Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)

Feldman, H. H., Luchsinger, J. A., Léger, G. C., Taylor, C., Jacobs, D. M., Salmon, D. P., Edland, S. D., Messer, K., Revta, C., Flowers, S. A., Jones, K. S., Koulman, A., Yarasheski, K. E., Verghese, P. B., Venkatesh, V., Zetterberg, H., Durant, J., Lupo, J.-L., & Gibson, G. E. (2024). Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer’s disease (BenfoTeam). PLOS ONE, 19(5), e0302998. https://doi.org/10.1371/journal.pone.0302998

Authors:

Howard H Feldman

José A Luchsinger

Gabriel C Léger

Curtis Taylor

Diane M Jacobs

David P Salmon

Steven D Edland

Karen Messer

Carolyn Revta

Sarah A Flowers

Kerry S Jones