Insulin-Secreting Cells

Displaying 1 - 16 of 16CSV
Matsui, M., Lynch, L. E., Distefano, I., Galante, A., Gade, A. R., Wang, H.-G., Gómez-Banoy, N., Towers, P., Sinden, D. S., Wei, E. Q., Barnett, A. S., Johnson, K., Lima, R., Rubio-Navarro, A., Li, A. K., Marx, S. O., McGraw, T. E., Thornton, P. S., Timothy, K. W., … Pitt, G. S. (2024). Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52885-3
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Accili, D., Talchai, S. C., Bouchi, R., Lee, A. Y., Du, W., Kitamoto, T., McKimpson, W. M., Belvedere, S., & Lin, H. V. (2024). Diabetes treatment by conversion of gut epithelial cells to insulin‐producing cells. Journal of Diabetes Investigation, 15(7), 797–804. Portico. https://doi.org/10.1111/jdi.14175
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Watanabe, H., Asahara, S., Son, J., McKimpson, W. M., de Cabo, R., & Accili, D. (2024). Cyb5r3 activation rescues secondary failure to sulfonylurea but not β-cell dedifferentiation. PLOS ONE, 19(2), e0297555. https://doi.org/10.1371/journal.pone.0297555
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Cherkaoui, I., Du, Q., Egli, D., Misra, S., & Rutter, G. A. (2024). Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells. Journal of Visualized Experiments, 204. https://doi.org/10.3791/65530
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Son, J., Du, W., Esposito, M., Shariati, K., Ding, H., Kang, Y., & Accili, D. (2023). Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36315-4
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Son, J., & Accili, D. (2023). Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes. Experimental & Molecular Medicine, 55(8), 1652–1658. https://doi.org/10.1038/s12276-023-01043-8
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Watanabe, H., Du, W., Son, J., Sui, L., Asahara, S., Kurland, I. J., Kuo, T., Kitamoto, T., Miyachi, Y., de Cabo, R., & Accili, D. (2023). Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes. Science Translational Medicine, 15(681). https://doi.org/10.1126/scitranslmed.abq4126
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Du, W., Wang, J., Kuo, T., Wang, L., McKimpson, W. M., Son, J., Watanabe, H., Kitamoto, T., Lee, Y., Creusot, R. J., Ratner, L. E., McCune, K., Chen, Y.-W., Grubbs, B. H., Thornton, M. E., Fan, J., Sultana, N., Diaz, B. S., Balasubramanian, I., … Accili, D. (2022). Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. Journal of Clinical Investigation, 132(24). https://doi.org/10.1172/jci162720
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Kitamoto, T., Lee, Y.-K., Sultana, N., Watanabe, H., McKimpson, W. M., Du, W., Fan, J., Diaz, B., Lin, H. V., Leibel, R. L., Belvedere, S., & Accili, D. (2022). Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes. Molecular Metabolism, 66, 101624. https://doi.org/10.1016/j.molmet.2022.101624
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Chu, C. M. J., Modi, H., Ellis, C., Krentz, N. A. J., Skovsø, S., Zhao, Y. B., Cen, H., Noursadeghi, N., Panzhinskiy, E., Hu, X., Dionne, D. A., Xia, Y. H., Xuan, S., Huising, M. O., Kieffer, T. J., Lynn, F. C., & Johnson, J. D. (2022). Dynamic Ins2 Gene Activity Defines β-Cell Maturity States. Diabetes, 71(12), 2612–2631. https://doi.org/10.2337/db21-1065
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McKimpson, W. M., & Kitsis, R. N. (2022). Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets. STAR Protocols, 3(2), 101287. https://doi.org/10.1016/j.xpro.2022.101287
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Son, J., Ding, H., Farb, T. B., Efanov, A. M., Sun, J., Gore, J. L., Syed, S. K., Lei, Z., Wang, Q., Accili, D., & Califano, A. (2021). BACH2 inhibition reverses β cell failure in type 2 diabetes models. Journal of Clinical Investigation, 131(24). https://doi.org/10.1172/jci153876
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Khosravi-Maharlooei, M., Madley, R., Borsotti, C., Ferreira, L. M. R., Sharp, R. C., Brehm, M. A., Greiner, D. L., Parent, A. V., Anderson, M. S., Sykes, M., & Creusot, R. J. (2022). Modeling human T1D-associated autoimmune processes. Molecular Metabolism, 56, 101417. https://doi.org/10.1016/j.molmet.2021.101417
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