.ccr-23-3775
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Ventin, M., Cattaneo, G., Arya, S., Jia, J., Gelmi, M. C., Sun, Y., Maggs, L., Ksander, B. R., Verdijk, R. M., Boland, G. M., Jenkins, R. W., Haq, R., Jager, M. J., Wang, X., Ryeom, S., & Ferrone, C. R. (2024). Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting. Clinical Cancer Research, 30(15), 3243–3258. https://doi.org/10.1158/1078-0432.ccr-24-0071
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Kinslow, C. J., DeStephano, D. M., Neugut, A. I., Taparra, K., Horowitz, D. P., Yu, J. B., & Cheng, S. K. (2024). Site-specific patterns of early-stage cancer diagnosis during the COVID-19 pandemic. JNCI Cancer Spectrum, 8(3). https://doi.org/10.1093/jncics/pkae022
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Wu, L. W., Tao, J. J., McDonnell, D., & Izar, B. (2024). Pseudoprogression in a patient with metastatic melanoma treated with PD-1 and LAG-3 inhibition. Melanoma Research, 34(4), 382–385. https://doi.org/10.1097/cmr.0000000000000974
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Yuan, H., Kehm, R. D., Daaboul, J. M., Lloyd, S. E., McDonald, J. A., Mu, L., Tehranifar, P., Zhang, K., Terry, M. B., & Yang, W. (2024). Cancer incidence trends in New York State and associations with common population-level exposures 2010–2018: an ecological study. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-56634-w
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Mendelson, K., Martin, T. C., Nguyen, C. B., Hsu, M., Xu, J., Lang, C. C. V., Dummer, R., Saenger, Y., Messina, J. L., Sondak, V. K., Desman, G., Hasson, D., Bernstein, E., Parsons, R. E., & Celebi, J. T. (2024). Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. JCI Insight. https://doi.org/10.1172/jci.insight.166611
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Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J.-W., Cuella-Martin, R., Hayward, S. B., Kesner, J. S., Ghasemzadeh, A., Nambiar, T. S., Ho, P., Rialdi, A., Hebrard, M., Li, Y., … Ciccia, A. (2024). SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell, 187(4), 861-881.e32. https://doi.org/10.1016/j.cell.2024.01.008
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Fahmy, L. M., Schreidah, C. M., McDonnell, D. E., Carvajal, R. D., Magro, C. M., & Geskin, L. J. (2024). Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma. Dermatology Online Journal, 29(6). https://doi.org/10.5070/d329662993
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Neo, S. Y., Oliveira, M. M. S., Tong, L., Chen, Y., Chen, Z., Cismas, S., Burduli, N., Malmerfelt, A., Teo, J. K. H., Lam, K.-P., Alici, E., Girnita, L., Wagner, A. K., Westerberg, L. S., & Lundqvist, A. (2024). Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease. Journal of Experimental & Clinical Cancer Research, 43(1). https://doi.org/10.1186/s13046-023-02917-5
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Ko, B., Tao, K., Brennan, L., Rakhade, S., Chan, C. X., Moone, J.-Y., Zhu, R., Sher, A., Wang, S., Bracero, Y., Fullerton, B., McLellan, B., Geskin, L. J., & Saenger, Y. M. (2024). Evaluating the efficacy of combination and single-agent immunotherapies in real-world patterns of disease progression and survival of metastatic melanoma patients. Melanoma Research, 34(2), 134–141. https://doi.org/10.1097/cmr.0000000000000945
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Lin, C.-C., Garralda, E., Schöffski, P., Hong, D. S., Siu, L. L., Martin, M., Maur, M., Hui, R., Soo, R. A., Chiu, J., Zhang, T., Ma, B., Kyi, C., Tan, D. S., Cassier, P. A., Sarantopoulos, J., Weickhardt, A., Carvajal, R. D., Spratlin, J., … De Braud, F. (2023). A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies. OncoImmunology, 13(1). https://doi.org/10.1080/2162402x.2023.2290787
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Melms, J. C., Ho, P., Rogava, M., & Izar, B. (2023). From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. Genes & Immunity, 25(1), 82–84. https://doi.org/10.1038/s41435-023-00224-9
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Wei, A. Z., Chen, L. N., Orloff, M., Ariyan, C. E., Asgari, M., Barker, C. A., Buchbinder, E., Chandra, S., Couts, K., Frumovitz, M. M., Futreal, A., Gershenwald, J. E., Hanna, E. Y., Izar, B., LeBlanc, A. K., Leitao, M. M., Lipson, E. J., Liu, D., McCarter, M., … Carvajal, R. D. (2023). Proceedings from the Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA). Pigment Cell & Melanoma Research, 36(6), 542–556. Portico. https://doi.org/10.1111/pcmr.13139
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Pavlick, A. C., Ariyan, C. E., Buchbinder, E. I., Davar, D., Gibney, G. T., Hamid, O., Hieken, T. J., Izar, B., Johnson, D. B., Kulkarni, R. P., Luke, J. J., Mitchell, T. C., Mooradian, M. J., Rubin, K. M., Salama, A. K., Shirai, K., Taube, J. M., Tawbi, H. A., Tolley, J. K., … Sullivan, R. J. (2023). Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0. Journal for ImmunoTherapy of Cancer, 11(10), e006947. https://doi.org/10.1136/jitc-2023-006947
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Liu, Y., Mullangi, S., Debono, D., Chen, X., Pham, T., Fisch, M. J., Gordon, A. S., & Hershman, D. L. (2023). Association Between Oncology Clinical Pathway Utilization and Toxicity and Cost Outcomes in Patients With Metastatic Solid Tumors. JCO Oncology Practice, 19(9), 731–740. https://doi.org/10.1200/op.23.00199
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Ho, P., Melms, J. C., Rogava, M., Frangieh, C. J., Poźniak, J., Shah, S. B., Walsh, Z., Kyrysyuk, O., Amin, A. D., Caprio, L., Fullerton, B. T., Soni, R. K., Ager, C. R., Biermann, J., Wang, Y., Khosravi-Maharlooei, M., Zanetti, G., Mu, M., Fatima, H., … Izar, B. (2023). The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity. Cancer Cell, 41(7), 1207-1221.e12. https://doi.org/10.1016/j.ccell.2023.05.014
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Hsu, C.-C., Fidler, T. P., Kanter, J. E., Kothari, V., Kramer, F., Tang, J., Tall, A. R., & Bornfeldt, K. E. (2023). Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis. Diabetes, 72(7), 999–1011. https://doi.org/10.2337/db22-0962
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Park, H.-R., Shiva, A., Cummings, P., Kim, S., Kim, S., Lee, E., Leong, A., Chowdhury, S., Shawber, C., Carvajal, R., Thurston, G., An, J.-Y., Lund, A. W., Yang, H. W., & Kim, M. (2023). Angiopoietin-2–Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma. Cancer Research, 83(12), 1968–1983. https://doi.org/10.1158/0008-5472.can-22-2838
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Kim, S., Carvajal, R., Kim, M., & Yang, H. W. (2023). Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma. Cell Reports, 42(6), 112570. https://doi.org/10.1016/j.celrep.2023.112570
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Ambrosini, G., Natale, C. A., Musi, E., Garyantes, T., & Schwartz, G. K. (2023). The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells. Cancer Research Communications, 3(4), 540–547. https://doi.org/10.1158/2767-9764.crc-22-0399
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Orlow, I., Sadeghi, K. D., Edmiston, S. N., Kenney, J. M., Lezcano, C., Wilmott, J. S., Cust, A. E., Scolyer, R. A., Mann, G. J., Lee, T. K., Burke, H., Jakrot, V., Shang, P., Ferguson, P. M., Boyce, T. W., Ko, J. S., Ngo, P., Funchain, P., … Rees, J. R. (2023). InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma. PLOS ONE, 18(4), e0269324. https://doi.org/10.1371/journal.pone.0269324
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Carvajal, R. D., Sacco, J. J., Jager, M. J., Eschelman, D. J., Olofsson Bagge, R., Harbour, J. W., Chieng, N. D., Patel, S. P., Joshua, A. M., & Piperno-Neumann, S. (2023). Advances in the clinical management of uveal melanoma. Nature Reviews Clinical Oncology, 20(2), 99–115. https://doi.org/10.1038/s41571-022-00714-1
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Gartrell, R. D., Enzler, T., Kim, P. S., Fullerton, B. T., Fazlollahi, L., Chen, A. X., Minns, H. E., Perni, S., Weisberg, S. P., Rizk, E. M., Wang, S., Oh, E. J., Guo, X. V., Chiuzan, C., Manji, G. A., Bates, S. E., Chabot, J., Schrope, B., Kluger, M., … Saenger, Y. M. (2022). Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma. OncoImmunology, 11(1). https://doi.org/10.1080/2162402x.2022.2066767
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Tanagala, K. K. K., Morin-Baxter, J., Carvajal, R., Cheema, M., Dubey, S., Nakagawa, H., Yoon, A., Cheng, Y.-S. L., Taylor, A., Nickerson, J., Mintz, A., & Momen-Heravi, F. (2022). SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Journal for ImmunoTherapy of Cancer, 10(12), e005088. https://doi.org/10.1136/jitc-2022-005088
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Wei, A. Z., Maniar, A. B., & Carvajal, R. D. (2022). New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma. Cancer Gene Therapy, 29(12), 1819–1826. https://doi.org/10.1038/s41417-022-00443-8
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Dercle, L., Ammari, S., Roblin, E., Bigorgne, A., Champiat, S., Taihi, L., Plaian, A., Hans, S., Lakiss, S., Tselikas, L., Rouanne, M., Deutsch, E., Schwartz, L. H., Gönen, M., Flynn, J., Massard, C., Soria, J.-C., Robert, C., & Marabelle, A. (2022). High serum LDH and liver metastases are the dominant predictors of primary cancer resistance to anti-PD(L)1 immunotherapy. European Journal of Cancer, 177, 80–93. https://doi.org/10.1016/j.ejca.2022.08.034
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Ascierto, P. A., Agarwala, S. S., Blank, C., Caracò, C., Carvajal, R. D., Ernstoff, M. S., Ferrone, S., Fox, B. A., Gajewski, T. F., Garbe, C., Grob, J.-J., Hamid, O., Krogsgaard, M., Lo, R. S., Lund, A. W., Madonna, G., Michielin, O., Neyns, B., Osman, I., … Thurin, M. (2022). Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd – 4th, 2021, Italy). Journal of Translational Medicine, 20(1). https://doi.org/10.1186/s12967-022-03592-4
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Capaccione, K. M., Valiplackal, J. P., Huang, A., Roa, T., Fruauff, A., Liou, C., Kim, E., Khurana, S., Maher, M., Ma, H., Ngyuen, P., Mak, S., Dumeer, S., Lala, S., D’souza, B., Laifer-Narin, S., Desperito, E., Ruzal-Shapiro, C., & Salvatore, M. M. (2022). Checkpoint Inhibitor Immune-Related Adverse Events: A Multimodality Pictorial Review. Academic Radiology, 29(12), 1869–1884. https://doi.org/10.1016/j.acra.2022.03.007
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Jung, S., Armstrong, E., Wei, A. Z., Ye, F., Lee, A., Carlino, M. S., Sullivan, R. J., Carvajal, R. D., Shoushtari, A. N., & Johnson, D. B. (2022). Clinical and genomic correlates of imatinib response in melanomas with KIT alterations. British Journal of Cancer, 127(9), 1726–1732. https://doi.org/10.1038/s41416-022-01942-z
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Luo, L., Shen, R., Arora, A., Orlow, I., Busam, K. J., Lezcano, C., Lee, T. K., Hernando, E., Gorlov, I., Amos, C., Ernstoff, M. S., Seshan, V. E., Cust, A. E., Wilmott, J., Scolyer, R. A., Mann, G., Nagore, E., Funchain, P., … Ko, J. (2022). Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study. Pigment Cell & Melanoma Research, 35(6), 605–612. Portico. https://doi.org/10.1111/pcmr.13058
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Carvajal, R. D., Butler, M. O., Shoushtari, A. N., Hassel, J. C., Ikeguchi, A., Hernandez-Aya, L., Nathan, P., Hamid, O., Piulats, J. M., Rioth, M., Johnson, D. B., Luke, J. J., Espinosa, E., Leyvraz, S., Collins, L., Goodall, H. M., Ranade, K., Holland, C., Abdullah, S. E., … Sato, T. (2022). Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial. Nature Medicine, 28(11), 2364–2373. https://doi.org/10.1038/s41591-022-02015-7
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Karras, P., Bordeu, I., Pozniak, J., Nowosad, A., Pazzi, C., Van Raemdonck, N., Landeloos, E., Van Herck, Y., Pedri, D., Bervoets, G., Makhzami, S., Khoo, J. H., Pavie, B., Lamote, J., Marin-Bejar, O., Dewaele, M., Liang, H., Zhang, X., Hua, Y., … Marine, J.-C. (2022). A cellular hierarchy in melanoma uncouples growth and metastasis. Nature, 610(7930), 190–198. https://doi.org/10.1038/s41586-022-05242-7
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Dimitriou, F., Namikawa, K., Reijers, I. L. M., Buchbinder, E. I., Soon, J. A., Zaremba, A., Teterycz, P., Mooradian, M. J., Armstrong, E., Nakamura, Y., Vitale, M. G., Tran, L. E., Bai, X., Allayous, C., Provent-Roy, S., Indini, A., Bhave, P., Farid, M., Kähler, K. C., … Long, G. V. (2022). Single-agent anti-PD-1 or combined with ipilimumab in patients with mucosal melanoma: an international, retrospective, cohort study. Annals of Oncology, 33(9), 968–980. https://doi.org/10.1016/j.annonc.2022.06.004
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Alvarez-Breckenridge, C., Markson, S. C., Stocking, J. H., Nayyar, N., Lastrapes, M., Strickland, M. R., Kim, A. E., de Sauvage, M., Dahal, A., Larson, J. M., Mora, J. L., Navia, A. W., Klein, R. H., Kuter, B. M., Gill, C. M., Bertalan, M., Shaw, B., Kaplan, A., Subramanian, M., … Carter, S. L. (2022). Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition. Cancer Immunology Research, 10(8), 996–1012. https://doi.org/10.1158/2326-6066.cir-21-0870
