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Gorman, B. R., Voloudakis, G., Igo, R. P., Kinzy, T., Halladay, C. W., Bigdeli, T. B., Zeng, B., Venkatesh, S., Cooke Bailey, J. N., Crawford, D. C., Markianos, K., Dong, F., Schreiner, P. A., Zhang, W., Fritsche, L. G., Igl, W., Cooke Bailey, J. N., … Iyengar, S. K. (2024). Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nature Genetics, 56(12), 2659–2671. https://doi.org/10.1038/s41588-024-01764-0

García-Marín, L. M., Campos, A. I., Diaz-Torres, S., Rabinowitz, J. A., Ceja, Z., Mitchell, B. L., Grasby, K. L., Thorp, J. G., Agartz, I., Alhusaini, S., Ames, D., Amouyel, P., Andreassen, O. A., Arfanakis, K., Arias-Vasquez, A., Armstrong, N. J., Athanasiu, L., Bastin, M. E., Beiser, A. S., … Rentería, M. E. (2024). Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature Genetics, 56(11), 2333–2344. https://doi.org/10.1038/s41588-024-01951-z

Janivara, R., Chen, W. C., Hazra, U., Baichoo, S., Agalliu, I., Kachambwa, P., Simonti, C. N., Brown, L. M., Tambe, S. P., Kim, M. S., Harlemon, M., Jalloh, M., Muzondiwa, D., Naidoo, D., Ajayi, O. O., Snyper, N. Y., Niang, L., Diop, H., Ndoye, M., … Rebbeck, T. R. (2024). Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa. Nature Genetics, 56(10), 2093–2103. https://doi.org/10.1038/s41588-024-01931-3

Abate-Shen, C. (2024). Context-specific targeting of the androgen receptor in prostate cancer. Nature Genetics, 56(10), 2000–2001. https://doi.org/10.1038/s41588-024-01935-z

Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Beecham, A. H., Patsopoulos, N. A., Cotsapas, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., … Cotsapas, C. (2024). Genetic mapping across autoimmune diseases reveals shared associations and mechanisms. Nature Genetics, 56(5), 838–845. https://doi.org/10.1038/s41588-024-01732-8

Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C.-Y., Choi, K. W., Coleman, J. R. I., Daskalakis, N. P., Duncan, L. E., Polimanti, R., Aaronson, C., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegoviç, E., Babić, D., Bacanu, S.-A., … Koenen, K. C. (2024). Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics, 56(5), 792–808. https://doi.org/10.1038/s41588-024-01707-9

Madden, E. B., Hindorff, L. A., Bonham, V. L., Akintobi, T. H., Burchard, E. G., Baker, K. E., Begay, R. L., Carpten, J. D., Cox, N. J., Di Francesco, V., Dillard, D. A., Fletcher, F. E., Fullerton, S. M., Garrison, N. A., Hammack-Aviran, C. M., Hiratsuka, V. Y., Hildreth, J. E. K., Horowitz, C. R., Hughes Halbert, C. A., … Green, E. D. (2024). Advancing genomics to improve health equity. Nature Genetics, 56(5), 752–757. https://doi.org/10.1038/s41588-024-01711-z

Zhao, Y., Chukanova, M., Kentistou, K. A., Fairhurst-Hunter, Z., Siegert, A. M., Jia, R. Y., Dowsett, G. K. C., Gardner, E. J., Lawler, K., Day, F. R., Kaisinger, L. R., Tung, Y.-C. L., Lam, B. Y. H., Chen, H.-J. C., Wang, Q., Berumen-Campos, J., Kuri-Morales, P., Tapia-Conyer, R., Alegre-Diaz, J., … Perry, J. R. B. (2024). Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature Genetics, 56(4), 579–584. https://doi.org/10.1038/s41588-024-01694-x

Sakaue, S., Weinand, K., Isaac, S., Dey, K. K., Jagadeesh, K., Kanai, M., Watts, G. F. M., Zhu, Z., Albrecht, J., Anolik, J. H., Apruzzese, W., Banda, N., Barnas, J. L., Bathon, J. M., Ben-Artzi, A., Boyce, B. F., Boyle, D. L., Bridges, S. L., … Bykerk, V. P. (2024). Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles. Nature Genetics, 56(4), 615–626. https://doi.org/10.1038/s41588-024-01682-1

Fujita, M., Gao, Z., Zeng, L., McCabe, C., White, C. C., Ng, B., Green, G. S., Rozenblatt-Rosen, O., Phillips, D., Amir-Zilberstein, L., Lee, H., Pearse, R. V., Khan, A., Vardarajan, B. N., Kiryluk, K., Ye, C. J., Klein, H.-U., Wang, G., Regev, A., … De Jager, P. L. (2024). Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain. Nature Genetics, 56(4), 605–614. https://doi.org/10.1038/s41588-024-01685-y

Xiao, F., Zhang, X., Morton, S. U., Kim, S. W., Fan, Y., Gorham, J. M., Zhang, H., Berkson, P. J., Mazumdar, N., Cao, Y., Chen, J., Hagen, J., Liu, X., Zhou, P., Richter, F., Shen, Y., Ward, T., Gelb, B. D., Seidman, J. G., … Pu, W. T. (2024). Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature Genetics, 56(3), 420–430. https://doi.org/10.1038/s41588-024-01669-y

Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., … McQuillin, A. (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56(2), 222–233. https://doi.org/10.1038/s41588-023-01596-4

Guo, M. H., Francioli, L. C., Stenton, S. L., Goodrich, J. K., Watts, N. A., Singer-Berk, M., Groopman, E., Darnowsky, P. W., Solomonson, M., Baxter, S., Abreu, M., Salinas, C. A. A., Ahmad, T., Albert, C. M., Alföldi, J., Ardissino, D., Armean, I. M., Atzmon, G., … Banks, E. (2023). Inferring compound heterozygosity from large-scale exome sequencing data. Nature Genetics, 56(1), 152–161. https://doi.org/10.1038/s41588-023-01608-3

Leeman-Neill, R. J., Song, D., Bizarro, J., Wacheul, L., Rothschild, G., Singh, S., Yang, Y., Sarode, A. Y., Gollapalli, K., Wu, L., Zhang, W., Chen, Y., Lauring, M. C., Whisenant, D. E., Bhavsar, S., Lim, J., Swerdlow, S. H., Bhagat, G., Zhao, Q., … Basu, U. (2023). Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nature Genetics, 55(12), 2160–2174. https://doi.org/10.1038/s41588-023-01561-1

Kang, J. B., Shen, A. Z., Gurajala, S., Nathan, A., Rumker, L., Aguiar, V. R. C., Valencia, C., Lagattuta, K. A., Zhang, F., Jonsson, A. H., Yazar, S., Alquicira-Hernandez, J., Khalili, H., Ananthakrishnan, A. N., Jagadeesh, K., Dey, K., Albrecht, J., Apruzzese, W., … Banda, N. (2023). Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution. Nature Genetics, 55(12), 2255–2268. https://doi.org/10.1038/s41588-023-01586-6

Sasse, A., Ng, B., Spiro, A. E., Tasaki, S., Bennett, D. A., Gaiteri, C., De Jager, P. L., Chikina, M., & Mostafavi, S. (2023). Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings. Nature Genetics, 55(12), 2060–2064. https://doi.org/10.1038/s41588-023-01524-6

Chapman, O. S., Luebeck, J., Sridhar, S., Wong, I. T.-L., Dixit, D., Wang, S., Prasad, G., Rajkumar, U., Pagadala, M. S., Larson, J. D., He, B. J., Hung, K. L., Lange, J. T., Dehkordi, S. R., Chandran, S., Adam, M., Morgan, L., Wani, S., Tiwari, A., … Chavez, L. (2023). Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature Genetics, 55(12), 2189–2199. https://doi.org/10.1038/s41588-023-01551-3

Miller, K. E., Rivaldi, A. C., Shinagawa, N., Sran, S., Navarro, J. B., Westfall, J. J., Miller, A. R., Roberts, R. D., Akkari, Y., Supinger, R., Hester, M. E., Marhabaie, M., Gade, M., Lu, J., Rodziyevska, O., Bhattacharjee, M. B., Von Allmen, G. K., Yang, E., Lidov, H. G. W., … Bedrosian, T. A. (2023). Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy. Nature Genetics, 55(11), 1920–1928. https://doi.org/10.1038/s41588-023-01547-z

Hirakawa, H., Gao, L., Tavakol, D. N., Vunjak-Novakovic, G., & Ding, L. (2023). Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration. Nature Genetics, 55(11), 1941–1952. https://doi.org/10.1038/s41588-023-01528-2

Burstein, D., Griffen, T. C., Therrien, K., Bendl, J., Venkatesh, S., Dong, P., Modabbernia, A., Zeng, B., Mathur, D., Hoffman, G., Sysko, R., Hildebrandt, T., Voloudakis, G., & Roussos, P. (2023). Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism. Nature Genetics, 55(9), 1462–1470. https://doi.org/10.1038/s41588-023-01464-1

Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X.-J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., … Gharavi, A. G. (2023). Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nature Genetics, 55(7), 1091–1105. https://doi.org/10.1038/s41588-023-01422-x

Yang, Z., Wang, C., Liu, L., Khan, A., Lee, A., Vardarajan, B., Mayeux, R., Kiryluk, K., & Ionita-Laza, I. (2023). CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses. Nature Genetics, 55(6), 1057–1065. https://doi.org/10.1038/s41588-023-01392-0

Ravi, A., Hellmann, M. D., Arniella, M. B., Holton, M., Freeman, S. S., Naranbhai, V., Stewart, C., Leshchiner, I., Kim, J., Akiyama, Y., Griffin, A. T., Vokes, N. I., Sakhi, M., Kamesan, V., Rizvi, H., Ricciuti, B., Forde, P. M., Anagnostou, V., Riess, J. W., … Gainor, J. F. (2023). Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer. Nature Genetics, 55(5), 807–819. https://doi.org/10.1038/s41588-023-01355-5

Puram, S. V., Mints, M., Pal, A., Qi, Z., Reeb, A., Gelev, K., Barrett, T. F., Gerndt, S., Liu, P., Parikh, A. S., Ramadan, S., Law, T., Mroz, E. A., Rocco, J. W., Adkins, D., Thorstad, W. L., Gay, H. A., Ding, L., Paniello, R. C., … Tirosh, I. (2023). Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma. Nature Genetics, 55(4), 640–650. https://doi.org/10.1038/s41588-023-01357-3

Shrine, N., Izquierdo, A. G., Chen, J., Packer, R., Hall, R. J., Guyatt, A. L., Batini, C., Thompson, R. J., Pavuluri, C., Malik, V., Hobbs, B. D., Moll, M., Kim, W., Tal-Singer, R., Bakke, P., Fawcett, K. A., John, C., Coley, K., Piga, N. N., … Tobin, M. D. (2023). Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nature Genetics, 55(3), 410–422. https://doi.org/10.1038/s41588-023-01314-0

Chen, F., Wang, X., Jang, S.-K., Quach, B. C., Weissenkampen, J. D., Khunsriraksakul, C., Yang, L., Sauteraud, R., Albert, C. M., Allred, N. D. D., Arnett, D. K., Ashley-Koch, A. E., Barnes, K. C., Barr, R. G., Becker, D. M., Bielak, L. F., Bis, J. C., Blangero, J., Boorgula, M. P., … Liu, D. J. (2023). Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nature Genetics, 55(2), 291–300. https://doi.org/10.1038/s41588-022-01282-x

Wang, Y., Fan, J. L., Melms, J. C., Amin, A. D., Georgis, Y., Barrera, I., Ho, P., Tagore, S., Abril-Rodríguez, G., He, S., Jin, Y., Biermann, J., Hofree, M., Caprio, L., Berhe, S., Khan, S. A., Henick, B. S., Ribas, A., Macosko, E. Z., … Izar, B. (2023). Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature Genetics, 55(1), 19–25. https://doi.org/10.1038/s41588-022-01268-9

Liu, H., Li, P., Zhang, S., Xiang, J., Yang, R., Liu, J., Shafiquzzaman, M., Biswas, S., Wei, Z., Zhang, Z., Zhou, X., Yin, F., Xie, Y., Goff, S. P., Chen, L., & Li, B. (2022). Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice. Nature Genetics, 54(12), 1946–1958. https://doi.org/10.1038/s41588-022-01227-4

Holstege, H., Hulsman, M., Charbonnier, C., Grenier-Boley, B., Quenez, O., Grozeva, D., van Rooij, J. G. J., Sims, R., Ahmad, S., Amin, N., Norsworthy, P. J., Dols-Icardo, O., Hummerich, H., Kawalia, A., Amouyel, P., Beecham, G. W., Berr, C., Bis, J. C., Boland, A., … Lambert, J.-C. (2022). Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease. Nature Genetics, 54(12), 1786–1794. https://doi.org/10.1038/s41588-022-01208-7

Zhou, X., Feliciano, P., Shu, C., Wang, T., Astrovskaya, I., Hall, J. B., Obiajulu, J. U., Wright, J. R., Murali, S. C., Xu, S. X., Brueggeman, L., Thomas, T. R., Marchenko, O., Fleisch, C., Barns, S. D., Snyder, L. G., Han, B., Chang, T. S., Turner, T. N., … Chung, W. K. (2022). Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nature Genetics, 54(9), 1305–1319. https://doi.org/10.1038/s41588-022-01148-2

Vujkovic, M., Ramdas, S., Lorenz, K. M., Guo, X., Darlay, R., Cordell, H. J., He, J., Gindin, Y., Chung, C., Myers, R. P., Schneider, C. V., Park, J., Lee, K. M., Serper, M., Carr, R. M., Kaplan, D. E., Haas, M. E., MacLean, M. T., Witschey, W. R., … Chang, K.-M. (2022). A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature Genetics, 54(6), 761–771. https://doi.org/10.1038/s41588-022-01078-z

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., … Lambert, J.-C. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436. https://doi.org/10.1038/s41588-022-01024-z

Huffman, J. E., Butler-Laporte, G., Khan, A., Pairo-Castineira, E., Drivas, T. G., Peloso, G. M., Nakanishi, T., Ganna, A., Verma, A., Baillie, J. K., Kiryluk, K., Richards, J. B., & Zeberg, H. (2022). Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. Nature Genetics, 54(2), 125–127. https://doi.org/10.1038/s41588-021-00996-8