Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Honig, L. S., Kang, M. S., Lee, A. J., Reyes-Dumeyer, D., Piriz, A., Soriano, B., Franco, Y., Coronado, Z. D., Recio, P., Mejía, D. R., Medrano, M., Lantigua, R. A., Teich, A. F., Dage, J. L., & Mayeux, R. (2023). Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity. JAMA Network Open, 6(4), e238214. https://doi.org/10.1001/jamanetworkopen.2023.8214
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Seblova, D., Eng, C., Avila‐Rieger, J. F., Dworkin, J. D., Peters, K., Lapham, S., Zahodne, L. B., Chapman, B., Prescott, C. A., Gruenewald, T. L., Arpawong, T. Em., Gatz, M., Jones, R. J., Glymour, M. M., & Manly, J. J. (2023). High school quality is associated with cognition 58 years later. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(2). Portico. https://doi.org/10.1002/dad2.12424
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Stern, Y., Albert, M., Barnes, C. A., Cabeza, R., Pascual-Leone, A., & Rapp, P. R. (2023). A framework for concepts of reserve and resilience in aging. Neurobiology of Aging, 124, 100–103. https://doi.org/10.1016/j.neurobiolaging.2022.10.015
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Grapsa, I., Mamalaki, E., Ntanasi, E., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Scarmeas, N., & Yannakoulia, M. (2023). Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study. Nutrients, 15(7), 1795. https://doi.org/10.3390/nu15071795
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Bassil, D. T., Farrell, M. T., Weerman, A., Guo, M., Wagner, R. G., Brickman, A. M., Glymour, M. M., Langa, K. M., Manly, J. J., Tipping, B., Butler, I., Tollman, S., & Berkman, L. F. (2023). Feasibility of an online consensus approach for the diagnosis of cognitive impairment and dementia in rural South Africa. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(2). Portico. https://doi.org/10.1002/dad2.12420
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Soh, Y., Whitmer, R. A., Mayeda, E. R., Glymour, M. M., Peterson, R. L., Eng, C. W., Quesenberry, C. P., Manly, J. J., & Gilsanz, P. (2023). State-Level Indicators of Childhood Educational Quality and Incident Dementia in Older Black and White Adults. JAMA Neurology, 80(4), 352. https://doi.org/10.1001/jamaneurol.2022.5337
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Palma‐Gudiel, H., Yu, L., Huo, Z., Yang, J., Wang, Y., Gu, T., Gao, C., De Jager, P. L., Jin, P., Bennett, D. A., & Zhao, J. (2022). Fine‐mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samples. Alzheimer’s & Dementia, 19(4), 1216–1226. Portico. https://doi.org/10.1002/alz.12761
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Schrauwen, I., Ghaffar, A., Bharadwaj, T., Shah, K., Rehman, S., Acharya, A., Liaqat, K., Lin, N. S., Everard, J. L., Khan, A., Ahmed, Z. M., Ahmad, W., Riazuddin, S., & Leal, S. M. (2022). Syntaxin 4 is essential for hearing in human and zebrafish. Human Molecular Genetics, 32(7), 1184–1192. https://doi.org/10.1093/hmg/ddac257
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Devanand, D. P., Masurkar, A. V., & Wisniewski, T. (2023). Vigorous, regular physical exercise may slow disease progression in Alzheimer’s disease. Alzheimer’s & Dementia, 19(4), 1592–1597. Portico. https://doi.org/10.1002/alz.12946
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Maraki, M. I., Yannakoulia, M., Xiromerisiou, G., Stefanis, L., Charisis, S., Giagkou, N., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Scarmeas, N., & Stamelou, M. (2023). Mediterranean diet is associated with a lower probability of prodromal Parkinson’s disease and risk for Parkinson’s disease/dementia with Lewy bodies: A longitudinal study. European Journal of Neurology, 30(4), 934–942. Portico. https://doi.org/10.1111/ene.15698
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Zhu, C. W., Gu, Y., Kociolek, A. J., Fernandez, K. K., Cosentino, S., & Stern, Y. (2023). Costs During the Last Five Years of Life for Patients with Clinical and Pathological Confirmed Diagnosis of Lewy Body Dementia and Alzheimer’s Disease. Journal of Alzheimer’s Disease, 92(2), 457–466. https://doi.org/10.3233/jad-221021
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Rizvi, B., Sathishkumar, M., Kim, S., Márquez, F., Granger, S. J., Larson, M. S., Miranda, B. A., Hollearn, M. K., McMillan, L., Nan, B., Tustison, N. J., Lao, P. J., Brickman, A. M., Greenia, D., Corrada, M. M., Kawas, C. H., & Yassa, M. A. (2023). Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults. NeuroImage: Clinical, 37, 103308. https://doi.org/10.1016/j.nicl.2022.103308
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Kulshreshtha, A., Alonso, A., McClure, L. A., Hajjar, I., Manly, J. J., & Judd, S. (2023). Association of Stress With Cognitive Function Among Older Black and White US Adults. JAMA Network Open, 6(3), e231860. https://doi.org/10.1001/jamanetworkopen.2023.1860
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Chapman, S., Rentería, M. A., Dworkin, J. D., Garriga, S. M., Barker, M. S., Avila-Rieger, J., Gonzalez, C., Joyce, J. L., Vonk, J. M. J., Soto, E., Manly, J. J., Brickman, A. M., Mayeux, R. P., & Cosentino, S. A. (2023). Association of Subjective Cognitive Decline With Progression to Dementia in a Cognitively Unimpaired Multiracial Community Sample. Neurology, 100(10). https://doi.org/10.1212/wnl.0000000000201658
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Gouveia Roque, C., Chung, K. M., McCurdy, E. P., Jagannathan, R., Randolph, L. K., Herline-Killian, K., Baleriola, J., & Hengst, U. (2023). CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer’s disease gene expression linked to neuropathology. Science Advances, 9(9). https://doi.org/10.1126/sciadv.add2671
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Briceño, E. M., Arce Rentería, M., Gross, A. L., Jones, R. N., Gonzalez, C., Wong, R., Weir, D. R., Langa, K. M., & Manly, J. J. (2023). A cultural neuropsychological approach to harmonization of cognitive data across culturally and linguistically diverse older adult populations. Neuropsychology, 37(3), 247–257. https://doi.org/10.1037/neu0000816
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Du, D. X., Simjanoska, M., & Fitzpatrick, A. W. P. (2023). Four-dimensional microED of conformational dynamics in protein microcrystals on the femto-to-microsecond timescales. Journal of Structural Biology, 215(1), 107941. https://doi.org/10.1016/j.jsb.2023.107941
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Louis, E. D., Martuscello, R. T., Gionco, J. T., Hartstone, W. G., Musacchio, J. B., Portenti, M., McCreary, M., Kuo, S.-H., Vonsattel, J.-P. G., & Faust, P. L. (2023). Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathologica, 145(3), 265–283. https://doi.org/10.1007/s00401-022-02535-z
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Huie, E. Z., Escudero, A., Saito, N., Harvey, D., Nguyen, M.-L., Lucot, K. L., LaGrande, J., Mungas, D., DeCarli, C., Lamar, M., Schneider, J. A., Kapasi, A., Rissman, R. A., Teich, A. F., & Dugger, B. N. (2023). TDP-43 Pathology in the Setting of Intermediate and High Alzheimer’s Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups. Journal of Alzheimer’s Disease, 91(4), 1291–1301. https://doi.org/10.3233/jad-220558
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Naderi, E., Cornejo-Sanchez, D. M., Li, G., Schrauwen, I., Wang, G. T., Dewan, A. T., & Leal, S. M. (2023). The genetic contribution of the X chromosome in age-related hearing loss. Frontiers in Genetics, 14. https://doi.org/10.3389/fgene.2023.1106328
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Liampas, I., Folia, V., Ntanasi, E., Yannakoulia, M., Sakka, P., Hadjigeorgiou, G., Scarmeas, N., Dardiotis, E., & Kosmidis, M. H. (2022). Longitudinal episodic memory trajectories in older adults with normal cognition. The Clinical Neuropsychologist, 37(2), 304–321. https://doi.org/10.1080/13854046.2022.2059011
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Beenken, A., Cerutti, G., Brasch, J., Guo, Y., Sheng, Z., Erdjument-Bromage, H., Aziz, Z., Robbins-Juarez, S. Y., Chavez, E. Y., Ahlsen, G., Katsamba, P. S., Neubert, T. A., Fitzpatrick, A. W. P., Barasch, J., & Shapiro, L. (2023). Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186(4), 821-836.e13. https://doi.org/10.1016/j.cell.2023.01.016
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Lin, W., Gandhi, S., Bhattarai, P., Kasa, K., Kizil, C., & Zhang, Y. (2023). Combining high throughput array synthesis and growth algorithm to discover TNF-α binders with new structures and properties. European Journal of Medicinal Chemistry, 248, 115078. https://doi.org/10.1016/j.ejmech.2022.115078
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Fleming, V., Helsel, B. C., Ptomey, L. T., Rosas, H. D., Handen, B., Laymon, C., Christian, B. T., Head, E., Mapstone, M., Lai, F., Krinsky-McHale, S., Zaman, S., Ances, B. M., Lee, J. H., & Hartley, S. L. (2023). Weight Loss and Alzheimer’s Disease in Down Syndrome. Journal of Alzheimer’s Disease, 91(3), 1215–1227. https://doi.org/10.3233/jad-220865
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Boyle, R., Connaughton, M., McGlinchey, E., Knight, S. P., De Looze, C., Carey, D., Stern, Y., Robertson, I. H., Kenny, R. A., & Whelan, R. (2022). Connectome‐based predictive modelling of cognitive reserve using task‐based functional connectivity. European Journal of Neuroscience, 57(3), 490–510. Portico. https://doi.org/10.1111/ejn.15896
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Vollstedt, E., Schaake, S., Lohmann, K., Padmanabhan, S., Brice, A., Lesage, S., Tesson, C., Vidailhet, M., Wurster, I., Hentati, F., Mirelman, A., Giladi, N., Marder, K., Waters, C., Fahn, S., Kasten, M., Brüggemann, N., Borsche, M., … Foroud, T. (2023). Embracing Monogenic Parkinson’s Disease: The MJFF Global Genetic PD Cohort. Movement Disorders, 38(2), 286–303. Portico. https://doi.org/10.1002/mds.29288
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Contador, I., Alzola, P., Stern, Y., de la Torre-Luque, A., Bermejo-Pareja, F., & Fernández-Calvo, B. (2023). Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis. Ageing Research Reviews, 84, 101814. https://doi.org/10.1016/j.arr.2022.101814
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Fountain-Zaragoza, S., Horn, O., Thorn, K. E., Kraal, A. Z., & Benitez, A. (2023). Validity of Normative Volumetric Estimates from Open Access Software in Amnestic Mild Cognitive Impairment. The Journal of Prevention of Alzheimer’s Disease. https://doi.org/10.14283/jpad.2023.19
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Selles, M. C., Fortuna, J. T. S., Cercato, M. C., Santos, L. E., Domett, L., Bitencourt, A. L. B., Carraro, M. F., Souza, A. S., Janickova, H., Azevedo, C. V., Campos, H. C., de Souza, J. M., Alves-Leon, S., Prado, V. F., Prado, M. A. M., Epstein, A. L., Salvetti, A., Longo, B. M., Arancio, O., … Ferreira, S. T. (2023). AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models. Molecular Therapy, 31(2), 409–419. https://doi.org/10.1016/j.ymthe.2022.11.002
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Hickman, R. A., Traynor, B. J., Marder, K. S., & Vonsattel, J.-P. (2022). Reply: More than a co-incidence? Exploring the increased frequency of amyotrophic lateral sclerosis in Huntington disease. Acta Neuropathologica, 145(2), 259–261. https://doi.org/10.1007/s00401-022-02532-2
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Lauriola, V., Brickman, A. M., Sloan, R. P., & Small, S. A. (2023). Anatomical biology guides a search for nutrients for the aging brain. Molecular Aspects of Medicine, 89, 101154. https://doi.org/10.1016/j.mam.2022.101154
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Smith, J. R., Gibbons, L. E., Crane, P. K., Mungas, D. M., Glymour, M. M., Manly, J. J., Zahodne, L. B., Rose Mayeda, E., Jones, R. N., & Gross, A. L. (2022). Shifting of Cognitive Assessments Between Face-to-Face and Telephone Administration: Measurement Considerations. The Journals of Gerontology: Series B, 78(2), 191–200. https://doi.org/10.1093/geronb/gbac135
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Ramos, J., Caywood, L. J., Prough, M. B., Clouse, J. E., Herington, S. D., Slifer, S. H., Fuzzell, M. D., Fuzzell, S. L., Hochstetler, S. D., Miskimen, K. L., Main, L. R., Osterman, M. D., Zaman, A. F., Whitehead, P. L., Adams, L. D., Laux, R. A., Song, Y. E., Foroud, T. M., Mayeux, R. P., … Scott, W. K. (2022). Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets. Alzheimer’s & Dementia, 19(2), 611–620. Portico. https://doi.org/10.1002/alz.12686
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Gordián-Arroyo, A., Reame, N., Gutierrez, J., Liu, J., Ganzhorn, S., Igwe, K. C., Laing, K., & Schnall, R. (2022). Do correlates of white matter features differ between older men and women living with human immunodeficiency virus? Menopause, 30(2), 149–155. https://doi.org/10.1097/gme.0000000000002102
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Argiris, G., Stern, Y., & Habeck, C. (2022). Neural similarity across task load relates to cognitive reserve and brain maintenance measures on the Letter Sternberg task: a longitudinal study. Brain Imaging and Behavior, 17(1), 100–113. https://doi.org/10.1007/s11682-022-00746-2
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Vöglein, J., Franzmeier, N., Morris, J. C., Dieterich, M., McDade, E., Simons, M., Preische, O., Hofmann, A., Hassenstab, J., Benzinger, T. L., Fagan, A., Noble, J. M., Berman, S. B., Graff‐Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J. P., Salloway, S., … Xiong, C. (2022). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & Dementia, 19(2), 632–645. Portico. https://doi.org/10.1002/alz.12684
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Brikou, D., Charisis, S., Drouka, A., Christodoulakou, S. M., Ntanasi, E., Mamalaki, E., Constadinides, V. C., Scarmeas, N., & Yannakoulia, M. (2023). Daily Energy Intake Distribution and Cognitive Performance in Non-Demented Individuals. Nutrients, 15(3), 673. https://doi.org/10.3390/nu15030673
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Jensen, A. M. G., Kitago, Y., Fazeli, E., Vægter, C. B., Small, S. A., Petsko, G. A., & Andersen, O. M. (2023). Dimerization of the Alzheimer’s disease pathogenic receptor SORLA regulates its association with retromer. Proceedings of the National Academy of Sciences, 120(4). https://doi.org/10.1073/pnas.2212180120
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He, H., Ahsan, A., Bera, R., McLain, N., Faulkner, R., Ramachandran, K. V., Margolis, S. S., & Cline, H. T. (2023). Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity. Proceedings of the National Academy of Sciences, 120(3). https://doi.org/10.1073/pnas.2216537120
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Slavi, N., Balasubramanian, R., Lee, M. A., Liapin, M., Oaks-Leaf, R., Peregrin, J., Potenski, A., Troy, C. M., Ross, M. E., Herrera, E., Kosmidis, S., John, S. W. M., & Mason, C. A. (2023). CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism. Neuron, 111(1), 49-64.e5. https://doi.org/10.1016/j.neuron.2022.10.025
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Felsky, D., Santa-Maria, I., Cosacak, M. I., French, L., Schneider, J. A., Bennett, D. A., De Jager, P. L., Kizil, C., & Tosto, G. (2023). The Caribbean-Hispanic Alzheimer’s disease brain transcriptome reveals ancestry-specific disease mechanisms. Neurobiology of Disease, 176, 105938. https://doi.org/10.1016/j.nbd.2022.105938
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Kim, Y. A., Siddiqui, T., Blaze, J., Cosacak, M. I., Winters, T., Kumar, A., Tein, E., Sproul, A. A., Teich, A. F., Bartolini, F., Akbarian, S., Kizil, C., Hargus, G., & Santa-Maria, I. (2022). RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathologica, 145(1), 29–48. https://doi.org/10.1007/s00401-022-02511-7
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Zahodne, L. B., Sharifian, N., Kraal, A. Z., Morris, E. P., Sol, K., Zaheed, A. B., Meister, L., Mayeux, R., Schupf, N., Manly, J. J., & Brickman, A. M. (2023). Longitudinal associations between racial discrimination and hippocampal and white matter hyperintensity volumes among older Black adults. Social Science & Medicine, 316, 114789. https://doi.org/10.1016/j.socscimed.2022.114789
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Liampas, I., Siokas, V., Ntanasi, E., Kosmidis, M. H., Yannakoulia, M., Sakka, P., Hadjigeorgiou, G. M., Scarmeas, N., & Dardiotis, E. (2022). Cognitive trajectories preluding the imminent onset of Alzheimer’s disease dementia in individuals with normal cognition: results from the HELIAD cohort. Aging Clinical and Experimental Research, 35(1), 41–51. https://doi.org/10.1007/s40520-022-02265-y
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He, H., Sun, X., Doose, J., Blankenship, A., Mclntosh, J., Saber, G., Faller, J., Lin, Y., Teves, J., Huffman, S., Pantazatos, S., Goldman, R., George, M., Brown, T., & Sajda, P. (2023). Whole-brain analysis of concurrent TMS-EEG-fMRI reveals brain-wide state-dependent TMS effects. Brain Stimulation, 16(1), 405. https://doi.org/10.1016/j.brs.2023.01.825
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Widom, C. S., Do, H. H., Lynch, K. S., & Manly, J. J. (2023). Childhood Maltreatment and Dementia Risk Factors in Midlife: A Prospective Investigation. Current Alzheimer Research, 20(9), 636–647. https://doi.org/10.2174/0115672050281539231222071355
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Mamalaki, E., Ntanasi, E., Hatzimanolis, A., Basta, M., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Scarmeas, N., & Yannakoulia, M. (2023). The Association of Adherence to the Mediterranean Diet with Depression in Older Adults Longitudinally Taking into Account Cognitive Status: Results from the HELIAD Study. Nutrients, 15(2), 359. https://doi.org/10.3390/nu15020359
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