Hedgehog Signaling in Development and Cancer

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Ager, C. R., Jugler, C., Zhu, Y., Chen, D., Athar, M., Izar, B., Bickers, D., & Kim, A. (2024). 791 Immunological correlates of response to vismodegib and PD-1 blockade in an autochthonous model of basal cell nevus (Gorlin-Goltz) syndrome. Regular and Young Investigator Award Abstracts, A896–A896. https://doi.org/10.1136/jitc-2024-sitc2024.0791
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Kim, A., Zhu, Y., Chen, D., Elmais, M., Athar, M., & Bickers, D. R. (2023). LB1763 Combinatorial BRD9 and SMO targeting synergistically suppress UV-induced BCC tumor burden in a murine model of Gorlin syndrome (GS). Journal of Investigative Dermatology, 143(9), B28. https://doi.org/10.1016/j.jid.2023.06.143
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Hussain, S., Nawaz, S., Khan, H., Acharya, A., Schrauwen, I., Ahmad, W., & Leal, S. M. (2022). A splice site variant in TCTN3 underlies an atypical form of orofaciodigital syndrome IV. Annals of Human Genetics, 86(6), 291–296. Portico. https://doi.org/10.1111/ahg.12462
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Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado Soto, N. M., Nwosu, Z. C., Johnson, C., Zhang, Y., Salas-Escabillas, D. J., Menjivar, R. E., Maurer, H. C., Crawford, H. C., Bednar, F., Olive, K. P., Pasca di Magliano, M., & Allen, B. L. (2022). Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. PLOS Genetics, 18(7), e1010315. https://doi.org/10.1371/journal.pgen.1010315
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Gounder, M. M., Rosenbaum, E., Wu, N., Dickson, M. A., Sheikh, T. N., D’Angelo, S. P., Chi, P., Keohan, M. L., Erinjeri, J. P., Antonescu, C. R., Agaram, N., Hameed, M. R., Martindale, M., Lefkowitz, R. A., Crago, A. M., Singer, S., Tap, W. D., Takebe, N., Qin, L.-X., & Schwartz, G. K. (2022). A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma. Clinical Cancer Research, 28(8), 1586–1594. https://doi.org/10.1158/1078-0432.ccr-21-3874
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