Parkinson Disease
Mehanna, R., Marras, C., Fleisher, J., Post, B., Kumar, K. R., Noyce, A., Alcalay, R., Morris, H. R., Hatano, T., Salari, M., Smilowska, K., Wu, Y. R., Zhang, B., Tan, E.-K., & Savica, R. (2025). Diagnostic work up when suspecting early onset Parkinson disease (EOPD). Recommendations from the MDS EOPD study group. Parkinsonism & Related Disorders, 135, 107852. https://doi.org/10.1016/j.parkreldis.2025.107852
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Rose, J., Burmon, C. W., & Rozehnal, J. (2025). Emergency department management of patients with complications of chronic neurologic disease: Parkinson disease, myasthenia gravis, and multiple sclerosis. Emergency medicine practice, 27(5), 1–24.
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Maayan Eshed, G., & Alcalay, R. N. (2025). Precision Medicine in Parkinson’s Disease. Neurologic Clinics, 43(2), 365–381. https://doi.org/10.1016/j.ncl.2024.12.011
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Goldstein, O., Shani, S., Gana-Weisz, M., Elkoshi, N., Casey, F., Sun, Y. H., Chandratre, K., Cedarbaum, J. M., Blauwendraat, C., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Orr-Urtreger, A., & Alcalay, R. N. (2025). The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers. Journal of Parkinson’s Disease. https://doi.org/10.1177/1877718x241310722
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Williams, G. P., Freuchet, A., Michaelis, T., Frazier, A., Tran, N. K., Rodrigues Lima-Junior, J., Phillips, E. J., Mallal, S. A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sidney, J., Sulzer, D., Sette, A., & Lindestam Arlehamn, C. S. (2024). PINK1 is a target of T cell responses in Parkinson’s disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci180478
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Shani, S., Gana-Weisz, M., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Alcalay, R. N., Orr-Urtreger, A., & Goldstein, O. (2024). P2RX7, an adaptive immune response gene, is associated with Parkinson’s disease risk and age at onset. Journal of Parkinson’s Disease. https://doi.org/10.1177/1877718x241296015
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Jones-Tabah, J., He, K., Karpilovsky, N., Senkevich, K., Deyab, G., Pietrantonio, I., Goiran, T., Cousineau, Y., Nikanorova, D., Goldsmith, T., del Cid Pellitero, E., Chen, C. X.-Q., Luo, W., You, Z., Abdian, N., Ahmad, J., Ruskey, J. A., Asayesh, F., Spiegelman, D., … Fon, E. A. (2024). The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. Molecular Neurodegeneration, 19(1). https://doi.org/10.1186/s13024-024-00779-9
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Curtis, J. A., Borders, J. C., Kiefer, B., Alcalay, R. N., Huber, J. E., & Troche, M. S. (2024). Respiratory–Swallow Coordination and Its Relationship With Pharyngeal Residue, Penetration, and Aspiration in People With Parkinson’s Disease. Journal of Speech, Language, and Hearing Research, 67(11), 4314–4338. https://doi.org/10.1044/2024_jslhr-24-00056
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Gallagher, J., Gochanour, C., Caspell-Garcia, C., Dobkin, R. D., Aarsland, D., Alcalay, R. N., Barrett, M. J., Chahine, L., Chen-Plotkin, A. S., Coffey, C. S., Dahodwala, N., Eberling, J. L., Espay, A. J., Leverenz, J. B., Litvan, I., Mamikonyan, E., Morley, J., Richard, I. H., Rosenthal, L., … Razzaque, J. (2024). Long-Term Dementia Risk in Parkinson Disease. Neurology, 103(5). https://doi.org/10.1212/wnl.0000000000209699
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Parrish, R. L., Buchman, A. S., Tasaki, S., Wang, Y., Avey, D., Xu, J., De Jager, P. L., Bennett, D. A., Epstein, M. P., & Yang, J. (2024). SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-50983-w
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Cook, L., Verbrugge, J., Schwantes-An, T.-H., Schulze, J., Foroud, T., Hall, A., Marder, K. S., Mata, I. F., Mencacci, N. E., Nance, M. A., Schwarzschild, M. A., Simuni, T., Bressman, S., Wills, A.-M., Fernandez, H. H., Litvan, I., Lyons, K. E., Shill, H. A., Singer, C., … Alcalay, R. N. (2024). Parkinson’s disease variant detection and disclosure: PD GENEration, a North American study. Brain, 147(8), 2668–2679. https://doi.org/10.1093/brain/awae142
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Barbuti, P. A. (2024). A-Syn(ful) MAM: A Fresh Perspective on a Converging Domain in Parkinson’s Disease. International Journal of Molecular Sciences, 25(12), 6525. https://doi.org/10.3390/ijms25126525
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Zhao, Y., Lai, Y., Konijnenberg, H., Huerta, J. M., Vinagre-Aragon, A., Sabin, J. A., Hansen, J., Petrova, D., Sacerdote, C., Zamora-Ros, R., Pala, V., Heath, A. K., Panico, S., Guevara, M., Masala, G., Lill, C. M., Miller, G. W., Peters, S., & Vermeulen, R. (2024). Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort. Neurology, 102(8). https://doi.org/10.1212/wnl.0000000000209201
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Tuncer, T., Dogan, S., Baygin, M., Barua, P. D., Palmer, E. E., March, S., Ciaccio, E. J., Tan, R.-S., & Acharya, U. R. (2024). FLP: Factor lattice pattern-based automated detection of Parkinson’s disease and specific language impairment using recorded speech. Computers in Biology and Medicine, 173, 108280. https://doi.org/10.1016/j.compbiomed.2024.108280
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Alessi, D. R., Cullen, P. J., Cookson, M., Merchant, K. M., & Small, S. A. (2024). Retromer-dependent lysosomal stress in Parkinson’s disease. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899). https://doi.org/10.1098/rstb.2022.0376
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Maayan Eshed, G., & Alcalay, R. N. (2024). GBA1-and LRRK2-directed Treatments: The Way Forward. Parkinsonism & Related Disorders, 122, 106039. https://doi.org/10.1016/j.parkreldis.2024.106039
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Adkins-Jackson, P. B., Taikeff, N., Akingbulu, J., Avila-Rieger, J. F., & Corona-Long, C. A. (2024). Parkinson’s Disease Inequities in Daily Cognitive Activities: An Intersectional Approach. Ethnicity & Disease, 34(2), 113–122. https://doi.org/10.18865/ed.34.2.113
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Shani, S., Gana-Weisz, M., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Alcalay, R. N., Goldstein, O., & Orr-Urtreger, A. (2023). MAPT Locus in Parkinson’s Disease Patients of Ashkenazi Origin: A Stratified Analysis. Genes, 15(1), 46. https://doi.org/10.3390/genes15010046
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Wang, Q., & Wang, Y. (2022). Multilayer Exponential Family Factor models for integrative analysis and learning disease progression. Biostatistics, 25(1), 203–219. https://doi.org/10.1093/biostatistics/kxac042
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Keavney, J. L., Mathur, S., Schroeder, K., Merrell, R., Castillo-Torres, S. A., Gao, V., Crotty, G. F., Schwarzschild, M. A., & Poma, J. M. (2024). Perspectives of People At-Risk on Parkinson’s Prevention Research. Journal of Parkinson’s Disease, 14(3), 399–414. https://doi.org/10.3233/jpd-230436
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Fernandez, H. H., Macklin, E. A., Hauser, R. A., Chou, K. L., Cakmak, Y. O., Ozsoy, B., & Fahn, S. (2024). Intrinsic auricular muscle zone stimulation for Parkinson disease: The EARSTIM-PD Phase II multi-center pilot study results. Parkinsonism & Related Disorders, 121, 105959. https://doi.org/10.1016/j.parkreldis.2023.105959
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Kipnis, D., Pacheco, A., Delfing, D., Toomer-Mensah, N., Macpherson, C. E., Rieger, J., Parker, A., Coley, R. B., Coley, D., Shah, H., & Quinn, L. (2024). Community-based participatory research approach to address healthcare disparities confronting members of the Black Diaspora with Parkinson’s disease. Parkinsonism & Related Disorders, 119, 105936. https://doi.org/10.1016/j.parkreldis.2023.105936
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Wang, Q., Tao, S., Xing, L., Liu, J., Xu, C., Xu, X., Ding, H., Shen, Q., Yu, X., & Zheng, Y. (2023). SNAP25 is a potential target for early stage Alzheimer’s disease and Parkinson’s disease. European Journal of Medical Research, 28(1). https://doi.org/10.1186/s40001-023-01360-8
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Zhao, Y., Walker, D. I., Lill, C. M., Bloem, B. R., Darweesh, S. K. L., Pinto-Pacheco, B., McNeil, B., Miller, G. W., Heath, A. K., Frissen, M., Petrova, D., Sánchez, M.-J., Chirlaque, M.-D., Guevara, M., Zibetti, M., Panico, S., Middleton, L., Katzke, V., Kaaks, R., … Vermeulen, R. (2023). Lipopolysaccharide-binding protein and future Parkinson’s disease risk: a European prospective cohort. Journal of Neuroinflammation, 20(1). https://doi.org/10.1186/s12974-023-02846-2
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Boruah, A. P., Thakur, K. T., Gadani, S. P., Kothari, K. U., Chomba, M., Guekht, A., Heydari, K., Hoo, F. K., Hwang, S., Michael, B. D., Pandit, M. V., Pardo, C. A., Prasad, K., Sardar, Z., Seeher, K., Solomon, T., Winkler, A. S., Wood, G. K., & Schiess, N. (2023). Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews. Journal of the Neurological Sciences, 455, 120858. https://doi.org/10.1016/j.jns.2023.120858
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Sun, J., Ludvigsson, J. F., Roelstraete, B., Pedersen, N. L., Pawitan, Y., Wirdefeldt, K., & Fang, F. (2022). Gastrointestinal biopsy of normal mucosa or nonspecific inflammation and risk of neurodegenerative disease: Nationwide matched cohort study. European Journal of Neurology, 30(11), 3430–3439. Portico. https://doi.org/10.1111/ene.15654
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Garretti, F., Monahan, C., Sloan, N., Bergen, J., Shahriar, S., Kim, S. W., Sette, A., Cutforth, T., Kanter, E., Agalliu, D., & Sulzer, D. (2023). Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease. Neuron, 111(21), 3397-3413.e5. https://doi.org/10.1016/j.neuron.2023.07.015
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Cook, L., Verbrugge, J., Schwantes-An, T.-H., Schulze, J., Beck, J. C., Naito, A., Hall, A., Chan, A. K., Casaceli, C. J., Marder, K., Nance, M., Schwarzschild, M. A., Simuni, T., Wills, A.-M., & Alcalay, R. N. (2023). Providing genetic testing and genetic counseling for Parkinson’s disease to the community. Genetics in Medicine, 25(10), 100907. https://doi.org/10.1016/j.gim.2023.100907
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Senkevich, K., Beletskaia, M., Dworkind, A., Yu, E., Ahmad, J., Ruskey, J. A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin‐Baer, S., Nagornov, I., Tyurin, A., Miliukhina, I., Timofeeva, A., … Gan‐Or, Z. (2023). Association of Rare Variants in ARSA with Parkinson’s Disease. Movement Disorders, 38(10), 1806–1812. Portico. https://doi.org/10.1002/mds.29521
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Krellman, J. W., & Mercuri, G. (2023). Cognitive Interventions for Neurodegenerative Disease. Current Neurology and Neuroscience Reports, 23(9), 461–468. https://doi.org/10.1007/s11910-023-01283-1
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Qi, R., Sammler, E., Gonzalez-Hunt, C. P., Barraza, I., Pena, N., Rouanet, J. P., Naaldijk, Y., Goodson, S., Fuzzati, M., Blandini, F., Erickson, K. I., Weinstein, A. M., Lutz, M. W., Kwok, J. B., Halliday, G. M., Dzamko, N., Padmanabhan, S., Alcalay, R. N., Waters, C., … Sanders, L. H. (2023). A blood-based marker of mitochondrial DNA damage in Parkinson’s disease. Science Translational Medicine, 15(711). https://doi.org/10.1126/scitranslmed.abo1557
