Cognitive Dysfunction

Displaying 1 - 50 of 162CSV
Janelidze, S., Collij, L. E., Mattsson-Carlgren, N., Antill, A., Laymon, C. M., Lott, I., Rosas, H. D., Minhas, D. S., Luo, W., Zaman, S., Mapstone, M., Head, E., Lai, F., Hartley, S. L., Ances, B. M., Krinsky-McHale, S. J., Lee, J. H., Ossenkoppele, R., Christian, B. T., … Hansson, O. (2025). Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. The Lancet Neurology, 24(7), 591–600. https://doi.org/10.1016/s1474-4422(25)00158-9
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Luchsinger, J. A., Devanand, D., Goldberg, T. E., Cammack, S., Hernández-Santiago, G., Oishi, K., Jagust, W., Baker, S., Landau, S., Yenokyan, G., Betz, J., Mayers, S., Eyzaguirre, L. M., & Hanley, D. (2025). Protocol for a Randomized Phase II/III Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Extended-Release Metformin in Amnestic Mild Cognitive Impairment. Alzheimer Disease & Associated Disorders, 39(2), 123–133. https://doi.org/10.1097/wad.0000000000000677
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Thakur, P., Lackinger, M., Diamantopoulou, A., Rao, S., Chen, Y., Khalizova, K., Ferng, A., Mazur, C., Kordasiewicz, H., Shprintzen, R. J., Markx, S., Xu, B., & Gogos, J. A. (2025). An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.103328
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Gross, A. L., Liu, Y., Zhang, Y. S., Zhao, Y., Li, C., Meijer, E., Lee, J., & Kobayashi, L. C. (2025). Language, literacy, and sensory impairments and missing cognitive test scores in the Harmonized Cognitive Assessment Protocol of the China Health and Retirement Longitudinal Study. Aging Clinical and Experimental Research, 37(1). https://doi.org/10.1007/s40520-025-03039-y
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Hojjati, S. H., Chiang, G. C., Butler, T. A., Chen, K., Khalafi, M., Yazdi, B. G., Foldi, N., Nayak, S., de Leon, M., Li, Y., Stern, Y., Luchsinger, J. A., & Razlighi, Q. R. (2025). Heterogeneous tau deposition patterns in the preclinical stage link to domain‐specific cognitive deficits. Alzheimer’s & Dementia, 21(5). Portico. https://doi.org/10.1002/alz.70153
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Kim, B., Thorpe, R. J., Szanton, S. L., Adkins-Jackson, P. B., & Samuel, L. J. (2025). Disparities in neighborhood food environment and cognitive decline among US older adults: a cohort study. BMC Medicine, 23(1). https://doi.org/10.1186/s12916-025-04091-1
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Columbia Affiliation
Williams, J. R., DeConne, T. M., Pewowaruk, R., Korcarz, C., Tanley, J., Carlsson, C., Heckbert, S. R., Habes, M., Nasrallah, I., Lockhart, S. N., Luchsinger, J. A., Ding, J., Hayden, K. M., Hughes, T. M., & Gepner, A. D. (2025). Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related Dementias Pathology: The Multi‐Ethnic Study of Atherosclerosis. Journal of the American Heart Association, 14(9). https://doi.org/10.1161/jaha.124.039925
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Zammit, A. R., Wang, T., Yu, L., Oveisgharan, S., Petyuk, V. A., De Jager, P. L., Schneider, J. A., Bennett, D. A., & Buchman, A. S. (2025). The temporal onset of associations of cortical proteins with cognitive resilience vary during late life. Neurobiology of Disease, 211, 106927. https://doi.org/10.1016/j.nbd.2025.106927
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Leavitt, V., Mostert, J., Comtois, J., Moral, E., Brieva, L., Repovic, P., Bowen, J. D., Uitdehaag, B., Strijbis, E., Cutter, G., & Koch, M. W. (2025). Measuring cognitive change in secondary progressive MS: an analysis of the ASCEND cognition substudy. Journal of Neurology, 272(5). https://doi.org/10.1007/s00415-025-13066-4
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Jenkins, M. R., Peven, J. C., Kubic, L., Handen, B. L., Krinsky-McHale, S. J., Hom, C. L., Lee, A., Tudorascu, D. L., McLachlan, M., Zammit, M., Minhas, D., Luo, W., Laymon, C., Lee, J. H., Lott, I., Cohen, A., Ances, B. M., Rosas, H. D., … Lai, F. (2025). Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome. Journal of Neurodevelopmental Disorders, 17(1). https://doi.org/10.1186/s11689-025-09604-w
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Springer, M. V., Whitney, R. T., Ye, W., Briceño, E. M., Gross, A. L., Aparicio, H. J., Beiser, A. S., Burke, J. F., Elkind, M. S. V., Ferber, R. A., Giordani, B., Gottesman, R. F., Hayward, R. A., Howard, V. J., Kollipara, A. S., Koton, S., Lazar, R. M., Longstreth, W. T., Pendlebury, S. T., … Levine, D. A. (2025). Education Levels and Poststroke Cognitive Trajectories. JAMA Network Open, 8(3), e252002. https://doi.org/10.1001/jamanetworkopen.2025.2002
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Fioriti, L., Wijesekara, N., Argyrousi, E. K., Matsuzaki, S., Takamura, H., Satoh, K., Han, K., Yamauchi, H., Staniszewski, A., Acquarone, E., Orsini, F., Martucci, A., Katayama, T., Arancio, O., & Fraser, P. E. (2025). Genetic and pharmacologic enhancement of SUMO2 conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer’s disease. Alzheimer’s & Dementia, 21(3). Portico. https://doi.org/10.1002/alz.70030
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Katsumi, Y., Touroutoglou, A., Brickhouse, M., Eloyan, A., Eckbo, R., Zaitsev, A., La Joie, R., Lagarde, J., Schonhaut, D., Thangarajah, M., Taurone, A., Vemuri, P., Jack, C. R., Dage, J. L., Nudelman, K. N. H., Foroud, T., Hammers, D. B., Ghetti, B., … Murray, M. E. (2025). Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer’s disease: A head‐to‐head comparison of the LEADS and ADNI cohorts. Alzheimer’s & Dementia, 21(2). Portico. https://doi.org/10.1002/alz.14489
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Siemers, E., Feaster, T., Sethuraman, G., Sundell, K., Skljarevski, V., Cline, E. N., Zhang, H., Jerecic, J., Honig, L. S., Salloway, S., Sperling, R., Trame, M. N., Dodds, M. G., & Johnson, K. (2025). INTERCEPT-AD, a phase 1 study of intravenous sabirnetug in participants with mild cognitive impairment or mild dementia due to Alzheimer’s disease. The Journal of Prevention of Alzheimer’s Disease, 12(1), 100005. https://doi.org/10.1016/j.tjpad.2024.100005
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Hammers, D. B., Eloyan, A., Taurone, A., Thangarajah, M., Gao, S., Beckett, L., Polsinelli, A. J., Kirby, K., Dage, J. L., Nudelman, K., Aisen, P., Reman, R., La Joie, R., Lagarde, J., Atri, A., Clark, D., Day, G. S., Duara, R., … Graff‐Radford, N. R. (2024). Longitudinal cognitive performance of participants with sporadic early onset Alzheimer’s disease from LEADS. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14439
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Zolnoori, M., Zolnour, A., Vergez, S., Sridharan, S., Spens, I., Topaz, M., Noble, J. M., Bakken, S., Hirschberg, J., Bowles, K., Onorato, N., & McDonald, M. V. (2024). Beyond electronic health record data: leveraging natural language processing and machine learning to uncover cognitive insights from patient-nurse verbal communications. Journal of the American Medical Informatics Association. https://doi.org/10.1093/jamia/ocae300
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Kever, A., Heuer, L. B., Simani, L., & Leavitt, V. M. (2024). Development and initial validation of the Cognitive Change Scale (CCS). Multiple Sclerosis Journal, 30(14), 1815–1824. https://doi.org/10.1177/13524585241290102
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Lin, Y., & Kuo, S.-H. (2024). The emerging role of the cerebellum in neurodegeneration linked to cognitive impairment. Journal of Alzheimer’s Disease, 102(1), 30–32. https://doi.org/10.1177/13872877241283678
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Gonzales, L., Saperstein, A. M., Qian, M., Gorecki, A., & Medalia, A. (2024). Psychiatric and functional correlates of stigma associated with cognitive impairment in schizophrenia. Psychiatry Research, 342, 116233. https://doi.org/10.1016/j.psychres.2024.116233
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Lo, J. W., Crawford, J. D., Lipnicki, D. M., Lipton, R. B., Katz, M. J., Preux, P.-M., Guerchet, M., d’Orsi, E., Quialheiro, A., Rech, C. R., Ritchie, K., Skoog, I., Najar, J., Sterner, T. R., Rolandi, E., Davin, A., Rossi, M., Riedel-Heller, S. G., Pabst, A., … Sachdev, P. S. (2024). Trajectory of Cognitive Decline Before and After Stroke in 14 Population Cohorts. JAMA Network Open, 7(10), e2437133. https://doi.org/10.1001/jamanetworkopen.2024.37133
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Lu, L., Zhang, Y., Angley, M., Bejerano, S., Brockman, J. D., McClure, L. A., Unverzagt, F. W., Fly, A. D., & Kahe, K. (2024). Association of Urinary Cadmium Concentration With Cognitive Impairment in US Adults. Neurology, 103(7). https://doi.org/10.1212/wnl.0000000000209808
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Qian, M., Motter, J., Deehan, E., Graff, J., Adhikari, A., Doraiswamy, P. M., Goldberg, T. E., & Devanand, D. P. (2024). Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial. Alzheimer Disease & Associated Disorders, 38(3), 227–234. https://doi.org/10.1097/wad.0000000000000639
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Simani, L., Molaeipour, L., Kian, S., & Leavitt, V. M. (2024). Correlation between cognitive changes and neuroradiological changes over time in multiple sclerosis: a systematic review and meta-analysis. Journal of Neurology, 271(8), 5498–5518. https://doi.org/10.1007/s00415-024-12517-8
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Cole, K. L., Boehme, A. K., Thacker, E. L., Longstreth Jr., W. T., Brown, B. L., Gale, S. D., Hedges, D. W., Anderson, J. K., & Elkind, M. S. V. (2023). Hospital-Acquired Infection at Time of Stroke and Cognitive Decline: The Cardiovascular Health Study. Cerebrovascular Diseases, 53(4), 382–390. Portico. https://doi.org/10.1159/000533568
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Tucker, A., Goldberg, T. E., & Kim, H. (2024). Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression. Expert Review of Molecular Diagnostics, 24(8), 649–657. https://doi.org/10.1080/14737159.2024.2389307
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Nichols, E., Gross, A. L., Zhang, Y. S., Meijer, E., Hayat, S., Steptoe, A., Langa, K. M., & Lee, J. (2024). Considerations for the use of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) in cross‐country comparisons of cognitive aging and dementia. Alzheimer’s & Dementia, 20(7), 4635–4648. Portico. https://doi.org/10.1002/alz.13895
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Zhang, A., Wengler, K., Zhu, X., Horga, G., Goldberg, T. E., & Lee, S. (2024). Altered Hierarchical Gradients of Intrinsic Neural Timescales in Mild Cognitive Impairment and Alzheimer’s Disease. The Journal of Neuroscience, 44(25), e2024232024. https://doi.org/10.1523/jneurosci.2024-23.2024
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Denham, M. W., Arnold, M. L., Sanchez, V. A., Lin, F. R., Tucker, L. H., Gomez, M. C., Fernandez, K., Arpi, P., Neil, H., Boyle, S., Selevan, S., Sussman, T. J., Gmelin, T., Fine, I., Glynn, N. W., Teresi, J., Noble, J. M., Goldberg, T., Luchsinger, J. A., & Golub, J. S. (2024). Design and Methods of the Early Age-Related Hearing Loss Investigation Randomized Controlled Trial. Otology & Neurotology, 45(5), 594–601. https://doi.org/10.1097/mao.0000000000004093
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Kerner, N., Goldberg, T. E., Cohen, H. R., Phillips, J. G., Cohen, D. E., Andrews, H., Pelton, G., & Devanand, D. P. (2024). Sleep–wake behavior, perceived fatigability, and cognitive reserve in older adults. Alzheimer’s & Dementia, 20(6), 4020–4031. Portico. https://doi.org/10.1002/alz.13802
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Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L., Zaman, S., Lott, I. T., … Mori, H. (2024). Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. The Lancet Neurology, 23(5), 500–510. https://doi.org/10.1016/s1474-4422(24)00084-x
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Ghanem, A., Berry, D. S., Burkes, A., Grill, N., Hall, T. M., Hart, K. A., Hernandez, N. C., Chapman, S., Sharma, V. D., Huey, E. D., Cosentino, S. A., & Louis, E. D. (2024). Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort. Annals of Neurology, 95(6), 1193–1204. Portico. https://doi.org/10.1002/ana.26927
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Edwin, T. H., Håberg, A. K., Zotcheva, E., Bratsberg, B., Jugessur, A., Engdahl, B., Bowen, C., Selbæk, G., Kohler, H.-P., Harris, J. R., Tom, S. E., Krokstad, S., Mekonnen, T., Stern, Y., Skirbekk, V. F., & Strand, B. H. (2024). Trajectories of Occupational Cognitive Demands and Risk of Mild Cognitive Impairment and Dementia in Later Life. Neurology, 102(9). https://doi.org/10.1212/wnl.0000000000209353
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Buchman, A. S., Yu, L., Klein, H.-U., Zammit, A. R., Oveisgharan, S., Nag, S., Tickotsky, N., Levy, H., Seyfried, N., Morgenstern, D., Levin, Y., Schnaider Beeri, M., & Bennett, D. A. (2024). Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults. Neurology, 102(7). https://doi.org/10.1212/wnl.0000000000209223
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GOYAL, P., DIDOMENICO, R. J., PRESSLER, S. J., IBEH, C., WHITE-WILLIAMS, C., ALLEN, L. A., GORODESKI, E. Z., Albert, N., Fudim, M., Lekavich, C., Watson, K., Gulati, S., Kalogeropoulos, A., & Lewsey, S. (2024). Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement. Journal of Cardiac Failure, 30(3), 488–504. https://doi.org/10.1016/j.cardfail.2024.01.003
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Yang, Y. C., Walsh, C. E., Shartle, K., Stebbins, R. C., Aiello, A. E., Belsky, D. W., Harris, K. M., Chanti-Ketterl, M., & Plassman, B. L. (2023). An Early and Unequal Decline: Life Course Trajectories of Cognitive Aging in the United States. Journal of Aging and Health, 36(3–4), 230–245. https://doi.org/10.1177/08982643231184593
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Poole, V. N., Ridwan, A. R., Arfanakis, K., Dawe, R. J., Seyfried, N. T., De Jager, P. L., Schneider, J. A., Leurgans, S. E., Yu, L., & Bennett, D. A. (2024). Associations of brain morphology with cortical proteins of cognitive resilience. Neurobiology of Aging, 137, 1–7. https://doi.org/10.1016/j.neurobiolaging.2024.02.005
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Tsapanou, A., Ghanem, A., Chapman, S., Stern, Y., Huey, E. D., Cosentino, S., & Louis, E. D. (2024). Sleep problems as predictors of cognitive decline in essential tremor: A prospective longitudinal cohort study. Sleep Medicine, 116, 13–18. https://doi.org/10.1016/j.sleep.2024.02.016
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Morales, C. D., Cotton-Samuel, D., Lao, P. J., Chang, J. F., Pyne, J. D., Alshikho, M. J., Lippert, R. V., Bista, K., Hale, C., Edwards, N. C., Igwe, K. C., Deters, K., Zimmerman, M. E., & Brickman, A. M. (2024). Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer’s clinical trial participants. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-024-01395-x
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Rossano, S. M., Johnson, A. S., Smith, A., Ziaggi, G., Roetman, A., Guzman, D., Okafor, A., Klein, J., Tomljanovic, Z., Stern, Y., Brickman, A. M., Lee, S., Kreisl, W. C., & Lao, P. (2024). Microglia measured by TSPO PET are associated with Alzheimer’s disease pathology and mediate key steps in a disease progression model. Alzheimer’s & Dementia, 20(4), 2397–2407. Portico. https://doi.org/10.1002/alz.13699
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Barbera, M., Lehtisalo, J., Perera, D., Aspö, M., Cross, M., De Jager Loots, C. A., Falaschetti, E., Friel, N., Luchsinger, J. A., Gavelin, H. M., Peltonen, M., Price, G., Neely, A. S., Thunborg, C., Tuomilehto, J., Mangialasche, F., Middleton, L., Ngandu, T., … Solomon, A. (2024). A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-023-01355-x
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Whitman, E. T., Ryan, C. P., Abraham, W. C., Addae, A., Corcoran, D. L., Elliott, M. L., Hogan, S., Ireland, D., Keenan, R., Knodt, A. R., Melzer, T. R., Poulton, R., Ramrakha, S., Sugden, K., Williams, B. S., Zhou, J., Hariri, A. R., Belsky, D. W., Moffitt, T. E., & Caspi, A. (2024). A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts. Neurobiology of Aging, 136, 23–33. https://doi.org/10.1016/j.neurobiolaging.2024.01.008
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Vyas, C. M., Manson, J. E., Sesso, H. D., Cook, N. R., Rist, P. M., Weinberg, A., Moorthy, M. V., Baker, L. D., Espeland, M. A., Yeung, L.-K., Brickman, A. M., & Okereke, O. I. (2024). Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. The American Journal of Clinical Nutrition, 119(3), 692–701. https://doi.org/10.1016/j.ajcnut.2023.12.011
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Gu, Y., Honig, L. S., Kang, M. S., Bahl, A., Sanchez, D., Reyes‐Dumeyer, D., Manly, J. J., Dage, J. L., Lantigua, R. A., Brickman, A. M., Vardarajan, B. N., & Mayeux, R. (2024). Risk of Alzheimer’s disease is associated with longitudinal changes in plasma biomarkers in the multi‐ethnic Washington Heights–Hamilton Heights–Inwood Columbia Aging Project (WHICAP) cohort. Alzheimer’s & Dementia, 20(3), 1988–1999. Portico. https://doi.org/10.1002/alz.13652
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Hojjati, S. H., Chiang, G. C., Butler, T. A., de Leon, M., Gupta, A., Li, Y., Sabuncu, M. R., Feiz, F., Nayak, S., Shteingart, J., Ozoria, S., Gholipour Picha, S., Stern, Y., Luchsinger, J. A., Devanand, D. P., & Razlighi, Q. R. (2024). Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent. Journal of Alzheimer’s Disease, 98(4), 1467–1482. https://doi.org/10.3233/jad-231362
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Jones, R. N., Manly, J. J., Langa, K. M., Ryan, L. H., Levine, D. A., McCammon, R., & Weir, D. (2023). Factor structure of the Harmonized Cognitive Assessment Protocol neuropsychological battery in the Health and Retirement Study. Journal of the International Neuropsychological Society, 30(1), 47–55. https://doi.org/10.1017/s135561772300019x
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Katayama, O., Stern, Y., Habeck, C., Lee, S., Harada, K., Makino, K., Tomida, K., Morikawa, M., Yamaguchi, R., Nishijima, C., Misu, Y., Fujii, K., Kodama, T., & Shimada, H. (2023). Neurophysiological markers in community-dwelling older adults with mild cognitive impairment: an EEG study. Alzheimer’s Research & Therapy, 15(1). https://doi.org/10.1186/s13195-023-01368-6
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Mehta, N. H., Zhou, L., Li, Y., McIntire, L. B., Nordvig, A., Butler, T., de Leon, M., & Chiang, G. C. (2023). Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-34012-2
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Mishkin, A. D., Prince, E. J., Leimbach, E. J., Mapara, M. Y., & Carroll, C. P. (2023). Psychiatric comorbidities in adults with sickle cell disease: A narrative review. British Journal of Haematology, 203(5), 747–759. Portico. https://doi.org/10.1111/bjh.18981
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