Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders

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Wu, C., Busch, R. M., Drane, D. L., Dugan, P., Serletis, D., Youngerman, B., & Jehi, L. (2025). Comparative Review of Seizure and Cognitive Outcomes in Resective, Ablative, and Neuromodulatory Temporal Lobe Epilepsy Surgery. Epilepsy Currents. https://doi.org/10.1177/15357597251318564
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Loushy, I., Goldstein, L., Devlin, K., Volski, A., Fletman, E., Alcala‐Zermeno, J. L., Porreca, L., & Sperling, M. R. (2025). Real‐world use of cenobamate in adults: Efficacy and predictors of treatment response. Epilepsia. Portico. https://doi.org/10.1111/epi.18297
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Hojjati, S. H., Butler, T. A., de Leon, M. J., Gupta, A. H., Nayak, S., Luchsinger, J. A., Chiang, G., & Razlighi, Q. R. (2024). Remote associations between beta‐amyloid and tau are mediated by between‐network connectivity. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.086460
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Buss, E. W., Lofaro, O. M., Barnett, A., Leroy, F., Santoro, B., Siegelbaum, S. A., & Bock, T. (2024). HCN1 hyperpolarization-activated cyclic nucleotide–gated channels enhance evoked GABA release from parvalbumin-positive interneurons. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2319246121
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Wang, W., Williams, D. J., Teoh, J. J., Soundararajan, D., Zuberi, A., Lutz, C. M., Frankel, W. N., & Makinson, C. D. (2024). Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2400709121
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Bulthuis, N. E., McGowan, J. C., Ladner, L. R., LaGamma, C. T., Lim, S. C., Shubeck, C. X., Brachman, R. A., Sydnor, E., Pavlova, I. P., Seo, D., Drew, M. R., & Denny, C. A. (2024). GluN2B on Adult-Born Granule Cells Modulates (R,S)-Ketamine’s Rapid-Acting Effects in Mice. International Journal of Neuropsychopharmacology, 27(10). https://doi.org/10.1093/ijnp/pyae036
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Rosch, R. E., Burrows, D. R. W., Lynn, C. W., & Ashourvan, A. (2024). Spontaneous Brain Activity Emerges from Pairwise Interactions in the Larval Zebrafish Brain. Physical Review X, 14(3). https://doi.org/10.1103/physrevx.14.031050
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Sahyoun, G. M., Do, T. D., Anqueira-Gonzàlez, A., Hornblass, A., & Canetta, S. E. (2024). Peripuberty Is a Sensitive Period for Prefrontal Parvalbumin Interneuron Activity to Impact Adult Cognitive Flexibility. Developmental Neuroscience, 1–12. Portico. https://doi.org/10.1159/000539584
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Gangwar, S. P., Yelshanskaya, M. V., Nadezhdin, K. D., Yen, L. Y., Newton, T. P., Aktolun, M., Kurnikova, M. G., & Sobolevsky, A. I. (2024). Kainate receptor channel opening and gating mechanism. Nature, 630(8017), 762–768. https://doi.org/10.1038/s41586-024-07475-0
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Jiang, S., Sydney, E. J., Runyan, A. M., Serpe, R., Srikanth, M., Figueroa, H. Y., Yang, M., & Myeku, N. (2024). 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy. Frontiers in Cellular Neuroscience, 18. https://doi.org/10.3389/fncel.2024.1338502
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Li, M., & Yang, G. (2024). A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45035-2
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Aoun, A., Shetler, O., Raghuraman, R., Rodriguez, G. A., & Hussaini, S. A. (2024). Beyond correlation: optimal transport metrics for characterizing representational stability and remapping in neurons encoding spatial memory. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1273283
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Hojjati, S. H., Chiang, G. C., Butler, T. A., de Leon, M., Gupta, A., Li, Y., Sabuncu, M. R., Feiz, F., Nayak, S., Shteingart, J., Ozoria, S., Gholipour Picha, S., Stern, Y., Luchsinger, J. A., Devanand, D. P., & Razlighi, Q. R. (2024). Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent. Journal of Alzheimer’s Disease, 98(4), 1467–1482. https://doi.org/10.3233/jad-231362
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Ruff, D. S., Balbo, I., Lai, R., Dieng, D., Hennessey, C., Vennam, K., Dwork, A. J., McCreary, M., Louis, E. D., Faust, P. L., & Kuo, S. (2023). Reduced Bergmann glial process terminations and lateral appendages in essential tremor. Annals of Clinical and Translational Neurology, 11(2), 377–388. Portico. https://doi.org/10.1002/acn3.51958
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Stanley, A. T., Post, M. R., Lacefield, C., Sulzer, D., & Miniaci, M. C. (2023). Norepinephrine release in the cerebellum contributes to aversive learning. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40548-8
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Chen, C., Sun, L., Adler, A., Zhou, H., Zhang, L., Zhang, L., Deng, J., Bai, Y., Zhang, J., Yang, G., Gan, W.-B., & Tang, P. (2023). Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36093-z
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Yu, H., Kim, W., Park, D. K., Phi, J. H., Lim, B. C., Chae, J., Kim, S., Kim, K. J., Provenzano, F. A., Khodagholy, D., & Gelinas, J. N. (2023). Interaction of interictal epileptiform activity with sleep spindles is associated with cognitive deficits and adverse surgical outcome in pediatric focal epilepsy. Epilepsia, 65(1), 190–203. Portico. https://doi.org/10.1111/epi.17810
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Parato, J., Peris, L., Qu, X., Goldberg, Y., Moutin, M.-J., Andrieux, A., & Bartolini, F. (2023). IMPAIRED α-TUBULIN RE-TYROSINATION LEADS TO SYNAPTIC DYSFUNCTION AND IS A FEATURE OF ALZHEIMER’S DISEASE. IBRO Neuroscience Reports, 15, S34. https://doi.org/10.1016/j.ibneur.2023.08.2116
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Chen, K., Gupta, R., Martín‐Ávila, A., Cui, M., Xie, Z., & Yang, G. (2023). Anesthesia‐induced hippocampal‐cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer’s disease. Alzheimer’s & Dementia, 20(1), 494–510. Portico. https://doi.org/10.1002/alz.13464
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Lu, J., Liang, F., Bai, P., Liu, C., Xu, M., Sun, Z., Tian, W., Dong, Y., Zhang, Y., Quan, Q., Khatri, A., Shen, Y., Marcantonio, E., Crosby, G., Culley, D. J., Wang, C., Yang, G., & Xie, Z. (2023). Blood tau‐PT217 contributes to the anesthesia/surgery‐induced delirium‐like behavior in aged mice. Alzheimer’s & Dementia, 19(9), 4110–4126. Portico. https://doi.org/10.1002/alz.13118
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Ghanem, A., Berry, D. S., Farrell, K., Cosentino, S., Crary, J. F., & Louis, E. D. (2023). Cognitive Performance as a Function of MAPT Haplotype: A Prospective Longitudinal Study of an Essential Tremor Cohort. Tremor and Other Hyperkinetic Movements, 13(1). https://doi.org/10.5334/tohm.768
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Colombo, S., Reddy, H. P., Petri, S., Williams, D. J., Shalomov, B., Dhindsa, R. S., Gelfman, S., Krizay, D., Bera, A. K., Yang, M., Peng, Y., Makinson, C. D., Boland, M. J., Frankel, W. N., Goldstein, D. B., & Dascal, N. (2023). Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1175895
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McSweeney, M., Morales, S., Valadez, E. A., Buzzell, G. A., Yoder, L., Fifer, W. P., Pini, N., Shuffrey, L. C., Elliott, A. J., Isler, J. R., & Fox, N. A. (2023). Age-related trends in aperiodic EEG activity and alpha oscillations during early- to middle-childhood. NeuroImage, 269, 119925. https://doi.org/10.1016/j.neuroimage.2023.119925
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Dahal, P., Rauhala, O. J., Khodagholy, D., & Gelinas, J. N. (2023). Hippocampal–cortical coupling differentiates long-term memory processes. Proceedings of the National Academy of Sciences, 120(7). https://doi.org/10.1073/pnas.2207909120
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Gangwar, S. P., Yen, L. Y., Yelshanskaya, M. V., & Sobolevsky, A. I. (2023). Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Reports, 42(2), 112124. https://doi.org/10.1016/j.celrep.2023.112124
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Canetta, S. E., Holt, E. S., Benoit, L. J., Teboul, E., Sahyoun, G. M., Ogden, R. T., Harris, A. Z., & Kellendonk, C. (2022). Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80324
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Nunnelly, L. F., Campbell, M., Lee, D. I., Dummer, P., Gu, G., Menon, V., & Au, E. (2022). St18 specifies globus pallidus projection neuron identity in MGE lineage. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35518-5
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Lee, A., Kondapalli, C., Virga, D. M., Lewis, T. L., Koo, S. Y., Ashok, A., Mairet-Coello, G., Herzig, S., Foretz, M., Viollet, B., Shaw, R., Sproul, A., & Polleux, F. (2022). Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-32130-5
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Platzer, K., Sticht, H., Bupp, C., Ganapathi, M., Pereira, E. M., Le Guyader, G., Bilan, F., Henderson, L. B., Lemke, J. R., Taschenberger, H., Brose, N., Abou Jamra, R., & Wojcik, S. M. (2022). De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. Annals of Neurology, 92(6), 958–973. Portico. https://doi.org/10.1002/ana.26485
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Shpokayte, M., McKissick, O., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F. R., Ruesch, E., Grella, S. L., White, J. A., Liu, X. S., & Ramirez, S. (2022). Hippocampal cells segregate positive and negative engrams. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03906-8
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Iqbal, J., Suarez, M. D., Yadav, P. K., Walsh, M. T., Li, Y., Wu, Y., Huang, Z., James, A. W., Escobar, V., Mokbe, A., Brickman, A. M., Luchsinger, J. A., Dai, K., Moreno, H., & Hussain, M. M. (2022). ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. Journal of Biological Chemistry, 298(10), 102411. https://doi.org/10.1016/j.jbc.2022.102411
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Saponaro, A., Vallese, F., Porro, A., & Clarke, O. B. (2022). Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.998176
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Tenza-Ferrer, H., Collodetti, M., Nicolau, E. de S., Birbrair, A., Magno, L. A. V., & Romano-Silva, M. A. (2022). Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.933874
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Paquelet, G. E., Carrion, K., Lacefield, C. O., Zhou, P., Hen, R., & Miller, B. R. (2022). Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors. Neuron, 110(16), 2664-2679.e8. https://doi.org/10.1016/j.neuron.2022.05.015
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Damuka, N., Orr, M. E., Bansode, A. H., Krizan, I., Miller, M., Lee, J., Macauley, S. L., Whitlow, C. T., Mintz, A., Craft, S., & Solingapuram Sai, K. K. (2022). Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Research, 12(1). https://doi.org/10.1186/s13550-022-00912-z
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Leal Santos, S., Chen, B. K., Pereira, G. R., Pham, V., & Denny, C. A. (2022). Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval. Frontiers in Behavioral Neuroscience, 16. https://doi.org/10.3389/fnbeh.2022.919831
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de Prisco, N., Chemiakine, A., Lee, W., Botta, S., & Gennarino, V. A. (2022). Protocol to assess the effect of disease-driving variants on mouse brain morphology and primary hippocampal neurons. STAR Protocols, 3(2), 101244. https://doi.org/10.1016/j.xpro.2022.101244
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Wang, Q., de Prisco, N., Tang, J., & Gennarino, V. A. (2022). Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice. STAR Protocols, 3(2), 101245. https://doi.org/10.1016/j.xpro.2022.101245
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Botta, S., Chemiakine, A., & Gennarino, V. A. (2022). Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers. STAR Protocols, 3(2), 101427. https://doi.org/10.1016/j.xpro.2022.101427
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Juneja, P., & Swor, D. (2022). An Evidence-Based Approach to Diagnosis and Prognosis in a Young Woman with New-Onset Super-Refractory Status Epilepticus: A Case Report. Case Reports in Neurology, 14(1), 5–11. Portico. https://doi.org/10.1159/000519947
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