Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

Strom, N. I., Gerring, Z. F., Galimberti, M., Yu, D., Halvorsen, M. W., Abdellaoui, A., Rodriguez-Fontenla, C., Sealock, J. M., Bigdeli, T., Coleman, J. R., Mahjani, B., Thorp, J. G., Bey, K., Burton, C. L., Luykx, J. J., Zai, G., Alemany, S., Andre, C., Askland, K. D., … Mattheisen, M. (2025). Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder. Nature Genetics. https://doi.org/10.1038/s41588-025-02189-z
Authors:
Nora I Strom
Zachary F Gerring
Marco Galimberti
Dongmei Yu
Matthew W Halvorsen
Abdel Abdellaoui
Cristina Rodriguez-Fontenla
Julia M Sealock
Tim Bigdeli
Jonathan R Coleman
Behrang Mahjani
Jackson G Thorp
Katharina Bey
Christie L Burton
Jurjen J Luykx
Gwyneth Zai
Silvia Alemany
Christine Andre
Kathleen D Askland
Julia Bäckman
Nerisa Banaj
Cristina Barlassina
Judith Becker Nissen
O Joseph Bienvenu
Donald Black
Michael H Bloch
Sigrid Børte
Rosa Bosch
Michael Breen
Brian P Brennan
Helena Brentani
Joseph D Buxbaum
Jonas Bybjerg-Grauholm
Enda M Byrne
Judit Cabana-Dominguez
Beatriz Camarena
Adrian Camarena
Carolina Cappi
Angel Carracedo
Miguel Casas
Maria Cristina Cavallini
Valentina Ciullo
Edwin H Cook
Jesse Crosby
Bernadette A Cullen
Elles J De Schipper
Richard Delorme
Srdjan Djurovic
Jason A Elias
Xavier Estivill
Martha J Falkenstein
Bengt T Fundin
Lauryn Garner
Christina Gironda
Fernando S Goes
Marco A Grados
Jakob Grove
Wei Guo
Jan Haavik
Kristen Hagen
Kelly Harrington
Alexandra Havdahl
Kira D Höffler
Ana G Hounie
Donald Hucks
Christina Hultman
Magdalena Janecka
Eric Jenike
Elinor K Karlsson
Kara Kelley
Julia Klawohn
Janice E Krasnow
Kristi Krebs
Christoph Lange
Nuria Lanzagorta
Daniel Levey
Kerstin Lindblad-Toh
Fabio Macciardi
Brion Maher
Brittany Mathes
Evonne McArthur
Nathaniel McGregor
Nicole C McLaughlin
Sandra Meier
Euripedes C Miguel
Maureen Mulhern
Paul S Nestadt
Erika L Nurmi
Kevin S O'Connell
Lisa Osiecki
Olga Therese Ousdal
Teemu Palviainen
Nancy L Pedersen
Fabrizio Piras
Federica Piras
Sriramya Potluri
Raquel Rabionet
Alfredo Ramirez
Scott Rauch
Abraham Reichenberg
Mark A Riddle
Stephan Ripke
Maria C Rosário
Aline S Sampaio
Miriam A Schiele
Anne Heidi Skogholt
Laura G Sloofman
Jan Smit
María Soler Artigas
Laurent F Thomas
Eric Tifft
Homero Vallada
Nathanial van Kirk
Jeremy Veenstra-VanderWeele
Nienke N Vulink
Christopher P Walker
Ying Wang
Jens R Wendland
Bendik S Winsvold
Yin Yao
Hang Zhou
Arpana Agrawal
Pino Alonso
Götz Berberich
Kathleen K Bucholz
Cynthia M Bulik
Danielle Cath
Damiaan Denys
Valsamma Eapen
Howard Edenberg
Peter Falkai
Thomas V Fernandez
Abby J Fyer
J M Gaziano
Dan A Geller
Hans J Grabe
Benjamin D Greenberg
Gregory L Hanna
Ian B Hickie
David M Hougaard
Norbert Kathmann
James Kennedy
Dongbing Lai
Mikael Landén
Stéphanie Le Hellard
Marion Leboyer
Christine Lochner
James T McCracken
Sarah E Medland
Preben B Mortensen
Benjamin M Neale
Humberto Nicolini
Merete Nordentoft
Michele Pato
Carlos Pato
David L Pauls
John Piacentini
Christopher Pittenger
Danielle Posthuma
Josep Antoni Ramos-Quiroga
Steven A Rasmussen
Margaret A Richter
David R Rosenberg
Stephan Ruhrmann
Jack F Samuels
Sven Sandin
Paul Sandor
Gianfranco Spalletta
Dan J Stein
S Evelyn Stewart
Eric A Storch
Barbara E Stranger
Maurizio Turiel
Thomas Werge
Ole A Andreassen
Anders D Børglum
Susanne Walitza
Kristian Hveem
Bjarne K Hansen
Christian Rück
Nicholas G Martin
Lili Milani
Ole Mors
Ted Reichborn-Kjennerud
Marta Ribasés
Gerd Kvale
David Mataix-Cols
Katharina Domschke
Edna Grünblatt
Michael Wagner
John-Anker Zwart
Gerome Breen
Gerald Nestadt
Jaakko Kaprio
Paul D Arnold
Dorothy E Grice
James A Knowles
Helga Ask
Karin J Verweij
Lea K Davis
Dirk J Smit
James J Crowley
Jeremiah M Scharf
Murray B Stein
Joel Gelernter
Carol A Mathews
Eske M Derks
Manuel Mattheisen
Affiliated Authors:
Jeremy Veenstra-VanderWeele
Abby J Fyer
Columbia Affiliation:
elink
Publication Type:
Article
Unique ID:
10.1038/s41588-025-02189-z
PMID:
40360802
DOI:
10.1038/s41588-025-02189-z
Journal:
Nature Genetics
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record

Record Created: