Pancreatic Neoplasms

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Resell, M., Rabben, H.-L., Sharma, A., Hagen, L., Hoang, L., Skogaker, N. T., Aarvik, A., Bjåstad, E. K., Svensson, M. K., Amrutkar, M., Verbeke, C. S., Batra, S. K., Qvigstad, G., Wang, T. C., Rustgi, A., Chen, D., & Zhao, C.-M. (2025). Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma. Scientific Data, 12(1). https://doi.org/10.1038/s41597-025-04522-x
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Patel, S. H., Colby, S., Sohal, D., Guthrie, K. A., Kachnic, L. A., Chiorean, E. G., Lowy, A. M., Rocha, F. G., Hochster, H. S., Philip, P. A., & Ahmad, S. A. (2025). Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505. Cancer, 131(4). Portico. https://doi.org/10.1002/cncr.35759
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May, M. S., Park, H., Moallem, D. H., Seeram, D., Dajiang, S., Hibshoosh, H., Jamison, J. K., Uhlemann, A.-C., & Manji, G. A. (2024). Low Bacterial Biomass in Human Pancreatic Cancer and Adjacent Normal Tissue. International Journal of Molecular Sciences, 26(1), 140. https://doi.org/10.3390/ijms26010140
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Stein, M. N., Dumbrava, E. E., Teply, B. A., Gergis, U. S., Guiterrez, M. E., Reshef, R., Subudhi, S. K., Jacquemont, C. F., Senesac, J. H., Bayle, J. H., Scripture, C. D., Chatwal, M. S., Bilen, M. A., Stadler, W. M., & Becerra, C. R. (2024). PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-53220-6
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Smith, L. M., Mahoney, D. W., Bamlet, W. R., Yu, F., Liu, S., Goggins, M. G., Darabi, S., Majumder, S., Wang, Q.-L., Coté, G. A., Demeure, M. J., Zhang, Z., Srivastava, S., Chawla, A., Izmirlian, G., Olson, J. E., Wolpin, B. M., Genkinger, J. M., Zaret, K. S., … Oberg, A. L. (2024). Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies. Pancreatology, 24(8), 1265–1279. https://doi.org/10.1016/j.pan.2024.10.012
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Carpenter, E. S., Vendramini-Costa, D. B., Hasselluhn, M. C., Maitra, A., Olive, K. P., Cukierman, E., Pasca di Magliano, M., & Sherman, M. H. (2024). Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here? Cancer Research, 84(21), 3505–3508. https://doi.org/10.1158/0008-5472.can-24-2860
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Huang, C., Hecht, E. M., Soloff, E. V., Tiwari, H. A., Bhosale, P. R., Dasayam, A., Galgano, S. J., Kambadakone, A., Kulkarni, N. M., Le, O., Liau, J., Luk, L., Rosenthal, M. H., Sangster, G. P., & Goenka, A. H. (2024). Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs. American Journal of Roentgenology, 223(2). https://doi.org/10.2214/ajr.24.31151
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Manukyan, I., Hsiao, S. J., Fazlollahi, L., Remotti, H., & Mansukhani, M. M. (2024). Molecular and morphologic characterization of intraductal tubulopapillary neoplasms of pancreas with novel potentially targetable fusions. Human Pathology, 150, 36–41. https://doi.org/10.1016/j.humpath.2024.06.014
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Blackford, A. L., Canto, M. I., Dbouk, M., Hruban, R. H., Katona, B. W., Chak, A., Brand, R. E., Syngal, S., Farrell, J., Kastrinos, F., Stoffel, E. M., Rustgi, A., Klein, A. P., Kamel, I., Fishman, E. K., He, J., Burkhart, R., Shin, E. J., Lennon, A. M., & Goggins, M. (2024). Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology, 10(8), 1087. https://doi.org/10.1001/jamaoncol.2024.1930
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Klomp, J. E., Diehl, J. N., Klomp, J. A., Edwards, A. C., Yang, R., Morales, A. J., Taylor, K. E., Drizyte-Miller, K., Bryant, K. L., Schaefer, A., Johnson, J. L., Huntsman, E. M., Yaron, T. M., Pierobon, M., Baldelli, E., Prevatte, A. W., Barker, N. K., Herring, L. E., Petricoin, E. F., … Stalnecker, C. A. (2024). Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science, 384(6700). https://doi.org/10.1126/science.adk0850
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Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z
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Jamison, J. K., May, M. S., Raufi, A. G., Luk, L., Wong, W., Mundi, P. S., & Manji, G. A. (2024). A Somatic BRCA2-Mutated Pancreatic Adenocarcinoma With Sustained Exceptional Response to Modified FOLFIRINOX. The Oncologist, 29(4), 350–355. https://doi.org/10.1093/oncolo/oyad315
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Schilling, K., Chen, H., Glabonjat, R. A., Debernardi, S., Blyuss, O., Navas-Acien, A., Halliday, A. N., & Crnogorac-Jurcevic, T. (2024). Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1332895
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Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
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Ben-Ami, R., Wang, Q.-L., Zhang, J., Supplee, J. G., Fahrmann, J. F., Lehmann-Werman, R., Brais, L. K., Nowak, J., Yuan, C., Loftus, M., Babic, A., Irajizad, E., Davidi, T., Zick, A., Hubert, A., Neiman, D., Piyanzin, S., Gal-Rosenberg, O., Horn, A., … Wolpin, B. M. (2023). Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer. Gut, gutjnl-2023-331074. https://doi.org/10.1136/gutjnl-2023-331074
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Vujasinovic, M., Elbe, P., Ekheden, I., Wang, Q.-L., Thuresson, M., Roelstraete, B., Ghazi, S., Löhr, J.-M., & Ludvigsson, J. F. (2024). Gastrointestinal cancer precursor risk and mortality in pancreatic intraductal papillary mucinous neoplasms: a nationwide cohort study. Scandinavian Journal of Gastroenterology, 59(5), 600–607. https://doi.org/10.1080/00365521.2024.2310162
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Hasselluhn, M. C., Decker-Farrell, A. R., Vlahos, L., Thomas, D. H., Curiel-Garcia, A., Maurer, H. C., Wasko, U. N., Tomassoni, L., Sastra, S. A., Palermo, C. F., Dalton, T. C., Ma, A., Li, F., Tolosa, E. J., Hibshoosh, H., Fernandez-Zapico, M. E., Muir, A., Califano, A., & Olive, K. P. (2023). Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression. Cancer Discovery, 14(2), 348–361. https://doi.org/10.1158/2159-8290.cd-23-0240
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de Rijk, F., Sissingh, N., Boel, T., Timmerhuis, H., de Jong, M., Pauw, H., van Veldhuisen, C., Hallensleben, N., Anten, M., Brink, M., Curvers, W., van Duijvendijk, P., Hazen, W., Kuiken, S., Poen, A., Quispel, R., Römkens, T., Spanier, B., … Tan, A. (2024). Development of pancreatic diseases during long‐term follow‐up after acute pancreatitis: a post‐hoc analysis of a prospective multicenter cohort. Journal of Gastroenterology and Hepatology, 39(4), 674–684. Portico. https://doi.org/10.1111/jgh.16453
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Park, J., Lim, F., Prest, M., Ferris, J. S., Aziz, Z., Agyekum, A., Wagner, S., Gulati, R., & Hur, C. (2023). Quantifying the potential benefits of early detection for pancreatic cancer through a counterfactual simulation modeling analysis. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-46751-3
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Decker-Farrell, A. R., Ma, A., Li, F., Muir, A., & Olive, K. P. (2023). Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants. STAR Protocols, 4(4), 102711. https://doi.org/10.1016/j.xpro.2023.102711
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Ferguson, L. P., Gatchalian, J., McDermott, M. L., Nakamura, M., Chambers, K., Rajbhandari, N., Lytle, N. K., Rosenthal, S. B., Hamilton, M., Albini, S., Wartenberg, M., Zlobec, I., Galván, J. A., Karamitopoulou, E., Vavinskaya, V., Wascher, A., Lowy, A. M., Schürch, C. M., Puri, P. L., … Reya, T. (2023). Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-35796-7
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Jung, H.-S., Lee, M., Han, Y., Thomas, A. S., Yun, W.-G., Cho, Y. J., Kluger, M. D., Jang, J.-Y., & Kwon, W. (2024). Inadequacy of the eighth edition of the American Joint Committee on Cancer pancreatic cancer staging system for invasive carcinoma associated with premalignant lesions in the pancreas: an analysis using the National Cancer Database. HPB, 26(3), 400–409. https://doi.org/10.1016/j.hpb.2023.11.015
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LaRose, M., Manji, G. A., & Bates, S. E. (2024). Beyond BRCA: Diagnosis and management of homologous recombination repair deficient pancreatic cancer. Seminars in Oncology, 51(1–2), 36–44. https://doi.org/10.1053/j.seminoncol.2023.11.001
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Boutin, R., Lee, H.-F., Guan, T. L., Nguyen, T. T., Huang, X. F., Waller, D. D., Lu, J., Christine Chio, I. I., Michel, R. P., Sebag, M., & Tsantrizos, Y. S. (2023). Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry, 66(23), 15776–15800. https://doi.org/10.1021/acs.jmedchem.3c01271
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Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., Lytle, N. K., McDermott, M., Diaz, E., Pettit, H., Kritzik, M., Han, H., Cridebring, D., Wen, K. W., Tsai, S., Goggins, M. G., Lowy, A. M., … Reya, T. (2023). Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell, 41(11), 1989-2005.e9. https://doi.org/10.1016/j.ccell.2023.09.008
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Hasselluhn, M. C., Schlösser, D., Versemann, L., Schmidt, G. E., Ulisse, M., Oschwald, J., Zhang, Z., Hamdan, F., Xiao, H., Kopp, W., Spitalieri, J., Kellner, C., Schneider, C., Reutlinger, K., Nagarajan, S., Steuber, B., Sastra, S. A., Palermo, C. F., Appelhans, J., … Hessmann, E. (2024). An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies. Gastroenterology, 166(2), 298-312.e14. https://doi.org/10.1053/j.gastro.2023.10.026
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Lee, M., Thomas, A. S., Lee, S. Y., Cho, Y. J., Jung, H.-S., Yun, W.-G., Han, Y., Jang, J.-Y., Kluger, M. D., & Kwon, W. (2023). Reconsidering the absence of extrapancreatic extension in T staging for pancreatic adenocarcinoma in the AJCC (8th ed) Staging Manual using the National Cancer Database. Journal of Gastrointestinal Surgery, 27(11), 2484–2492. https://doi.org/10.1007/s11605-023-05850-2
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Lee, E., O’Keefe, S., Leong, A., Park, H.-R., Varadarajan, J., Chowdhury, S., Hiner, S., Kim, S., Shiva, A., Friedman, R. A., Remotti, H., Fojo, T., Yang, H. W., Thurston, G., & Kim, M. (2023). Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. Journal of Clinical Investigation, 133(20). https://doi.org/10.1172/jci167994
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de la Fuente, J., Chatterjee, A., Lui, J., Nehra, A. K., Bell, M. G., Lennon, R. J., Kassmeyer, B. A., Graham, R. P., Nagayama, H., Schulte, P. J., Doering, K. A., Delgado, A. M., Vege, S. S., Chari, S. T., Takahashi, N., & Majumder, S. (2023). Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms. JAMA Network Open, 6(10), e2337799. https://doi.org/10.1001/jamanetworkopen.2023.37799
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Irajizad, E., Kenney, A., Tang, T., Vykoukal, J., Wu, R., Murage, E., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., Chabot, J. A., Kluger, M. D., Kastrinos, F., Brais, L., Babic, A., Jajoo, K., Lee, L. S., Clancy, T. E., Ng, K., … Fahrmann, J. F. (2023). A blood-based metabolomic signature predictive of risk for pancreatic cancer. Cell Reports Medicine, 4(9), 101194. https://doi.org/10.1016/j.xcrm.2023.101194
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Jiang, Z., Wu, F., Laise, P., Takayuki, T., Na, F., Kim, W., Kobayashi, H., Chang, W., Takahashi, R., Valenti, G., Sunagawa, M., White, R. A., Macchini, M., Renz, B. W., Middelhoff, M., Hayakawa, Y., Dubeykovskaya, Z. A., Tan, X., Chu, T. H., … Wang, T. C. (2023). Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis. Cell Stem Cell, 30(8), 1091-1109.e7. https://doi.org/10.1016/j.stem.2023.07.002
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Yun, W., Han, Y., Lee, M., Cho, Y. J., Jung, H., Thomas, A. S., Kluger, M. D., Kwon, W., & Jang, J. (2023). The role of local treatment including pancreatectomy for pancreatic ductal adenocarcinoma patients with isolated synchronous liver metastasis: Propensity score‐matched analyses. Journal of Hepato-Biliary-Pancreatic Sciences, 30(8), 1036–1045. Portico. https://doi.org/10.1002/jhbp.1313
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Goel, N., Rhim, A. D., Xi, H., Olive, K. P., Thomas, A. S., Kwon, W., Schwartz, J., Sugahara, K. N., Schrope, B. A., Chabot, J. A., & Kluger, M. D. (2022). Transfusion of salvaged red blood cells during pancreatic ductal adenocarcinoma operations. British Journal of Surgery, 110(8), 917–919. https://doi.org/10.1093/bjs/znac393
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Schleimer, L. E., Chabot, J. A., & Kluger, M. D. (2023). Innovation in the Surgical Management of Pancreatic Cystic Neoplasms. Gastrointestinal Endoscopy Clinics of North America, 33(3), 655–677. https://doi.org/10.1016/j.giec.2023.03.003
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Ko, A. H., Kim, K.-P., Siveke, J. T., Lopez, C. D., Lacy, J., O’Reilly, E. M., Macarulla, T., Manji, G. A., Lee, J., Ajani, J., Alsina Maqueda, M., Rha, S.-Y., Lau, J., Al-Sakaff, N., Allen, S., Lu, D., Shemesh, C. S., Gan, X., Cha, E., & Oh, D.-Y. (2023). Atezolizumab Plus PEGPH20 Versus Chemotherapy in Advanced Pancreatic Ductal Adenocarcinoma and Gastric Cancer: MORPHEUS Phase Ib/II Umbrella Randomized Study Platform. The Oncologist, 28(6), 553-e472. https://doi.org/10.1093/oncolo/oyad022
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Lo, E. K. W., Mears, B. M., Maurer, H. C., Idrizi, A., Hansen, K. D., Thompson, E. D., Hruban, R. H., Olive, K. P., & Feinberg, A. P. (2023). Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis. Cancer Research, 83(11), 1905–1916. https://doi.org/10.1158/0008-5472.can-22-4052
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Katona, B. W., Klute, K., Brand, R. E., Everett, J. N., Farrell, J. J., Hawthorne, K., Kaul, V., Kupfer, S. S., Paiella, S., Simeone, D. M., Sussman, D. A., Zogopoulos, G., Lucas, A. L., Kastrinos, F., Bi, Y., Brentnall, T., Chung, D., Earl, J., … Wadlow, R. (2023). Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance. Cancer Prevention Research, 16(6), 343–352. https://doi.org/10.1158/1940-6207.capr-22-0529
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Suben, J., Goyal, A., Rao, R., & Sung, S. (2023). Diagnostic implication of extracellular mucin in pancreatic/biliary brushing and stent cytology. Cancer Cytopathology, 131(6), 360–364. Portico. https://doi.org/10.1002/cncy.22685
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Perez, K., Chiarella, A. M., Cleary, J. M., Horick, N., Weekes, C., Abrams, T., Blaszkowsky, L., Enzinger, P., Giannakis, M., Goyal, L., Meyerhardt, J. A., Rubinson, D., Yurgelun, M. B., Goessling, W., Giantonio, B. J., Brais, L., Germon, V., Stonely, D., Raghavan, S., … Wolpin, B. M. (2023). Phase Ib and Expansion Study of Gemcitabine,Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. The Oncologist, 28(5), 425–432. https://doi.org/10.1093/oncolo/oyad002
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May, M. S., Jamison, J. K., Wong, W., Michel, A., Raufi, A. G., Neugut, A. I., & Manji, G. A. (2023). Smoking is Not Associated with Lung Metastasis in Pancreatic Cancer. Cancer Investigation, 41(5), 487–490. https://doi.org/10.1080/07357907.2023.2203747
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Fulop, D. J., Zylberberg, H. M., Wu, Y. L., Aronson, A., Labiner, A. J., Wisnivesky, J., Cohen, D. J., Sigel, K. M., & Lucas, A. L. (2023). Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy. JAMA Network Open, 6(3), e234254. https://doi.org/10.1001/jamanetworkopen.2023.4254
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McBrearty, N., Cho, C., Chen, J., Zahedi, F., Peck, A. R., Radaelli, E., Assenmacher, C.-A., Pavlak, C., Devine, A., Yu, P., Lu, Z., Zhang, H., Li, J., Pitarresi, J. R., Astsaturov, I., Cukierman, E., Rustgi, A. K., Stanger, B. Z., Rui, H., & Fuchs, S. Y. (2022). Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. Molecular Cancer Research, 21(3), 228–239. https://doi.org/10.1158/1541-7786.mcr-22-0602
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Raufi, A. G., May, M. S., Hadfield, M. J., Seyhan, A. A., & El-Deiry, W. S. (2023). Advances in Liquid Biopsy Technology and Implications for Pancreatic Cancer. International Journal of Molecular Sciences, 24(4), 4238. https://doi.org/10.3390/ijms24044238
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Filip, I., Wang, A., Kravets, O., Orenbuch, R., Zhao, J., Perea-Chamblee, T. E., Manji, G. A., López de Maturana, E., Malats, N., Olive, K. P., & Rabadan, R. (2023). Pervasiveness of HLA allele-specific expression loss across tumor types. Genome Medicine, 15(1). https://doi.org/10.1186/s13073-023-01154-x
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Yeh, C., Zhou, M., Sigel, K., Jameson, G., White, R., Safyan, R., Saenger, Y., Hecht, E., Chabot, J., Schreibman, S., Juzyna, B., Ychou, M., Conroy, T., Fojo, T., Manji, G. A., Von Hoff, D., & Bates, S. E. (2022). Tumor Growth Rate Informs Treatment Efficacy in Metastatic Pancreatic Adenocarcinoma: Application of a Growth and Regression Model to Pivotal Trial and Real-World Data. The Oncologist, 28(2), 139–148. https://doi.org/10.1093/oncolo/oyac217
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Parejo-Alonso, B., Royo-García, A., Espiau-Romera, P., Courtois, S., Curiel-García, Á., Zagorac, S., Villaoslada, I., Olive, K. P., Heeschen, C., & Sancho, P. (2023). Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma. Biomedicine & Pharmacotherapy, 158, 114162. https://doi.org/10.1016/j.biopha.2022.114162
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Chu, L. C., Wang, Z. J., Kambadakone, A., Hecht, E. M., He, J., Narang, A. K., Laheru, D. A., Arif-Tiwari, H., Bhosale, P., Bolan, C. W., Brook, O. R., Bezuidenhout, A. F., Do, R. K. G., Galgano, S. J., Goenka, A. H., Guimaraes, A. R., Hough, D. M., Kulkarni, N., Le, O., … Zaheer, A. (2022). Postoperative surveillance of pancreatic ductal adenocarcinoma (PDAC) recurrence: practice pattern on standardized imaging and reporting from the society of abdominal radiology disease focus panel on PDAC. Abdominal Radiology, 48(1), 318–339. https://doi.org/10.1007/s00261-022-03693-0
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Kim, H. S., Song, W., Choo, W., Lee, S., Han, Y., Bassi, C., Salvia, R., Marchegiani, G., Wolfgang, C. L., He, J., Blair, A. B., Kluger, M. D., Su, G. H., Kim, S. C., Song, K., Yamamoto, M., Hatori, T., Yang, C., Yamaue, H., … Jang, J. (2021). Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study. Journal of Hepato-Biliary-Pancreatic Sciences, 30(1), 133–143. Portico. https://doi.org/10.1002/jhbp.962
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Gartrell, R. D., Enzler, T., Kim, P. S., Fullerton, B. T., Fazlollahi, L., Chen, A. X., Minns, H. E., Perni, S., Weisberg, S. P., Rizk, E. M., Wang, S., Oh, E. J., Guo, X. V., Chiuzan, C., Manji, G. A., Bates, S. E., Chabot, J., Schrope, B., Kluger, M., … Saenger, Y. M. (2022). Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma. OncoImmunology, 11(1). https://doi.org/10.1080/2162402x.2022.2066767
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