U01CA224145

NIH – National Cancer Institute

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Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer

Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado Soto, N. M., Nwosu, Z. C., Johnson, C., Zhang, Y., Salas-Escabillas, D. J., Menjivar, R. E., Maurer, H. C., Crawford, H. C., Bednar, F., Olive, K. P., Pasca di Magliano, M., & Allen, B. L. (2022). Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. PLOS Genetics, 18(7), e1010315. https://doi.org/10.1371/journal.pgen.1010315
Authors:
Michael K. Scales
Ashley Velez-Delgado
Nina G. Steele
Hannah E. Schrader
Anna M. Stabnick
Wei Yan
Nayanna M. Mercado Soto
Zeribe C. Nwosu
Craig Johnson
Shouxin Zhang
Daniel J. Sålas-Escabillas
Rosa E. Menjivar
H. Carlo Maurer
Howard C. Crawford
Filip Bednar
Kenneth P. Olive
Marina Pasca di Magliano
Benjamin L. Allen
Affiliated Authors:
H. Carlo Maurer
Kenneth P. Olive
Columbia Affiliation:
Subjects:
Hedgehog Proteins (MeSH)
Pancreatic Neoplasms (MeSH)
Hedgehog Signaling in Development and Cancer (OpenAlex Topic)
Pancreatic Cancer Research and Treatment (OpenAlex Topic)
Granular Cell Tumor: Clinical and Pathological Characteristics (OpenAlex Topic)
Grants:
T32HD007505 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
F31CA247037 (NIH – National Cancer Institute)
R01CA198074 (NIH – National Cancer Institute)
R50CA232985 (NIH – National Cancer Institute)
K99CA263154 (NIH – National Cancer Institute)
R01CA151588 (NIH – National Cancer Institute)
T32CA009676 (NIH – National Cancer Institute)
F31CA257533 (NIH – National Cancer Institute)
U01CA224145 (NIH – National Cancer Institute)
F31CA232655 (NIH – National Cancer Institute)
R01CA264843 (NIH – National Cancer Institute)
R01GM118751 (NIH – National Institute of General Medical Sciences)
T32GM007315 (NIH – National Institute of General Medical Sciences)
T32GM008353 (NIH – National Institute of General Medical Sciences)
R25GM086262 (NIH – National Institute of General Medical Sciences)
R01DC014428 (NIH – National Institute On Deafness and Other Communication Disorders)
Publication Type:
Article
Unique ID:
10.1371/journal.pgen.1010315
PMID:
35867772
DOI:
10.1371/journal.pgen.1010315
Journal:
PLOS Genetics
Publication Date:
Data Source:
OpenAlex
Source Link:
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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Kremer, D. M., Nelson, B. S., Lin, L., Yarosz, E. L., Halbrook, C. J., Kerk, S. A., Sajjakulnukit, P., Myers, A., Thurston, G., Hou, S. W., Carpenter, E. S., Andren, A. C., Nwosu, Z. C., Cusmano, N., Wisner, S., Mbah, N. E., Shan, M., Das, N. K., Magnuson, B., … Lyssiotis, C. A. (2021). GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24859-2
Authors:
Daniel M. Kremer
Barbara S. Nelson
Lin Lin
Emily L. Yarosz
Christopher J. Halbrook
Samuel A. Kerk
Peter Sajjakulnukit
Amy Myers
Galloway Thurston
Sean W. Hou
Eileen S. Carpenter
Anthony C. Andren
Zeribe C. Nwosu
Nicholas Cusmano
Stephanie Wisner
Nneka E. Mbah
Mengrou Shan
Nupur K. Das
Brian Magnuson
Andrew C. Little
Milan R. Savani
Johanna Ramos
Tina Gao
Stephen A. Sastra
Carmine F. Palermo
Michael A. Badgley
Li Zhang
John M. Asara
Samuel K. McBrayer
Marina Pasca di Magliano
Howard C. Crawford
Yatrik M. Shah
Kenneth P. Olive
Costas A. Lyssiotis
Affiliated Authors:
Stephen A. Sastra
Carmine F. Palermo
Michael A. Badgley
Kenneth P. Olive
Columbia Affiliation:
Subjects:
Mechanisms and Implications of Ferroptosis in Cancer (OpenAlex Topic)
Epigenetic Modifications and Their Functional Implications (OpenAlex Topic)
Pancreatic Cancer Research and Treatment (OpenAlex Topic)
Aspartate Aminotransferase, Cytoplasmic (MeSH)
Ferroptosis (MeSH)
Pancreatic Neoplasms (MeSH)
Grants:
R37CA237421 (NIH – National Cancer Institute)
K22CA237752 (NIH – National Cancer Institute)
P30CA046592 (NIH – National Cancer Institute)
R01CA248160 (NIH – National Cancer Institute)
T32CA009676 (NIH – National Cancer Institute)
R01CA151588 (NIH – National Cancer Institute)
R01CA244931 (NIH – National Cancer Institute)
R01CA215607 (NIH – National Cancer Institute)
R01CA245546 (NIH – National Cancer Institute)
U01CA224145 (NIH – National Cancer Institute)
R01CA148828 (NIH – National Cancer Institute)
R01CA198074 (NIH – National Cancer Institute)
R01DK095201 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
T32DK094775 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41467-021-24859-2
PMID:
34381026
DOI:
10.1038/s41467-021-24859-2
Journal:
Nature Communications
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created:

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