Organoids
Syphers, J. L., Wright, J. A., Liu, S., Gee, Y. S., Gao, F., Mudududdla, R., Che, D. Q., Chang, A., Sloan, E. K., Narasimhan, V., Heriot, A., Ramsay, R. G., de Nys, R., Silva, T. N., Vrbanac, L., Sammour, T., Lawrence, M. J., Tin, T., Maddern, G. J., … Baell, J. B. (2025). Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids. Journal of Medicinal Chemistry, 68(8), 8065–8090. https://doi.org/10.1021/acs.jmedchem.4c02541
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Columbia Affiliation
Xu, C., He, S., Zhu, Y., Crasto, G., Chen, C., Clay, M. L., Lao, Y.-H., & Leong, K. W. (2024). Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells. Journal of Visualized Experiments, 214. https://doi.org/10.3791/67125
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Buonfiglioli, A., Kübler, R., Missall, R., De Jong, R., Chan, S., Haage, V., Wendt, S., Lin, A. J., Mattei, D., Graziani, M., Latour, B., Gigase, F., Chiu, R., Zhang, Y., Nygaard, H. B., De Jager, P. L., & De Witte, L. D. (2025). A microglia-containing cerebral organoid model to study early life immune challenges. Brain, Behavior, and Immunity, 123, 1127–1146. https://doi.org/10.1016/j.bbi.2024.11.008
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Su, S. H., Mitani, Y., Li, T., Sachdeva, U., Flashner, S., Klein-Szanto, A., Dunbar, K. J., Abrams, J., Nakagawa, H., & Gabre, J. (2024). Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State. Biomolecules, 14(9), 1195. https://doi.org/10.3390/biom14091195
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Columbia Affiliation
Shimonosono, M., Morimoto, M., Hirose, W., Tomita, Y., Matsuura, N., Flashner, S., Ebadi, M. S., Okayasu, E. H., Lee, C. Y., Britton, W. R., Martin, C., Wuertz, B. R., Parikh, A. S., Sachdeva, U. M., Ondrey, F. G., Atigadda, V. R., Elmets, C. A., Abrams, J. A., Muir, A. B., … Nakagawa, H. (2024). Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids. Biomolecules, 14(9), 1126. https://doi.org/10.3390/biom14091126
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Columbia Affiliation
Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
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Columbia Affiliation
Kim, H. S., Xiao, Y., Chen, X., He, S., Im, J., Willner, M. J., Finlayson, M. O., Xu, C., Zhu, H., Choi, S. J., Mosharov, E. V., Kim, H., Xu, B., & Leong, K. W. (2024). Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids. Advanced Science, 11(21). Portico. https://doi.org/10.1002/advs.202400847
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Columbia Affiliation
Buckley, K. H., Beyries, K. A., Ryeom, S., Yoon, S. S., & Katona, B. W. (2024). Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium. Journal of Visualized Experiments, 203. https://doi.org/10.3791/66094
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Columbia Affiliation
Santos, A. K., Scalzo, S., de Souza, R. T. V., Santana, P. H. G., Marques, B. L., Oliveira, L. F., Filho, D. M., Kihara, A. H., da Costa Santiago, H., Parreira, R. C., Birbrair, A., Ulrich, H., & Resende, R. R. (2023). Strategic use of organoids and organs-on-chip as biomimetic tools. Seminars in Cell & Developmental Biology, 144, 3–10. https://doi.org/10.1016/j.semcdb.2022.09.010
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de Oliveira, L. F., Filho, D. M., Marques, B. L., Maciel, G. F., Parreira, R. C., do Carmo Neto, J. R., Da Silva, P. E. F., Guerra, R. O., da Silva, M. V., Santiago, H. da C., Birbrair, A., Kihara, A. H., Dias da Silva, V. J., Glaser, T., Resende, R. R., & Ulrich, H. (2023). Organoids as a novel tool in modelling infectious diseases. Seminars in Cell & Developmental Biology, 144, 87–96. https://doi.org/10.1016/j.semcdb.2022.09.003
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Kim, H., Kamm, R. D., Vunjak-Novakovic, G., & Wu, J. C. (2022). Progress in multicellular human cardiac organoids for clinical applications. Cell Stem Cell, 29(4), 503–514. https://doi.org/10.1016/j.stem.2022.03.012
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Christin, J. R., & Shen, M. M. (2022). Modeling tumor plasticity in organoid models of human cancer. Trends in Cancer, 8(3), 161–163. https://doi.org/10.1016/j.trecan.2021.12.004
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Duan, X., Wang, H., Ho, D. D., Schwartz, R. E., Evans, T., & Chen, S. (2021). Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection.’ Journal of Molecular Cell Biology, 14(1). https://doi.org/10.1093/jmcb/mjab075
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Columbia Affiliation
Gil, V., Miranda, S., Riisnaes, R., Gurel, B., D’Ambrosio, M., Vasciaveo, A., Crespo, M., Ferreira, A., Brina, D., Troiani, M., Sharp, A., Sheehan, B., Christova, R., Seed, G., Figueiredo, I., Lambros, M., Dolling, D., Rekowski, J., Alajati, A., … de Bono, J. (2021). HER3 Is an Actionable Target in Advanced Prostate Cancer. Cancer Research, 81(24), 6207–6218. https://doi.org/10.1158/0008-5472.can-21-3360
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Columbia Affiliation
de Jong, J. O., Llapashtica, C., Genestine, M., Strauss, K., Provenzano, F., Sun, Y., Zhu, H., Cortese, G. P., Brundu, F., Brigatti, K. W., Corneo, B., Migliori, B., Tomer, R., Kushner, S. A., Kellendonk, C., Javitch, J. A., Xu, B., & Markx, S. (2021). Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24358-4
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Columbia Affiliation
Stavros Niarchos Foundation Center for Precision Psychiatry & Mental Health; Vagelos College of Physicians and Surgeons; Department of Psychiatry; Department of Neurology; Division of Molecular Therapeutics; Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Systems Biology; Department of Molecular Pharmacology and Therapeutics
Karakasheva, T. A., Gabre, J. T., Sachdeva, U. M., Cruz-Acuña, R., Lin, E. W., DeMarshall, M., Falk, G. W., Ginsberg, G. G., Yang, Z., Kim, M. M., Diffenderfer, E. S., Pitarresi, J. R., Li, J., Muir, A. B., Hamilton, K. E., Nakagawa, H., Bass, A. J., & Rustgi, A. K. (2021). Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-00706-8
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Columbia Affiliation
Duan, X., Tang, X., Nair, M. S., Zhang, T., Qiu, Y., Zhang, W., Wang, P., Huang, Y., Xiang, J., Wang, H., Schwartz, R. E., Ho, D. D., Evans, T., & Chen, S. (2021). An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Reports, 37(6), 109920. https://doi.org/10.1016/j.celrep.2021.109920
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