Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

Xie, S. C., Metcalfe, R. D., Mizutani, H., Puhalovich, T., Hanssen, E., Morton, C. J., Du, Y., Dogovski, C., Huang, S.-C., Ciavarri, J., Hales, P., Griffin, R. J., Cohen, L. H., Chuang, B.-C., Wittlin, S., Deni, I., Yeo, T., Ward, K. E., Barry, D. C., … Tilley, L. (2021). Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences, 118(39). https://doi.org/10.1073/pnas.2107213118
Authors:
Stanley C Xie
Riley D Metcalfe
Hirotake Mizutani
Tanya Puhalovich
Eric Hanssen
Craig J Morton
Yawei Du
Con Dogovski
Shih-Chung Huang
Jeffrey Ciavarri
Paul Hales
Robert J Griffin
Lawrence H Cohen
Bei-Ching Chuang
Sergio Wittlin
Ioanna Deni
Tomas Yeo
Kurt E Ward
Daniel C Barry
Boyin Liu
David L Gillett
Benigno F Crespo-Fernandez
Sabine Ottilie
Nimisha Mittal
Alisje Churchyard
Daniel Ferguson
Anna Caroline C Aguiar
Rafael V C Guido
Jake Baum
Kirsten K Hanson
Elizabeth A Winzeler
Francisco-Javier Gamo
David A Fidock
Delphine Baud
Michael W Parker
Stephen Brand
Lawrence R Dick
Michael D W Griffin
Alexandra E Gould
Leann Tilley
Affiliated Authors:
Ioanna Deni
Tomas Yeo
Kurt E Ward
David A Fidock
Columbia Affiliation:
Subjects:
Ubiquitin-Proteasome Proteolytic Pathway (OpenAlex Topic)
Malaria (OpenAlex Topic)
Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)
Boron Compounds (MeSH)
Malaria, Falciparum (MeSH)
Plasmodium falciparum (MeSH)
Proteasome Endopeptidase Complex (MeSH)
Proteasome Inhibitors (MeSH)
Author Keywords:
plasmodium
proteasome
antimalarial drug
peptide boronate
cryo-em
elink
Publication Type:
Article
Unique ID:
10.1073/pnas.2107213118
PMID:
34548400
DOI:
10.1073/pnas.2107213118
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: