Nature

Displaying 51 - 88 of 88
Shih, J., Sarmashghi, S., Zhakula-Kostadinova, N., Zhang, S., Georgis, Y., Hoyt, S. H., Cuoco, M. S., Gao, G. F., Spurr, L. F., Berger, A. C., Ha, G., Rendo, V., Shen, H., Meyerson, M., Cherniack, A. D., Taylor, A. M., & Beroukhim, R. (2023). Cancer aneuploidies are shaped primarily by effects on tumour fitness. Nature, 619(7971), 793–800. https://doi.org/10.1038/s41586-023-06266-3
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Rawal, Y., Jia, L., Meir, A., Zhou, S., Kaur, H., Ruben, E. A., Kwon, Y., Bernstein, K. A., Jasin, M., Taylor, A. B., Burma, S., Hromas, R., Mazin, A. V., Zhao, W., Zhou, D., Wasmuth, E. V., Greene, E. C., Sung, P., & Olsen, S. K. (2023). Structural insights into BCDX2 complex function in homologous recombination. Nature, 619(7970), 640–649. https://doi.org/10.1038/s41586-023-06219-w
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Chen, L., Fu, L., Sun, J., Huang, Z., Fang, M., Zinkle, A., Liu, X., Lu, J., Pan, Z., Wang, Y., Liang, G., Li, X., Chen, G., & Mohammadi, M. (2023). Structural basis for FGF hormone signalling. Nature, 618(7966), 862–870. https://doi.org/10.1038/s41586-023-06155-9
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Paredes, A., Justo-Méndez, R., Jiménez-Blasco, D., Núñez, V., Calero, I., Villalba-Orero, M., Alegre-Martí, A., Fischer, T., Gradillas, A., Sant’Anna, V. A. R., Were, F., Huang, Z., Hernansanz-Agustín, P., Contreras, C., Martínez, F., Camafeita, E., Vázquez, J., Ruiz-Cabello, J., Area-Gómez, E., … Ricote, M. (2023). γ-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature, 618(7964), 365–373. https://doi.org/10.1038/s41586-023-06068-7
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Ken, M. L., Roy, R., Geng, A., Ganser, L. R., Manghrani, A., Cullen, B. R., Schulze-Gahmen, U., Herschlag, D., & Al-Hashimi, H. M. (2023). RNA conformational propensities determine cellular activity. Nature, 617(7962), 835–841. https://doi.org/10.1038/s41586-023-06080-x
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Kesner, J. S., Chen, Z., Shi, P., Aparicio, A. O., Murphy, M. R., Guo, Y., Trehan, A., Lipponen, J. E., Recinos, Y., Myeku, N., & Wu, X. (2023). Noncoding translation mitigation. Nature, 617(7960), 395–402. https://doi.org/10.1038/s41586-023-05946-4
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Zhang, D., Deng, Y., Kukanja, P., Agirre, E., Bartosovic, M., Dong, M., Ma, C., Ma, S., Su, G., Bao, S., Liu, Y., Xiao, Y., Rosoklija, G. B., Dwork, A. J., Mann, J. J., Leong, K. W., Boldrini, M., Wang, L., Haeussler, M., … Fan, R. (2023). Spatial epigenome–transcriptome co-profiling of mammalian tissues. Nature, 616(7955), 113–122. https://doi.org/10.1038/s41586-023-05795-1
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Johnson, J. L., Yaron, T. M., Huntsman, E. M., Kerelsky, A., Song, J., Regev, A., Lin, T.-Y., Liberatore, K., Cizin, D. M., Cohen, B. M., Vasan, N., Ma, Y., Krismer, K., Robles, J. T., van de Kooij, B., van Vlimmeren, A. E., Andrée-Busch, N., Käufer, N. F., Dorovkov, M. V., … Cantley, L. C. (2023). An atlas of substrate specificities for the human serine/threonine kinome. Nature, 613(7945), 759–766. https://doi.org/10.1038/s41586-022-05575-3
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Iketani, S., Mohri, H., Culbertson, B., Hong, S. J., Duan, Y., Luck, M. I., Annavajhala, M. K., Guo, Y., Sheng, Z., Uhlemann, A.-C., Goff, S. P., Sabo, Y., Yang, H., Chavez, A., & Ho, D. D. (2022). Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Nature, 613(7944), 558–564. https://doi.org/10.1038/s41586-022-05514-2
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Erwin, G. S., Gürsoy, G., Al-Abri, R., Suriyaprakash, A., Dolzhenko, E., Zhu, K., Hoerner, C. R., White, S. M., Ramirez, L., Vadlakonda, A., Vadlakonda, A., von Kraut, K., Park, J., Brannon, C. M., Sumano, D. A., Kirtikar, R. A., Erwin, A. A., Metzner, T. J., Yuen, R. K. C., … Snyder, M. P. (2022). Recurrent repeat expansions in human cancer genomes. Nature, 613(7942), 96–102. https://doi.org/10.1038/s41586-022-05515-1
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Saunders, G. R. B., Wang, X., Chen, F., Jang, S.-K., Liu, M., Wang, C., Gao, S., Jiang, Y., Khunsriraksakul, C., Otto, J. M., Addison, C., Akiyama, M., Albert, C. M., Aliev, F., Alonso, A., Arnett, D. K., Ashley-Koch, A. E., Ashrani, A. A., Barnes, K. C., … Vrieze, S. (2022). Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature, 612(7941), 720–724. https://doi.org/10.1038/s41586-022-05477-4
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Eappen, A. G., Li, T., Marquette, M., Chakravarty, S., KC, N., Zanghi, G., Hoffman, B. U., Hettiarachchi, H., Patil, A., Abebe, Y., Tran, C., Yossef, A. A., McWilliams, I., Morrison, R. D., Rathakrishnan, A., Inbar, E., Aly, A. S. I., De La Vega, P., Belmonte, M., … Hoffman, S. L. (2022). In vitro production of infectious Plasmodium falciparum sporozoites. Nature, 612(7940), 534–539. https://doi.org/10.1038/s41586-022-05466-7
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Ravera, S., Nicola, J. P., Salazar-De Simone, G., Sigworth, F. J., Karakas, E., Amzel, L. M., Bianchet, M. A., & Carrasco, N. (2022). Structural insights into the mechanism of the sodium/iodide symporter. Nature, 612(7941), 795–801. https://doi.org/10.1038/s41586-022-05530-2
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Galeano Niño, J. L., Wu, H., LaCourse, K. D., Kempchinsky, A. G., Baryiames, A., Barber, B., Futran, N., Houlton, J., Sather, C., Sicinska, E., Taylor, A., Minot, S. S., Johnston, C. D., & Bullman, S. (2022). Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature, 611(7937), 810–817. https://doi.org/10.1038/s41586-022-05435-0
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Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y.-C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., … Debette, S. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature, 611(7934), 115–123. https://doi.org/10.1038/s41586-022-05165-3
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Xu, J., Song, F., Lyu, H., Kobayashi, M., Zhang, B., Zhao, Z., Hou, Y., Wang, X., Luan, Y., Jia, B., Stasiak, L., Wong, J. H., Wang, Q., Jin, Q., Jin, Q., Fu, Y., Yang, H., Hardison, R. C., Dovat, S., … Yue, F. (2022). Subtype-specific 3D genome alteration in acute myeloid leukaemia. Nature, 611(7935), 387–398. https://doi.org/10.1038/s41586-022-05365-x
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Li, M., Tan, H.-E., Lu, Z., Tsang, K. S., Chung, A. J., & Zuker, C. S. (2022). Gut–brain circuits for fat preference. Nature, 610(7933), 722–730. https://doi.org/10.1038/s41586-022-05266-z
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Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., Sun, Q., Savage, T. M., Wilson-Kanamori, J. R., Caviglia, J. M., Chin, L., Chen, D., Wang, X., Caruso, S., Kang, J. K., … Schwabe, R. F. (2022). Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature, 610(7931), 356–365. https://doi.org/10.1038/s41586-022-05289-6
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Karras, P., Bordeu, I., Pozniak, J., Nowosad, A., Pazzi, C., Van Raemdonck, N., Landeloos, E., Van Herck, Y., Pedri, D., Bervoets, G., Makhzami, S., Khoo, J. H., Pavie, B., Lamote, J., Marin-Bejar, O., Dewaele, M., Liang, H., Zhang, X., Hua, Y., … Marine, J.-C. (2022). A cellular hierarchy in melanoma uncouples growth and metastasis. Nature, 610(7930), 190–198. https://doi.org/10.1038/s41586-022-05242-7
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Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S.-H., Ferreira, T., Highland, H. H., … Hirschhorn, J. N. (2022). A saturated map of common genetic variants associated with human height. Nature, 610(7933), 704–712. https://doi.org/10.1038/s41586-022-05275-y
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Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., Li, Y., Dozier, S., Nair, A., Filliol, A., Sinchai, N., Rosenthal, S. B., Santini, J., Metallo, C. M., Molina, A., … Karin, M. (2022). Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature, 610(7931), 366–372. https://doi.org/10.1038/s41586-022-05169-z
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Greene, A. S., Shen, X., Noble, S., Horien, C., Hahn, C. A., Arora, J., Tokoglu, F., Spann, M. N., Carrión, C. I., Barron, D. S., Sanacora, G., Srihari, V. H., Woods, S. W., Scheinost, D., & Constable, R. T. (2022). Brain–phenotype models fail for individuals who defy sample stereotypes. Nature, 609(7925), 109–118. https://doi.org/10.1038/s41586-022-05118-w
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Deng, Y., Bartosovic, M., Ma, S., Zhang, D., Kukanja, P., Xiao, Y., Su, G., Liu, Y., Qin, X., Rosoklija, G. B., Dwork, A. J., Mann, J. J., Xu, M. L., Halene, S., Craft, J. E., Leong, K. W., Boldrini, M., Castelo-Branco, G., & Fan, R. (2022). Spatial profiling of chromatin accessibility in mouse and human tissues. Nature, 609(7926), 375–383. https://doi.org/10.1038/s41586-022-05094-1
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Wang, Q., Guo, Y., Iketani, S., Nair, M. S., Li, Z., Mohri, H., Wang, M., Yu, J., Bowen, A. D., Chang, J. Y., Shah, J. G., Nguyen, N., Chen, Z., Meyers, K., Yin, M. T., Sobieszczyk, M. E., Sheng, Z., Huang, Y., Liu, L., & Ho, D. D. (2022). Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5. Nature, 608(7923), 603–608. https://doi.org/10.1038/s41586-022-05053-w
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Glinos, D. A., Garborcauskas, G., Hoffman, P., Ehsan, N., Jiang, L., Gokden, A., Dai, X., Aguet, F., Brown, K. L., Garimella, K., Bowers, T., Costello, M., Ardlie, K., Jian, R., Tucker, N. R., Ellinor, P. T., Harrington, E. D., Tang, H., Snyder, M., … Cummings, B. B. (2022). Transcriptome variation in human tissues revealed by long-read sequencing. Nature, 608(7922), 353–359. https://doi.org/10.1038/s41586-022-05035-y
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Bal, E., Kumar, R., Hadigol, M., Holmes, A. B., Hilton, L. K., Loh, J. W., Dreval, K., Wong, J. C. H., Vlasevska, S., Corinaldesi, C., Soni, R. K., Basso, K., Morin, R. D., Khiabanian, H., Pasqualucci, L., & Dalla-Favera, R. (2022). Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature, 607(7920), 808–815. https://doi.org/10.1038/s41586-022-04906-8
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Khan, K., Karim, F., Cele, S., Reedoy, K., San, J. E., Lustig, G., Tegally, H., Rosenberg, Y., Bernstein, M., Jule, Z., Ganga, Y., Ngcobo, N., Mazibuko, M., Mthabela, N., Mhlane, Z., Mbatha, N., Miya, Y., Giandhari, J., Ramphal, Y., … Sigal, A. (2022). Omicron infection enhances Delta antibody immunity in vaccinated persons. Nature, 607(7918), 356–359. https://doi.org/10.1038/s41586-022-04830-x
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Campisi, L., Chizari, S., Ho, J. S. Y., Gromova, A., Arnold, F. J., Mosca, L., Mei, X., Fstkchyan, Y., Torre, D., Beharry, C., Garcia-Forn, M., Jiménez-Alcázar, M., Korobeynikov, V. A., Prazich, J., Fayad, Z. A., Seldin, M. M., De Rubeis, S., Bennett, C. L., Ostrow, L. W., … Marazzi, I. (2022). Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature, 606(7916), 945–952. https://doi.org/10.1038/s41586-022-04844-5
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Gaebler, C., Nogueira, L., Stoffel, E., Oliveira, T. Y., Breton, G., Millard, K. G., Turroja, M., Butler, A., Ramos, V., Seaman, M. S., Reeves, J. D., Petroupoulos, C. J., Shimeliovich, I., Gazumyan, A., Jiang, C. S., Jilg, N., Scheid, J. F., Gandhi, R., Walker, B. D., … Nussenzweig, M. C. (2022). Prolonged viral suppression with anti-HIV-1 antibody therapy. Nature, 606(7913), 368–374. https://doi.org/10.1038/s41586-022-04597-1
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Iketani, S., Liu, L., Guo, Y., Liu, L., Chan, J. F.-W., Huang, Y., Wang, M., Luo, Y., Yu, J., Chu, H., Chik, K. K.-H., Yuen, T. T.-T., Yin, M. T., Sobieszczyk, M. E., Huang, Y., Yuen, K.-Y., Wang, H. H., Sheng, Z., & Ho, D. D. (2022). Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature, 604(7906), 553–556. https://doi.org/10.1038/s41586-022-04594-4
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Trubetskoy, V., Pardiñas, A. F., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T. B., Bryois, J., Chen, C.-Y., Dennison, C. A., Hall, L. S., Lam, M., Watanabe, K., Frei, O., Ge, T., Harwood, J. C., Koopmans, F., Magnusson, S., Richards, A. L., Sidorenko, J., … van Os, J. (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604(7906), 502–508. https://doi.org/10.1038/s41586-022-04434-5
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Ashraf, K. U., Nygaard, R., Vickery, O. N., Erramilli, S. K., Herrera, C. M., McConville, T. H., Petrou, V. I., Giacometti, S. I., Dufrisne, M. B., Nosol, K., Zinkle, A. P., Graham, C. L. B., Loukeris, M., Kloss, B., Skorupinska-Tudek, K., Swiezewska, E., Roper, D. I., Clarke, O. B., Uhlemann, A.-C., … Mancia, F. (2022). Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604(7905), 371–376. https://doi.org/10.1038/s41586-022-04555-x
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DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L.-M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J., … Suthar, M. S. (2022). Defining the risk of SARS-CoV-2 variants on immune protection. Nature, 605(7911), 640–652. https://doi.org/10.1038/s41586-022-04690-5
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Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Bampton, A., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Gatt, A., Hallegger, M., Fagegaltier, D., Phatnani, H., Phatnani, H., Kwan, J., Sareen, D., … Fratta, P. (2022). TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature, 603(7899), 131–137. https://doi.org/10.1038/s41586-022-04436-3
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Cele, S., Jackson, L., Khoury, D. S., Khan, K., Moyo-Gwete, T., Tegally, H., San, J. E., Cromer, D., Scheepers, C., Amoako, D. G., Karim, F., Bernstein, M., Lustig, G., Archary, D., Smith, M., Ganga, Y., Jule, Z., Reedoy, K., Hwa, S.-H., … Sigal, A. (2021). Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature, 602(7898), 654–656. https://doi.org/10.1038/s41586-021-04387-1
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Liu, L., Iketani, S., Guo, Y., Chan, J. F.-W., Wang, M., Liu, L., Luo, Y., Chu, H., Huang, Y., Nair, M. S., Yu, J., Chik, K. K.-H., Yuen, T. T.-T., Yoon, C., To, K. K.-W., Chen, H., Yin, M. T., Sobieszczyk, M. E., Huang, Y., … Ho, D. D. (2021). Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature, 602(7898), 676–681. https://doi.org/10.1038/s41586-021-04388-0
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Kschonsak, M., Chua, H. C., Weidling, C., Chakouri, N., Noland, C. L., Schott, K., Chang, T., Tam, C., Patel, N., Arthur, C. P., Leitner, A., Ben-Johny, M., Ciferri, C., Pless, S. A., & Payandeh, J. (2021). Structural architecture of the human NALCN channelosome. Nature, 603(7899), 180–186. https://doi.org/10.1038/s41586-021-04313-5
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Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., … Willer, C. J. (2021). The power of genetic diversity in genome-wide association studies of lipids. Nature, 600(7890), 675–679. https://doi.org/10.1038/s41586-021-04064-3
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