Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

Deni, I., Stokes, B. H., Ward, K. E., Fairhurst, K. J., Pasaje, C. F. A., Yeo, T., Akbar, S., Park, H., Muir, R., Bick, D. S., Zhan, W., Zhang, H., Liu, Y. J., Ng, C. L., Kirkman, L. A., Almaliti, J., Gould, A. E., Duffey, M., O’Donoghue, A. J., … Fidock, D. A. (2023). Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30(5), 470-485.e6. https://doi.org/10.1016/j.chembiol.2023.03.002
Authors:
Ioanna Deni
Barbara H. Stokes
Kurt E. Ward
Kate J. Fairhurst
Charisse Flerida A. Pasaje
Tomas Yeo
Shirin Akbar
Heekuk Park
Ryan T. Muir
Daniella S. Bick
Wenhu Zhan
Hao Zhang
Yi Jing Liu
Caroline L. Ng
Laura A. Kirkman
Jehad Almaliti
Alexandra E. Gould
Maëlle Duffey
Anthony J. O’Donoghue
Anne‐Catrin Uhlemann
Jacquin C. Niles
da Fonseca
William H. Gerwick
Gang Lin
Matthew Bogyo
David A. Fidock
Affiliated Authors:
Ioanna Deni
Barbara H. Stokes
Kurt E. Ward
Kate J. Fairhurst
Tomas Yeo
Heekuk Park
Daniella S. Bick
Anne‐Catrin Uhlemann
David A. Fidock
Author Keywords:
artemisinin
conditional knockdown
covalent inhibitors
crispr/cas9 gene editing
drug discovery
malaria
minimum inoculum of resistance
molecular modeling
plasmodium falciparum
proteasome
Publication Type:
Article
Unique ID:
10.1016/j.chembiol.2023.03.002
PMID:
Publication Date:
Data Source:
OpenAlex

Record Created: