Three prime repair exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural, and conformational properties

Prakash, P., Khodke, P., Balasubramaniam, M., Davids, B.-O., Hollis, T., Davis, J., Kumbhar, B., & Dash, C. (2024). Three prime repair exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural, and conformational properties. Journal of Biological Chemistry, 300(7), 107438. https://doi.org/10.1016/j.jbc.2024.107438
Authors:
Prem Prakash
Purva Khodke
Muthukumar Balasubramaniam
Benem-Orom Davids
Thomas Hollis
Jamaine Davis
Bajarang Kumbhar
Chandravanu Dash
Affiliated Authors:
Benem-Orom Davids
Columbia Affiliation:
Subjects:
Exodeoxyribonucleases (MeSH)
HIV-1 (MeSH)
Phosphoproteins (MeSH)
DNA, Viral (MeSH)
Author Keywords:
hiv-1
trex1
catalysis
dissociation constant
enzyme
exonuclease
integration
k((cat))
kinetics
molecular dynamics
nucleotides
thermodynamic
elink
Publication Type:
Article
Unique ID:
10.1016/j.jbc.2024.107438
PMID:
38838778
DOI:
10.1016/j.jbc.2024.107438
Journal:
Journal of Biological Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: