Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Quinn, L., Playle, R., Drew, C. J. G., Taiyari, K., Williams-Thomas, R., Muratori, L. M., Hamana, K., Griffin, B. A., Kelson, M., Schubert, R., Friel, C., Morgan-Jones, P., Rosser, A., Busse, M., Montojo, T., Ruiz Idiago, J. M., Hershberg, J., Marder, K., Bordelon, Y., … Landwehrmeyer, B. (2022). Physical activity and exercise outcomes in Huntington’s disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington’s disease. Parkinsonism & Related Disorders, 101, 75–89. https://doi.org/10.1016/j.parkreldis.2022.06.013
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Sorosina, M., Barizzone, N., Clarelli, F., Anand, S., Lupoli, S., Salvi, E., Mangano, E., Bordoni, R., Roostaei, T., Mascia, E., Zuccalà, M., Vecchio, D., Cavalla, P., Santoro, S., Ferrè, L., Zollo, A., Florio, L., Ragonese, P., … Martinelli Boneschi, F. (2022). A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility. Journal of Neurology, 269(8), 4510–4522. https://doi.org/10.1007/s00415-022-11109-8
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Buhl, E., Kim, Y. A., Parsons, T., Zhu, B., Santa-Maria, I., Lefort, R., & Hodge, J. J. L. (2022). Effects of Eph/ephrin signalling and human Alzheimer’s disease-associated EphA1 on Drosophila behaviour and neurophysiology. Neurobiology of Disease, 170, 105752. https://doi.org/10.1016/j.nbd.2022.105752
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Janelidze, S., Christian, B. T., Price, J., Laymon, C., Schupf, N., Klunk, W. E., Lott, I., Silverman, W., Rosas, H. D., Zaman, S., Mapstone, M., Lai, F., Ances, B. M., Handen, B. L., & Hansson, O. (2022). Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA Neurology, 79(8), 797. https://doi.org/10.1001/jamaneurol.2022.1740
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Melgarejo, J. D., Eijgen, J. V., Maestre, G. E., Al-Aswad, L. A., Thijs, L., Mena, L. J., Lee, J. H., Terwilliger, J. D., Petitto, M., Chávez, C. A., Brito, M., Calmon, G., Silva, E., Wei, D.-M., Cutsforth, E., Keer, K. V., Gustavo De Moraes, C., Vanassche, T., Janssens, S., … Zhang, Z.-Y. (2022). Open-Angle Glaucomatous Optic Neuropathy Is Related to Dips Rather Than Increases in the Mean Arterial Pressure Over 24-H. American Journal of Hypertension, 35(8), 703–714. https://doi.org/10.1093/ajh/hpac028
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Rabin, J. S., Nichols, E., La Joie, R., Casaletto, K. B., Palta, P., Dams-O’Connor, K., Kumar, R. G., George, K. M., Satizabal, C. L., Schneider, J. A., Pa, J., & Brickman, A. M. (2022). Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline. Brain, 145(8), 2823–2833. https://doi.org/10.1093/brain/awac178
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Weintraub, S., Karpouzian‐Rogers, T., Peipert, J. D., Nowinski, C., Slotkin, J., Wortman, K., Ho, E., Rogalski, E., Carlsson, C., Giordani, B., Goldstein, F., Lucas, J., Manly, J. J., Rentz, D., Salmon, D., Snitz, B., Dodge, H. H., Riley, M., Eldes, F., … Gershon, R. (2021). ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods. Alzheimer’s & Dementia, 18(8), 1449–1460. Portico. https://doi.org/10.1002/alz.12497
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Ntanasi, E., Charisis, S., Yannakoulia, M., Georgiadi, K., Balomenos, V., Kosmidis, M. H., Dardiotis, Ε., Hadjigeorgiou, G., Sakka, P., Maraki, M., & Scarmeas, N. (2022). Adherence to the Mediterranean diet and incident frailty: Results from a longitudinal study. Maturitas, 162, 44–51. https://doi.org/10.1016/j.maturitas.2022.05.001
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Vollmer, B. L., Solowey, J., Chen, X., Chang, B. P., Williams, O., Kulick, E. R., Elkind, M. S. V., & Boehme, A. K. (2022). Individual and Joint Effects of Influenza-Like Illness and Vaccinations on Stroke in the Young: A Case-Control Study. Stroke, 53(8), 2585–2593. https://doi.org/10.1161/strokeaha.121.038403
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Liampas, I., Hatzimanolis, A., Siokas, V., Yannakoulia, M., Kosmidis, M. H., Sakka, P., Hadjigeorgiou, G. M., Scarmeas, N., & Dardiotis, E. (2022). Antihypertensive Medication Class and the Risk of Dementia and Cognitive Decline in Older Adults: A Secondary Analysis of the Prospective HELIAD Cohort. Journal of Alzheimer’s Disease, 89(2), 709–719. https://doi.org/10.3233/jad-220439
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Barral, S., Andersen, S. L., Perls, T. T., Bae, H., Sebastiani, P., Christensen, K., Thyagarajan, B., Lee, J., & Schupf, N. (2022). Association between late maternal age and age-related endophenotypes in the Long Life Family Study. Neuroscience Letters, 784, 136737. https://doi.org/10.1016/j.neulet.2022.136737
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Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., O’Bryant, S., Minihane, A. M., Craft, S., Fink, H. A., Judd, S., Andrieu, S., Bowman, G. L., Richard, E., Albensi, B., … Schneider, L. S. (2022). Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. The Lancet Healthy Longevity, 3(7), e501–e512. https://doi.org/10.1016/s2666-7568(22)00120-9
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Kairov, U., Molkenov, A., Sharip, A., Rakhimova, S., Seidualy, M., Rhie, A., Kozhamkulov, U., Zhabagin, M., Kim, J.-I., Lee, J. H., Terwilliger, J. D., Seo, J.-S., Zhumadilov, Z., & Akilzhanova, A. (2022). Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals. Frontiers in Genetics, 13. https://doi.org/10.3389/fgene.2022.902804
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Aschenbrenner, A. J., Hassenstab, J., Wang, G., Li, Y., Xiong, C., McDade, E., Clifford, D. B., Salloway, S., Farlow, M., Yaari, R., Cheng, E. Y. J., Holdridge, K. C., Mummery, C. J., Masters, C. L., Hsiung, G.-Y., Surti, G., Day, G. S., Weintraub, S., Honig, L. S., … Bateman, R. J. (2022). Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials. Frontiers in Aging Neuroscience, 14. https://doi.org/10.3389/fnagi.2022.883131
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Rajabli, F., Beecham, G. W., Hendrie, H. C., Baiyewu, O., Ogunniyi, A., Gao, S., Kushch, N. A., Lipkin-Vasquez, M., Hamilton-Nelson, K. L., Young, J. I., Dykxhoorn, D. M., Nuytemans, K., Kunkle, B. W., Wang, L., Jin, F., Liu, X., Feliciano-Astacio, B. E., Schellenberg, G. D., … Vance, J. M. (2022). A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry. PLOS Genetics, 18(7), e1009977. https://doi.org/10.1371/journal.pgen.1009977
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Lee, A. J., Raghavan, N. S., Bhattarai, P., Siddiqui, T., Sariya, S., Reyes-Dumeyer, D., Flowers, X. E., Cardoso, S. A. L., De Jager, P. L., Bennett, D. A., Schneider, J. A., Menon, V., Wang, Y., Lantigua, R. A., Medrano, M., Rivera, D., Jiménez-Velázquez, I. Z., Kukull, W. A., Brickman, A. M., … Mayeux, R. (2022). FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. Acta Neuropathologica, 144(1), 59–79. https://doi.org/10.1007/s00401-022-02431-6
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Eissman, J. M., Dumitrescu, L., Mahoney, E. R., Smith, A. N., Mukherjee, S., Lee, M. L., Scollard, P., Choi, S. E., Bush, W. S., Engelman, C. D., Lu, Q., Fardo, D. W., Trittschuh, E. H., Mez, J., Kaczorowski, C. C., Hernandez Saucedo, H., Widaman, K. F., Buckley, R. F., Properzi, M. J., … Hohman, T. J. (2022). Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease. Brain, 145(7), 2541–2554. https://doi.org/10.1093/brain/awac177
