Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor

Colombo, S., Reddy, H. P., Petri, S., Williams, D. J., Shalomov, B., Dhindsa, R. S., Gelfman, S., Krizay, D., Bera, A. K., Yang, M., Peng, Y., Makinson, C. D., Boland, M. J., Frankel, W. N., Goldstein, D. B., & Dascal, N. (2023). Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1175895
Authors:
Sophie Colombo
Haritha P. Reddy
Sabrina Petri
Damian J. Williams
Boris Shalomov
Ryan S. Dhindsa
Sahar Gelfman
Daniel Krizay
Anup Kumar Bera
Mu Yang
Yueqing Peng
Christopher D. Makinson
Michael J. Boland
Wayne N. Frankel
David B. Goldstein
Nathan Dascal
Affiliated Authors:
Sophie Colombo
Sabrina Petri
Damian J. Williams
Ryan S. Dhindsa
Sahar Gelfman
Daniel Krizay
Mu Yang
Yueqing Peng
Christopher D. Makinson
Michael J. Boland
Wayne N. Frankel
David B. Goldstein
Columbia Affiliation:
Subjects:
Structure and Function of G Protein-Coupled Receptors (OpenAlex Topic)
Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders (OpenAlex Topic)
Molecular Regulation and Clinical Applications of PDEs (OpenAlex Topic)
Author Keywords:
g protein
girk
gnb1
absence seizures
animal model
ethosuximide
neurodevelopmental disorder
spike-wave discharges
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Publication Type:
Article
Unique ID:
10.3389/fncel.2023.1175895
PMID:
37275776
DOI:
10.3389/fncel.2023.1175895
Journal:
Frontiers in Cellular Neuroscience
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
View PubMed Record

Record Created: