Diabetes Mellitus, Type 2

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Wang, S., Lenzini, P., Thyagarajan, B., Lee, J. H., Vardarajan, B. N., Yashin, A., Miljkovic, I., Daw, E. W., Lin, S. J., Patti, G. J., Brent, M. R., Zmuda, J. M., Perls, T. T., Christensen, K., Province, M. A., & An, P. (2025). Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study. Physiological Genomics, 57(5), 293–298. https://doi.org/10.1152/physiolgenomics.00137.2024
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Guzman, H., Hasan, L. Z., & Reid, T. J. (2025). Treatment of Type 2 Diabetes in Patients with Obesity. Endocrinology and Metabolism Clinics of North America, 54(1), 163–173. https://doi.org/10.1016/j.ecl.2024.10.004
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Mielke, M. M., Evans, J. K., Neiberg, R. H., Molina-Henry, D. P., Marcovina, S. M., Johnson, K. C., Carmichael, O. T., Rapp, S. R., Sachs, B. C., Ding, J., Shappell, H. M., Luchsinger, J. A., Espeland, M. A., & Hayden, K. M. (2025). Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity. JAMA Network Open, 8(2), e2458149. https://doi.org/10.1001/jamanetworkopen.2024.58149
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Munshi, M. N., Venditti, E. M., Tjaden, A. H., Knowler, W. C., Boyko, E. J., Middelbeek, R. J. W., Luchsinger, J. A., Lee, C. G., Hazuda, H. P., Salive, M. E., Edelstein, S. L., & Storer, T. W. (2024). Long-term impact of Diabetes Prevention Program interventions on walking endurance. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1470035
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Geng, J., Ruan, X., Wu, X., Chen, X., Fu, T., Gill, D., Burgess, S., Chen, J., Ludvigsson, J. F., Larsson, S. C., Li, X., Du, Z., & Yuan, S. (2024). Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease. Diabetes, Obesity and Metabolism. Portico. https://doi.org/10.1111/dom.16087
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Seaquist, E. R., Phillips, L. S., Ghosh, A., Baker, C., Bergenstal, R. M., Crandall, J. P., Goland, R. S., Gramzinski, M. R., Hox, S. H., Hsia, D. S., Johnson, M. L., Lachin, J. M., Raskin, P., Valencia, W. M., Waltje, A. H., & Younes, N. (2024). Glycemia reduction in type 2 diabetes—Hypoglycemia outcomes: A randomized clinical trial. PLOS ONE, 19(11), e0309907. https://doi.org/10.1371/journal.pone.0309907
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Díaz-Rizzolo, D. A., Santos Baez, L. S., Popp, C. J., Borhan, R., Sordi-Guth, A., Manoogian, E. N. C., Panda, S., Cheng, B., & Laferrère, B. (2024). Late eating is associated with poor glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 diabetes. Nutrition & Diabetes, 14(1). https://doi.org/10.1038/s41387-024-00347-6
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Tahmi, M., Benitez, R., & Luchsinger, J. A. (2024). Metformin as a Potential Prevention Strategy for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias. Journal of Alzheimer’s Disease, 101(s1), S345–S356. https://doi.org/10.3233/jad-240495
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Chaput, J.-P., Biswas, R. K., Ahmadi, M., Cistulli, P. A., Sabag, A., St-Onge, M.-P., & Stamatakis, E. (2024). Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults. Diabetes Care, 47(12), 2139–2145. https://doi.org/10.2337/dc24-1208
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Patel, M., Battarbee, A. N., Refuerzo, J. S., Zork, N., Eichelberger, K., Ramos, G. A., Olson, G., Durnwald, C., Landon, M. B., Aagaard, K. M., Wallace, K., Scifres, C., Rosen, T., Mulla, W., Valent, A., Longo, S., & Boggess, K. A. (2024). Association Between Metformin Use in Early Gestational or Type 2 Diabetes in Pregnancy and Preterm Preeclampsia. Obstetrics & Gynecology, 144(5), 733–739. https://doi.org/10.1097/aog.0000000000005720
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Khera, R., Aminorroaya, A., Dhingra, L. S., Thangaraj, P. M., Pedroso Camargos, A., Bu, F., Ding, X., Nishimura, A., Anand, T. V., Arshad, F., Blacketer, C., Chai, Y., Chattopadhyay, S., Cook, M., Dorr, D. A., Duarte-Salles, T., DuVall, S. L., Falconer, T., French, T. E., … Suchard, M. A. (2024). Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes. Journal of the American College of Cardiology, 84(10), 904–917. https://doi.org/10.1016/j.jacc.2024.05.069
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Lumey, L. H., Li, C., Khalangot, M., Levchuk, N., & Wolowyna, O. (2024). Fetal exposure to the Ukraine famine of 1932–1933 and adult type 2 diabetes mellitus. Science, 385(6709), 667–671. https://doi.org/10.1126/science.adn4614
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van Sloten, T. T., Luchsinger, J. A., Launer, L. J., Strachan, M., Cukierman-Yaffe, T., Gerstein, H. C., Sattar, N., & Biessels, G. J. (2024). Call for effective therapies for preventing dementia in people with type 2 diabetes. The Lancet Diabetes & Endocrinology, 12(8), 510–513. https://doi.org/10.1016/s2213-8587(24)00158-x
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Abel, E. D., Gloyn, A. L., Evans-Molina, C., Joseph, J. J., Misra, S., Pajvani, U. B., Simcox, J., Susztak, K., & Drucker, D. J. (2024). Diabetes mellitus—Progress and opportunities in the evolving epidemic. Cell, 187(15), 3789–3820. https://doi.org/10.1016/j.cell.2024.06.029
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Spaur, M., Galvez-Fernandez, M., Chen, Q., Lombard, M. A., Bostick, B. C., Factor-Litvak, P., Fretts, A. M., Shea, S. J., Navas-Acien, A., & Nigra, A. E. (2024). Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study. Diabetes Care, 47(7), 1143–1151. https://doi.org/10.2337/dc23-2231
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Ashby‐Thompson, M., Heshka, S., Anderson, A., Pownall, H., Laferrère, B., Balasubramanyam, A., Heymsfield, S. B., Wadden, T. A., & Gallagher, D. (2024). Long‐term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes. Obesity, 32(6), 1093–1101. Portico. https://doi.org/10.1002/oby.24025
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Shapiro, A. L. B., Tjaden, A. H., Edelstein, S. L., Kahn, S. E., Srikanthan, P., Knowler, W. C., Venditti, E. M., Golden, S. H., Carmichael, O., & Luchsinger, J. A. (2024). The association of insulin responses and insulin sensitivity with cognition in adults with pre-diabetes: The Diabetes Prevention Program Outcomes Study. Journal of Diabetes and Its Complications, 38(6), 108764. https://doi.org/10.1016/j.jdiacomp.2024.108764
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Duquenne, P., Samieri, C., Chambaron, S., Brindisi, M.-C., Kesse-Guyot, E., Galan, P., Hercberg, S., Touvier, M., Léger, D., Fezeu, L. K., & Andreeva, V. A. (2024). Chronic insomnia, high trait anxiety and their comorbidity as risk factors for incident type 2 diabetes mellitus. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-62675-y
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Ding, J., Nguyen, A. T., Lohman, K., Hensley, M. T., Parker, D., Hou, L., Taylor, J., Voora, D., Sawyer, J. K., Boudyguina, E., Bancks, M. P., Bertoni, A., Pankow, J. S., Rotter, J. I., Goodarzi, M. O., Tracy, R. P., Murdoch, D. M., Rich, S. S., Psaty, B. M., … Liu, Y. (2024). LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes. Journal of Clinical Investigation, 134(10). https://doi.org/10.1172/jci173278
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Santos-Báez, L. S., Díaz-Rizzolo, D. A., Popp, C. J., Shaw, D., Fine, K. S., Altomare, A., St-Onge, M.-P., Manoogian, E. N. C., Panda, S., Cheng, B., & Laferrère, B. (2024). Diet and Meal Pattern Determinants of Glucose Levels and Variability in Adults with and without Prediabetes or Early-Onset Type 2 Diabetes: A Pilot Study. Nutrients, 16(9), 1295. https://doi.org/10.3390/nu16091295
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Wang, X., Liu, M., Nogues, I.-E., Chen, T., Xiong, X., Bonzel, C.-L., Zhang, H., Hong, C., Xia, Y., Dahal, K., Costa, L., Cui, J., Muralidhar, S., Moser, J., Deen, J. E., Tsao, P. S., Muralidhar, S., Gaziano, J. M., … Hauser, E. (2024). Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-54063-3
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Zhao, Y., Chukanova, M., Kentistou, K. A., Fairhurst-Hunter, Z., Siegert, A. M., Jia, R. Y., Dowsett, G. K. C., Gardner, E. J., Lawler, K., Day, F. R., Kaisinger, L. R., Tung, Y.-C. L., Lam, B. Y. H., Chen, H.-J. C., Wang, Q., Berumen-Campos, J., Kuri-Morales, P., Tapia-Conyer, R., Alegre-Diaz, J., … Perry, J. R. B. (2024). Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature Genetics, 56(4), 579–584. https://doi.org/10.1038/s41588-024-01694-x
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Smalls, B. L., Kruse-Diehr, A., Ortz, C. L., Douthitt, K., McLouth, C., Shelton, R., Taylor, Z., & Williams, E. (2024). Older adults using social support to improve self-care (OASIS): Adaptation, implementation and feasibility of peer support for older adults with T2D in appalachia: A feasibility study protocol. PLOS ONE, 19(3), e0300196. https://doi.org/10.1371/journal.pone.0300196
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Gostoli, S., Raimondi, G., Popa, A. P., Giovannini, M., Benasi, G., & Rafanelli, C. (2024). Behavioral Lifestyle Interventions for Weight Loss in Overweight or Obese Patients with Type 2 Diabetes: A Systematic Review of the Literature. Current Obesity Reports, 13(2), 224–241. https://doi.org/10.1007/s13679-024-00552-5
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Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., … Schroeder, P. (2024). Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), 347–357. https://doi.org/10.1038/s41586-024-07019-6
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Watanabe, H., Asahara, S., Son, J., McKimpson, W. M., de Cabo, R., & Accili, D. (2024). Cyb5r3 activation rescues secondary failure to sulfonylurea but not β-cell dedifferentiation. PLOS ONE, 19(2), e0297555. https://doi.org/10.1371/journal.pone.0297555
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Suda, N., Bartolomé, A., Liang, J., Son, J., Yagishita, Y., Siebel, C., Accili, D., Ding, H., & Pajvani, U. B. (2024). β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice. Molecular Metabolism, 81, 101894. https://doi.org/10.1016/j.molmet.2024.101894
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Steffen, B. T., McDonough, D. J., Pankow, J. S., Tang, W., Rooney, M. R., Demmer, R. T., Lutsey, P. L., Guan, W., Gabriel, K. P., Palta, P., Moser, E. D., & Pereira, M. A. (2023). Plasma Neuronal Growth Regulator 1 May Link Physical Activity to Reduced Risk of Type 2 Diabetes: A Proteome-Wide Study of ARIC Participants. Diabetes, 73(2), 318–324. https://doi.org/10.2337/db23-0383
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Barbera, M., Lehtisalo, J., Perera, D., Aspö, M., Cross, M., De Jager Loots, C. A., Falaschetti, E., Friel, N., Luchsinger, J. A., Gavelin, H. M., Peltonen, M., Price, G., Neely, A. S., Thunborg, C., Tuomilehto, J., Mangialasche, F., Middleton, L., Ngandu, T., … Solomon, A. (2024). A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-023-01355-x
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Kwak, S. H., Srinivasan, S., Chen, L., Todd, J., Mercader, J. M., Jensen, E. T., Divers, J., Mottl, A. K., Pihoker, C., Gandica, R. G., Laffel, L. M., Isganaitis, E., Haymond, M. W., Levitsky, L. L., Pollin, T. I., Florez, J. C., & Flannick, J. (2024). Genetic architecture and biology of youth-onset type 2 diabetes. Nature Metabolism, 6(2), 226–237. https://doi.org/10.1038/s42255-023-00970-0
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Columbia Affiliation
Bradfield, J. P., Kember, R. L., Ulrich, A., Balkhiyarova, Z., Alyass, A., Aris, I. M., Bell, J. A., Broadaway, K. A., Chen, Z., Chai, J.-F., Davies, N. M., Fernandez-Orth, D., Bustamante, M., Fore, R., Ganguli, A., Heiskala, A., Hottenga, J.-J., Íñiguez, C., … Kobes, S. (2024). Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. Genome Biology, 25(1). https://doi.org/10.1186/s13059-023-03136-z
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Liu, B., Xie, D., Huang, X., Jin, S., Dai, Y., Sun, X., Li, D., Bennett, A. M., Diano, S., & Huang, Y. (2024). Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia, 67(4), 724–737. https://doi.org/10.1007/s00125-023-06073-5
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Jacobson, P. T., Vilarello, B. J., Tervo, J. P., Waring, N. A., Gudis, D. A., Goldberg, T. E., Devanand, D. P., & Overdevest, J. B. (2024). Associations between olfactory dysfunction and cognition: a scoping review. Journal of Neurology, 271(3), 1170–1203. https://doi.org/10.1007/s00415-023-12057-7
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Doumbia, L., Findley, S., Ba, H. O., Maiga, B., Ba, A., Béréthé, R. K., Sangaré, H. M., Kachur, S. P., Besançon, S., & Doumbia, S. (2024). Formative research to adapt the ‘Diabetes Prevention Program- Power to Prevent’ for implementation in Bamako, Mali. BMC Health Services Research, 24(1). https://doi.org/10.1186/s12913-023-10515-6
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Columbia Affiliation
Rasouli, N., Younes, N., Ghosh, A., Albu, J., Cohen, R. M., DeFronzo, R. A., Diaz, E., Sayyed Kassem, L., Luchsinger, J. A., McGill, J. B., Sivitz, W. I., Tamborlane, W. V., Utzschneider, K. M., Kahn, S. E., Crandall, J. P., McKee, M. D., Behringer-Massera, S., Brown-Friday, J., … Xhori, E. (2024). Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial. Diabetes Care, 47(4), 580–588. https://doi.org/10.2337/dc23-1070
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Higbee, D. H., Lirio, A., Hamilton, F., Granell, R., Wyss, A. B., London, S. J., Bartz, T. M., Gharib, S. A., Cho, M. H., Wan, E., Silverman, E., Crapo, J. D., Lominchar, J. V. T., Hansen, T., Grarup, N., Dantoft, T., Kårhus, L., Linneberg, A., O’Connor, G. T., … Dodd, J. W. (2023). Genome-wide association study of preserved ratio impaired spirometry (PRISm). European Respiratory Journal, 63(1), 2300337. https://doi.org/10.1183/13993003.00337-2023
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Boggess, K. A., Valint, A., Refuerzo, J. S., Zork, N., Battarbee, A. N., Eichelberger, K., Ramos, G. A., Olson, G., Durnwald, C., Landon, M. B., Aagaard, K. M., Wallace, K., Scifres, C., Rosen, T., Mulla, W., Valent, A., Longo, S., Young, L., Marquis, M. A., … Berry, D. (2023). Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy. JAMA, 330(22), 2182. https://doi.org/10.1001/jama.2023.22949
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Sarnowski, C., Huan, T., Ma, Y., Joehanes, R., Beiser, A., DeCarli, C. S., Heard-Costa, N. L., Levy, D., Lin, H., Liu, C.-T., Liu, C., Meigs, J. B., Satizabal, C. L., Florez, J. C., Hivert, M.-F., Dupuis, J., De Jager, P. L., Bennett, D. A., Seshadri, S., & Morrison, A. C. (2023). Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus. Clinical Epigenetics, 15(1). https://doi.org/10.1186/s13148-023-01589-4
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Son, J., Du, W., Esposito, M., Shariati, K., Ding, H., Kang, Y., & Accili, D. (2023). Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36315-4
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Thaker, V. V., Kwee, L. C., Chen, H., Bahnson, J., Ilkayeva, O., Muehlbauer, M. J., Wolfe, B., Purnell, J. Q., Pi‐Sunyer, X., Newgard, C. B., Shah, S. H., & Laferrère, B. (2023). Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions. Obesity, 32(2), 304–314. Portico. https://doi.org/10.1002/oby.23943
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Gadde, K. M., Yin, X., Goldberg, R. B., Orchard, T. J., Schlögl, M., Dabelea, D., Ibebuogu, U. N., Watson, K. E., Pi‐Sunyer, F. X., Crandall, J. P., Temprosa, M., & Luchsinger, J. A. (2023). Coronary Artery Calcium and Cognitive Decline in the Diabetes Prevention Program Outcomes Study. Journal of the American Heart Association, 12(21). https://doi.org/10.1161/jaha.123.029671
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Flanagan, E. W., Spann, R., Berry, S. E., Berthoud, H., Broyles, S., Foster, G. D., Krakoff, J., Loos, R. J. F., Lowe, M. R., Ostendorf, D. M., Powell‐Wiley, T. M., Redman, L. M., Rosenbaum, M., Schauer, P. R., Seeley, R. J., Swinburn, B. A., Hall, K., & Ravussin, E. (2023). New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium. Obesity, 31(12), 2895–2908. Portico. https://doi.org/10.1002/oby.23905
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Sekerak, R., Lerner, J. B.-A., Prasad, P., & Prasad, M. (2023). Should I start an SGLT-2 inhibitor in my patient with heart failure and chronic kidney disease? Cleveland Clinic Journal of Medicine, 90(10), 607–609. https://doi.org/10.3949/ccjm.90a.23004
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Kitamoto, T., & Accili, D. (2023). Unraveling the mysteries of hepatic insulin signaling: deconvoluting the nuclear targets of insulin. Endocrine Journal, 70(9), 851–866. https://doi.org/10.1507/endocrj.ej23-0150
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