The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers

Goldstein, O., Shani, S., Gana-Weisz, M., Elkoshi, N., Casey, F., Sun, Y. H., Chandratre, K., Cedarbaum, J. M., Blauwendraat, C., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Orr-Urtreger, A., & Alcalay, R. N. (2025). The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers. Journal of Parkinson’s Disease. https://doi.org/10.1177/1877718x241310722
Authors:
Orly Goldstein
Shachar Shani
Mali Gana‐Weisz
Nadav Elkoshi
Fergal Casey
Yu Sun
Khyati Chandratre
Jesse M. Cedarbaum
Cornelis Blauwendraat
Anat Bar‐Shira
Avner Thaler
Tanya Gurevich
Anat Mirelman
Nir Giladi
Avi Orr‐Urtreger
Roy N. Alcalay
Affiliated Authors:
Roy N. Alcalay
Columbia Affiliation:
Subjects:
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (MeSH)
Glucosylceramidase (MeSH)
Parkinson Disease (MeSH)
Heterozygote (MeSH)
Phenotype (MeSH)
Genetic Predisposition to Disease (MeSH)
Pathophysiology of Parkinson's Disease (OpenAlex Topic)
Ginkgo biloba and Cashew Applications (OpenAlex Topic)
Functions and Regulation of RNA Editing by ADARs (OpenAlex Topic)
Author Keywords:
alpha-synuclein
gba1
lrrk2
parkinson's disease
polygenic risk score
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Publication Type:
Article
Unique ID:
10.1177/1877718x241310722
DOI:
10.1177/1877718x241310722
Journal:
Journal of Parkinson's Disease
Publication Date:
Data Source:
OpenAlex
Source Link:
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