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Mamalaki, E., Charisis, S., Anastasiou, C. A., Ntanasi, E., Georgiadi, K., Balomenos, V., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G., Sakka, P., Scarmeas, N., & Yannakoulia, M. (2022). The Longitudinal Association of Lifestyle with Cognitive Health and Dementia Risk: Findings from the HELIAD Study. Nutrients, 14(14), 2818. https://doi.org/10.3390/nu14142818
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Raghuraman, R., Manakkadan, A., Richter-Levin, G., & Sajikumar, S. (2022). Inhibitory Metaplasticity in Juvenile Stressed Rats Restores Associative Memory in Adulthood by Regulating Epigenetic Complex G9a/GLP. International Journal of Neuropsychopharmacology, 25(7), 576–589. https://doi.org/10.1093/ijnp/pyac008
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Samieri, C., Yassine, H. N., Melo van Lent, D., Lefèvre‐Arbogast, S., van de Rest, O., Bowman, G. L., & Scarmeas, N. (2021). Personalized nutrition for dementia prevention. Alzheimer’s & Dementia, 18(7), 1424–1437. Portico. https://doi.org/10.1002/alz.12486
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Balomenos, V., Bounou, L., Charisis, S., Stamelou, M., Ntanasi, E., Georgiadi, K., Mourtzinos, I., Tzima, K., Anastasiou, C. A., Xiromerisiou, G., Maraki, M., Yannakoulia, M., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G., Sakka, P., Stefanis, L., & Scarmeas, N. (2022). Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study. The Journal of Nutritional Biochemistry, 105, 108994. https://doi.org/10.1016/j.jnutbio.2022.108994
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Yalcouyé, A., Traoré, O., Diarra, S., Schrauwen, I., Esoh, K., Kadlubowska, M. K., Bharadwaj, T., Adadey, S. M., Kéita, M., Guinto, C. O., Leal, S. M., Landouré, G., & Wonkam, A. (2022). A monoallelic variant in EYA1 is associated with Branchio‐Otic syndrome in a Malian family. Molecular Genetics & Genomic Medicine, 10(7). Portico. https://doi.org/10.1002/mgg3.1995
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Le Guen, Y., Belloy, M. E., Grenier-Boley, B., de Rojas, I., Castillo-Morales, A., Jansen, I., Nicolas, A., Bellenguez, C., Dalmasso, C., Küçükali, F., Eger, S. J., Rasmussen, K. L., Thomassen, J. Q., Deleuze, J.-F., He, Z., Napolioni, V., Amouyel, P., Jessen, F., Kehoe, P. G., … Rujescu, D. (2022). Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA Neurology, 79(7), 652. https://doi.org/10.1001/jamaneurol.2022.1166
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Wu, X., Sosunov, A. A., Lado, W., Teoh, J. J., Ham, A., Li, H., Al-Dalahmah, O., Gill, B. J. A., Arancio, O., Schevon, C. A., Frankel, W. N., McKhann, G. M., Sulzer, D., Goldman, J. E., & Tang, G. (2022). Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Reports, 40(3), 111085. https://doi.org/10.1016/j.celrep.2022.111085
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Acharya, A., Kavus, H., Dunn, P., Nasir, A., Folk, L., Withrow, K., Wentzensen, I. M., Ruzhnikov, M. R. Z., Fallot, C., Smol, T., Rama, M., Brown, K., Whalen, S., Ziegler, A., Barth, M., Chassevent, A., Smith-Hicks, C., Afenjar, A., Courtin, T., … Schrauwen, I. (2021). Delineating the genotypic and phenotypic spectrum of HECW2-related neurodevelopmental disorders. Journal of Medical Genetics, 59(7), 669–677. https://doi.org/10.1136/jmedgenet-2021-107871
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Fang, Y., Idnay, B., Sun, Y., Liu, H., Chen, Z., Marder, K., Xu, H., Schnall, R., & Weng, C. (2022). Combining human and machine intelligence for clinical trial eligibility querying. Journal of the American Medical Informatics Association, 29(7), 1161–1171. https://doi.org/10.1093/jamia/ocac051
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Geronikola, N., Zalonis, I., Ntanasi, E., Charisis, S., Kosmidis, M. H., Anastasiou, C. A., Dardiotis, E., Hadjigeorgiou, G., Megalou, M., Velonakis, G., Karavasilis, E., Gargalionis, A. N., Patas, K., Piperidi, A., Chatzipanagiotou, S., Sakka, P., Paraskevas, G., Yannakoulia, M., & Scarmeas, N. (2022). Sex Differences in Frailty Incidence in Greek Community-Dwelling Older People: The HELIAD Study. Journal of Frailty & Aging. https://doi.org/10.14283/jfa.2022.39
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Peris, L., Parato, J., Qu, X., Soleilhac, J. M., Lanté, F., Kumar, A., Pero, M. E., Martínez-Hernández, J., Corrao, C., Falivelli, G., Payet, F., Gory-Fauré, S., Bosc, C., Blanca Ramirez, M., Sproul, A., Brocard, J., Di Cara, B., Delagrange, P., Buisson, A., … Andrieux, A. (2022). Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease. Brain, 145(7), 2486–2506. https://doi.org/10.1093/brain/awab436
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Consens, M. E., Chen, Y., Menon, V., Wang, Y., Schneider, J. A., De Jager, P. L., Bennett, D. A., Tripathy, S. J., & Felsky, D. (2022). Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 15. https://doi.org/10.3389/fnmol.2022.903175
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Cosentino, S., & Shih, L. C. (2022). Does essential tremor increase risk of cognitive impairment and dementia? Yes. Essential Tremor: Current Concepts and Controversies, 195–231. https://doi.org/10.1016/bs.irn.2022.02.011
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Inglese, M., Patel, N., Linton-Reid, K., Loreto, F., Win, Z., Perry, R. J., Carswell, C., Grech-Sollars, M., Crum, W. R., Lu, H., Malhotra, P. A., Silbert, L. C., Lind, B., Crissey, R., Kaye, J. A., Carter, R., Dolen, S., Quinn, J., … Aboagye, E. O. (2022). A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease. Communications Medicine, 2(1). https://doi.org/10.1038/s43856-022-00133-4
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Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J.-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., … Heid, I. M. (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03448-z
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Cosacak, M. I., Bhattarai, P., De Jager, P. L., Menon, V., Tosto, G., & Kizil, C. (2022). Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease. Cells, 11(11), 1807. https://doi.org/10.3390/cells11111807
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Sunderaraman, P., Lee, S., Varangis, E., Habeck, C., Chapman, S., Joyce, J. L., Hartstone, W., Brickman, A. M., Stern, Y., & Cosentino, S. (2021). Self-awareness for financial decision making abilities is linked to right temporal cortical thickness in older adults. Brain Imaging and Behavior, 16(3), 1139–1147. https://doi.org/10.1007/s11682-021-00590-w
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Kumar, J. S. D., Molotkov, A., Kim, J., Carberry, P., Idumonyi, S., Castrillon, J., Duff, K., Shneider, N. A., & Mintz, A. (2022). Preclinical evaluation of a microtubule PET ligand [11C]MPC-6827 in tau and amyotrophic lateral sclerosis animal models. Pharmacological Reports, 74(3), 539–544. https://doi.org/10.1007/s43440-022-00359-y
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Dugue, R., Schnall, R., Liu, M., Brickman, A. M., Pavol, M., Porra, T., & Gutierrez, J. (2022). Uncontrolled HIV and inflammation is associated with intracranial saccular aneurysm presence. AIDS, 36(7), 991–996. https://doi.org/10.1097/qad.0000000000003202
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Queder, N., Phelan, M. J., Taylor, L., Tustison, N., Doran, E., Hom, C., Nguyen, D., Lai, F., Pulsifer, M., Price, J., Kreisl, W. C., Rosas, H. D., Krinsky‐McHale, S., Brickman, A. M., Yassa, M. A., Schupf, N., Silverman, W., Lott, I. T., … Head, E. (2022). Joint‐label fusion brain atlases for dementia research in Down syndrome. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1). Portico. https://doi.org/10.1002/dad2.12324
