Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature

Bosticardo, M., Dobbs, K., Delmonte, O. M., Martins, A. J., Pala, F., Kawai, T., Kenney, H., Magro, G., Rosen, L. B., Yamazaki, Y., Yu, H.-H., Calzoni, E., Lee, Y. N., Liu, C., Stoddard, J., Niemela, J., Fink, D., Castagnoli, R., Ramba, M., … Gentile, N. (2025). Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adq1697
Authors:
Marita Bosticardo
Kerry Dobbs
Ottavia M. Delmonte
Andrew J. Martins
Francesca Pala
Tomoki Kawai
Heather Kenney
Gloria Magro
Lindsey B. Rosen
Yasuhiro Yamazaki
Hsin‐Hui Yu
Enrica Calzoni
Yu Nee Lee
Can Liu
Jennifer Stoddard
Julie E. Niemela
Danielle Fink
Riccardo Castagnoli
Meredith Ramba
Aristine Cheng
Deanna Riley
Vasileios Oikonomou
Elana Shaw
Brahim Belaid
Sevgi Keleş
Waleed Al‐Herz
Caterina Cancrini
Cristina Cifaldi
Safa Barış
Svetlana O. Sharapova
Catharina Schuetz
Andrew R. Gennery
Alexandra F. Freeman
Raz Somech
Sharon Choo
Silvia Giliani
Tayfun Güngör
Daniel Drozdov
Isabelle Meyts
Despina Moshous
Bénédicte Neven
Roshini S. Abraham
Aisha Elmarsafy
Maria Kanariou
Alejandra King
Francesco Licciardi
Mario Ernesto Cruz-Muñoz
G. Olivieri
M. Cecilia Poli
Mehdi Adeli
Mattia Algeri
Fayhan Alroqi
Paul Bastard
Jenna Bergerson
Claire Booth
Ana Brett
Siobhan O. Burns
Manish J. Butte
Nurcicek Padem
Maite de la Morena
Ghassan Dbaibo
Suk See De Ravin
Dimana Dimitrova
Réda Djidjik
Mayra de Barros Dorna
Cullen M. Dutmer
Reem Elfeky
Fabio Facchetti
Ramsay Fuleihan
R S Geha
Luis Ignacio González‐Granado
Liis Haljasmägi
Hanadys Ale
Anthony Hayward
Anna Hilfanova
Winnie Ip
Blanka Kaplan
Neena Kapoor
Elif Karakoç-Aydıner
Jaanika Kärner
Michael D. Keller
Blachy J. Dávila Saldaña
Ayça Kıykım
Taco W. Kuijpers
Elena Kuznetsova
Elena A. Latysheva
Jennifer W. Leiding
Franco Locatelli
Guisela Alva‐Lozada
Christine McCusker
Fatih Çelmeli
Megan Morsheimer
Ahmet Özen
Nima Parvaneh
Srdjan Pašić
Alessandro Plebani
Kahn Preece
Susan E. Prockop
Inga Sakovich
Elena E. Starkova
Affiliated Authors:
Ramsay Fuleihan
Columbia Affiliation:
Subjects:
Inflammation (MeSH)
Natural Killer Cells in Immunity (OpenAlex Topic)
Innate Lymphoid Cells in Immunity (OpenAlex Topic)
Genetics and Pathogenesis of Type 1 Diabetes (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1126/sciimmunol.adq1697
PMID:
39792639
DOI:
10.1126/sciimmunol.adq1697
Journal:
Science Immunology
Publication Date:
Data Source:
OpenAlex
Source Link:
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