Center for Translational Immunology

Displaying 151 - 196 of 196CSV
Postigo-Fernandez, J., Firdessa-Fite, R., & Creusot, R. J. (2022). Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes. Proceedings of the National Academy of Sciences, 119(15). https://doi.org/10.1073/pnas.2110987119
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Nauman, G., Danzl, N. M., Lee, J., Borsotti, C., Madley, R., Fu, J., Hölzl, M. A., Dahmani, A., Dorronsoro Gonzalez, A., Chavez, É., Campbell, S. R., Yang, S., Satwani, P., Liu, K., & Sykes, M. (2022). Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs. The Journal of Immunology, 208(7), 1652–1663. https://doi.org/10.4049/jimmunol.2100966
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Merola, J., Shamim, A., & Weiner, J. (2022). Update on immunosuppressive strategies in intestinal transplantation. Current Opinion in Organ Transplantation, 27(2), 119–125. https://doi.org/10.1097/mot.0000000000000958
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Huang, J. J., Gaines, S. B., Amezcua, M. L., Lubell, T. R., Dayan, P. S., Dale, M., Boneparth, A. D., Hicar, M. D., Winchester, R., & Gorelik, M. (2022). Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome. Journal of Allergy and Clinical Immunology, 149(3), 912–922. https://doi.org/10.1016/j.jaci.2021.10.015
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Bansal, R., Park, H., Taborda, C. C., Gordillo, C., Mapara, M. Y., Assal, A., Uhlemann, A.-C., & Reshef, R. (2022). Antibiotic Exposure, Not Alloreactivity, Is the Major Driver of Microbiome Changes in Hematopoietic Cell Transplantation. Transplantation and Cellular Therapy, 28(3), 135–144. https://doi.org/10.1016/j.jtct.2021.12.015
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Kanter, J., Walters, M. C., Krishnamurti, L., Mapara, M. Y., Kwiatkowski, J. L., Rifkin-Zenenberg, S., Aygun, B., Kasow, K. A., Pierciey, F. J., Bonner, M., Miller, A., Zhang, X., Lynch, J., Kim, D., Ribeil, J.-A., Asmal, M., Goyal, S., Thompson, A. A., & Tisdale, J. F. (2022). Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease. New England Journal of Medicine, 386(7), 617–628. https://doi.org/10.1056/nejmoa2117175
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Menghrajani, K., Gomez-Arteaga, A., Madero-Marroquin, R., Zhang, M.-J., Bo-Subait, K., Sanchez, J., Wang, H.-L., Aljurf, M., Assal, A., Bacher, V. U., Badawy, S. M., Bejanyan, N., Bhatt, V. R., Bredeson, C., Byrne, M., Castillo, P., Cerny, J., Chhabra, S., Ciurea, S. O., … Saber, W. (2022). Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML. Blood Advances, 6(3), 828–847. https://doi.org/10.1182/bloodadvances.2021004881
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Lopez-Bujanda, Z. A., Haffner, M. C., Chaimowitz, M. G., Chowdhury, N., Venturini, N. J., Patel, R. A., Obradovic, A., Hansen, C. S., Jacków, J., Maynard, J. P., Sfanos, K. S., Abate-Shen, C., Bieberich, C. J., Hurley, P. J., Selby, M. J., Korman, A. J., Christiano, A. M., De Marzo, A. M., & Drake, C. G. (2021). Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression. Nature Cancer, 2(8), 803–818. https://doi.org/10.1038/s43018-021-00227-3
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Lombardo, K. A., Obradovic, A., Singh, A. K., Liu, J. L., Joice, G., Kates, M., Bishai, W., McConkey, D., Chaux, A., Eich, M., Rezaei, M. K., Netto, G. J., Drake, C. G., Tran, P., Matoso, A., & Bivalacqua, T. J. (2021). BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer. The Journal of Pathology, 256(2), 223–234. Portico. https://doi.org/10.1002/path.5830
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Hawley, J. E., Pan, S., Kandadi, H., Chaimowitz, M. G., Sheikh, N., & Drake, C. G. (2021). Analysis of Circulating Immune Biomarkers by Race in Men With Metastatic Castration-Resistant Prostate Cancer Treated With Sipuleucel-T. JNCI: Journal of the National Cancer Institute, 114(2), 314–317. https://doi.org/10.1093/jnci/djab145
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Jain, R., Habal, M. V., Clerkin, K. J., Latif, F., Restaino, S. W., Zorn, E., Takeda, K., Naka, Y., Yuzefpolskaya, M., Farr, M. A., Colombo, P. C., Sayer, G. T., Uriel, N., & Topkara, V. K. (2021). De Novo Human Leukocyte Antigen Allosensitization in Heartmate 3 Versus Heartmate II Left Ventricular Assist Device Recipients. ASAIO Journal, 68(2), 226–232. https://doi.org/10.1097/mat.0000000000001451
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Mor, A., & Strazza, M. (2022). Bridging the Gap: Connecting the Mechanisms of Immune-Related Adverse Events and Autoimmunity Through PD-1. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.790386
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Macedo, R., Pasin, C., Ganetsky, A., Harle, D., Wang, X. K., Belay, K., Richman, L. P., Huffman, A. P., Vonderheide, R. H., Yates, A. J., Porter, D. L., Wang, Y., Zhang, Y., & Reshef, R. (2022). Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature. Transplantation and Cellular Therapy, 28(1), 18.e1-18.e10. https://doi.org/10.1016/j.jtct.2021.09.017
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Wu, Y., Fu, J., Wang, H., & Yu, X.-Z. (2021). Donor T-Cell Repertoire Profiling in Recipient Lymphoid and Parenchyma Organs Reveals GVHD Pathogenesis at Clonal Levels After Bone Marrow Transplantation in Mice. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.778996
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Khosravi-Maharlooei, M., Madley, R., Borsotti, C., Ferreira, L. M. R., Sharp, R. C., Brehm, M. A., Greiner, D. L., Parent, A. V., Anderson, M. S., Sykes, M., & Creusot, R. J. (2022). Modeling human T1D-associated autoimmune processes. Molecular Metabolism, 56, 101417. https://doi.org/10.1016/j.molmet.2021.101417
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Thapa, P., Guyer, R. S., Yang, A. Y., Parks, C. A., Brusko, T. M., Brusko, M., Connors, T. J., & Farber, D. L. (2021). Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling. Science Immunology, 6(66). https://doi.org/10.1126/sciimmunol.abj0789
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Vecchione, A., Jofra, T., Gerosa, J., Shankwitz, K., Di Fonte, R., Galvani, G., Ippolito, E., Cicalese, M. P., Schultz, A. R., Seay, H. R., Favellato, M., Milardi, G., Stabilini, A., Ragogna, F., Grogan, P., Bianconi, E., Laurenzi, A., Caretto, A., Nano, R., … Fousteri, G. (2021). Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes. Diabetes, 70(12), 2892–2902. https://doi.org/10.2337/db21-0091
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Strazza, M., Azoulay-Alfaguter, I., Peled, M., Adam, K., & Mor, A. (2021). Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells. Communications Biology, 4(1). https://doi.org/10.1038/s42003-021-02225-8
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Cordero, H., King, R. G., Dogra, P., Dufeu, C., See, S. B., Chong, A. M., Uhlemann, A.-C., Ho, S.-H., Kalfa, D. M., Bacha, E. A., Kearney, J. F., & Zorn, E. (2021). Intrathymic differentiation of natural antibody-producing plasma cells in human neonates. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26069-2
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Miron, M., Meng, W., Rosenfeld, A. M., Dvorkin, S., Poon, M. M. L., Lam, N., Kumar, B. V., Louzoun, Y., Luning Prak, E. T., & Farber, D. L. (2021). Maintenance of the human memory T cell repertoire by subset and tissue site. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-021-00918-7
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Pasin, C., Moy, R. H., Reshef, R., & Yates, A. J. (2021). Variable selection methods for predicting clinical outcomes following allogeneic hematopoietic cell transplantation. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-82562-0
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Teng, F., Tachó-Piñot, R., Sung, B., Farber, D. L., Worgall, S., Hammad, H., Lambrecht, B. N., Hepworth, M. R., & Sonnenberg, G. F. (2021). ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell Reports, 37(8), 110051. https://doi.org/10.1016/j.celrep.2021.110051
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Li, S., Fu, J., Yang, J., Ma, H., Mapara, M. Y., Marcireau, C., & Lentzsch, S. (2021). MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma. Blood, 138(Supplement 1), 2662–2662. https://doi.org/10.1182/blood-2021-151844
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Park, J. H., Nikiforow, S., Kim, S., Hu, Z.-H., Moskop, A., Ahmed, S., Bilal Abid, M., Badar, T., Bredeson, C., Brown, V., Cairo, M. S., Díaz, M., Dholaria, B., Ganguly, S., Grover, N. S., Hanna, R., Hematti, P., Kohorst, M. A., Lazarus, H., … Perales, M.-A. (2021). Impact of Allogeneic Hematopoietic Cell Transplantation (HCT) As Consolidation Following CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy for Treatment of Relapsed Acute Lymphoblastic Leukemia (ALL). Blood, 138(Supplement 1), 3880–3880. https://doi.org/10.1182/blood-2021-148652
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Walters, M. C., Tisdale, J. F., Mapara, M. Y., Krishnamurti, L., Kwiatkowski, J. L., Aygun, B., Kasow, K. A., Rifkin-Zenenberg, S., Jaroscak, J., Garbinsky, D., Chirila, C., Gallagher, M. E., Zhang, X., Ho, P.-R., Thompson, A. A., & Kanter, J. (2021). Sustained Improvements in Patient-Reported Quality of Life up to 24 Months Post-Treatment with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy. Blood, 138(Supplement 1), 7–7. https://doi.org/10.1182/blood-2021-146905
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Tisdale, J. F., Thompson, A. A., Mapara, M. Y., Kwiatkowski, J. L., Krishnamurti, L., Aygun, B., Kasow, K. A., Rifkin-Zenenberg, S., Schmidt, M., Pierciey, F. J., Whitney, D., Rogers, C., Nnamani, M., Foos, M., Miller, A., Zhang, X., Lynch, J., Walters, M. C., Kanter, J., & Bonner, M. (2021). Polyclonality Strongly Correlates with Biological Outcomes and Is Significantly Increased Following Improvements to the Phase 1/2 HGB-206 Protocol and Manufacturing of LentiGlobin for Sickle Cell Disease (SCD; bb1111) Gene Therapy (GT). Blood, 138(Supplement 1), 561–561. https://doi.org/10.1182/blood-2021-147760
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Hill, B. T., Roth, C. J., Kositsky, R., Dave, T., Love, C., McKinney, M., Galal, A., Neff, J. L., Mian, A., Kendall, E., Ondrejka, S. L., Chiaramonte, M., Bhagat, G., Ofori, K., Reshef, R., Kovach, A. E., Sethi, T., Mason, E. F., Bhaskar, S., … Dave, S. S. (2021). Impact of Molecular Features of Diffuse Large B-Cell Lymphoma on Treatment Outcomes with Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy. Blood, 138(Supplement 1), 165–165. https://doi.org/10.1182/blood-2021-145764
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Aschauer, C., Jelencsics, K., Hu, K., Heinzel, A., Gregorich, M. G., Vetter, J., Schaller, S., Winkler, S. M., Weinberger, J., Pimenov, L., Gualdoni, G. A., Eder, M., Kainz, A., Troescher, A. R., Regele, H., Reindl-Schwaighofer, R., Wekerle, T., Huppa, J. B., Sykes, M., & Oberbauer, R. (2021). Prospective Tracking of Donor-Reactive T-Cell Clones in the Circulation and Rejecting Human Kidney Allografts. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.750005
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Strazza, M., Bukhari, S., Tocheva, A. S., & Mor, A. (2021). PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature. Immunology, 164(3), 555–568. Portico. https://doi.org/10.1111/imm.13388
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Soni, M., Migliori, E., Assal, A., Chan, H. T., Ciubotariu, R., Pan, J. B., Cicero, K., Pereira, M., Mapara, M. Y., & Muranski, P. (2021). Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection. Cytotherapy, 23(11), 980–984. https://doi.org/10.1016/j.jcyt.2021.05.005
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Oran, B., Ahn, K. W., Fretham, C., Beitinjaneh, A., Bashey, A., Pawarode, A., Wirk, B., Scott, B. L., Savani, B. N., Bredeson, C., Weisdorf, D., Marks, D. I., Rizzieri, D., Copelan, E., Hildebrandt, G. C., Hale, G. A., Murthy, H. S., Lazarus, H. M., Cerny, J., … Saber, W. (2021). Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improve Transplantation Outcomes in Older Patients with Myelodysplastic Syndromes. Transplantation and Cellular Therapy, 27(11), 921.e1-921.e10. https://doi.org/10.1016/j.jtct.2021.08.007
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Takeuchi, K., Ariyoshi, Y., Shimizu, A., Okumura, Y., Cara‐Fuentes, G., Garcia, G. E., Pomposelli, T., Watanabe, H., Boyd, L., Ekanayake‐Alper, D. K., Amarnath, D., Sykes, M., Sachs, D. H., Johnson, R. J., & Yamada, K. (2021). Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation. Xenotransplantation, 28(6). Portico. https://doi.org/10.1111/xen.12708
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Mantell, B. S., Cordero, H., See, S. B., Clerkin, K. J., Vasilescu, R., Marboe, C. C., Naka, Y., Restaino, S., Colombo, P. C., Addonizio, L. J., Farr, M. A., & Zorn, E. (2021). Transcriptomic heterogeneity of antibody mediated rejection after heart transplant with or without donor specific antibodies. The Journal of Heart and Lung Transplantation, 40(11), 1472–1480. https://doi.org/10.1016/j.healun.2021.06.012
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Zorn, E., & See, S. B. (2021). Antibody Responses to Minor Histocompatibility Antigens After Solid Organ Transplantation. Transplantation, 106(4), 749–753. https://doi.org/10.1097/tp.0000000000003969
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van Besouw, N. M., Rojas, A. M., See, S. B., de Kuiper, R., Dieterich, M., Roelen, D. L., Clahsen-van Groningen, M. C., Hesselink, D. A., Zorn, E., & Baan, C. C. (2021). Natural Antibodies and Alloreactive T Cells Long after Kidney Transplantation. Journal of Transplantation, 2021, 1–9. https://doi.org/10.1155/2021/7005080
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Pellegrino, B., Tommasi, C., Cursio, O. E., Musolino, A., Migliori, E., De Silva, P., Senevirathne, T. H., Schena, M., Scartozzi, M., Farci, D., Willard-Gallo, K., & Solinas, C. (2021). A review of immune checkpoint blockade in breast cancer. Seminars in Oncology, 48(3), 208–225. https://doi.org/10.1053/j.seminoncol.2021.09.002
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Giangreco, N. P., Lebreton, G., Restaino, S., Jane Farr, M., Zorn, E., Colombo, P. C., Patel, J., Levine, R., Truby, L., Soni, R. K., Leprince, P., Kobashigawa, J., Tatonetti, N. P., & Fine, B. M. (2021). Plasma kallikrein predicts primary graft dysfunction after heart transplant. The Journal of Heart and Lung Transplantation, 40(10), 1199–1211. https://doi.org/10.1016/j.healun.2021.07.001
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Lerrer, S., Tocheva, A. S., Bukhari, S., Adam, K., & Mor, A. (2021). PD-1-stimulated T cell subsets are transcriptionally and functionally distinct. IScience, 24(9), 103020. https://doi.org/10.1016/j.isci.2021.103020
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Ager, C. R., Boda, A., Rajapakshe, K., Lea, S. T., Di Francesco, M. E., Jayaprakash, P., Slay, R. B., Morrow, B., Prasad, R., Dean, M. A., Duffy, C. R., Coarfa, C., Jones, P., & Curran, M. A. (2021). High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege. Journal for ImmunoTherapy of Cancer, 9(8), e003246. https://doi.org/10.1136/jitc-2021-003246
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Strazza, M., Adam, K., Lerrer, S., Straube, J., Sandigursky, S., Ueberheide, B., & Mor, A. (2021). SHP2 Targets ITK Downstream of PD-1 to Inhibit T Cell Function. Inflammation, 44(4), 1529–1539. https://doi.org/10.1007/s10753-021-01437-8
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Waffarn, E. E., Khosravi‐Maharlooei, M., Vecchione, A., Shao, S., Vishwasrao, P., HÖlzl, M. A., Frangaj, K., Sykes, M., & Li, H. W. (2021). Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model. Xenotransplantation, 28(4). Portico. https://doi.org/10.1111/xen.12691
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