Alzheimer Disease

Displaying 51 - 100 of 328CSV
Hojjati, S. H., Butler, T. A., Luchsinger, J. A., Benitez, R., de Leon, M., Nayak, S., Razlighi, Q. R., & Chiang, G. C. (2024). Increased between-network connectivity: A risk factor for tau elevation and disease progression. Neuroscience Letters, 840, 137943. https://doi.org/10.1016/j.neulet.2024.137943
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Burke, M. R., Sotiropoulos, I., & Waites, C. L. (2024). The multiple roles of chronic stress and glucocorticoids in Alzheimer’s disease pathogenesis. Trends in Neurosciences, 47(11), 933–948. https://doi.org/10.1016/j.tins.2024.08.015
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Nho, K., Risacher, S. L., Apostolova, L. G., Bice, P. J., Brosch, J. R., Deardorff, R., Faber, K., Farlow, M. R., Foroud, T., Gao, S., Rosewood, T., Kim, J. P., Nudelman, K., Yu, M., Aisen, P., Sperling, R., Hooli, B., Shcherbinin, S., Svaldi, D., … Saykin, A. J. (2024). CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52298-2
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Beckers, L., Rashid, M., Lee, A. J., Chatila, Z. K., Tamucci, K. A., Talcoff, R. C., Hall, J. L., Bennett, D. A., Vardarajan, B. N., & Bradshaw, E. M. (2024). CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s Disease. Genes, 15(9), 1204. https://doi.org/10.3390/genes15091204
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Bathini, P., Brai, E., Balin, B. J., Bimler, L., Corry, D. B., Devanand, D. P., Doty, R. L., Ehrlich, G. D., Eimer, W. A., Fulop, T., Hahn, D. L., Hammond, C. J., Infanti, J., Itzhaki, R., Lathe, R., Little, C. S., McLeod, R., Moein, S. T., Nelson, A. R., … Alberi Auber, L. (2024). Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer’s Disease. The Journal of Infectious Diseases, 230(Supplement_2), S150–S164. https://doi.org/10.1093/infdis/jiae328
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Lennon, M. J., Lipnicki, D. M., Lam, B. C. P., Crawford, J. D., Schutte, A. E., Peters, R., Rydberg-Sterner, T., Najar, J., Skoog, I., Riedel-Heller, S. G., Röhr, S., Pabst, A., Lobo, A., De-la-Cámara, C., Lobo, E., Lipton, R. B., Katz, M. J., Derby, C. A., … Kim, K. W. (2024). Blood Pressure, Antihypertensive Use, and Late-Life Alzheimer and Non-Alzheimer Dementia Risk. Neurology, 103(5). https://doi.org/10.1212/wnl.0000000000209715
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Gunasekaran, T. I., Reyes‐Dumeyer, D., Faber, K. M., Goate, A., Boeve, B., Cruchaga, C., Pericak‐Vance, M., Haines, J. L., Rosenberg, R., Tsuang, D., Mejia, D. R., Medrano, M., Lantigua, R. A., Sweet, R. A., Bennett, D. A., Wilson, R. S., Alba, C., Dalgard, C., Foroud, T., … Mayeux, R. (2024). Missense and loss‐of‐function variants at GWAS loci in familial Alzheimer’s disease. Alzheimer’s & Dementia, 20(11), 7580–7594. Portico. https://doi.org/10.1002/alz.14221
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Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., Sigalov, A., Wang, Y., Regev, A., Klein, H.-U., Menon, V., Bennett, D. A., Habib, N., & De Jager, P. L. (2024). Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease. Nature, 633(8030), 634–645. https://doi.org/10.1038/s41586-024-07871-6
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Perreira, K. M., Hotz, V. J., Duke, N. N., Aiello, A. E., Belsky, D. W., Brown, T., Jensen, T., & Harris, K. M. (2024). The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias. Journal of Alzheimer’s Disease, 101(2), 681–691. https://doi.org/10.3233/jad-240201
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Chen, Q., Aguirre, L., Liang, G., Zhao, H., Dong, T., Borrego, F., de Rojas, I., Hu, Q., Reyes, C., Su, L.-Y., Zhang, B., Lechleiter, J. D., Göring, H. H. H., De Jager, P. L., Kleinman, J. E., Hyde, T. M., Li, P. P., Ruiz, A., Weinberger, D. R., … Ma, L. (2024). Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease. Molecular Neurodegeneration, 19(1). https://doi.org/10.1186/s13024-024-00751-7
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L’Esperance, O. J., McGhee, J., Davidson, G., Niraula, S., Smith, A. S., Sosunov, A. A., Yan, S. S., & Subramanian, J. (2024). Functional Connectivity Favors Aberrant Visual Network c-Fos Expression Accompanied by Cortical Synapse Loss in a Mouse Model of Alzheimer’s Disease. Journal of Alzheimer’s Disease, 101(1), 111–131. https://doi.org/10.3233/jad-240776
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Ma, Y., Reyes-Dumeyer, D., Piriz, A., Recio, P., Mejia, D. R., Medrano, M., Lantigua, R. A., Vonsattel, J. P. G., Tosto, G., Teich, A. F., Ciener, B., Leskinen, S., Sivakumar, S., DeTure, M., Ranjan, D., Dickson, D., Murray, M., Lee, E., Wolk, D. A., … Vardarajan, B. N. (2024). Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathologica, 148(1). https://doi.org/10.1007/s00401-024-02778-y
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Chen, S., Cao, Z., Nandi, A., Counts, N., Jiao, L., Prettner, K., Kuhn, M., Seligman, B., Tortorice, D., Vigo, D., Wang, C., & Bloom, D. E. (2024). The global macroeconomic burden of Alzheimer’s disease and other dementias: estimates and projections for 152 countries or territories. The Lancet Global Health, 12(9), e1534–e1543. https://doi.org/10.1016/s2214-109x(24)00264-x
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Columbia Affiliation
Bae, S., Liu, K., Pouliopoulos, A. N., Ji, R., Jiménez-Gambín, S., Yousefian, O., Kline-Schoder, A. R., Batts, A. J., Tsitsos, F. N., Kokossis, D., Mintz, A., Honig, L. S., & Konofagou, E. E. (2024). Transcranial blood-brain barrier opening in Alzheimer’s disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping. Theranostics, 14(11), 4519–4535. https://doi.org/10.7150/thno.94206
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Parrish, R. L., Buchman, A. S., Tasaki, S., Wang, Y., Avey, D., Xu, J., De Jager, P. L., Bennett, D. A., Epstein, M. P., & Yang, J. (2024). SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-50983-w
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Tayran, H., Yilmaz, E., Bhattarai, P., Min, Y., Wang, X., Ma, Y., Wang, N., Jeong, I., Nelson, N., Kassara, N., Cosacak, M. I., Dogru, R. M., Reyes-Dumeyer, D., Stenersen, J. M., Reddy, J. S., Qiao, M., Flaherty, D., Gunasekaran, T. I., Yang, Z., … Kizil, C. (2024). ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling. Cell Genomics, 4(9), 100642. https://doi.org/10.1016/j.xgen.2024.100642
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Ribeiro, F. C., Cozachenco, D., Argyrousi, E. K., Staniszewski, A., Wiebe, S., Calixtro, J. D., Soares‐Neto, R., Al‐Chami, A., Sayegh, F. E., Bermudez, S., Arsenault, E., Cossenza, M., Lacaille, J., Nader, K., Sun, H., De Felice, F. G., Lourenco, M. V., Arancio, O., Aguilar‐Valles, A., … Ferreira, S. T. (2024). The ketamine metabolite (2R,6R)‐hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease. Alzheimer’s & Dementia, 20(8), 5398–5410. Portico. https://doi.org/10.1002/alz.14034
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Kharaghani, A., Tio, E. S., Milic, M., Bennett, D. A., De Jager, P. L., Schneider, J. A., Sun, L., & Felsky, D. (2024). Association of whole-person eigen-polygenic risk scores with Alzheimer’s disease. Human Molecular Genetics, 33(15), 1315–1327. https://doi.org/10.1093/hmg/ddae067
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Wang, Q., Antone, J., Alsop, E., Reiman, R., Funk, C., Bendl, J., Dudley, J. T., Liang, W. S., Karr, T. L., Roussos, P., Bennett, D. A., De Jager, P. L., Serrano, G. E., Beach, T. G., Van Keuren-Jensen, K., Mastroeni, D., Reiman, E. M., & Readhead, B. P. (2024). Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49790-0
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Oveisgharan, S., Yu, L., de Paiva Lopes, K., Tasaki, S., Wang, Y., Menon, V., Schneider, J. A., Seyfried, N. T., & Bennett, D. A. (2024). Proteins linking APOE ɛ4 with Alzheimer’s disease. Alzheimer’s & Dementia, 20(7), 4499–4511. Portico. https://doi.org/10.1002/alz.13867
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Qu, W., Lam, M., McInvale, J. J., Mares, J. A., Kwon, S., Humala, N., Mahajan, A., Nguyen, T., Jakubiak, K. A., Mun, J.-Y., Tedesco, T. G., Al-Dalahmah, O., Hussaini, S. A., Sproul, A. A., Siegelin, M. D., De Jager, P. L., Canoll, P., Menon, V., & Hargus, G. (2024). Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02755-5
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Cortese, G. P., Bartosch, A. M. W., Xiao, H., Gribkova, Y., Lam, T. G., Argyrousi, E. K., Sivakumar, S., Cardona, C., & Teich, A. F. (2024). ZCCHC17 knockdown phenocopies Alzheimer’s disease-related loss of synaptic proteins and hyperexcitability. Journal of Neuropathology & Experimental Neurology, 83(7), 626–635. https://doi.org/10.1093/jnen/nlae033
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İş, Ö., Wang, X., Reddy, J. S., Min, Y., Yilmaz, E., Bhattarai, P., Patel, T., Bergman, J., Quicksall, Z., Heckman, M. G., Tutor-New, F. Q., Can Demirdogen, B., White, L., Koga, S., Krause, V., Inoue, Y., Kanekiyo, T., Cosacak, M. I., Nelson, N., … Ertekin-Taner, N. (2024). Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48926-6
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Zhang, A., Wengler, K., Zhu, X., Horga, G., Goldberg, T. E., & Lee, S. (2024). Altered Hierarchical Gradients of Intrinsic Neural Timescales in Mild Cognitive Impairment and Alzheimer’s Disease. The Journal of Neuroscience, 44(25), e2024232024. https://doi.org/10.1523/jneurosci.2024-23.2024
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Zhu, Y., Park, S., Kolady, R., Zha, W., Ma, Y., Dias, A., McGuire, K., Hardi, A., Lin, S., Ismail, Z., Adkins‐Jackson, P. B., Trani, J., & Babulal, G. M. (2024). A systematic review/meta‐analysis of prevalence and incidence rates illustrates systemic underrepresentation of individuals racialized as Asian and/or Asian‐American in ADRD research. Alzheimer’s & Dementia, 20(6), 4315–4330. Portico. https://doi.org/10.1002/alz.13820
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Teresi, J. A., Ocepek-Welikson, K., Eimicke, J. P., Ramirez, M., Liu, S., Silver, S., & Luchsinger, J. A. (2024). Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders. Alzheimer Disease & Associated Disorders, 38(2), 178–188. https://doi.org/10.1097/wad.0000000000000625
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Lao, P., Edwards, N., Flores-Aguilar, L., Alshikho, M., Rizvi, B., Tudorascu, D., Rosas, H. D., Yassa, M., Christian, B. T., Mapstone, M., Handen, B., Zimmerman, M. E., Gutierrez, J., Wilcock, D., Head, E., & Brickman, A. M. (2024). Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-61962-y
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Feldman, H. H., Luchsinger, J. A., Léger, G. C., Taylor, C., Jacobs, D. M., Salmon, D. P., Edland, S. D., Messer, K., Revta, C., Flowers, S. A., Jones, K. S., Koulman, A., Yarasheski, K. E., Verghese, P. B., Venkatesh, V., Zetterberg, H., Durant, J., Lupo, J.-L., & Gibson, G. E. (2024). Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer’s disease (BenfoTeam). PLOS ONE, 19(5), e0302998. https://doi.org/10.1371/journal.pone.0302998
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Wang, H.-P., Scalco, R., Saito, N., Beckett, L., Nguyen, M.-L., Huie, E. Z., Honig, L. S., DeCarli, C., Rissman, R. A., Teich, A. F., Mungas, D. M., Jin, L.-W., & Dugger, B. N. (2024). The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathologica Communications, 12(1). https://doi.org/10.1186/s40478-024-01773-4
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Oveisgharan, S., Yu, L., de Paiva Lopes, K., Petyuk, V. A., Tasaki, S., Vialle, R., Menon, V., Wang, Y., De Jager, P. L., Schneider, J. A., & Bennett, D. A. (2024). G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06272-9
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Honig, L. S., Sabbagh, M. N., van Dyck, C. H., Sperling, R. A., Hersch, S., Matta, A., Giorgi, L., Gee, M., Kanekiyo, M., Li, D., Purcell, D., Dhadda, S., Irizarry, M., & Kramer, L. (2024). Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-024-01441-8
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Rawlley, B., Gupta, K., Khalid, S. N., Vaishnav, P. P., Sanchez, A. C., Somerville, A., Anuforo, A., Pruthi, S., & Chaudhuri, D. (2024). Memantine and Incident Atrial Fibrillation or Flutter in Alzheimer’s Disease. JACC: Clinical Electrophysiology, 10(6), 1197–1199. https://doi.org/10.1016/j.jacep.2024.03.028
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Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L., Zaman, S., Lott, I. T., … Mori, H. (2024). Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. The Lancet Neurology, 23(5), 500–510. https://doi.org/10.1016/s1474-4422(24)00084-x
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Idnay, B., Liu, J., Fang, Y., Hernandez, A., Kaw, S., Etwaru, A., Juarez Padilla, J., Ramírez, S. O., Marder, K., Weng, C., & Schnall, R. (2024). Sociotechnical feasibility of natural language processing-driven tools in clinical trial eligibility prescreening for Alzheimer’s disease and related dementias. Journal of the American Medical Informatics Association, 31(5), 1062–1073. https://doi.org/10.1093/jamia/ocae032
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D’Acunzo, P., Argyrousi, E. K., Ungania, J. M., Kim, Y., DeRosa, S., Pawlik, M., Goulbourne, C. N., Arancio, O., & Levy, E. (2024). Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity. Molecular Neurodegeneration, 19(1). https://doi.org/10.1186/s13024-024-00721-z
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Bhattarai, P., Gunasekaran, T. I., Belloy, M. E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E. M., Hupalo, D. N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., … Vardarajan, B. N. (2024). Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02721-1
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Haq, I., Ngo, J. C., Roy, N., Pan, R. L., Nawsheen, N., Chiu, R., Zhang, Y., Fujita, M., Soni, R. K., Wu, X., Bennett, D. A., Menon, V., Olah, M., & Sher, F. (2024). An integrated toolkit for human microglia functional genomics. Stem Cell Research & Therapy, 15(1). https://doi.org/10.1186/s13287-024-03700-9
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Hudgins, A. D., Zhou, S., Arey, R. N., Rosenfeld, M. G., Murphy, C. T., & Suh, Y. (2024). A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory function. Neuron, 112(13), 2112-2129.e4. https://doi.org/10.1016/j.neuron.2024.04.009
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Dressman, D., Tasaki, S., Yu, L., Schneider, J., Bennett, D. A., Elyaman, W., & Vardarajan, B. (2024). Polygenic risk associated with Alzheimer’s disease and other traits influences genes involved in T cell signaling and activation. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1337831
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Fujita, M., Gao, Z., Zeng, L., McCabe, C., White, C. C., Ng, B., Green, G. S., Rozenblatt-Rosen, O., Phillips, D., Amir-Zilberstein, L., Lee, H., Pearse, R. V., Khan, A., Vardarajan, B. N., Kiryluk, K., Ye, C. J., Klein, H.-U., Wang, G., Regev, A., … De Jager, P. L. (2024). Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain. Nature Genetics, 56(4), 605–614. https://doi.org/10.1038/s41588-024-01685-y
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Wang, Y., Sarnowski, C., Lin, H., Pitsillides, A. N., Heard‐Costa, N. L., Choi, S. H., Wang, D., Bis, J. C., Blue, E. E., Boerwinkle, E., De Jager, P. L., Fornage, M., Wijsman, E. M., Seshadri, S., Dupuis, J., Peloso, G. M., & DeStefano, A. L. (2024). Key variants via the Alzheimer’s Disease Sequencing Project whole genome sequence data. Alzheimer’s & Dementia, 20(5), 3290–3304. Portico. https://doi.org/10.1002/alz.13705
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Buchman, A. S., Yu, L., Klein, H.-U., Zammit, A. R., Oveisgharan, S., Nag, S., Tickotsky, N., Levy, H., Seyfried, N., Morgenstern, D., Levin, Y., Schnaider Beeri, M., & Bennett, D. A. (2024). Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults. Neurology, 102(7). https://doi.org/10.1212/wnl.0000000000209223
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Maestre, G., Hill, C., Griffin, P., Hall, S., Hu, W., Flatt, J., Babulal, G., Thorpe, R., Henderson, J. N., Buchwald, D., Manson, S., Cicero, E., Gilmore‐Bykovskyi, A., Gamaldo, A., Glover, C., Barnes, L., Kind, A., James, B., Zeki Al Hazzouri, A., … Carrillo, M. (2024). Promoting diverse perspectives: Addressing health disparities related to Alzheimer’s and all dementias. Alzheimer’s & Dementia, 20(4), 3099–3107. Portico. https://doi.org/10.1002/alz.13752
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Malamon, J. S., Farrell, J. J., Xia, L. C., Dombroski, B. A., Das, R. G., Way, J., Kuzma, A. B., Valladares, O., Leung, Y. Y., Scanlon, A. J., Lopez, I. A. B., Brehony, J., Worley, K. C., Zhang, N. R., Wang, L.-S., Farrer, L. A., Schellenberg, G. D., Lee, W.-P., & Vardarajan, B. N. (2024). A comparative study of structural variant calling in WGS from Alzheimer’s disease families. Life Science Alliance, 7(5), e202302181. https://doi.org/10.26508/lsa.202302181
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Wang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre‐Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., … Fox, N. C. (2024). Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2698–2706. Portico. https://doi.org/10.1002/alz.13735
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Joseph‐Mathurin, N., Feldman, R. L., Lu, R., Shirzadi, Z., Toomer, C., Saint Clair, J. R., Ma, Y., McKay, N. S., Strain, J. F., Kilgore, C., Friedrichsen, K. A., Chen, C. D., Gordon, B. A., Chen, G., Hornbeck, R. C., Massoumzadeh, P., McCullough, A. A., Wang, Q., … Li, Y. (2024). Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage. Alzheimer’s & Dementia, 20(4), 2680–2697. Portico. https://doi.org/10.1002/alz.13729
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Xicota, L., Cosentino, S., Vardarajan, B., Mayeux, R., Perls, T. T., Andersen, S. L., Zmuda, J. M., Thyagarajan, B., Yashin, A., Wojczynski, M. K., Krinsky‐McHale, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M. E., Schupf, N., Lee, J. H., & Barral, S. (2024). Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2670–2679. Portico. https://doi.org/10.1002/alz.13718
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Herman, M., Randall, G. W., Spiegel, J. L., Maldonado, D. J., & Simoes, S. (2024). Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899). https://doi.org/10.1098/rstb.2022.0387
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