Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

Kim, S., Carvajal, R., Kim, M., & Yang, H. W. (2023). Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma. Cell Reports, 42(6), 112570. https://doi.org/10.1016/j.celrep.2023.112570
Authors:
Sung Soo Kim
Richard D. Carvajal
Minah Kim
Hee Won Yang
Affiliated Authors:
Sung Soo Kim
Richard D. Carvajal
Minah Kim
Hee Won Yang
Columbia Affiliation:
Subjects:
Melanoma (MeSH)
Mitogen-Activated Protein Kinase Kinases (MeSH)
Mammalian MAP Kinase Signaling Pathways (OpenAlex Topic)
Computational Methods in Drug Discovery (OpenAlex Topic)
Role of Pim Oncogenes in Tumorigenesis (OpenAlex Topic)
Author Keywords:
braf
cp: cancer
erk
melanoma
persister cells
rtk
signaling dynamics
elink
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2023.112570
PMID:
37252843
DOI:
10.1016/j.celrep.2023.112570
Journal:
Cell Reports
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created: