A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients

Chang, L.-C., Yin, M. T., Laird, G. M., Ritter, K. D., Shah, J. G., & Debnath, A. K. (2025). A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients. International Journal of Molecular Sciences, 26(6), 2772. https://doi.org/10.3390/ijms26062772
Authors:
Lin-Chun Chang
Michael T Yin
Gregory M Laird
Kristen D Ritter
Jayesh G Shah
Asim K Debnath
Affiliated Authors:
Michael T Yin
Jayesh G Shah
Columbia Affiliation:
Subjects:
Virus Latency (MeSH)
Proto-Oncogene Proteins c-bcl-2 (MeSH)
HIV-1 (MeSH)
HIV Infections (MeSH)
bcl-X Protein (MeSH)
CD4-Positive T-Lymphocytes (MeSH)
Author Keywords:
hiv latency
viral reservoirs
bcl-2/bcl-xl
protein degrader
non-canonical
nf-kb
elink
Publication Type:
Article
Unique ID:
10.3390/ijms26062772
PMID:
40141414
DOI:
10.3390/ijms26062772
Journal:
International Journal of Molecular Sciences
Publication Date:
Data Source:
PubMed
Source Link:
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