Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator

Qu, W., Lam, M., McInvale, J. J., Mares, J. A., Kwon, S., Humala, N., Mahajan, A., Nguyen, T., Jakubiak, K. A., Mun, J.-Y., Tedesco, T. G., Al-Dalahmah, O., Hussaini, S. A., Sproul, A. A., Siegelin, M. D., De Jager, P. L., Canoll, P., Menon, V., & Hargus, G. (2024). Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02755-5
Authors:
Wenhui Qu
Matti Lam
Julie J McInvale
Jason A Mares
Sam Kwon
Nelson Humala
Aayushi Mahajan
Trang Nguyen
Kelly A Jakubiak
Jeong-Yeon Mun
Thomas G Tedesco
Osama Al-Dalahmah
Syed A Hussaini
Andrew A Sproul
Markus D Siegelin
Philip L De Jager
Peter Canoll
Vilas Menon
Gunnar Hargus
Affiliated Authors:
Wenhui Qu
Matti Lam
Julie J McInvale
Jason A Mares
Sam Kwon
Nelson Humala
Aayushi Mahajan
Trang Nguyen
Kelly A Jakubiak
Jeong-Yeon Mun
Thomas G Tedesco
Osama Al-Dalahmah
Syed A Hussaini
Andrew A Sproul
Markus D Siegelin
Philip L De Jager
Peter Canoll
Vilas Menon
Gunnar Hargus
Author Keywords:
alzheimer’s disease
disease modeling
grafts
induced pluripotent stem cells
ipscs
single-nucleus rna sequencing
snrna-seq
transplantation
alzheimer's disease
Publication Type:
Article
Unique ID:
10.1007/s00401-024-02755-5
PMID:
Publication Date:
Data Source:
PubMed

Record Created: