SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response

Tanagala, K. K. K., Morin-Baxter, J., Carvajal, R., Cheema, M., Dubey, S., Nakagawa, H., Yoon, A., Cheng, Y.-S. L., Taylor, A., Nickerson, J., Mintz, A., & Momen-Heravi, F. (2022). SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Journal for ImmunoTherapy of Cancer, 10(12), e005088. https://doi.org/10.1136/jitc-2022-005088
Authors:
Kranthi Kiran Kishore Tanagala
Joshua Morin‐Baxter
Richard D. Carvajal
Maryum Cheema
Sunil Dubey
Hiroshi Nakagawa
Angela J. Yoon
Yi‐Shing Lisa Cheng
Alison M. Taylor
Jeffrey A. Nickerson
Akiva Mintz
Fatemeh Momen‐Heravi
Affiliated Authors:
Kranthi Kiran Kishore Tanagala
Joshua Morin‐Baxter
Richard D. Carvajal
Maryum Cheema
Sunil Dubey
Hiroshi Nakagawa
Alison M. Taylor
Akiva Mintz
Fatemeh Momen‐Heravi
Columbia Affiliation:
Subjects:
Head and Neck Neoplasms (MeSH)
Melanoma (MeSH)
Macrophage Activation and Polarization (OpenAlex Topic)
Epigenetic Modifications and Their Functional Implications (OpenAlex Topic)
Mechanisms and Implications of Ferroptosis in Cancer (OpenAlex Topic)
Author Keywords:
head and neck neoplasms
biomarkers
tumor
immunotherapy
macrophages
biomarkers, tumor
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Publication Type:
Article
Unique ID:
10.1136/jitc-2022-005088
PMID:
36600652
DOI:
10.1136/jitc-2022-005088
Journal:
Journal for ImmunoTherapy of Cancer
Publication Date:
Data Source:
OpenAlex
Source Link:
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