Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y.-C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., … Debette, S. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature, 611(7934), 115–123. https://doi.org/10.1038/s41586-022-05165-3
Authors:
Aniket Mishra
Rainer Malik
Tsuyoshi Hachiya
Tuuli Jürgenson
Shinichi Namba
Daniel C Posner
Frederick K Kamanu
Masaru Koido
Quentin Le Grand
Mingyang Shi
Yunye He
Marios K Georgakis
Ilana Caro
Kristi Krebs
Yi-Ching Liaw
Felix C Vaura
Kuang Lin
Bendik Slagsvold Winsvold
Vinodh Srinivasasainagendra
Livia Parodi
Hee-Joon Bae
Ganesh Chauhan
Michael R Chong
Liisa Tomppo
Rufus Akinyemi
Gennady V Roshchupkin
Naomi Habib
Yon Ho Jee
Jesper Qvist Thomassen
Vida Abedi
Jara Cárcel-Márquez
Marianne Nygaard
Hampton L Leonard
Chaojie Yang
Ekaterina Yonova-Doing
Maria J Knol
Adam J Lewis
Renae L Judy
Tetsuro Ago
Philippe Amouyel
Nicole D Armstrong
Mark K Bakker
Traci M Bartz
David A Bennett
Joshua C Bis
Constance Bordes
Sigrid Børte
Anael Cain
Paul M Ridker
Kelly Cho
Zhengming Chen
Carlos Cruchaga
John W Cole
Phil L de Jager
Rafael de Cid
Matthias Endres
Leslie E Ferreira
Mirjam I Geerlings
Natalie C Gasca
Vilmundur Gudnason
Jun Hata
Jing He
Alicia K Heath
Yuk-Lam Ho
Aki S Havulinna
Jemma C Hopewell
Hyacinth I Hyacinth
Michael Inouye
Mina A Jacob
Christina E Jeon
Christina Jern
Masahiro Kamouchi
Keith L Keene
Takanari Kitazono
Steven J Kittner
Takahiro Konuma
Amit Kumar
Paul Lacaze
Lenore J Launer
Keon-Joo Lee
Kaido Lepik
Jiang Li
Liming Li
Ani Manichaikul
Hugh S Markus
Nicholas A Marston
Thomas Meitinger
Braxton D Mitchell
Felipe A Montellano
Takayuki Morisaki
Thomas H Mosley
Mike A Nalls
Børge G Nordestgaard
Martin J O'Donnell
Yukinori Okada
N Charlotte Onland-Moret
Bruce Ovbiagele
Annette Peters
Bruce M Psaty
Stephen S Rich
Jonathan Rosand
Marc S Sabatine
Ralph L Sacco
Danish Saleheen
Else Charlotte Sandset
Veikko Salomaa
Muralidharan Sargurupremraj
Makoto Sasaki
Claudia L Satizabal
Carsten O Schmidt
Atsushi Shimizu
Nicholas L Smith
Kelly L Sloane
Yoichi Sutoh
Yan V Sun
Kozo Tanno
Steffen Tiedt
Turgut Tatlisumak
Nuria P Torres-Aguila
Hemant K Tiwari
David-Alexandre Trégouët
Stella Trompet
Anil Man Tuladhar
Anne Tybjærg-Hansen
Marion van Vugt
Riina Vibo
Shefali S Verma
Kerri L Wiggins
Patrik Wennberg
Daniel Woo
Peter W F Wilson
Huichun Xu
Qiong Yang
Kyungheon Yoon
Iona Y Millwood
Christian Gieger
Toshiharu Ninomiya
Hans J Grabe
J Wouter Jukema
Ina L Rissanen
Daniel Strbian
Young Jin Kim
Pei-Hsin Chen
Ernst Mayerhofer
Joanna M M Howson
Marguerite R Irvin
Hieab Adams
Sylvia Wassertheil-Smoller
Kaare Christensen
Mohammad A Ikram
Tatjana Rundek
Bradford B Worrall
G Mark Lathrop
Moeen Riaz
Eleanor M Simonsick
Janika Kõrv
Paulo H C França
Ramin Zand
Kameshwar Prasad
Ruth Frikke-Schmidt
Frank-Erik de Leeuw
Thomas Liman
Karl Georg Haeusler
Ynte M Ruigrok
Peter Ulrich Heuschmann
W T Longstreth
Keum Ji Jung
Lisa Bastarache
Guillaume Paré
Scott M Damrauer
Daniel I Chasman
Jerome I Rotter
Christopher D Anderson
John-Anker Zwart
Teemu J Niiranen
Myriam Fornage
Yung-Po Liaw
Sudha Seshadri
Israel Fernández-Cadenas
Robin G Walters
Christian T Ruff
Mayowa O Owolabi
Jennifer E Huffman
Lili Milani
Yoichiro Kamatani
Martin Dichgans
Stephanie Debette
Affiliated Authors:
Phil L de Jager
Danish Saleheen
Columbia Affiliation:
Subjects:
Drug Discovery (MeSH)
Genetic Predisposition to Disease (MeSH)
Ischemic Stroke (MeSH)
elink
Publication Type:
Article
Unique ID:
10.1038/s41586-022-05165-3
PMID:
36180795
DOI:
10.1038/s41586-022-05165-3
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created: