Role of Microglia in Neurological Disorders

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Xiang, X., Tang, X., Yu, Y., Xie, S., Liu, L., Chen, M., Zhang, R., Kang, X., Zheng, Y., Yang, G., Gan, S., & Zhu, S. (2022). Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia. Journal of Neuroinflammation, 19(1). https://doi.org/10.1186/s12974-022-02455-5
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Shpokayte, M., McKissick, O., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F. R., Ruesch, E., Grella, S. L., White, J. A., Liu, X. S., & Ramirez, S. (2022). Hippocampal cells segregate positive and negative engrams. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03906-8
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Dhanwani, R., Lima-Junior, J. R., Sethi, A., Pham, J., Williams, G., Frazier, A., Xu, Y., Amara, A. W., Standaert, D. G., Goldman, J. G., Litvan, I., Alcalay, R. N., Peters, B., Sulzer, D., Arlehamn, C. S. L., & Sette, A. (2022). Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures. Npj Parkinson’s Disease, 8(1). https://doi.org/10.1038/s41531-022-00282-2
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Lee, A., Kondapalli, C., Virga, D. M., Lewis, T. L., Koo, S. Y., Ashok, A., Mairet-Coello, G., Herzig, S., Foretz, M., Viollet, B., Shaw, R., Sproul, A., & Polleux, F. (2022). Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-32130-5
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Ostkamp, P., Deffner, M., Schulte-Mecklenbeck, A., Wünsch, C., Lu, I.-N., Wu, G. F., Goelz, S., De Jager, P. L., Kuhlmann, T., Gross, C. C., Klotz, L., Meyer zu Hörste, G., Wiendl, H., Schneider-Hohendorf, T., & Schwab, N. (2022). A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis. Science Translational Medicine, 14(673). https://doi.org/10.1126/scitranslmed.adc9778
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Gupta, P., Dang, M., Hao, D., Bojja, K., Tran, T., Shehwana, H., Kamiya-Matsuoka, C., Li, J., Audia, A., Kassab, C., Ott, M., Gumin, J., Alenazy, S., Goldman, A., Seth, S., Maheshwari, A., Balasubramaniyan, V., Vaillant, B., Groot, J. de, … Bhat, K. (2022). 1001 Immunophenotyping of brain tumors identifies interferon enriched phagocytes in human gliomas. Regular and Young Investigator Award Abstracts, A1043–A1043. https://doi.org/10.1136/jitc-2022-sitc2022.1001
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Seto, M., Weiner, R. L., Dumitrescu, L., Mahoney, E. R., Hansen, S. L., Janve, V., Khan, O. A., Liu, D., Wang, Y., Menon, V., De Jager, P. L., Schneider, J. A., Bennett, D. A., Gifford, K. A., Jefferson, A. L., & Hohman, T. J. (2022). RNASE6 is a novel modifier of APOE-ε4 effects on cognition. Neurobiology of Aging, 118, 66–76. https://doi.org/10.1016/j.neurobiolaging.2022.06.011
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Mishra, R., Phan, T., Kumar, P., Morrissey, Z., Gupta, M., Hollands, C., Shetti, A., Lopez, K. L., Maienschein-Cline, M., Suh, H., Hen, R., & Lazarov, O. (2022). Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons. Journal of Experimental Medicine, 219(9). https://doi.org/10.1084/jem.20220391
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Li, Z., Wang, D., Guo, W., Zhang, S., Chen, L., Zhang, Y.-H., Lu, L., Pan, X., Huang, T., & Cai, Y.-D. (2022). Identification of cortical interneuron cell markers in mouse embryos based on machine learning analysis of single-cell transcriptomics. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.841145
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Consens, M. E., Chen, Y., Menon, V., Wang, Y., Schneider, J. A., De Jager, P. L., Bennett, D. A., Tripathy, S. J., & Felsky, D. (2022). Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 15. https://doi.org/10.3389/fnmol.2022.903175
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de Prisco, N., Chemiakine, A., Lee, W., Botta, S., & Gennarino, V. A. (2022). Protocol to assess the effect of disease-driving variants on mouse brain morphology and primary hippocampal neurons. STAR Protocols, 3(2), 101244. https://doi.org/10.1016/j.xpro.2022.101244
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Botta, S., Chemiakine, A., & Gennarino, V. A. (2022). Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers. STAR Protocols, 3(2), 101427. https://doi.org/10.1016/j.xpro.2022.101427
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Cosacak, M. I., Bhattarai, P., De Jager, P. L., Menon, V., Tosto, G., & Kizil, C. (2022). Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease. Cells, 11(11), 1807. https://doi.org/10.3390/cells11111807
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Connor, S. M., Rashid, M., Ryan, K. J., Patel, K., Boyd, J. D., Smith, J., Elyaman, W., Bennett, D. A., & Bradshaw, E. M. (2022). GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.894601
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Minns, H. E., Padilla, O., Wei, H.-J., Webster-Carrion, A., Tazhibi, M., McQuillan, N., Zhang, X., Yeh, R., Zhang, Z., Szalontay, L., Pavisic, J., Garty, G., Garvin, J., Zacharoulis, S., Canoll, P., Vanpouille-Box, C. I., Menon, V., Olah, M., Rabadan, R., … Gartrell, R. D. (2022). DIPG-45. Radiation induces a robust interferon response in Diffuse Midline Glioma (DMG), improving the potential for combination immunotherapy. Neuro-Oncology, 24(Supplement_1), i28–i29. https://doi.org/10.1093/neuonc/noac079.102
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Cohn, W., Melnik, M., Huang, C., Teter, B., Chandra, S., Zhu, C., McIntire, L. B., John, V., Gylys, K. H., & Bilousova, T. (2021). Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.766082
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Beebe-Wang, N., Celik, S., Weinberger, E., Sturmfels, P., De Jager, P. L., Mostafavi, S., & Lee, S.-I. (2021). Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer’s disease neuropathologies. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25680-7
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Gupta, P., Dang, M., Hao, D. H., Bojja, K., Tran, T. M., Shehwana, H., Kamiya-Matsuoka, C., Li, J., Audia, A., Kassab, C., Ott, M., Gumin, J., Al-enazy, S., Balasubramaniyan, V., DeGroot, J., Lang, F., Iavarone, A., Navin, N. E., Heimberger, A. B., … Bhat, K. (2021). IMMU-43. IMMUNE CONTEXTURE OF ISOCITRATE DEHYDROGENASE STRATIFIED HUMAN GLIOMAS REVEALED BY SINGLE-CELL TRANSCRIPTOMICS AND ACCESSIBLE CHROMATIN. Neuro-Oncology, 23(Supplement_6), vi102–vi102. https://doi.org/10.1093/neuonc/noab196.402
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Siddiqui, T., Bhattarai, P., Popova, S., Cosacak, M. I., Sariya, S., Zhang, Y., Mayeux, R., Tosto, G., & Kizil, C. (2021). KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer’s Disease. Cells, 10(10), 2748. https://doi.org/10.3390/cells10102748
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Bakken, T. E., van Velthoven, C. T., Menon, V., Hodge, R. D., Yao, Z., Nguyen, T. N., Graybuck, L. T., Horwitz, G. D., Bertagnolli, D., Goldy, J., Yanny, A. M., Garren, E., Parry, S., Casper, T., Shehata, S. I., Barkan, E. R., Szafer, A., Levi, B. P., Dee, N., … Tasic, B. (2021). Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.64875
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