Mechanisms of Alzheimer's Disease

Displaying 101 - 146 of 146CSV
Bushnell, J., Hammers, D. B., Aisen, P., Dage, J. L., Eloyan, A., Foroud, T., Grinberg, L. T., Iaccarino, L., Jack, C. R., Kirby, K., Kramer, J., Koeppe, R., Kukull, W. A., La Joie, R., Mundada, N. S., Murray, M. E., Nudelman, K., Rumbaugh, M., … Soleimani‐Meigooni, D. N. (2023). Influence of amyloid and diagnostic syndrome on non‐traditional memory scores in early‐onset Alzheimer’s disease. Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13434
Publication Date
Polsinelli, A. J., Wonderlin, R. J., Hammers, D. B., Garcia, A. P., Eloyan, A., Taurone, A., Thangarajah, M., Beckett, L., Gao, S., Wang, S., Kirby, K., Logan, P. E., Aisen, P., Dage, J. L., Foroud, T., Griffin, P., Iaccarino, L., Kramer, J. H., … Koeppe, R. (2023). Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early‐Onset Alzheimer’s Disease Study (LEADS) cohort. Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13344
Publication Date
Nemes, S., Logan, P. E., Manchella, M. K., Mundada, N. S., La Joie, R., Polsinelli, A. J., Hammers, D. B., Koeppe, R. A., Foroud, T. M., Nudelman, K. N., Eloyan, A., Iaccarino, L., Dorsant‐Ardón, V., Taurone, A., Thangarajah, M., Dage, J. L., Aisen, P., Grinberg, L. T., … Jack, C. R. (2023). Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early‐onset Alzheimer’s disease. Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13403
Publication Date
Touroutoglou, A., Katsumi, Y., Brickhouse, M., Zaitsev, A., Eckbo, R., Aisen, P., Beckett, L., Dage, J. L., Eloyan, A., Foroud, T., Ghetti, B., Griffin, P., Hammers, D., Jack, C. R., Kramer, J. H., Iaccarino, L., Joie, R. L., Mundada, N. S., … Koeppe, R. (2023). The Sporadic Early‐onset Alzheimer’s Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early‐onset Alzheimer’s Disease Study (LEADS) Cohort. Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13466
Publication Date
Fernández, K. K., Kociolek, A. J., Lao, P. J., Stern, Y., Manly, J. J., & Vonk, J. M. J. (2023). Longitudinal decline in semantic versus letter fluency, but not their ratio, marks incident Alzheimer’s disease in Latinx Spanish-speaking older individuals. Journal of the International Neuropsychological Society, 29(8), 775–782. https://doi.org/10.1017/s1355617722000856
Publication Date
Parato, J., Peris, L., Qu, X., Goldberg, Y., Moutin, M.-J., Andrieux, A., & Bartolini, F. (2023). IMPAIRED α-TUBULIN RE-TYROSINATION LEADS TO SYNAPTIC DYSFUNCTION AND IS A FEATURE OF ALZHEIMER’S DISEASE. IBRO Neuroscience Reports, 15, S34. https://doi.org/10.1016/j.ibneur.2023.08.2116
Publication Date
Jain, L., Khrestian, M., Formica, S., Tuason, E. D., Pillai, J. A., Rao, S., Oguh, O., Lippa, C. F., Lopez, O. L., Berman, S. B., Tsuang, D. W., Zabetian, C. P., Irwin, D. J., Galasko, D. R., Litvan, I., Marder, K. S., Honig, L. S., Fleisher, J. E., Galvin, J. E., … Bekris, L. M. (2023). ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium. Alzheimer’s & Dementia, 20(1), 549–562. Portico. https://doi.org/10.1002/alz.13398
Publication Date
Wagemann, O., Li, Y., Hassenstab, J., Aschenbrenner, A. J., McKay, N. S., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Cruchaga, C., Renton, A. E., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Farlow, M. R., Day, G. S., Ikeuchi, T., Jucker, M., Lopera, F., … Mori, H. (2023). Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network. Alzheimer’s & Dementia, 20(1), 47–62. Portico. https://doi.org/10.1002/alz.13460
Publication Date
Cho, H., Mundada, N. S., Apostolova, L. G., Carrillo, M. C., Shankar, R., Amuiri, A. N., Zeltzer, E., Windon, C. C., Soleimani‐Meigooni, D. N., Tanner, J. A., Heath, C. L., Lesman‐Segev, O. H., Aisen, P., Eloyan, A., Lee, H. S., Hammers, D. B., Kirby, K., Dage, J. L., … Fagan, A. (2023). Amyloid and tau‐PET in early‐onset AD: Baseline data from the Longitudinal Early‐onset Alzheimer’s Disease Study (LEADS). Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13453
Publication Date
Qi, R., Sammler, E., Gonzalez-Hunt, C. P., Barraza, I., Pena, N., Rouanet, J. P., Naaldijk, Y., Goodson, S., Fuzzati, M., Blandini, F., Erickson, K. I., Weinstein, A. M., Lutz, M. W., Kwok, J. B., Halliday, G. M., Dzamko, N., Padmanabhan, S., Alcalay, R. N., Waters, C., … Sanders, L. H. (2023). A blood-based marker of mitochondrial DNA damage in Parkinson’s disease. Science Translational Medicine, 15(711). https://doi.org/10.1126/scitranslmed.abo1557
Publication Date
McKay, N. S., Gordon, B. A., Hornbeck, R. C., Dincer, A., Flores, S., Keefe, S. J., Joseph-Mathurin, N., Jack, C. R., Koeppe, R., Millar, P. R., Ances, B. M., Chen, C. D., Daniels, A., Hobbs, D. A., Jackson, K., Koudelis, D., Massoumzadeh, P., McCullough, A., Nickels, M. L., … la Fougère, C. (2023). Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience, 26(8), 1449–1460. https://doi.org/10.1038/s41593-023-01359-8
Publication Date
Agrawal, R. R., Larrea, D., Xu, Y., Shi, L., Zirpoli, H., Cummins, L. G., Emmanuele, V., Song, D., Yun, T. D., Macaluso, F. P., Min, W., Kernie, S. G., Deckelbaum, R. J., & Area-Gomez, E. (2022). Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury. Cellular and Molecular Neurobiology, 43(5), 2219–2241. https://doi.org/10.1007/s10571-022-01299-0
Publication Date
Ali, M., Mafimoghaddam, S., Sung, Y. J., Wang, F., Fernandez, M. V., Archer, D. B., Hohman, T. J., Satizabal, C. L., Yang, Q., Beiser, A. S., Wang, R., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Morris, J. C., Bateman, R. J., Karch, C. M., McDade, E., Goate, A., … Cruchaga, C. (2023). Using amyloid PET as a biomarker to detect progression of early Alzheimer disease. Alzheimer’s & Dementia, 19(S3). Portico. https://doi.org/10.1002/alz.066189
Publication Date
Columbia Affiliation
Hayden, K. M., Evans, J. K., Culkin, M. C., Molina‐Henry, D. P., Marcovina, S., Shappell, H. M., Rapp, S. R., Sachs, B. C., Ding, J., Mielke, M. M., Luchsinger, J. A., & Espeland, M. A. (2023). The association between Alzheimer’s disease blood‐based biomarkers and cognitive impairment and probable dementia in Look AHEAD MIND. Alzheimer’s & Dementia, 19(S2). Portico. https://doi.org/10.1002/alz.063408
Publication Date
Vöglein, J., Franzmeier, N., Morris, J. C., Dieterich, M., McDade, E., Simons, M., Preische, O., Hofmann, A., Hassenstab, J., Benzinger, T. L., Fagan, A., Noble, J. M., Berman, S. B., Graff‐Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J. P., Salloway, S., … Xiong, C. (2022). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & Dementia, 19(2), 632–645. Portico. https://doi.org/10.1002/alz.12684
Publication Date
Shuping, J. L., Matthews, D. C., Adamczuk, K., Scott, D., Rowe, C. C., Kreisl, W. C., Johnson, S. C., Lukic, A. S., Johnson, K. A., Rosa‐Neto, P., Andrews, R. D., Van Laere, K., Cordes, L., Ward, L., Wilde, C. L., Barakos, J., Purcell, D. D., Devanand, D. P., Stern, Y., … Evelhoch, J. L. (2023). Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 9(1). Portico. https://doi.org/10.1002/trc2.12372
Publication Date
Hani Hojjati, S., Butler, T. A., Chiang, G. C., Habeck, C., RoyChoudhury, A., Feiz, F., Shteingart, J., Nayak, S., Ozoria, S., Fernández, A., Stern, Y., Luchsinger, J. A., Devanand, D. P., & Razlighi, Q. R. (2023). Distinct and joint effects of low and high levels of Aβ and tau deposition on cortical thickness. NeuroImage: Clinical, 38, 103409. https://doi.org/10.1016/j.nicl.2023.103409
Publication Date
Lee, A., Kondapalli, C., Virga, D. M., Lewis, T. L., Koo, S. Y., Ashok, A., Mairet-Coello, G., Herzig, S., Foretz, M., Viollet, B., Shaw, R., Sproul, A., & Polleux, F. (2022). Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-32130-5
Publication Date
Duong, M. T., Das, S. R., Lyu, X., Xie, L., Richardson, H., Xie, S. X., Yushkevich, P. A., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J. C., … Nasrallah, I. M. (2022). Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-28941-1
Publication Date
Pichet Binette, A., Franzmeier, N., Spotorno, N., Ewers, M., Brendel, M., Biel, D., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., … Hansson, O. (2022). Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34129-4
Publication Date
Joseph‐Mathurin, N., Llibre‐Guerra, J. J., Li, Y., McCullough, A. A., Hofmann, C., Wojtowicz, J., Park, E., Wang, G., Preboske, G. M., Wang, Q., Gordon, B. A., Chen, C. D., Flores, S., Aggarwal, N. T., Berman, S. B., Bird, T. D., Black, S. E., Borowski, B., … Brooks, W. S. (2022). Amyloid‐Related Imaging Abnormalities in the DIAN‐TU‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease. Annals of Neurology, 92(5), 729–744. Portico. https://doi.org/10.1002/ana.26511
Publication Date
Ostrowitzki, S., Bittner, T., Sink, K. M., Mackey, H., Rabe, C., Honig, L. S., Cassetta, E., Woodward, M., Boada, M., van Dyck, C. H., Grimmer, T., Selkoe, D. J., Schneider, A., Blondeau, K., Hu, N., Quartino, A., Clayton, D., Dolton, M., Dang, Y., … Doody, R. S. (2022). Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease. JAMA Neurology, 79(11), 1113. https://doi.org/10.1001/jamaneurol.2022.2909
Publication Date
Seto, M., Weiner, R. L., Dumitrescu, L., Mahoney, E. R., Hansen, S. L., Janve, V., Khan, O. A., Liu, D., Wang, Y., Menon, V., De Jager, P. L., Schneider, J. A., Bennett, D. A., Gifford, K. A., Jefferson, A. L., & Hohman, T. J. (2022). RNASE6 is a novel modifier of APOE-ε4 effects on cognition. Neurobiology of Aging, 118, 66–76. https://doi.org/10.1016/j.neurobiolaging.2022.06.011
Publication Date
Mishra, R., Phan, T., Kumar, P., Morrissey, Z., Gupta, M., Hollands, C., Shetti, A., Lopez, K. L., Maienschein-Cline, M., Suh, H., Hen, R., & Lazarov, O. (2022). Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons. Journal of Experimental Medicine, 219(9). https://doi.org/10.1084/jem.20220391
Publication Date
Manzali, S. B., Yu, E., Ravona-Springer, R., Livny, A., Golan, S., Ouyang, Y., Lesman-Segev, O., Liu, L., Ganmore, I., Alkelai, A., Gan-Or, Z., Lin, H.-M., Heymann, A., Schnaider Beeri, M., & Greenbaum, L. (2022). Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes. Frontiers in Aging Neuroscience, 14. https://doi.org/10.3389/fnagi.2022.853695
Publication Date
Columbia Affiliation
Martínez-Hernández, J., Parato, J., Sharma, A., Soleilhac, J.-M., Qu, X., Tein, E., Sproul, A., Andrieux, A., Goldberg, Y., Moutin, M.-J., Bartolini, F., & Peris, L. (2022). Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.926914
Publication Date
Rabin, J. S., Nichols, E., La Joie, R., Casaletto, K. B., Palta, P., Dams-O’Connor, K., Kumar, R. G., George, K. M., Satizabal, C. L., Schneider, J. A., Pa, J., & Brickman, A. M. (2022). Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline. Brain, 145(8), 2823–2833. https://doi.org/10.1093/brain/awac178
Publication Date
Damuka, N., Orr, M. E., Bansode, A. H., Krizan, I., Miller, M., Lee, J., Macauley, S. L., Whitlow, C. T., Mintz, A., Craft, S., & Solingapuram Sai, K. K. (2022). Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Research, 12(1). https://doi.org/10.1186/s13550-022-00912-z
Publication Date
Peris, L., Parato, J., Qu, X., Soleilhac, J. M., Lanté, F., Kumar, A., Pero, M. E., Martínez-Hernández, J., Corrao, C., Falivelli, G., Payet, F., Gory-Fauré, S., Bosc, C., Blanca Ramirez, M., Sproul, A., Brocard, J., Di Cara, B., Delagrange, P., Buisson, A., … Andrieux, A. (2022). Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease. Brain, 145(7), 2486–2506. https://doi.org/10.1093/brain/awab436
Publication Date
Eissman, J. M., Dumitrescu, L., Mahoney, E. R., Smith, A. N., Mukherjee, S., Lee, M. L., Scollard, P., Choi, S. E., Bush, W. S., Engelman, C. D., Lu, Q., Fardo, D. W., Trittschuh, E. H., Mez, J., Kaczorowski, C. C., Hernandez Saucedo, H., Widaman, K. F., Buckley, R. F., Properzi, M. J., … Hohman, T. J. (2022). Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease. Brain, 145(7), 2541–2554. https://doi.org/10.1093/brain/awac177
Publication Date
Consens, M. E., Chen, Y., Menon, V., Wang, Y., Schneider, J. A., De Jager, P. L., Bennett, D. A., Tripathy, S. J., & Felsky, D. (2022). Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 15. https://doi.org/10.3389/fnmol.2022.903175
Publication Date
Wang, Q., de Prisco, N., Tang, J., & Gennarino, V. A. (2022). Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice. STAR Protocols, 3(2), 101245. https://doi.org/10.1016/j.xpro.2022.101245
Publication Date
Connor, S. M., Rashid, M., Ryan, K. J., Patel, K., Boyd, J. D., Smith, J., Elyaman, W., Bennett, D. A., & Bradshaw, E. M. (2022). GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.894601
Publication Date
Chang, A., Xiang, X., Wang, J., Lee, C., Arakhamia, T., Simjanoska, M., Wang, C., Carlomagno, Y., Zhang, G., Dhingra, S., Thierry, M., Perneel, J., Heeman, B., Forgrave, L. M., DeTure, M., DeMarco, M. L., Cook, C. N., Rademakers, R., Dickson, D. W., … Fitzpatrick, A. W. P. (2022). Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185(8), 1346-1355.e15. https://doi.org/10.1016/j.cell.2022.02.026
Publication Date
Barker, M. S., Gottesman, R. T., Manoochehri, M., Chapman, S., Appleby, B. S., Brushaber, D., Devick, K. L., Dickerson, B. C., Domoto-Reilly, K., Fields, J. A., Forsberg, L. K., Galasko, D. R., Ghoshal, N., Goldman, J., Graff-Radford, N. R., Grossman, M., Heuer, H. W., Hsiung, G.-Y., Knopman, D. S., … Weintraub, S. (2022). Proposed research criteria for prodromal behavioural variant frontotemporal dementia. Brain, 145(3), 1079–1097. https://doi.org/10.1093/brain/awab365
Publication Date
Singh, H. N., Swarup, V., Dubey, N. K., Jha, N. K., Singh, A. K., Lo, W.-C., & Kumar, S. (2022). Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease. Biomedicines, 10(3), 611. https://doi.org/10.3390/biomedicines10030611
Publication Date
Zammit, A. R., Yu, L., Petyuk, V., Schneider, J. A., De Jager, P. L., Klein, H.-U., Bennett, D. A., & Buchman, A. S. (2022). Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults. Neurology, 98(13). https://doi.org/10.1212/wnl.0000000000200017
Publication Date
Zhuravleva, V., Vaz-Silva, J., Zhu, M., Gomes, P., Silva, J. M., Sousa, N., Sotiropoulos, I., & Waites, C. L. (2021). Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death & Disease, 12(12). https://doi.org/10.1038/s41419-021-04433-w
Publication Date
Lao, P. J., Berroa, J., Benavides, A., Tejeda, E., Shouel, H., Igwe, K., Maas, B., Schupf, N., Mayeux, R., Manly, J. J., & Brickman, A. M. (2021). Amyloid and tau PET in a middle‐aged, racially and ethnically diverse, community‐based cohort. Alzheimer’s & Dementia, 17(S4). Portico. https://doi.org/10.1002/alz.050953
Publication Date
Dubois, B., Villain, N., Frisoni, G., Rabinovici, G. D., Sabbagh, M. N., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., Habert, M., Nordberg, A. K., Blennow, K., Galasko, D. R., Stern, Y., Rowe, C. C., Salloway, S. P., Schneider, L. S., Cummings, J. L., & Feldman, H. (2021). Recommendations of the International Working Group for the clinical diagnosis of Alzheimer’s disease. Alzheimer’s & Dementia, 17(S5). Portico. https://doi.org/10.1002/alz.057538
Publication Date
Beebe-Wang, N., Celik, S., Weinberger, E., Sturmfels, P., De Jager, P. L., Mostafavi, S., & Lee, S.-I. (2021). Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer’s disease neuropathologies. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25680-7
Publication Date
Llibre‐Guerra, J. J., Li, Y., Franklin, E. E., Miller, C. A., Teich, A. F., Kofler, J., Dickson, D. W., Ghetti, B. F., Frosch, M. P., Halliday, G. M., McLean, C., Lashley, T., Gordon, B. A., Schindler, S. E., Chen, C. D., Fagan, A. M., Benzinger, T. L. S., Wang, G., Hassenstab, J., … McDade, E. (2021). Presence of co‐pathology in sporadic early‐onset Alzheimer disease versus dominantly inherited Alzheimer disease. Alzheimer’s & Dementia, 17(S3). Portico. https://doi.org/10.1002/alz.055045
Publication Date
Hunsberger, H. C., Setti, S. E., Rudy, C. C., Weitzner, D. S., Pfitzer, J. C., McDonald, K. L., Hong, H., Bhattacharya, S., Suppiramaniam, V., & Reed, M. N. (2021). Differential Effects of Human P301L Tau Expression in Young versus Aged Mice. International Journal of Molecular Sciences, 22(21), 11637. https://doi.org/10.3390/ijms222111637
Publication Date
Kim, S. H., Farrell, K., Cosentino, S., Vonsattel, J.-P. G., Faust, P. L., Cortes, E. P., Bennet, D. A., Louis, E. D., & Crary, J. F. (2021). Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies. Journal of Neuropathology & Experimental Neurology, 80(9), 835–843. https://doi.org/10.1093/jnen/nlab073
Publication Date