Genetics and Pathogenesis of Type 1 Diabetes

Displaying 1 - 25 of 25CSV
Pita-Juarez, Y., Karagkouni, D., Kalavros, N., Melms, J. C., Niezen, S., Delorey, T. M., Essene, A. L., Brook, O. R., Pant, D., Skelton-Badlani, D., Naderi, P., Huang, P., Pan, L., Hether, T., Andrews, T. S., Ziegler, C. G. K., Reeves, J., Myloserdnyy, A., Chen, R., … Vlachos, I. S. (2025). A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Genome Biology, 26(1). https://doi.org/10.1186/s13059-025-03499-5
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Craig-Schapiro, R., Li, G., Chen, K., Gomez-Salinero, J. M., Nachman, R., Kopacz, A., Schreiner, R., Chen, X., Zhou, Q., Rafii, S., & Redmond, D. (2025). Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55415-3
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Riemann, L., Gutierrez, R., Odak, I., Barros-Martins, J., Roesner, L. M., Leon Lara, X., Falk, C., Schulz, T. F., Hansen, G., Werfel, T., Förster, R., Bošnjak, B., Jenniches, F., Klopp, N., Lesker, T. R., & Stangel, M. (2025). Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits. EBioMedicine, 112, 105558. https://doi.org/10.1016/j.ebiom.2025.105558
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Stark, H., Ho, Q. Y., Cross, A., Alessandrini, A., Bertaina, A., Brennan, D., Busque, S., Demetris, A., Devey, L., Fruhwirth, G., Fuchs, E., Friend, P., Geissler, E., Guillonneau, C., Hester, J., Isaacs, J., Jaeckel, E., Kawai, T., Lakkis, F., … Issa, F. (2025). Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance. Transplantation. https://doi.org/10.1097/tp.0000000000005311
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Bosticardo, M., Dobbs, K., Delmonte, O. M., Martins, A. J., Pala, F., Kawai, T., Kenney, H., Magro, G., Rosen, L. B., Yamazaki, Y., Yu, H.-H., Calzoni, E., Lee, Y. N., Liu, C., Stoddard, J., Niemela, J., Fink, D., Castagnoli, R., Ramba, M., … Gentile, N. (2025). Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adq1697
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Sun, J., Yao, J., Olén, O., Halfvarsson, J., Bergman, D., Ebrahimi, F., Carlsson, S., Ludvigsson, J., & Ludvigsson, J. F. (2024). Bidirectional association between inflammatory bowel disease and type 1 diabetes: a nationwide matched cohort and case-control study. The Lancet Regional Health - Europe, 46, 101056. https://doi.org/10.1016/j.lanepe.2024.101056
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Yang, L., Han, Y., Zhang, T., Dong, X., Ge, J., Roy, A., Zhu, J., Lu, T., Jeya Vandana, J., de Silva, N., Robertson, C. C., Xiang, J. Z., Pan, C., Sun, Y., Que, J., Evans, T., Liu, C., Wang, W., Naji, A., … Chen, S. (2024). Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. https://doi.org/10.1016/j.stem.2024.08.007
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Firdessa-Fite, R., Johnson, S. N., Bechi Genzano, C., Leon, M. A., Ku, A., Ocampo Gonzalez, F. A., Milner, J. D., Sestak, J. O., Berkland, C., & Creusot, R. J. (2024). Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1258369
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Etra, A., El Jurdi, N., Katsivelos, N., Kwon, D., Gergoudis, S., Morales, G., Spyrou, N., Kowalyk, S., Aguayo-Hiraldo, P., Akahoshi, Y., Ayuk, F., Baez, J., Betts, B. C., Chanswangphuwana, C., Chen, Y.-B., Choe, H., DeFilipp, Z., Gleich, S., Hexner, E., … Holtan, S. (2024). Amphiregulin, ST2, and REG3α biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD. Blood Advances, 8(12), 3284–3292. https://doi.org/10.1182/bloodadvances.2023011049
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Levine, S. R., Myers, M. G., Barunas, R., Chang, D. S., Dutta, S., Maddess, T., Liebmann, J. M., Sherman, S., Eydelman, M., Sun, J. K., Chambers, W., Wickström, K., Luhmann, U. F. O., Pallinat, M., Glassman, A., Aiello, L. P., Markel, D. S., & Gardner, T. W. (2023). Report From the 2022 Mary Tyler Moore Vision Initiative Diabetic Retinal Disease Clinical Endpoints Workshop. Translational Vision Science & Technology, 12(11), 33. https://doi.org/10.1167/tvst.12.11.33
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Le Voyer, T., Parent, A. V., Liu, X., Cederholm, A., Gervais, A., Rosain, J., Nguyen, T., Perez Lorenzo, M., Rackaityte, E., Rinchai, D., Zhang, P., Bizien, L., Hancioglu, G., Ghillani-Dalbin, P., Charuel, J.-L., Philippot, Q., Gueye, M. S., Maglorius Renkilaraj, M. R. L., … Ogishi, M. (2023). Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. Nature, 623(7988), 803–813. https://doi.org/10.1038/s41586-023-06717-x
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Luchsinger, J. A., Pang, D., Krinsky‐McHale, S. J., Schupf, N., Lee, J. H., Silverman, W., & Zigman, W. B. (2023). Obesity, diabetes and their metabolic correlates in middle‐aged adults with Down syndrome. Journal of Intellectual Disability Research, 68(3), 212–222. Portico. https://doi.org/10.1111/jir.13103
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Thomas, T. A., Qiu, A., Kim, C. Y., Gordy, D. E., Miller, A., Tredicine, M., Dzieciatkowska, M., Dei Zotti, F., Hod, E. A., D’Alessandro, A., Zimring, J. C., Spitalnik, S. L., & Hudson, K. E. (2023). Reticulocytes in donor blood units enhance red blood cell alloimmunization. Haematologica, 108(10), 2639–2651. https://doi.org/10.3324/haematol.2023.282815
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Jajosky, R. P., Patel, S. R., Wu, S.-C., Patel, K. R., Covington, M. L., Vallecillo-Zúniga, M. L., Ayona, D., Bennett, A., Luckey, C. J., Hudson, K. E., Hendrickson, J. E., Eisenbarth, S. C., Josephson, C. D., Zerra, P. E., Stowell, S. R., & Arthur, C. M. (2023). Prior Immunization to an Intracellular Antigen Enhances Subsequent Red Blood Cell Alloimmunization in Mice. Blood. https://doi.org/10.1182/blood.2022016588
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Mashiko, S., Shihab, R. R., See, S. B., Schahadat, L. G. Z., Aguiar, T. F. M., Roy, P., Porcheray, F., & Zorn, E. (2023). Broad responses to chemical adducts shape the natural antibody repertoire in early infancy. Science Advances, 9(19). https://doi.org/10.1126/sciadv.ade8872
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Chu, C. M. J., Modi, H., Ellis, C., Krentz, N. A. J., Skovsø, S., Zhao, Y. B., Cen, H., Noursadeghi, N., Panzhinskiy, E., Hu, X., Dionne, D. A., Xia, Y. H., Xuan, S., Huising, M. O., Kieffer, T. J., Lynn, F. C., & Johnson, J. D. (2022). Dynamic Ins2 Gene Activity Defines β-Cell Maturity States. Diabetes, 71(12), 2612–2631. https://doi.org/10.2337/db21-1065
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Cardwell, F. S., Elliott, S. J., Chin, R., St Pierre, Y., Choi, M. Y., Urowitz, M. B., Ruiz-Irastorza, G., Bernatsky, S., Wallace, D. J., Petri, M. A., Manzi, S., Bae, S.-C., Shin, J.-M., Mak, A., Cho, J., Peschken, C. A., Ramsey-Goldman, R., Fortin, P. R., Hanly, J. G., … Clarke, A. E. (2022). Health information use by patients with systemic lupus erythematosus (SLE) pre and during the COVID-19 pandemic. Lupus Science & Medicine, 9(1), e000755. https://doi.org/10.1136/lupus-2022-000755
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Jacobson, A. M., Braffett, B. H., Erus, G., Ryan, C. M., Biessels, G. J., Luchsinger, J. A., Bebu, I., Gubitosi-Klug, R. A., Desiderio, L., Lorenzi, G. M., Trapani, V. R., Lachin, J. M., Bryan, R. N., Habes, M., & Nasrallah, I. M. (2022). Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study. Diabetes Care, 45(8), 1779–1787. https://doi.org/10.2337/dc21-2438
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Schilperoort, M., Ngai, D., & Tabas, I. (2022). Efferocytosis induces a transient burst of glycolysis in macrophages to promote lactate-driven binding and continuing removal of apoptotic cells. Atherosclerosis, 355, 1–2. https://doi.org/10.1016/j.atherosclerosis.2022.06.091
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Guo, J., Lin, W.-H. W., Zucker, J. E., Nandakumar, R., Uhlemann, A.-C., Wang, S., & Shivakoti, R. (2022). Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 107(5), e1961–e1968. https://doi.org/10.1210/clinem/dgac003
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Postigo-Fernandez, J., Firdessa-Fite, R., & Creusot, R. J. (2022). Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes. Proceedings of the National Academy of Sciences, 119(15). https://doi.org/10.1073/pnas.2110987119
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Son, J., Ding, H., Farb, T. B., Efanov, A. M., Sun, J., Gore, J. L., Syed, S. K., Lei, Z., Wang, Q., Accili, D., & Califano, A. (2021). BACH2 inhibition reverses β cell failure in type 2 diabetes models. Journal of Clinical Investigation, 131(24). https://doi.org/10.1172/jci153876
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