Neuroimmune Interaction in Psychiatric Disorders

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Elyaman, W., Stern, L. J., Jiang, N., Dressman, D., Bradley, P., Klatzmann, D., Bradshaw, E. M., Farber, D. L., Kent, S. C., Chizari, S., Funk, K., Devanand, D., Thakur, K. T., Raj, T., Dalahmah, O. A., Sarkis, R. A., Weiner, H. L., Shneider, N. A., & Przedborski, S. (2025). Exploring the role of T cells in Alzheimer’s and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14548
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Riemann, L., Gutierrez, R., Odak, I., Barros-Martins, J., Roesner, L. M., Leon Lara, X., Falk, C., Schulz, T. F., Hansen, G., Werfel, T., Förster, R., Bošnjak, B., Jenniches, F., Klopp, N., Lesker, T. R., & Stangel, M. (2025). Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits. EBioMedicine, 112, 105558. https://doi.org/10.1016/j.ebiom.2025.105558
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Ifediora, N. E., Nimmagadda, N., Lee, E., Canoll, P. D., Schneider, J. A., Bennett, D. A., Menon, V., Barnes, L. L., & Olah, M. (2024). Mapping the neuroimmune landscape of Alzheimer’s disease in African Americans. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091633
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Green, J. L., Dressman, D., Rashid, M., Hobson, R., Elyaman, W., & Bradshaw, E. M. (2024). CD33 competitive inhibitor peptide IMAD‐001 modulates innate immunity in Alzheimer’s disease. Alzheimer’s & Dementia, 20(S6). Portico. https://doi.org/10.1002/alz.089331
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Zammit, A. R., Wang, T., Yu, L., Oveisgharan, S., Jager, P. L. D., Petyuk, V. A., Bennett, D. A., & Buchman, A. S. (2024). Temporal dynamic effects of cortical resilience proteins on trajectories of cognitive aging. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.089162
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Damuka, N., Gollepalli, K. K., Krizan, I., Bhoopal, B., Miller, M., Deep, O., Bashetti, N., Kumar, J. S., Orr, M. E., Macauley, S. L., Whitlow, C. T., Mintz, A., Lockhart, S. N., Craft, S., & Sai, K. K. S. (2024). Exploring Microtubule Dynamics in Alzheimer’s Disease: Longitudinal Assessment Using [11C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.090993
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Qiao, M. N., Rookyard, A. N., Das, L. N., Zerlin‐Esteves, M., Reyes‐Dumeyer, D., Lee, A. J., Lantigua, R. A., Medrano, M., Mejia, D. R., Honig, L. S., Brown, L. M., Mayeux, R., & Vardarajan, B. N. (2024). Association of CSF Proteome with CSF P‐tau181 levels and other biomarkers of Alzheimer’s Disease. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091398
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Seifar, F., Fox, E. J., Shantaraman, A., Liu, Y., Dammer, E. B., Modeste, E., Duong, D. M., Yin, L., Trautwig, A. N., Guo, Q., Xu, K., Ping, L., Reddy, J. S., Allen, M., Quicksall, Z., Heath, L., Scanlan, J., Wang, E., Wang, M., … Seyfried, N. T. (2024). Large‐scale deep proteomic analysis in Alzheimer’s disease brain regions across race and ethnicity. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14360
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Jones, A. A., Ramos‐Miguel, A., Gicas, K. M., Petyuk, V. A., Leurgans, S. E., De Jager, P. L., Schneider, J. A., Bennett, D. A., Honer, W. G., & Casaletto, K. B. (2024). A multilayer network analysis of Alzheimer’s disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity. Alzheimer’s & Dementia, 20(11), 8012–8027. Portico. https://doi.org/10.1002/alz.14286
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Formánek, T., Potočár, L., Wolfova, K., Melicharová, H., Mladá, K., Wiedemann, A., Chen, D., Mohr, P., Winkler, P., Jones, P. B., & Jarkovský, J. (2024). Deaths with COVID-19 and from all-causes following first-ever SARS-CoV-2 infection in individuals with preexisting mental disorders: A national cohort study from Czechia. PLOS Medicine, 21(7), e1004422. https://doi.org/10.1371/journal.pmed.1004422
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Wang, Q., Antone, J., Alsop, E., Reiman, R., Funk, C., Bendl, J., Dudley, J. T., Liang, W. S., Karr, T. L., Roussos, P., Bennett, D. A., De Jager, P. L., Serrano, G. E., Beach, T. G., Van Keuren-Jensen, K., Mastroeni, D., Reiman, E. M., & Readhead, B. P. (2024). Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49790-0
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Mares, J., Costa, A. P., Dartora, W. J., Wartchow, K. M., Lazarian, A., Bennett, D. A., Nuriel, T., Menon, V., & McIntire, L. B. J. (2024). Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment. Frontiers in Aging Neuroscience, 16. https://doi.org/10.3389/fnagi.2024.1419253
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Demaestri, C., Pisciotta, M., Altunkeser, N., Berry, G., Hyland, H., Breton, J., Darling, A., Williams, B., & Bath, K. G. (2024). Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49828-3
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Trumpff, C., Monzel, A. S., Sandi, C., Menon, V., Klein, H.-U., Fujita, M., Lee, A., Petyuk, V. A., Hurst, C., Duong, D. M., Seyfried, N. T., Wingo, A. P., Wingo, T. S., Wang, Y., Thambisetty, M., Ferrucci, L., Bennett, D. A., De Jager, P. L., & Picard, M. (2024). Psychosocial experiences are associated with human brain mitochondrial biology. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2317673121
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Yu, H., Nishio, H., Barbi, J., Mitchell-Flack, M., Vignali, P. D., Zheng, Y., Lebid, A., Chang, K.-Y., Fu, J., Higgins, M., Huang, C.-T., Zhang, X., Li, Z., Blosser, L., Tam, A., Drake, C., & Pardoll, D. (2024). Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96812
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Haq, I., Ngo, J. C., Roy, N., Pan, R. L., Nawsheen, N., Chiu, R., Zhang, Y., Fujita, M., Soni, R. K., Wu, X., Bennett, D. A., Menon, V., Olah, M., & Sher, F. (2024). An integrated toolkit for human microglia functional genomics. Stem Cell Research & Therapy, 15(1). https://doi.org/10.1186/s13287-024-03700-9
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Sajid, S., Galfalvy, H. C., Keilp, J. G., Burke, A. K., Mann, J. J., & Grunebaum, M. F. (2024). Acute Dissociation and Ketamine’s Antidepressant and Anti-Suicidal Ideation Effects in a Midazolam-Controlled Trial. International Journal of Neuropsychopharmacology, 27(4). https://doi.org/10.1093/ijnp/pyae017
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Patel, R., Cosentino, S., Zheng, E. Z., Schupf, N., Barral, S., Feitosa, M., Andersen, S. L., Sebastiani, P., Ukraintseva, S., Christensen, K., Zmuda, J., Thyagarajan, B., & Gu, Y. (2024). Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS). Brain, Behavior, & Immunity - Health, 37, 100746. https://doi.org/10.1016/j.bbih.2024.100746
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Baune, B. T., Minelli, A., Carpiniello, B., Contu, M., Domínguez Barragán, J., Donlo, C., Ferensztajn-Rochowiak, E., Glaser, R., Kelch, B., Kobelska, P., Kolasa, G., Kopeć, D., Martínez de Lagrán Cabredo, M., Martini, P., Mayer, M.-A., Menesello, V., Paribello, P., Perera Bel, J., Perusi, G., … Dierssen, M. (2024). An integrated precision medicine approach in major depressive disorder: a study protocol to create a new algorithm for the prediction of treatment response. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1279688
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Columbia Affiliation
Telpoukhovskaia, M. A., Murdy, T. J., Marola, O. J., Charland, K., MacLean, M., Luquez, T., Lish, A. M., Neuner, S., Dunn, A., Onos, K. D., Wiley, J., Archer, D., Huentelman, M. J., Arnold, M., Menon, V., Goate, A., Van Eldik, L. J., Territo, P. R., … Howell, G. R. (2024). New directions for Alzheimer’s disease research from the Jackson Laboratory Center for Alzheimer’s and Dementia Research 2022 workshop. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 10(1). Portico. https://doi.org/10.1002/trc2.12458
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Rivest, J., Longpré-Poirier, C., Desbeaumes Jodoin, V., Martineau, J. T., Chammas, M., Aubin, F., Caron, D., & Levenson, J. A. (2023). Biomarkers use in psycho-oncology practice: Are we there yet? Palliative and Supportive Care, 21(6), 963–966. https://doi.org/10.1017/s1478951523001438
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Kaeberlein, T. L., Green, A. S., Haddad, G., Hudson, J., Isman, A., Nyquist, A., Rosen, B. S., Suh, Y., Zalzala, S., Zhang, X., Blagosklonny, M. V., An, J. Y., & Kaeberlein, M. (2023). Evaluation of off-label rapamycin use to promote healthspan in 333 adults. GeroScience, 45(5), 2757–2768. https://doi.org/10.1007/s11357-023-00818-1
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Bartlett, E. A., Yttredahl, A. A., Boldrini, M., Tyrer, A. E., Hill, K. R., Ananth, M. R., Milak, M. S., Oquendo, M. A., Mann, J. J., DeLorenzo, C., & Parsey, R. V. (2023). In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity. European Psychiatry, 66(1). https://doi.org/10.1192/j.eurpsy.2023.4
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Gibson, G. E., Feldman, H. H., Zhang, S., Flowers, S. A., & Luchsinger, J. A. (2022). Pharmacological thiamine levels as a therapeutic approach in Alzheimer’s disease. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.1033272
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Blackett, J. W., Sun, Y., Purpura, L., Margolis, K. G., Elkind, M. S. V., O’Byrne, S., Wainberg, M., Abrams, J. A., Wang, H. H., Chang, L., & Freedberg, D. E. (2022). DECREASED GUT MICROBIOME TRYPTOPHAN METABOLISM AND SEROTONERGIC SIGNALING IN PATIENTS WITH PERSISTENT MENTAL HEALTH AND GASTROINTESTINAL SYMPTOMS AFTER COVID-19. Clinical and Translational Gastroenterology. https://doi.org/10.14309/ctg.0000000000000524
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Mastrodonato, A., Pavlova, I., Kee, N. C., Pham, V. A., McGowan, J. C., Mann, J. J., & Denny, C. A. (2022). Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice. International Journal of Neuropsychopharmacology, 25(6), 512–523. https://doi.org/10.1093/ijnp/pyac020
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Mastrodonato, A., Pavlova, I., Kee, N., McGowan, J. C., Mann, J. J., & Denny, C. A. (2022). Acute (R,S)-Ketamine Administration Induces Sex-Specific Behavioral Effects in Adolescent but Not Aged Mice. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.852010
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Galán-Díez, M., Borot, F., Ali, A. M., Zhao, J., Gil-Iturbe, E., Shan, X., Luo, N., Liu, Y., Huang, X.-P., Bisikirska, B., Labella, R., Kurland, I., Roth, B. L., Quick, M., Mukherjee, S., Rabadán, R., Carroll, M., Raza, A., & Kousteni, S. (2022). Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia. Cancer Discovery, 12(4), 1106–1127. https://doi.org/10.1158/2159-8290.cd-21-0692
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Zammit, A. R., Yu, L., Petyuk, V., Schneider, J. A., De Jager, P. L., Klein, H.-U., Bennett, D. A., & Buchman, A. S. (2022). Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults. Neurology, 98(13). https://doi.org/10.1212/wnl.0000000000200017
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