Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes

Gattu, A. K., Tanzer, M., Yaron-Barir, T. M., Johnson, J. L., Jayavelu, A. K., Pan, H., Dreyfuss, J. M., Cantley, L. C., Mann, M., & Kahn, C. R. (2025). Cell-intrinsic insulin signaling defects in human iPS cell–derived hepatocytes in type 2 diabetes. Journal of Clinical Investigation, 135(8). https://doi.org/10.1172/jci183513
Authors:
Arijeet K Gattu
Maria Tanzer
Tomer M Yaron-Barir
Jared L Johnson
Ashok Kumar Jayavelu
Hui Pan
Jonathan M Dreyfuss
Lewis C Cantley
Matthias Mann
C Ronald Kahn
Affiliated Authors:
Tomer M Yaron-Barir
Columbia Affiliation:
Subjects:
Diabetes Mellitus, Type 2 (MeSH)
Hepatocytes (MeSH)
Induced Pluripotent Stem Cells (MeSH)
Signal Transduction (MeSH)
Insulin (MeSH)
Author Keywords:
adult stem cells
diabetes
endocrinology
hepatology
metabolism
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Publication Type:
Article
Unique ID:
10.1172/jci183513
PMID:
40231468
DOI:
10.1172/jci183513
Journal:
Journal of Clinical Investigation
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: