Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques

Morris, D. J., Gorman, J., Zhou, T., Lora, J., Connell, A. J., Li, H., Liu, W., Roark, R. S., Campion, M. S., Carey, J. W., Habib, R., Li, Y., Martella, C. L., Park, Y., Singh, A., Sowers, K. J., Teng, I.-T., Wang, S., Chohan, N., … Shaw, G. M. (2025). Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. Cell Reports, 44(6), 115848. https://doi.org/10.1016/j.celrep.2025.115848
Authors:
Daniel J Morris
Jason Gorman
Tongqing Zhou
Jinery Lora
Andrew J Connell
Hui Li
Weimin Liu
Ryan S Roark
Mary S Campion
John W Carey
Rumi Habib
Yingying Li
Christian L Martella
Younghoon Park
Ajay Singh
Kirsten J Sowers
I-Ting Teng
Shuyi Wang
Neha Chohan
Wenge Ding
Craig Lauer
Emily Lewis
Rosemarie D Mason
Juliette M Rando
Lowrey Peyton
Chaim A Schramm
Kshitij Wagh
Bette Korber
Michael S Seaman
Daniel C Douek
Barton F Haynes
Daniel W Kulp
Mario Roederer
Beatrice H Hahn
Peter D Kwong
George M Shaw
Affiliated Authors:
Ryan S Roark
Peter D Kwong
Columbia Affiliation:
Subjects:
Polysaccharides (MeSH)
Simian Immunodeficiency Virus (MeSH)
Simian Acquired Immunodeficiency Syndrome (MeSH)
CD4 Antigens (MeSH)
Antibodies, Neutralizing (MeSH)
HIV-1 (MeSH)
Broadly Neutralizing Antibodies (MeSH)
HIV Antibodies (MeSH)
Author Keywords:
broadly neutralizing antibody
cd4-binding site
co-evolution
cp: immunology
glycan deletion
hiv-1
simian-human immunodeficiency virus (shiv)
structure-guided vaccine design
elink
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2025.115848
PMID:
40516049
DOI:
10.1016/j.celrep.2025.115848
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record
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Record Created: