Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

Zhao, Y., Chukanova, M., Kentistou, K. A., Fairhurst-Hunter, Z., Siegert, A. M., Jia, R. Y., Dowsett, G. K. C., Gardner, E. J., Lawler, K., Day, F. R., Kaisinger, L. R., Tung, Y.-C. L., Lam, B. Y. H., Chen, H.-J. C., Wang, Q., Berumen-Campos, J., Kuri-Morales, P., Tapia-Conyer, R., Alegre-Diaz, J., … Perry, J. R. B. (2024). Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature Genetics, 56(4), 579–584. https://doi.org/10.1038/s41588-024-01694-x
Authors:
Yajie Zhao
Maria Chukanova
Katherine A Kentistou
Zammy Fairhurst-Hunter
Anna Maria Siegert
Raina Y Jia
Georgina K C Dowsett
Eugene J Gardner
Katherine Lawler
Felix R Day
Lena R Kaisinger
Yi-Chun Loraine Tung
Brian Yee Hong Lam
Hsiao-Jou Cortina Chen
Quanli Wang
Jaime Berumen-Campos
Pablo Kuri-Morales
Roberto Tapia-Conyer
Jesus Alegre-Diaz
Inês Barroso
Jonathan Emberson
Jason M Torres
Rory Collins
Danish Saleheen
Katherine R Smith
Dirk S Paul
Florian Merkle
I Sadaf Farooqi
Nick J Wareham
Slavé Petrovski
Stephen O'Rahilly
Ken K Ong
Giles S H Yeo
John R B Perry
Affiliated Authors:
Danish Saleheen
Columbia Affiliation:
Subjects:
Diabetes Mellitus, Type 2 (MeSH)
Induced Pluripotent Stem Cells (MeSH)
Liver Diseases (MeSH)
Nerve Tissue Proteins (MeSH)
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Publication Type:
Article
Unique ID:
10.1038/s41588-024-01694-x
PMID:
38575728
DOI:
10.1038/s41588-024-01694-x
Journal:
Nature Genetics
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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