The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

Jones-Tabah, J., He, K., Karpilovsky, N., Senkevich, K., Deyab, G., Pietrantonio, I., Goiran, T., Cousineau, Y., Nikanorova, D., Goldsmith, T., del Cid Pellitero, E., Chen, C. X.-Q., Luo, W., You, Z., Abdian, N., Ahmad, J., Ruskey, J. A., Asayesh, F., Spiegelman, D., … Fon, E. A. (2024). The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. Molecular Neurodegeneration, 19(1). https://doi.org/10.1186/s13024-024-00779-9
Authors:
Jace Jones-Tabah
Kathy He
Nathan Karpilovsky
Konstantin Senkevich
Ghislaine Deyab
Isabella Pietrantonio
Thomas Goiran
Yuting Cousineau
Daria Nikanorova
Taylor Goldsmith
Esther del Cid‐Pellitero
Carol X.‐Q. Chen
Wen Luo
Zhipeng You
Narges Abdian
Jamil Ahmad
Jennifer A. Ruskey
Farnaz Asayesh
Dan Spiegelman
Stanley Fahn
Cheryl Waters
Oury Monchi
Yves Dauvilliers
Nicolas Dupré
Irina Miliukhina
A. A. Timofeeva
Anton Emelyanov
Sofya Pchelina
Lior Greenbaum
Sharon Hassin‐Baer
Roy N. Alcalay
Austen J. Milnerwood
Thomas M. Durcan
Ziv Gan‐Or
Edward A. Fon
Affiliated Authors:
Stanley Fahn
Cheryl Waters
Roy N. Alcalay
Columbia Affiliation:
Subjects:
alpha-Synuclein (MeSH)
Parkinson Disease (MeSH)
Lysosomes (MeSH)
Cathepsin B (MeSH)
Glucosylceramidase (MeSH)
Dopaminergic Neurons (MeSH)
Pathophysiology of Parkinson's Disease (OpenAlex Topic)
Lysosomal Storage Disorders in Human Health and Disease (OpenAlex Topic)
Neurodegeneration with Brain Iron Accumulation (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1186/s13024-024-00779-9
PMID:
39587654
DOI:
10.1186/s13024-024-00779-9
Journal:
Molecular Neurodegeneration
Publication Date:
Data Source:
OpenAlex
Source Link:
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