R01DK048280

NIH – National Institute of Diabetes and Digestive and Kidney Diseases

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Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity

Zhang, Y., Sui, L., Du, Q., Haataja, L., Yin, Y., Viola, R., Xu, S., Nielsson, C. U., Leibel, R. L., Barbetti, F., Arvan, P., & Egli, D. (2024). Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity. Molecular Metabolism, 80, 101879. https://doi.org/10.1016/j.molmet.2024.101879
Authors:
Yuwei Zhang
Lina Sui
Qian Du
Leena Haataja
Yishu Yin
Ryan Viola
Shuangyi Xu
Christian Ulrik Nielsson
Rudolph L Leibel
Fabrizio Barbetti
Peter Arvan
Dieter Egli
Affiliated Authors:
Yuwei Zhang
Lina Sui
Qian Du
Yishu Yin
Ryan Viola
Shuangyi Xu
Christian Ulrik Nielsson
Rudolph L Leibel
Dieter Egli
Columbia Affiliation:
Subjects:
Insulin (MeSH)
Diabetes Mellitus (MeSH)
Author Keywords:
insulin
er stress
ips cells
gene correction
cell therapy
beta cell de-differentiation
permanent neonatal diabetes
Grants:
P30CA013696 (NIH – National Cancer Institute)
P30DK026687 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK048280 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK063608 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK020572 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.molmet.2024.101879
PMID:
38237895
DOI:
10.1016/j.molmet.2024.101879
Journal:
Molecular Metabolism
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size

Sui, L., Xin, Y., Du, Q., Georgieva, D., Diedenhofen, G., Haataja, L., Su, Q., Zuccaro, M. V., Kim, J., Fu, J., Xing, Y., He, Y., Baum, D., Goland, R. S., Wang, Y., Oberholzer, J., Barbetti, F., Arvan, P., Kleiner, S., & Egli, D. (2021). Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size. JCI Insight, 6(5). https://doi.org/10.1172/jci.insight.141553
Authors:
Lina Sui
Qian Du
Daniela Georgieva
Giacomo Diedenhofen
Jiayu Fu
Danielle Baum
Robin S. Goland
Dieter Egli
Yurong Xin
Qi Su
Jinrang Kim
Sandra Kleiner
Leena Haataja
Michael Zuccaro
Yuan Xing
Yi He
Yong Wang
Jose Oberholzer
Fabrizio Barbetti
Peter Arvan
Affiliated Authors:
Lina Sui
Qian Du
Daniela Georgieva
Giacomo Diedenhofen
Jiayu Fu
Danielle Baum
Robin S. Goland
Dieter Egli
Michael Zuccaro
Columbia Affiliation:
Subjects:
Cell Cycle (MeSH)
Cell Differentiation (MeSH)
DNA Replication (MeSH)
Diabetes Mellitus (MeSH)
Induced Pluripotent Stem Cells (MeSH)
Insulin-Secreting Cells (MeSH)
Stem Cell Transplantation (MeSH)
Author Keywords:
beta cells
cell biology
cell cycle
stem cell transplantation
stem cells
Grants:
TL1TR001875 (NIH – National Center for Advancing Translational Sciences)
S10RR027050 (NIH – National Center for Research Resources)
R01DK111174 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK063608 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK103585 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK048280 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
UC4DK104207 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK020572 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
S10OD020056 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1172/jci.insight.141553
PMID:
33529174
DOI:
10.1172/jci.insight.141553
Journal:
JCI Insight
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record
View Scopus Record
View PubMed Record

Record Created:

CSV