Epidemiology and Treatment of Chagas Disease

Displaying 1 - 9 of 9CSV
Miotto, M. C., Luna-Figueroa, E., Tchagou, C., Bahlouli, L., Reiken, S., Dridi, H., Liu, Y., Weninger, G., & Marks, A. R. (2025). Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2422082122
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Woodland, J. G., Coertzen, D., Wicht, K. J., Hidalgo, V. F., Pasaje, C. F. A., Godoy, L. C., Qahash, T., Mmonwa, M. M., Dziwornu, G. A., Wambua, L., Harries, S., Korkor, C. M., Njoroge, M., Krugmann, L., Taylor, D., Leshabane, M., Langeveld, H., Rabie, T., Reader, J., … Chibale, K. (2025). The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria. Angewandte Chemie International Edition. Portico. https://doi.org/10.1002/anie.202425206
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Somerville, E. N., Krohn, L., Senkevich, K., Yu, E., Ahmad, J., Asayesh, F., Ruskey, J. A., Spiegelman, D., Fahn, S., Waters, C., Sardi, S. P., Alcalay, R. N., & Gan-Or, Z. (2025). Genome-Wide Association Study of Glucocerebrosidase Activity Modifiers. Molecular Neurobiology. https://doi.org/10.1007/s12035-025-04996-1
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Merello Oyarzún, G., Olivares-Costa, M., Basile, L., Pástor, T. P., Mendoza-Soto, P., Padilla-Santiago, L., Mardones, G. A., Binda, C., & Opazo, J. C. (2025). Evolutionary and Functional Analysis of Monoamine Oxidase F (MAO F): A Novel Member of the MAO Gene Family. Genome Biology and Evolution. https://doi.org/10.1093/gbe/evae280
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Chang, S., Zhan, X., Liu, Y., Song, H., Gong, Z., Han, L., Maegawa, G. H. B., Gu, X., & Zhang, H. (2024). Newborn Screening for 6 Lysosomal Storage Disorders in China. JAMA Network Open, 7(5), e2410754. https://doi.org/10.1001/jamanetworkopen.2024.10754
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Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M., & Fidock, D. A. (2024). Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. MBio, 15(1). https://doi.org/10.1128/mbio.01832-23
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Ashton, T. D., Dans, M. G., Favuzza, P., Ngo, A., Lehane, A. M., Zhang, X., Qiu, D., Chandra Maity, B., De, N., Schindler, K. A., Yeo, T., Park, H., Uhlemann, A.-C., Churchyard, A., Baum, J., Fidock, D. A., Jarman, K. E., Lowes, K. N., Baud, D., … Sleebs, B. E. (2023). Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4. Journal of Medicinal Chemistry, 66(5), 3540–3565. https://doi.org/10.1021/acs.jmedchem.2c02092
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Kucharski, M., Wirjanata, G., Nayak, S., Boentoro, J., Dziekan, J. M., Assisi, C., van der Pluijm, R. W., Miotto, O., Mok, S., Dondorp, A. M., & Bozdech, Z. (2023). Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum. PLOS Pathogens, 19(1), e1011118. https://doi.org/10.1371/journal.ppat.1011118
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Paloque, L., Coppée, R., Stokes, B. H., Gnädig, N. F., Niaré, K., Augereau, J.-M., Fidock, D. A., Clain, J., & Benoit-Vical, F. (2022). Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance. Antimicrobial Agents and Chemotherapy, 66(1). https://doi.org/10.1128/aac.01320-21
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