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Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Tan, E.-K. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences, 120(36). https://doi.org/10.1073/pnas.2302720120
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Giladi, N., Alcalay, R. N., Cutter, G., Gasser, T., Gurevich, T., Höglinger, G. U., Marek, K., Pacchetti, C., Schapira, A. H. V., Scherzer, C. R., Simuni, T., Minini, P., Sardi, S. P., & Peterschmitt, M. J. (2023). Safety and efficacy of venglustat in GBA1-associated Parkinson’s disease: an international, multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet Neurology, 22(8), 661–671. https://doi.org/10.1016/s1474-4422(23)00205-3
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Saunders‐Pullman, R., Raymond, D., Ortega, R. A., Shalash, A., Gatto, E., Salari, M., Markgraf, M., Alcalay, R. N., Mascalzoni, D., Mencacci, N. E., Bonifati, V., Merello, M., Chung, S. J., Novakovic, I., Bardien, S., Pal, G., Hall, A., Hattori, N., Lynch, T., … Simuni, T. (2023). International Genetic Testing and Counseling Practices for Parkinson’s Disease. Movement Disorders, 38(8), 1527–1535. Portico. https://doi.org/10.1002/mds.29442
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Pal, G., Cook, L., Schulze, J., Verbrugge, J., Alcalay, R. N., Merello, M., Sue, C. M., Bardien, S., Bonifati, V., Chung, S. J., Foroud, T., Gatto, E., Hall, A., Hattori, N., Lynch, T., Marder, K., Mascalzoni, D., Novaković, I., Thaler, A., … Klein, C. (2023). Genetic Testing in Parkinson’s Disease. Movement Disorders, 38(8), 1384–1396. Portico. https://doi.org/10.1002/mds.29500
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Agin‐Liebes, J., Hickman, R. A., Vonsattel, J. P., Faust, P. L., Flowers, X., Utkina Sosunova, I., Ntiri, J., Mayeux, R., Surface, M., Marder, K., Fahn, S., Przedborski, S., & Alcalay, R. N. (2023). Patterns of TDP‐43 Deposition in Brains with LRRK2 G2019S Mutations. Movement Disorders, 38(8), 1541–1545. Portico. https://doi.org/10.1002/mds.29449
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Di Maio, A., Nuzzo, T., Gilio, L., Serra, M., Buttari, F., Errico, F., De Rosa, A., Bassi, M. S., Morelli, M., Sasabe, J., Sulzer, D., Carta, M., Centonze, D., & Usiello, A. (2023). Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson’s disease patients. Neurobiology of Disease, 184, 106203. https://doi.org/10.1016/j.nbd.2023.106203
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Outeiro, T. F., Alcalay, R. N., Antonini, A., Attems, J., Bonifati, V., Cardoso, F., Chesselet, M., Hardy, J., Madeo, G., McKeith, I., Mollenhauer, B., Moore, D. J., Rascol, O., Schlossmacher, M. G., Soreq, H., Stefanis, L., & Ferreira, J. J. (2023). Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson’s Disease.” Movement Disorders, 38(7), 1127–1142. Portico. https://doi.org/10.1002/mds.29419
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Goldstein, O., Gana-Weisz, M., Banfi, S., Nigro, V., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Alcalay, R. N., & Orr-Urtreger, A. (2023). Novel variants in genes related to vesicle-mediated-transport modify Parkinson’s disease risk. Molecular Genetics and Metabolism, 139(2), 107608. https://doi.org/10.1016/j.ymgme.2023.107608
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York, M. K., & Alcalay, R. N. (2023). Enough vs. More: Neuropsychological testing is more useful than genetic testing in the baseline evaluation of Parkinson disease. Parkinsonism & Related Disorders, 111, 105403. https://doi.org/10.1016/j.parkreldis.2023.105403
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Shani, S., Goldstein, O., Gana-Weisz, M., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Alcalay, R. N., & Orr-Urtreger, A. (2023). Variants in PSMB9 and FGR differentially affect Parkinson’s disease risk in GBA and LRRK2 mutation carriers. Parkinsonism & Related Disorders, 111, 105398. https://doi.org/10.1016/j.parkreldis.2023.105398
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Senkevich, K., Zorca, C. E., Dworkind, A., Rudakou, U., Somerville, E., Yu, E., Ermolaev, A., Nikanorova, D., Ahmad, J., Ruskey, J. A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., … Gan-Or, Z. (2022). GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease. Brain, 146(5), 1859–1872. https://doi.org/10.1093/brain/awac413
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Siderowf, A., Concha-Marambio, L., Lafontant, D.-E., Farris, C. M., Ma, Y., Urenia, P. A., Nguyen, H., Alcalay, R. N., Chahine, L. M., Foroud, T., Galasko, D., Kieburtz, K., Merchant, K., Mollenhauer, B., Poston, K. L., Seibyl, J., Simuni, T., Tanner, C. M., Weintraub, D., … Soto, C. (2023). Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study. The Lancet Neurology, 22(5), 407–417. https://doi.org/10.1016/s1474-4422(23)00109-6
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Blauwendraat, C., Tayebi, N., Woo, E. G., Lopez, G., Fierro, L., Toffoli, M., Limbachiya, N., Hughes, D., Pitz, V., Patel, D., Vitale, D., Koretsky, M. J., Hernandez, D., Real, R., Alcalay, R. N., Nalls, M. A., Morris, H. R., Schapira, A. H. V., Balwani, M., & Sidransky, E. (2023). Polygenic Parkinson’s Disease Genetic Risk Score as Risk Modifier of Parkinsonism in Gaucher Disease. Movement Disorders, 38(5), 899–903. Portico. https://doi.org/10.1002/mds.29342
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Wilkins, K. B., Kehnemouyi, Y. M., Petrucci, M. N., Anderson, R. W., Parker, J. E., Trager, M. H., Neuville, R. S., Koop, M. M., Velisar, A., Blumenfeld, Z., Quinn, E. J., & Bronte‐Stewart, H. M. (2023). Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence. Annals of Neurology, 93(5), 1029–1039. Portico. https://doi.org/10.1002/ana.26605
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Vidyadhara, D. J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Shashaank, N., Ribaudo, J., Gupta, J., Lam, T. T., Sames, D., Greene, L. E., Sulzer, D. L., & Chandra, S. S. (2023). Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports, 42(3), 112231. https://doi.org/10.1016/j.celrep.2023.112231
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Hauser, R. A., LeWitt, P. A., Waters, C. H., Grosset, D. G., & Blank, B. (2023). The Clinical Development of Levodopa Inhalation Powder. Clinical Neuropharmacology, 46(2), 66–78. https://doi.org/10.1097/wnf.0000000000000540
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Louis, E. D., Martuscello, R. T., Gionco, J. T., Hartstone, W. G., Musacchio, J. B., Portenti, M., McCreary, M., Kuo, S.-H., Vonsattel, J.-P. G., & Faust, P. L. (2023). Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathologica, 145(3), 265–283. https://doi.org/10.1007/s00401-022-02535-z
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Buchman, A. S., Yu, L., Klein, H.-U., Zammit, A. R., Oveisgharan, S., Grodstein, F., Tasaki, S., Levey, A. I., Seyfried, N. T., & Bennett, D. A. (2022). Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults. The Journals of Gerontology: Series A, 78(3), 494–503. https://doi.org/10.1093/gerona/glac105
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Marras, C., Alcalay, R. N., Siderowf, A., & Postuma, R. B. (2023). Challenges in the study of individuals at risk for Parkinson disease. Precision Medicine in Neurodegenerative Disorders, Part I, 219–229. https://doi.org/10.1016/b978-0-323-85538-9.00014-6
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