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Marín-Chollom, A. M., Hale, C., Koch, P., Gaffney, A. O., Contento, I., Shen, H., Hershman, D. L., Brickman, A. M., & Greenlee, H. (2021). Cognitive Functioning and Health in Hispanic/Latina Breast Cancer Survivors. Journal of Immigrant and Minority Health, 24(3), 597–604. https://doi.org/10.1007/s10903-021-01300-w
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Kizil, C., Sariya, S., Kim, Y. A., Rajabli, F., Martin, E., Reyes-Dumeyer, D., Vardarajan, B., Maldonado, A., Haines, J. L., Mayeux, R., Jiménez-Velázquez, I. Z., Santa-Maria, I., & Tosto, G. (2022). Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1. Molecular Psychiatry, 27(6), 2813–2820. https://doi.org/10.1038/s41380-022-01526-6
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Bernardin, A., Colombani, S., Brugg, B., Jacotot, E., Meli, A., & Lacampagne, A. (2022). Neuro-cardiac organ-a-chip using patient specific induced pluripotent stem cells and microfluidic devices. Archives of Cardiovascular Diseases Supplements, 14(2), 209. https://doi.org/10.1016/j.acvdsp.2022.04.117
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Leaffer, E. B., De Vivo, D. C., Engelstad, K., Fryer, R. H., Gu, Y., Shungu, D. C., Hirano, M., DiMauro, S., & Hinton, V. J. (2022). Visual memory failure presages conversion to MELAS phenotype. Annals of Clinical and Translational Neurology, 9(6), 841–852. Portico. https://doi.org/10.1002/acn3.51564
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Gilmore-Bykovskyi, A., Croff, R., Glover, C. M., Jackson, J. D., Resendez, J., Perez, A., Zuelsdorff, M., Green-Harris, G., & Manly, J. J. (2021). Traversing the Aging Research and Health Equity Divide: Toward Intersectional Frameworks of Research Justice and Participation. The Gerontologist, 62(5), 711–720. https://doi.org/10.1093/geront/gnab107
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Cornejo-Sanchez, D. M., Acharya, A., Bharadwaj, T., Marin-Gomez, L., Pereira-Gomez, P., Nouel-Saied, L. M., Nickerson, D. A., Bamshad, M. J., Mefford, H. C., Schrauwen, I., Carrizosa-Moog, J., Cornejo-Ochoa, W., Pineda-Trujillo, N., & Leal, S. M. (2022). SCN1A Variants as the Underlying Cause of Genetic Epilepsy with Febrile Seizures Plus in Two Multi-Generational Colombian Families. Genes, 13(5), 754. https://doi.org/10.3390/genes13050754
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Gu, Y., Kociolek, A., Fernandez, K. K., Cosentino, S. A., Zhu, C. W., Jin, Z., Leverenz, J. B., & Stern, Y. B. (2022). Clinical Trajectories at the End of Life in Autopsy-Confirmed Dementia Patients With Alzheimer Disease and Lewy Bodies Pathologies. Neurology, 98(21). https://doi.org/10.1212/wnl.0000000000200259
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Liu, M., Sariya, S., Khasiyev, F., Tosto, G., Dueker, N. D., Cheung, Y. K., Wright, C. B., Sacco, R. L., Rundek, T., Elkind, M. S. V., & Gutierrez, J. (2022). Genetic determinants of intracranial large artery stenosis in the northern Manhattan study. Journal of the Neurological Sciences, 436, 120218. https://doi.org/10.1016/j.jns.2022.120218
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McRae, C., Dunk, M., Russell, D., Ellgring, H., Stern, Y., Greene, P., Fahn, S., & Henchcliffe, C. (2021). Baseline Differences in Long-term Survivors and Nonsurvivors of the Colorado/Columbia Fetal Implant Trial. Journal of the International Neuropsychological Society, 28(5), 452–459. https://doi.org/10.1017/s1355617721000680
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