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Gartrell, R. D., Blake, Z., Rizk, E. M., Perez-Lorenzo, R., Weisberg, S. P., Simoes, I., Esancy, C., Fu, Y., Davari, D. R., Barker, L., Finkel, G., Mondal, M., Minns, H. E., Wang, S. W., Fullerton, B. T., Lozano, F., Chiuzan, C., Horst, B., & Saenger, Y. M. (2022). Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro-environment in transgenic BRAF murine melanoma. Cancer Immunology, Immunotherapy, 71(8), 1837–1849. https://doi.org/10.1007/s00262-021-03088-y
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Biermann, J., Melms, J. C., Amin, A. D., Wang, Y., Caprio, L. A., Karz, A., Tagore, S., Barrera, I., Ibarra-Arellano, M. A., Andreatta, M., Fullerton, B. T., Gretarsson, K. H., Sahu, V., Mangipudy, V. S., Nguyen, T. T. T., Nair, A., Rogava, M., Ho, P., Koch, P. D., … Izar, B. (2022). Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. Cell, 185(14), 2591-2608.e30. https://doi.org/10.1016/j.cell.2022.06.007
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Carvajal, R. D., Nathan, P., Sacco, J. J., Orloff, M., Hernandez-Aya, L. F., Yang, J., Luke, J. J., Butler, M. O., Stanhope, S., Collins, L., McAlpine, C., Holland, C., Abdullah, S. E., & Sato, T. (2022). Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma. Journal of Clinical Oncology, 40(17), 1939–1948. https://doi.org/10.1200/jco.21.01805
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Verginadis, I. I., Avgousti, H., Monslow, J., Skoufos, G., Chinga, F., Kim, K., Leli, N. M., Karagounis, I. V., Bell, B. I., Velalopoulou, A., Salinas, C. S., Wu, V. S., Li, Y., Ye, J., Scott, D. A., Osterman, A. L., Sengupta, A., Weljie, A., Huang, M., … Koumenis, C. (2022). A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Nature Cell Biology, 24(6), 940–953. https://doi.org/10.1038/s41556-022-00918-8
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Dieng, M., Lord, S. J., Turner, R. M., Nieweg, O. E., Menzies, A. M., Saw, R. P. M., Einstein, A. J., Emmett, L., Thompson, J. F., Lo, S. N., & Morton, R. L. (2022). The Impact of Surveillance Imaging Frequency on the Detection of Distant Disease for Patients with Resected Stage III Melanoma. Annals of Surgical Oncology, 29(5), 2871–2881. https://doi.org/10.1245/s10434-021-11231-3
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Ambrosini, G., Rai, A. J., Carvajal, R. D., & Schwartz, G. K. (2022). Uveal Melanoma Exosomes Induce a Prometastatic Microenvironment through Macrophage Migration Inhibitory Factor. Molecular Cancer Research, 20(4), 661–669. https://doi.org/10.1158/1541-7786.mcr-21-0526
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Dieng, M., Turner, R. M., Lord, S. J., Einstein, A. J., Menzies, A. M., Saw, R. P. M., Nieweg, O. E., Thompson, J. F., & Morton, R. L. (2022). Cost-Effectiveness of PET/CT Surveillance Schedules to Detect Distant Recurrence of Resected Stage III Melanoma. International Journal of Environmental Research and Public Health, 19(4), 2331. https://doi.org/10.3390/ijerph19042331
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Liu, A. W., Wei, A. Z., Maniar, A. B., & Carvajal, R. D. (2022). Tebentafusp in advanced uveal melanoma: proof of principle for the efficacy of T-cell receptor therapeutics and bispecifics in solid tumors. Expert Opinion on Biological Therapy, 22(8), 997–1004. https://doi.org/10.1080/14712598.2022.2031970
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Palmer, A. C., Izar, B., Hwangbo, H., & Sorger, P. K. (2022). Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors. Clinical Cancer Research, 28(2), 368–377. https://doi.org/10.1158/1078-0432.ccr-21-2275
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Dercle, L., Zhao, B., Gönen, M., Moskowitz, C. S., Firas, A., Beylergil, V., Connors, D. E., Yang, H., Lu, L., Fojo, T., Carvajal, R., Karovic, S., Maitland, M. L., Goldmacher, G. V., Oxnard, G. R., Postow, M. A., & Schwartz, L. H. (2022). Early Readout on Overall Survival of Patients With Melanoma Treated With Immunotherapy Using a Novel Imaging Analysis. JAMA Oncology, 8(3), 385. https://doi.org/10.1001/jamaoncol.2021.6818
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