The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity

Ho, P., Melms, J. C., Rogava, M., Frangieh, C. J., Poźniak, J., Shah, S. B., Walsh, Z., Kyrysyuk, O., Amin, A. D., Caprio, L., Fullerton, B. T., Soni, R. K., Ager, C. R., Biermann, J., Wang, Y., Khosravi-Maharlooei, M., Zanetti, G., Mu, M., Fatima, H., … Izar, B. (2023). The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity. Cancer Cell, 41(7), 1207-1221.e12. https://doi.org/10.1016/j.ccell.2023.05.014
Authors:
Patricia Ho
Johannes C Melms
Meri Rogava
Chris J Frangieh
Joanna Poźniak
Shivem B Shah
Zachary Walsh
Oleksandr Kyrysyuk
Amit Dipak Amin
Lindsay Caprio
Benjamin T Fullerton
Rajesh Kumar Soni
Casey R Ager
Jana Biermann
Yiping Wang
Mohsen Khosravi-Maharlooei
Giorgia Zanetti
Michael Mu
Hijab Fatima
Emily K Moore
Neil Vasan
Samuel F Bakhoum
Steven L Reiner
Chantale Bernatchez
Megan Sykes
Emily M Mace
Kai W Wucherpfennig
Dirk Schadendorf
Oliver Bechter
Parin Shah
Gary K Schwartz
Jean-Christophe Marine
Benjamin Izar
Affiliated Authors:
Patricia Ho
Johannes C Melms
Meri Rogava
Shivem B Shah
Zachary Walsh
Amit Dipak Amin
Lindsay Caprio
Benjamin T Fullerton
Rajesh Kumar Soni
Casey R Ager
Jana Biermann
Yiping Wang
Mohsen Khosravi-Maharlooei
Giorgia Zanetti
Michael Mu
Hijab Fatima
Emily K Moore
Neil Vasan
Steven L Reiner
Megan Sykes
Emily M Mace
Parin Shah
Gary K Schwartz
Benjamin Izar
Columbia Affiliation:
Subjects:
Cancer Immunotherapy (OpenAlex Topic)
Immunobiology of Dendritic Cells (OpenAlex Topic)
Role of Chemokine Receptors in Cancer Metastasis (OpenAlex Topic)
B7-H1 Antigen (MeSH)
Melanoma (MeSH)
Author Keywords:
balance of co-inhibitory/co-stimulator
cancer immune evasion
cancer immunology
cancer immunotherapy
cd2
cd58
crispr-cas9 screen
immune checkpoint blockade
mass spec screen
pdl1
resistance to immune checkpoint blockade
single-cell rna-sequencing
elink
Publication Type:
Article
Unique ID:
10.1016/j.ccell.2023.05.014
PMID:
37327789
DOI:
10.1016/j.ccell.2023.05.014
Journal:
Cancer Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View OpenAlex Record

Record Created: