U01HG004610

NIH – National Human Genome Research Institute

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Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways

Bradley, J., Pottier, C., da Fonseca, E. L., Kurup, J. T., Western, D., Wang, C., Neupane, A., Ray, N. R., Jean‐Francois, M., Ali, M., Timsina, J., Bergmann, K., Budde, J., Martin, E. R., Pericak‐Vance, M. A., Cuccaro, M., Naj, A. C., Kunkle, B. W., … Cruchaga, C. (2025). Novel early‐onset Alzheimer‐associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. Alzheimer’s & Dementia, 21(6). Portico. https://doi.org/10.1002/alz.70377
Authors:
Joseph Bradley
Cyril Pottier
Daniel Western
Ciyang Wang
Achal Neupane
Muhammad Ali
Jigyasha Timsina
Kristy Bergmann
John Budde
Victoria Fernandez
Carlos Cruchaga
Eder Lucio da Fonseca
Melissa Jean-Francois
Eden R. Martin
Margaret A. Pericak-Vance
Michael Cuccaro
Brian W. Kunkle
Gary W. Beecham
Jiji Thulaseedhara Kurup
Nicholas R. Ray
Christiane Reitz
Adam C. Naj
Gerard D. Schellenberg
Jonathan Haines
John C. Morris
David M. Holtzman
Richard J. Perrin
Affiliated Authors:
Jiji Thulaseedhara Kurup
Nicholas R. Ray
Christiane Reitz
Columbia Affiliation:
Author Keywords:
adgc
alzheimer's disease risk
early onset alzheimer's disease
gene-mapping
genetic ancestry
gwas
late onset alzheimer's disease
meta-analysis
multi-ancestry
glutamic acid
aged
alzheimer disease
female
genetic predisposition
genetics
genome-wide association study
human
immunology
male
metabolism
middle aged
onset age
quantitative trait locus
signal transduction
single nucleotide polymorphism
age of onset
genetic predisposition to disease
humans
polymorphism, single nucleotide
quantitative trait loci
gene‐mapping
meta‐analysis
multi‐ancestry
Grants:
KL2RR024151 (NIH – National Center for Research Resources)
P01AG002219 (NIH – National Institute On Aging)
P01AG003949 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P01AG009464 (NIH – National Institute on Aging)
P01AG010491 (NIH – National Institute On Aging)
P01AG017216 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
P30AG008017 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
P30AG066515 (NIH – National Institute On Aging)
P30AG072975 (NIH – National Institute On Aging)
P50AG005128 (NIH – National Institute on Aging)
P50AG005131 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P50AG005144 (NIH – National Institute on Aging)
P50AG005146 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
P50AG008671 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P50AG025711 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
P50MH060451 (NIH – National Institute of Mental Health)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
R00AG062723 (NIH – National Institute on Aging)
R01AG009029 (NIH – National Institute on Aging)
R01AG009956 (NIH – National Institute On Aging)
R01AG012101 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
R01AG018023 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
R01AG019757 (NIH – National Institute on Aging)
R01AG020688 (NIH – National Institute on Aging)
R01AG021547 (NIH – National Institute on Aging)
R01AG022018 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
R01AG026390 (NIH – National Institute On Aging)
R01AG026916 (NIH – National Institute on Aging)
R01AG027944 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
R01AG030653 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
R01AG041232 (NIH – National Institute On Aging)
R01AG041718 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
R01AG044546 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
R01AG058501 (NIH – National Institute on Aging)
R01AG074007 (NIH – National Institute on Aging)
R01CA129769 (NIH – National Cancer Institute)
R01MH080295 (NIH – National Institute of Mental Health)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)
R37AG015473 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
RF1AG015473 (NIH – National Institute On Aging)
RF1AG015819 (NIH – National Institute On Aging)
RF1AG022018 (NIH – National Institute On Aging)
RF1AG044546 (NIH – National Institute On Aging)
RF1AG053303 (NIH – National Institute On Aging)
RF1AG057440 (NIH – National Institute On Aging)
RF1AG058501 (NIH – National Institute On Aging)
RF1AG074007 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
U01AG006786 (NIH – National Institute On Aging)
U01AG010483 (NIH – National Institute On Aging)
U01AG017173 (NIH – National Institute on Aging)
U01AG024904 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
U01AG046170 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
U01AG058922 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
U01HG004610 (NIH – National Human Genome Research Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U24AG021886 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
U24AG061340 (NIH – National Institute on Aging)
U24AG072122 (NIH – National Institute On Aging)
U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)
U54AG052427 (NIH – National Institute On Aging)
UL1RR029893 (NIH – National Center for Research Resources)
Publication Type:
Article
Unique ID:
10.1002/alz.70377
PMID:
40556318
DOI:
10.1002/alz.70377
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record
View Scopus Record
View Scopus Record
View PubMed Record

Record Created:

Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry

Ray, N. R., Kunkle, B. W., Hamilton‐Nelson, K., Kurup, J. T., Rajabli, F., Qiao, M., Vardarajan, B. N., Cosacak, M. I., Kizil, C., Jean‐Francois, M., Cuccaro, M., Reyes‐Dumeyer, D., Cantwell, L., Kuzma, A., Vance, J. M., Gao, S., Hendrie, H. C., Baiyewu, O., … Ogunniyi, A. (2024). Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer’s disease in individuals of African ancestry. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.13880
Authors:
Nicholas R Ray
Brian W Kunkle
Kara Hamilton-Nelson
Jiji T Kurup
Farid Rajabli
Min Qiao
Badri N Vardarajan
Mehmet I Cosacak
Caghan Kizil
Melissa Jean-Francois
Michael Cuccaro
Dolly Reyes-Dumeyer
Laura Cantwell
Amanda Kuzma
Jeffery M Vance
Sujuan Gao
Hugh C Hendrie
Olusegun Baiyewu
Adesola Ogunniyi
Rufus O Akinyemi
Wan-Ping Lee
Eden R Martin
Li-San Wang
Gary W Beecham
William S Bush
Wanying Xu
Fulai Jin
Liyong Wang
Lindsay A Farrer
Jonathan L Haines
Goldie S Byrd
Gerard D Schellenberg
Richard Mayeux
Margaret A Pericak-Vance
Christiane Reitz
Affiliated Authors:
Nicholas R Ray
Jiji T Kurup
Min Qiao
Badri N Vardarajan
Caghan Kizil
Dolly Reyes-Dumeyer
Richard Mayeux
Christiane Reitz
Columbia Affiliation:
Author Keywords:
african americans
african genome panel
alzheimer's disease
genome-wide association study
genome‐wide association study
Grants:
R01CA129769 (NIH – National Cancer Institute)
R01CA267872 (NIH – National Cancer Institute)
UL1RR029893 (NIH – National Center for Research Resources)
KL2RR024151 (NIH – National Center for Research Resources)
R01HG009658 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
R01HG012384 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
R01DK131437 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01MH080295 (NIH – National Institute of Mental Health)
P50MH060451 (NIH – National Institute of Mental Health)
UG3NS132061 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
R01AG012101 (NIH – National Institute On Aging)
U01AG062943 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
R01AG072547 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
U01AG072579 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
R01AG030653 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
U19AG074865 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
R01AG026390 (NIH – National Institute On Aging)
R01AG041718 (NIH – National Institute On Aging)
P30AG066462 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
U01AG010483 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
U01AG024904 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
U01AG057659 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
U01AG046161 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
RF1AG059018 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
P30AG066518 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
RF1AG057473 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
U54AG052427 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
R01AG041232 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
R01AG048015 (NIH – National Institute On Aging)
R01AG064614 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
R01AG036042 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
RC2AG036547 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
P01AG002219 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
P50AG008671 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
P01AG010491 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
Publication Type:
Article
Unique ID:
10.1002/alz.13880
PMID:
38958117
DOI:
10.1002/alz.13880
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews

Li, D., Farrell, J. J., Mez, J., Martin, E. R., Bush, W. S., Ruiz, A., Boada, M., de Rojas, I., Mayeux, R., Haines, J. L., Vance, M. A. P., Wang, L., Schellenberg, G. D., Lunetta, K. L., & Farrer, L. A. (2023). Novel loci for Alzheimer’s disease identified by a genome‐wide association study in Ashkenazi Jews. Alzheimer’s & Dementia, 19(12), 5550–5562. Portico. https://doi.org/10.1002/alz.13117
Authors:
Donghe Li
John J. Farrell
Jesse Mez
Eden R. Martin
William S. Bush
Agustin Ruiz
Mercè Boada
Itziar de Rojas
Richard Mayeux
Jonathan L. Haines
Margaret A. Pericak Vance
Li-San Wang
Gerard D. Schellenberg
Kathryn L. Lunetta
Lindsay A. Farrer
Affiliated Authors:
Richard Mayeux
Columbia Affiliation:
Author Keywords:
alzheimer's disease
ashkenazi jews
founder population
genome-wide association study
Grants:
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
U01HL096812 (NIH – National Heart, Lung, and Blood Institute)
U01HL096902 (NIH – National Heart, Lung, and Blood Institute)
U01HL096899 (NIH – National Heart, Lung, and Blood Institute)
U01HL130114 (NIH – National Heart, Lung, and Blood Institute)
U01HL096917 (NIH – National Heart, Lung, and Blood Institute)
R01HL085083 (NIH – National Heart, Lung, and Blood Institute)
U01HL096814 (NIH – National Heart, Lung, and Blood Institute)
RC2HL102419 (NIH – National Heart, Lung, and Blood Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U54HG003067 (NIH – National Human Genome Research Institute)
U54HG003273 (NIH – National Human Genome Research Institute)
U54HG003079 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
RC2HG005605 (NIH – National Human Genome Research Institute)
R01NS017950 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS069719 (NIH – National Institute of Neurological Disorders and Stroke)
U01NS041588 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS029993 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS071674 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
P01NS026630 (NIH – National Institute of Neurological Disorders and Stroke)
P50AG005681 (NIH – National Institute On Aging)
R01AG049607 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
U19AG024904 (NIH – National Institute On Aging)
R01AG020098 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
R56AG051876 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
RF1AG054052 (NIH – National Institute On Aging)
U01AG057659 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
U01AG049508 (NIH – National Institute On Aging)
K23AG030944 (NIH – National Institute On Aging)
RF1AG057519 (NIH – National Institute On Aging)
RF1AG058066 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
U19AG068753 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
U01AG052409 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
R01AG023629 (NIH – National Institute On Aging)
P30AG035982 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG072978 (NIH – National Institute On Aging)
U01AG058635 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
RF1AG054074 (NIH – National Institute On Aging)
RF1AG015473 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
U01AG058589 (NIH – National Institute On Aging)
U01AG062602 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
P50AG047270 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
U01AG052411 (NIH – National Institute On Aging)
R01AG033040 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
U01AG062943 (NIH – National Institute On Aging)
RF1AG054023 (NIH – National Institute On Aging)
U01AG049506 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
U54AG052427 (NIH – National Institute On Aging)
P50AG047366 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
RF1AG058267 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
U01AG049505 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
RF1AG051504 (NIH – National Institute On Aging)
P50AG047266 (NIH – National Institute On Aging)
R01AG018016 (NIH – National Institute On Aging)
U01AG049507 (NIH – National Institute On Aging)
UF1AG047133 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
R01AG017919 (NIH – National Institute On Aging)
R01AG011101 (NIH – National Institute On Aging)
RC4AG039085 (NIH – National Institute On Aging)
R01AG021136 (NIH – National Institute On Aging)
R01AG031272 (NIH – National Institute On Aging)
R01AG011380 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1002/alz.13117
PMID:
37260021
DOI:
10.1002/alz.13117
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record

Record Created:

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease

Archer, D. B., Eissman, J. M., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Cuccaro, M. L., Pericak‐Vance, M. A., Farrer, L. A., Wang, L., Schellenberg, G. D., Mayeux, R. P., … Haines, J. L. (2023). Longitudinal change in memory performance as a strong endophenotype for Alzheimer’s disease. Alzheimer’s & Dementia, 20(2), 1268–1283. Portico. https://doi.org/10.1002/alz.13508
Authors:
Derek B Archer
Jaclyn M Eissman
Shubhabrata Mukherjee
Michael L Lee
Seo-Eun Choi
Phoebe Scollard
Emily H Trittschuh
Jesse B Mez
William S Bush
Brian W Kunkle
Adam C Naj
Katherine A Gifford
Michael L Cuccaro
Margaret A Pericak-Vance
Lindsay A Farrer
Li-San Wang
Gerard D Schellenberg
Richard P Mayeux
Jonathan L Haines
Angela L Jefferson
Walter A Kukull
C Dirk Keene
Andrew J Saykin
Paul M Thompson
Eden R Martin
David A Bennett
Lisa L Barnes
Julie A Schneider
Paul K Crane
Logan Dumitrescu
Timothy J Hohman
Affiliated Authors:
Richard P Mayeux
Columbia Affiliation:
Subjects:
Genomic Studies and Association Analyses (OpenAlex Topic)
Molecular Basis of Rett Syndrome and Related Disorders (OpenAlex Topic)
MicroRNA Regulation in Cancer and Development (OpenAlex Topic)
Alzheimer Disease (MeSH)
Author Keywords:
alzheimer's disease
genetics
gwas
memory
Grants:
K12HD043483 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
UL1TR000445 (NIH – National Center for Advancing Translational Sciences)
U01HG004610 (NIH – National Human Genome Research Institute)
UF1NS100598 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS100980 (NIH – National Institute of Neurological Disorders and Stroke)
R01AG042210 (NIH – National Institute On Aging)
U01AG068057 (NIH – National Institute On Aging)
R01AG048015 (NIH – National Institute On Aging)
P30AG066518 (NIH – National Institute On Aging)
P30AG072946 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
P30AG072973 (NIH – National Institute On Aging)
R01AG062634 (NIH – National Institute On Aging)
P30AG072977 (NIH – National Institute On Aging)
U01AG024904 (NIH – National Institute On Aging)
P30AG066530 (NIH – National Institute On Aging)
U19AG066567 (NIH – National Institute On Aging)
P20AG068077 (NIH – National Institute On Aging)
RF1AG054080 (NIH – National Institute On Aging)
R01AG064614 (NIH – National Institute On Aging)
P30AG072972 (NIH – National Institute On Aging)
F31AG077791 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
R01AG062826 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
P30AG066519 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
RF1AG057473 (NIH – National Institute On Aging)
P30AG066515 (NIH – National Institute On Aging)
K24AG046373 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
R01AG061518 (NIH – National Institute On Aging)
P30AG072958 (NIH – National Institute On Aging)
K23AG045966 (NIH – National Institute On Aging)
R01AG056534 (NIH – National Institute On Aging)
U24AG072122 (NIH – National Institute On Aging)
P30AG066462 (NIH – National Institute On Aging)
P30AG066546 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
P30AG072975 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
P30AG066507 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
K01AG049164 (NIH – National Institute On Aging)
P30AG072947 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
P30AG072978 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
R01AG079280 (NIH – National Institute On Aging)
P20AG068024 (NIH – National Institute On Aging)
P30AG062421 (NIH – National Institute On Aging)
P30AG062715 (NIH – National Institute On Aging)
P30AG062677 (NIH – National Institute On Aging)
P30AG072976 (NIH – National Institute On Aging)
R01AG064877 (NIH – National Institute On Aging)
P30AG066512 (NIH – National Institute On Aging)
R01AG073439 (NIH – National Institute On Aging)
RF1AG058501 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
RF1AG053303 (NIH – National Institute On Aging)
U01AG046161 (NIH – National Institute On Aging)
P30AG066506 (NIH – National Institute On Aging)
P30AG072931 (NIH – National Institute On Aging)
R21AG059941 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
P30AG066511 (NIH – National Institute On Aging)
P30AG066508 (NIH – National Institute On Aging)
U54AG052427 (NIH – National Institute On Aging)
R01AG044546 (NIH – National Institute On Aging)
R01AG034962 (NIH – National Institute On Aging)
P20AG068082 (NIH – National Institute On Aging)
U01AG058922 (NIH – National Institute On Aging)
P20AG068053 (NIH – National Institute On Aging)
R01AG059716 (NIH – National Institute On Aging)
U19AG068753 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
K01AG073584 (NIH – National Institute On Aging)
U24AG074855 (NIH – National Institute On Aging)
P30AG062429 (NIH – National Institute On Aging)
R01AG036042 (NIH – National Institute On Aging)
P30AG066468 (NIH – National Institute On Aging)
P30AG066514 (NIH – National Institute On Aging)
P30AG072959 (NIH – National Institute On Aging)
RC2AG036547 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
S10OD023680 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1002/alz.13508
PMID:
37985223
DOI:
10.1002/alz.13508
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View OpenAlex Record

Record Created:

Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Heath, L., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., Martin, E. R., Naj, A. C., Ertekin-Taner, N., Golde, T. E., Hood, L., Price, N. D., Abner, E., Adams, P. M., … Zhao, Y. (2022). Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-09825-2
Authors:
Laura Heath
John C. Earls
Andrew T. Magis
Sergey A. Kornilov
Jennifer C. Lovejoy
Cory C. Funk
Noa Rappaport
Benjamin A. Logsdon
Lara M. Mangravite
Brian W. Kunkle
Eden R. Martin
Adam C. Naj
Nilüfer Ertekin-Taner
Todd E. Golde
Leroy Hood
Nathan D. Price
Erin Abner
Perrie M. Adams
Marilyn S. Albert
Roger L. Albin
Mariet Allen
Alexandre Amlie-Wolf
Liana G. Apostolova
Steven E. Arnold
Sanjay Asthana
Craig S. Atwood
Clinton T. Baldwin
Robert C. Barber
Lisa L. Barnes
Sandra Barral
Thomas G. Beach
James T. Becker
Gary W. Beecham
Duane Beekly
David Bennett
Eileen H. Bigio
Thomas D. Bird
Deborah Blacker
Bradley F. Boeve
James D. Bowen
Adam Boxer
James R. Burke
Jeffrey M. Burns
Will Bush
Mariusz Butkiewicz
Joseph D. Buxbaum
Nigel J. Cairns
Laura B. Cantwell
Chuanhai Cao
Chris S. Carlson
Cynthia M. Carlsson
Regina M. Carney
Helena C. Chui
Paul K. Crane
David H. Cribbs
Elizabeth A. Crocco
Michael L. Cuccaro
Philip L. De Jager
Charles DeCarli
Malcolm Dick
Dennis W. Dickson
Beth A. Dombroski
Rachelle S. Doody
Ranjan Duara
Nilufer Ertekin-Taner
Denis A. Evans
Kelley M. Faber
Thomas J. Fairchild
Kenneth B. Fallon
David W. Fardo
Martin R. Farlow
Lindsay A. Farrer
Steven Ferris
Tatiana M. Foroud
Matthew P. Frosch
Douglas R. Galasko
Marla Gearing
Daniel H. Geschwind
Bernardino Ghetti
John R. Gilbert
Alison M. Goate
Robert C. Green
John H. Growdon
Jonathan Haines
Hakon Hakonarson
Ronald L. Hamilton
Kara L. Hamilton-Nelson
Lindy E. Harrell
Lawrence S. Honig
Ryan M. Huebinger
Matthew J. Huentelman
Christine M. Hulette
Bradley T. Hyman
Gail P. Jarvik
Lee-Way Jin
Gyungah R. Jun
M. Ilyas Kamboh
Anna Karydas
Mindy J. Katz
Jeffrey A. Kaye
C. Dirk Keene
Ronald Kim
Neil W. Kowall
Joel H. Kramer
Walter A. Kukull
Amanda B. Kuzma
Frank M. LaFerla
James J. Lah
Eric B. Larson
James B. Leverenz
Allan I. Levey
Andrew P. Lieberman
Richard B. Lipton
Kathryn L. Lunetta
Constantine G. Lyketsos
John Malamon
Daniel C. Marson
Frank Martiniuk
Deborah C. Mash
Eliezer Masliah
Richard Mayeux
Wayne C. McCormick
Susan M. McCurry
Andrew N. McDavid
Ann C. McKee
Marsel Mesulam
Bruce L. Miller
Carol A. Miller
Joshua W. Miller
Thomas J. Montine
John C. Morris
Shubhabrata Mukherjee
Amanda J. Myers
Adam C. Naj
Sid O’Bryant
John M. Olichney
Joseph E. Parisi
Henry L. Paulson
Margaret A. Pericak-Vance
William R. Perry
Elaine Peskind
Ronald C. Petersen
Aimee Pierce
Wayne W. Poon
Huntington Potter
Liming Qu
Joseph F. Quinn
Ashok Raj
Murray Raskind
Eric M. Reiman
Barry Reisberg
Joan S. Reisch
Christiane Reitz
John M. Ringman
Erik D. Roberson
Ekaterina Rogaeva
Howard J. Rosen
Roger N. Rosenberg
Donald R. Royall
Mark A. Sager
Mary Sano
Andrew J. Saykin
Gerard D. Schellenberg
Julie A. Schneider
Lon S. Schneider
William W. Seeley
Susan Slifer
Amanda G. Smith
Yeunjoo Song
Joshua A. Sonnen
Salvatore Spina
Peter St George-Hyslop
Robert A. Stern
Russell H. Swerdlow
Mitchell Tang
Rudolph E. Tanzi
John Q. Trojanowski
Juan C. Troncoso
Debby W. Tsuang
Otto Valladares
Vivianna M. Van Deerlin
Linda J. Van Eldik
Jeffery Vance
Badri N. Vardarajan
Harry V. Vinters
Jean Paul Vonsattel
Li-San Wang
Sandra Weintraub
Kathleen A. Welsh-Bohmer
Patrice Whitehead
Kirk C. Wilhelmsen
Jennifer Williamson
Thomas S. Wingo
Randall L. Woltjer
Clinton B. Wright
Chuang-Kuo Wu
Steven G. Younkin
Chang-En Yu
Lei Yu
Yi Zhao
Affiliated Authors:
Sandra Barral
Philip L. De Jager
Lawrence S. Honig
Richard Mayeux
Christiane Reitz
John M. Ringman
Badri N. Vardarajan
Jean Paul Vonsattel
Jennifer Williamson
Columbia Affiliation:
Grants:
R01CA129769 (NIH – National Cancer Institute)
KL2RR024151 (NIH – National Center for Research Resources)
UL1RR029893 (NIH – National Center for Research Resources)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
R01MH080295 (NIH – National Institute of Mental Health)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
P30AG010129 (NIH – National Institute On Aging)
P30AG066518 (NIH – National Institute On Aging)
P30AG072980 (NIH – National Institute On Aging)
P30AG072977 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
P30AG072976 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
R01AG061796 (NIH – National Institute On Aging)
P30AG072972 (NIH – National Institute On Aging)
U01AG010483 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
U19AG023122 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
R01AG012101 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
RF1AG051504 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
R01AG062634 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
P30AG072975 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
U01AG024904 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
P50AG008671 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
P01AG002219 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
Publication Type:
Article
Unique ID:
10.1038/s41598-022-09825-2
PMID:
35413975
DOI:
10.1038/s41598-022-09825-2
Journal:
Scientific Reports
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record

Record Created:

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

Jun, G. R., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Bennett, D. A., Foroud, T. M., Wang, L., Haines, J. L., Mayeux, R., Pericak‐Vance, M. A., Schellenberg, G. D., Au, R., Lunetta, K. L., Ikezu, T., … Farrer, L. A. (2022). Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer’s disease. Alzheimer’s & Dementia, 18(11), 2042–2054. Portico. https://doi.org/10.1002/alz.12607
Authors:
Gyungah R. Jun
Yang You
Congcong Zhu
Gaoyuan Meng
Jaeyoon Chung
Rebecca Panitch
Junming Hu
Weiming Xia
David A. Bennett
Tatiana M. Foroud
Li-San Wang
Jonathan L. Haines
Richard Mayeux
Margaret A. Pericak-Vance
Gerard D. Schellenberg
Rhoda Au
Kathryn L. Lunetta
Tsuneya Ikezu
Thor D. Stein
Lindsay A. Farrer
Affiliated Authors:
Richard Mayeux
Columbia Affiliation:
Author Keywords:
alzheimer's disease
apolipoprotein e
c4b
human induced pluripotent stem cells
ppp2cb
tau protein
Grants:
R01CA129769 (NIH – National Cancer Institute)
R01CA109650 (NIH – National Cancer Institute)
KL2RR024151 (NIH – National Center for Research Resources)
UL1RR029893 (NIH – National Center for Research Resources)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
R01MH080295 (NIH – National Institute of Mental Health)
P50MH060451 (NIH – National Institute of Mental Health)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
R21NS104609 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
P50AG005146 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
U19AG068753 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
R01AG067763 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
R01AG041718 (NIH – National Institute On Aging)
U01AG010483 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
RF1AG054199 (NIH – National Institute On Aging)
U01AG062602 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
RF1AG054156 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
R01AG072719 (NIH – National Institute On Aging)
R01AG030653 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
RF1AG057519 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
R01AG012101 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
P30AG062715 (NIH – National Institute On Aging)
P30AG072978 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
R01AG041232 (NIH – National Institute On Aging)
RF1AG057768 (NIH – National Institute On Aging)
R01AG008122 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
R01AG066429 (NIH – National Institute On Aging)
R01AG054672 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
R56AG069130 (NIH – National Institute On Aging)
P30AG072975 (NIH – National Institute On Aging)
RF1AG015819 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
R01AG026390 (NIH – National Institute On Aging)
P30AG072976 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
P01AG010491 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
P50AG008671 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
P01AG002219 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
I01CX001038 (NIH – Veterans Affairs)
Publication Type:
Article
Unique ID:
10.1002/alz.12607
PMID:
35142023
DOI:
10.1002/alz.12607
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View Web of Science Record

Record Created:

Multiancestral polygenic risk score for pediatric asthma

Namjou, B., Lape, M., Malolepsza, E., DeVore, S. B., Weirauch, M. T., Dikilitas, O., Jarvik, G. P., Kiryluk, K., Kullo, I. J., Liu, C., Luo, Y., Satterfield, B. A., Smoller, J. W., Walunas, T. L., Connolly, J., Sleiman, P., Mersha, T. B., Mentch, F. D., Hakonarson, H., … Kottyan, L. (2022). Multiancestral polygenic risk score for pediatric asthma. Journal of Allergy and Clinical Immunology, 150(5), 1086–1096. https://doi.org/10.1016/j.jaci.2022.03.035
Authors:
Bahram Namjou
Michael Lape
Edyta Malolepsza
Stanley B DeVore
Matthew T Weirauch
Ozan Dikilitas
Gail P Jarvik
Krzysztof Kiryluk
Iftikhar J Kullo
Cong Liu
Yuan Luo
Benjamin A Satterfield
Jordan W Smoller
Theresa L Walunas
John Connolly
Patrick Sleiman
Tesfaye B Mersha
Frank D Mentch
Hakon Hakonarson
Cynthia A Prows
Jocelyn M Biagini
Gurjit K Khurana Hershey
Lisa J Martin
Leah Kottyan
Affiliated Authors:
Krzysztof Kiryluk
Cong Liu
Columbia Affiliation:
Subjects:
Genome-Wide Association Study (MeSH)
Asthma (MeSH)
Author Keywords:
genetics
asthma
gwas
polygenic risk score
prs
phewas
Grants:
R01HD089458 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R01HD099775 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R01HL135114 (NIH – National Heart, Lung, and Blood Institute)
R01HL132344 (NIH – National Heart, Lung, and Blood Institute)
R01HL132153 (NIH – National Heart, Lung, and Blood Institute)
R21HL145422 (NIH – National Heart, Lung, and Blood Institute)
U01HG006380 (NIH – National Human Genome Research Institute)
U01HG006378 (NIH – National Human Genome Research Institute)
U01HG011181 (NIH – National Human Genome Research Institute)
U01HG011176 (NIH – National Human Genome Research Institute)
R01HG011411 (NIH – National Human Genome Research Institute)
U01HG006382 (NIH – National Human Genome Research Institute)
U01HG008666 (NIH – National Human Genome Research Institute)
U01HG008680 (NIH – National Human Genome Research Institute)
U01HG011169 (NIH – National Human Genome Research Institute)
U01HG008672 (NIH – National Human Genome Research Institute)
U01HG006830 (NIH – National Human Genome Research Institute)
U01HG011172 (NIH – National Human Genome Research Institute)
R01HG010730 (NIH – National Human Genome Research Institute)
U01HG011167 (NIH – National Human Genome Research Institute)
U01HG008679 (NIH – National Human Genome Research Institute)
U01HG006388 (NIH – National Human Genome Research Institute)
U01HG006379 (NIH – National Human Genome Research Institute)
U01HG011166 (NIH – National Human Genome Research Institute)
U01HG008684 (NIH – National Human Genome Research Institute)
U01HG008676 (NIH – National Human Genome Research Institute)
U01HG008673 (NIH – National Human Genome Research Institute)
U01HG008685 (NIH – National Human Genome Research Institute)
U01HG006389 (NIH – National Human Genome Research Institute)
U01HG011175 (NIH – National Human Genome Research Institute)
U01HG008664 (NIH – National Human Genome Research Institute)
R01HG010166 (NIH – National Human Genome Research Institute)
U01HG008701 (NIH – National Human Genome Research Institute)
U01HG006385 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG004603 (NIH – National Human Genome Research Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG006828 (NIH – National Human Genome Research Institute)
U01HG004609 (NIH – National Human Genome Research Institute)
U01HG004438 (NIH – National Human Genome Research Institute)
U01HG004424 (NIH – National Human Genome Research Institute)
U01HG004599 (NIH – National Human Genome Research Institute)
U01HG004608 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
U19AI070235 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI127392 (NIH – National Institute of Allergy and Infectious Diseases)
U54AI117804 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI130830 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI150748 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI148276 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI139126 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI024717 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI141569 (NIH – National Institute of Allergy and Infectious Diseases)
R01AR073228 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)
P30AR070549 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)
R01DK107502 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01GM055479 (NIH – National Institute of General Medical Sciences)
R25GM129808 (NIH – National Institute of General Medical Sciences)
R01NS099068 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS096053 (NIH – National Institute of Neurological Disorders and Stroke)
UG3OD023282 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.jaci.2022.03.035
PMID:
35595084
DOI:
10.1016/j.jaci.2022.03.035
Journal:
Journal of Allergy and Clinical Immunology
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., … Lambert, J.-C. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436. https://doi.org/10.1038/s41588-022-01024-z
Authors:
Celine Bellenguez
Benjamin Grenier-Boley
Vincent Damotte
Marcos R. Costa
Julien Chapuis
Philippe Amouyel
Jean-Charles Lambert
Fahri Kucukali
Christine Van Broeckhoven
Jasper Van Dongen
Kristel Sleegers
Iris E. Jansen
Sven J. van der Lee
Henne Holstege
Marc Hulsman
Yolande A. L. Pijnenburg
Philip Scheltens
Niccolo Tesi
Wiesje M. van der Flier
Danielle Posthuma
Luca Kleineidam
Victor Andrade
Michael T. Heneka
Wolfgang Maier
Anja Schneider
Michael Wagner
Frank Jessen
Alfredo Ramirez
Rafael Campos-Martin
Maria Carolina Dalmasso
Klaus Fliessbach
Matthias Schmid
Annika Spottke
Sonia Moreno-Grau
Itziar De Rojas
Pablo Garcia-Gonzalez
Carla Abdelnour
Emilio Alarcon-Martin
Montserrat Alegret
Merce Boada
Miguel Calero
Ana Espinosa
Isabel Hernandez
Marta Marquie
Laura Montrreal
Adelina Orellana
Gemma Ortega
Alba Perez-Cordon
Raquel Puerta
Natalia Roberto
Maitee Rosende-Roca
Oscar Sotolongo-Grau
Juan Pablo Tartan
Lluis Tarraga
Sergi Valero
Agustin Ruiz
Daniel Alcolea
Rafael Blesa
Dolores Buiza-Rueda
Laura Cervera-Carles
Juan Fortea
Maria J. Bullido
Ana Frank-Garcia
Jose Maria Garcia-Alberca
Carmen Lage
Alberto Lleo
Adolfo Lopez de Munain
Angel Martin Montes
Miguel Medina
Pablo Mir
Fermin Moreno
Jordi Perez-Tur
Alberto Rabano
Eloy Rodriguez-Rodriguez
Ingvild Saltvedt
Pascual Sanchez Juan
Miren Zulaica
Jordi Clarimon
Najaf Amin
Amber Yaqub
Ivana Prokic
Shahzad Ahmad
Mohsen Ghanbari
M. Arfan Ikram
Cornelia M. van Duijn
Adam C. Naj
Jin Sha
Valentina Escott-Price
Pavel P. Kuksa
Chien-Yueh Lee
Otto Valladares
Li-San Wang
Yi Zhao
Gerard D. Schellenberg
Peter A. Holmans
Catherine Bresner
Janet Harwood
Lauren Luckcuck
Rachel Marshall
Julie Williams
Rebecca Sims
Anne Boland
Celine Besse
Delphine Daian
Bertrand Fin
Robert Olaso
Jean-Francois Deleuze
Yiyi Ma
Mikko Hiltunen
Teemu Kuulasmaa
Alexa Beiser
Anita Destefano
Kathryn L. Lunetta
Gina Peloso
Ruiqi Wang
Lindsay A. Farrer
Qiong Yang
Lena Kilander
Malin Lowemark
Claudia L. Satizabal
Sudha Seshadri
Oscar Lopez
Bruce M. Psaty
Joshua C. Bis
Vilmantas Giedraitis
Martin Ingelsson
Dag Aarsland
Ignacio Alvarez
Monica Diez-Fairen
Pau Pastor
Victoria Alvarez
Irene Rosas Allende
Carmen Martinez Rodriguez
Manuel Menendez-Gonzalez
Nicola J. Armstrong
Henry Brodaty
Anbupalam Thalamuthu
Perminder Sachdev
Karen Mather
Anthoula Tsolaki
Tegos Thomas
Magda Tsolaki
Carmen Antunez
Ildebrando Appollonio
Elisa Conti
Lucio Tremolizzo
Marina Arcaro
Daniela Galimberti
Elio Scarpini
Silvana Archetti
Alfonso Arias Pastor
Raquel Huerto Vilas
Gerard Pinol-Ripoll
Beatrice Arosio
Simona Ciccone
Paolo Dionigi Rossi
Evelyn Ferri
Lavinia Athanasiu
Srdjan Djurovic
Alexey A. Shadrin
Ole A. Andreassen
Henri Bailly
Emmanuelle Duron
Olivier Hanon
Jean-Sebastien Vidal
Nerisa Banaj
Gianfranco Spalletta
Miquel Baquero
Sandra Barral
Richard Mayeux
Nikolaos Scarmeas
Giuseppe Tosto
Badri N. Vardarajan
Marco Spallazzi
Shima Mehrabian
Latchezar Traykov
Ana Belen Pastor
Teodoro del Ser
Jennifer E. Below
Penelope Benchek
William S. Bush
Michelle Grunin
Jonathan L. Haines
Yeunjoo Song
Luisa Benussi
Giuliano Binetti
Silvia Fostinelli
Roberta Ghidoni
Claudine Berr
Valentina Bessi
Benedetta Nacmias
Sandro Sorbi
Alessandra Bizarro
Alessandra Lauria
Eric Boerwinkle
Jan Bressler
Chloe Sarnowski
Alessandro Padovani
Barbara Borroni
Innocenzo Rainero
Silvia Boschi
Paola Bossu
Sigrid B. Sando
Geir Brathen
Myriam Fornage
Keeley J. Brookes
Luis Ignacio Brusco
Carolina Muchnik
Merel Mol
Jeroen van Rooij
John van Swieten
Katharina Burger
Martin Dichgans
Michael Ewers
Vanessa Burholt
Laura B. Cantwell
Amanda B. Kuzma
Genevieve Chene
Carole Dufouil
Jaeyoon Chung
Gyungah R. Jun
Michael L. Cuccaro
Jeffery Vance
Ines Quintela
Roberta Cecchetti
Patrizia Mecocci
Michela Scamosci
Camille Charbonnier
Gael Nicolas
Olivier Quenez
Hung-Hsin Chen
Caterina Chillotti
Jurgen A. H. R. Claassen
Christopher Clark
Anais Corma-Gomez
Marta Fernandez-Fuertes
Juan Macias
Juan A. Pineda
Luis M. Real
Emanuele Costantini
Antonio Daniele
Michela Orsini
Carlo Custodero
Vincenzo Solfrizzi
Efthimios Dardiotis
Jean-Francois Dartigues
Stephanie Debette
Peter Paul de Deyn
Katia de Paiva Lopes
Jack Humphrey
Towfique Raj
Lot D. De Witte
Gijsje J. L. Snijders
Jurgen Deckert
Martin J. Herrmann
Thomas Polak
Nicola Denning
Alun Meggy
Janine Diehl-Schmid
Oliver Goldhardt
Timo Grimmer
Emrah Duzel
Gudny Eiriksdottir
Sebastiaan Engelborghs
Kelley M. Faber
Tatiana M. Foroud
Tagliavini Fabrizio
Giaccone Giorgio
Giacomina Rossi
Sune Fallgaard Nielsen
Borge G. Nordestgaard
David W. Fardo
Lucia Farotti
Lucilla Parnetti
Chiara Fenoglio
Raffaele Ferrari
John Hardy
Catarina B. Ferreira
Alexandre de Mendonca
Peter Fischer
Tormod Fladby
Geir Selbaek
Bernard Fongang
Xueqiu Jian
Habil Zare
Nick C. Fox
Jonathan M. Schott
Emlio Franco-Macias
Maria Bernal Sanchez-Arjona
Lutz Froelich
Lucrezia Hausner
Brian Fulton-Howard
Alison M. Goate
Silvia Mendoza
Sebastian Garcia-Madrona
Guillermo Garcia-Ribas
Ina Giegling
Annette M. Hartmann
Dan Rujescu
Duber Gomez-Fonseca
Antonio Gonzalez-Perez
Maria Eugenia Saez
Caroline Graff
Charlotte Johansson
Anne Kinhult Stahlbom
Abbe Ullgren
Giulia Grande
Erika J. Laukka
Goran Papenberg
Emma Green
Edna Grunblatt
Vilmundur Gudnason
Tamar Guetta-Baranes
Kevin Morgan
Annakaisa Haapasalo
Margaret A. Pericak-Vance
Georgios Hadjigeorgiou
Brian W. Kunkle
Kara L. Hamilton-Nelson
Eden R. Martin
Farid Rajabli
Susan Slifer
Harald Hampel
Stefanie Heilmann-Heimbach
Per Hoffmann
Markus M. Nothen
Seppo Helisalmi
Anne Koivisto
Jenni Lehtisalo
Hilkka Soininen
Alina Solomon
Clive Holmes
Geert Jan Biessels
Yuriko Kastumata
John Kauwe
Patrick G. Kehoe
Seth Love
Olivia Skrobot
Miia Kivipelto
Francesca Mangialasche
Johannes Kornhuber
Mary H. Kosmidis
Walter A. Kukull
William Longstreth
Lenore Launer
Jakub Hort
Tiia Ngandu
Ondrej Lerch
Martin Vyhnalek
Dolly Reyes-Dumeyer
Catherine A. Macleod
Gill Windle
Bob Woods
Carlo Masullo
Christiane Reitz
Simon Mead
Susanne Moebus
Laura Molina-Porcel
Laura Morelli
Thomas Mosley
Shubhabrata Mukherjee
Anne Tybjaerg-Hansen
Ruth Frikke-Schmidt
Caffarra Paolo
Florence Pasquier
Pierre Pericard
Oliver Peters
Josef Priller
Laudia Pisanu
Julius Popp
Jesper Qvist Thomassen
Inez Ramakers
Frans Verhey
Marcel J. T. Reinders
Perry Ridge
Steffi Riedel-Heller
Peter Riederer
Arvid Rongve
Jose Luis Royo
Elisa Rubino
Paraskevi Sakka
Florentino Sanchez-Garcia
Raquel Sanchez-Valle
Norbert Scherbaum
Martin Scherer
Leonie Weinhold
Ingun Ulstein
Davide Seripa
Manuel Serrano
Alessio Squassina
Eystein Stordal
Andre Uitterlinden
Aad van der Lugt
Rik Vandenberghe
Jonathan Vogelgsang
Jens Wiltfang
David Wallon
Mary Yannakoulia
Xiaoling Zhang
Congcong Zhu
Affiliated Authors:
Yiyi Ma
Sandra Barral
Richard Mayeux
Nikolaos Scarmeas
Giuseppe Tosto
Badri N. Vardarajan
Dolly Reyes-Dumeyer
Christiane Reitz
Columbia Affiliation:
Grants:
R01CA129769 (NIH – National Cancer Institute)
UL1TR001445 (NIH – National Center for Advancing Translational Sciences)
UL1RR029893 (NIH – National Center for Research Resources)
KL2RR024151 (NIH – National Center for Research Resources)
T32EY007157 (NIH – National Eye Institute)
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
U01HL130114 (NIH – National Heart, Lung, and Blood Institute)
R01HL085083 (NIH – National Heart, Lung, and Blood Institute)
R01HL120393 (NIH – National Heart, Lung, and Blood Institute)
R01HL103612 (NIH – National Heart, Lung, and Blood Institute)
R01HL087652 (NIH – National Heart, Lung, and Blood Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
P30DK063491 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01MH080295 (NIH – National Institute of Mental Health)
UH2NS100605 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS017950 (NIH – National Institute of Neurological Disorders and Stroke)
U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS118146 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
U01AG046161 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P01AG003949 (NIH – National Institute On Aging)
U01AG052409 (NIH – National Institute On Aging)
RF1AG059421 (NIH – National Institute On Aging)
R01AG033040 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
U01AG049505 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
R01AG030653 (NIH – National Institute On Aging)
P30AG066530 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
R01AG023651 (NIH – National Institute On Aging)
R01AG023629 (NIH – National Institute On Aging)
F99AG073565 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
R01AG041718 (NIH – National Institute On Aging)
P30AG072976 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
R01AG041232 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
U01AG006786 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
U01AG068880 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
ZIAAG007270 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
P30AG053760 (NIH – National Institute On Aging)
R56AG055824 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
R01AG020098 (NIH – National Institute On Aging)
U01AG024904 (NIH – National Institute On Aging)
U19AG068753 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
R01AG036042 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
R01AG054005 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
U19AG062418 (NIH – National Institute On Aging)
K08AG065463 (NIH – National Institute On Aging)
P30AG066512 (NIH – National Institute On Aging)
P30AG066511 (NIH – National Institute On Aging)
P30AG062715 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
P01AG066597 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
U19AG024904 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
P30AG072977 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R01AG037985 (NIH – National Institute On Aging)
R01AG018023 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
RF1AG057473 (NIH – National Institute On Aging)
R01AG062622 (NIH – National Institute On Aging)
P30AG072980 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
P01AG017586 (NIH – National Institute On Aging)
R21AG063130 (NIH – National Institute On Aging)
R01AG048015 (NIH – National Institute On Aging)
K99AG066849 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
RF1AG061872 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
P30AG066514 (NIH – National Institute On Aging)
R01AG049607 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
U24AG072122 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
R01AG012101 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
P30AG066462 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
P30AG072972 (NIH – National Institute On Aging)
R56AG057191 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
RF1AG057519 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
P01AG017216 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
RF1AG061351 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
P50AG025711 (NIH – National Institute On Aging)
R01AG011101 (NIH – National Institute On Aging)
RC2AG036547 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
P01AG002219 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
P01AG010491 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
Publication Type:
Article
Unique ID:
10.1038/s41588-022-01024-z
PMID:
35379992
DOI:
10.1038/s41588-022-01024-z
Journal:
Nature Genetics
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record

Record Created:

An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns

Jin, B., Capra, J. A., Benchek, P., Wheeler, N., Naj, A. C., Hamilton-Nelson, K. L., Farrell, J. J., Leung, Y. Y., Kunkle, B., Vadarajan, B., Schellenberg, G. D., Mayeux, R., Wang, L.-S., Farrer, L. A., Pericak-Vance, M. A., Martin, E. R., Haines, J. L., Crawford, D. C., & Bush, W. S. (2022). An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer’s disease–related patterns. Genome Research, 32(4), 778–790. https://doi.org/10.1101/gr.276069.121
Authors:
Bowen Jin
John A. Capra
Penelope Benchek
Nicholas Wheeler
Jonathan L. Haines
Dana C. Crawford
William S. Bush
Adam C. Naj
Yuk Yee Leung
Gerard D. Schellenberg
Li-San Wang
Kara L. Hamilton-Nelson
Brian Kunkle
Margaret A. Pericak-Vance
Eden R. Martin
John J. Farrell
Lindsay A. Farrer
Badri Vadarajan
Richard Mayeux
Affiliated Authors:
Badri Vadarajan
Richard Mayeux
Columbia Affiliation:
Grants:
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
U01HL096902 (NIH – National Heart, Lung, and Blood Institute)
U01HL096917 (NIH – National Heart, Lung, and Blood Institute)
U01HL096814 (NIH – National Heart, Lung, and Blood Institute)
R01HL085083 (NIH – National Heart, Lung, and Blood Institute)
U01HL096812 (NIH – National Heart, Lung, and Blood Institute)
U01HL096899 (NIH – National Heart, Lung, and Blood Institute)
U01HL130114 (NIH – National Heart, Lung, and Blood Institute)
RC2HL102419 (NIH – National Heart, Lung, and Blood Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U54HG003273 (NIH – National Human Genome Research Institute)
U54HG003079 (NIH – National Human Genome Research Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U54HG003067 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
RC2HG005605 (NIH – National Human Genome Research Institute)
R01GM126249 (NIH – National Institute of General Medical Sciences)
U01NS041588 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS071674 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS029993 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS069719 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS017950 (NIH – National Institute of Neurological Disorders and Stroke)
P01NS026630 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
R01AG032990 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
R03AG054936 (NIH – National Institute On Aging)
U01AG058589 (NIH – National Institute On Aging)
RF1AG054074 (NIH – National Institute On Aging)
U01AG062943 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
U01AG052409 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
RF1AG058267 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
U01AG062602 (NIH – National Institute On Aging)
U01AG057659 (NIH – National Institute On Aging)
K23AG030944 (NIH – National Institute On Aging)
P30AG035982 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
P50AG047270 (NIH – National Institute On Aging)
P50AG047366 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
R01AG049607 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
RF1AG058066 (NIH – National Institute On Aging)
RF1AG051504 (NIH – National Institute On Aging)
R01AG023629 (NIH – National Institute On Aging)
UF1AG047133 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
U54AG052427 (NIH – National Institute On Aging)
RF1AG054023 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
U01AG049507 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
U01AG049505 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
U01AG049506 (NIH – National Institute On Aging)
U01AG052411 (NIH – National Institute On Aging)
R56AG051876 (NIH – National Institute On Aging)
P30AG066518 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
RF1AG057519 (NIH – National Institute On Aging)
R01AG018016 (NIH – National Institute On Aging)
RF1AG015473 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
R01AG020098 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
U01AG049508 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
P50AG047266 (NIH – National Institute On Aging)
U19AG024904 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
RF1AG054052 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
U01AG058635 (NIH – National Institute On Aging)
R01AG033040 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
RC4AG039085 (NIH – National Institute On Aging)
R01AG021136 (NIH – National Institute On Aging)
R01AG011380 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
R01AG031272 (NIH – National Institute On Aging)
R01AG011101 (NIH – National Institute On Aging)
R01AG017919 (NIH – National Institute On Aging)
R01LM012535 (NIH – National Library of Medicine)
Publication Type:
Article
Unique ID:
10.1101/gr.276069.121
PMID:
35210353
DOI:
10.1101/gr.276069.121
Journal:
Genome Research
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record

Record Created:

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

Kunkle, B. W., Schmidt, M., Klein, H.-U., Naj, A. C., Hamilton-Nelson, K. L., Larson, E. B., Evans, D. A., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Ertekin-Taner, N., Barnes, L. L., Fallin, M. D., Manly, J. J., Go, R. C. P., Obisesan, T. O., Kamboh, M. I., Bennett, D. A., Hall, K. S., … Kukull, W. A. (2021). Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel. JAMA Neurology, 78(1), 102. https://doi.org/10.1001/jamaneurol.2020.3536
Authors:
Brian W. Kunkle
Michael Schmidt
Hans-Ulrich Klein
Adam C. Naj
Kara L. Hamilton-Nelson
Eric B. Larson
Denis A. Evans
Phil L. De Jager
Paul K. Crane
Joe D. Buxbaum
Nilufer Ertekin-Taner
Lisa L. Barnes
M. Daniele Fallin
Jennifer J. Manly
Rodney C. P. Go
Thomas O. Obisesan
M. Ilyas Kamboh
David A. Bennett
Kathleen S. Hall
Alison M. Goate
Tatiana M. Foroud
Eden R. Martin
Li-Sao Wang
Goldie S. Byrd
Lindsay A. Farrer
Jonathan L. Haines
Gerard D. Schellenberg
Richard Mayeux
Margaret A. Pericak-Vance
Christiane Reitz
Neill R. Graff-Radford
Izri Martinez
Temitope Ayodele
Mark W. Logue
Laura B. Cantwell
Melissa Jean-Francois
Amanda B. Kuzma
L.D. Adams
Jeffery M. Vance
Michael L. Cuccaro
Jaeyoon Chung
Jesse Mez
Kathryn L. Lunetta
Gyungah R. Jun
Oscar L. Lopez
Hugh C. Hendrie
Eric M. Reiman
Neil W. Kowall
James B. Leverenz
Scott A. Small
Allan I. Levey
Todd E. Golde
Andrew J. Saykin
Takiyah D. Starks
Marilyn S. Albert
Bradley T. Hyman
Ronald C. Petersen
Mary Sano
Thomas Wisniewski
Robert Vassar
Jeffrey A. Kaye
Victor W. Henderson
Charles Decarli
Frank M. Laferla
James B. Brewer
Bruce L. Miller
Russell H. Swerdlow
Linda J. Van Eldik
Henry L. Paulson
John Q. Trojanowski
Helena C. Chui
Roger N. Rosenberg
Suzanne Craft
Thomas J. Grabowski
Sanjay Asthana
John C. Morris
Stephen M. Strittmatter
Walter A. Kukull
Affiliated Authors:
Hans-Ulrich Klein
Phil L. De Jager
Jennifer J. Manly
Richard Mayeux
Christiane Reitz
Izri Martinez
Temitope Ayodele
Scott A. Small
Columbia Affiliation:
Subjects:
Black or African American (MeSH)
Alzheimer Disease (MeSH)
Genetic Predisposition to Disease (MeSH)
Grants:
UL1TR001863 (NIH – National Center for Advancing Translational Sciences)
UL1TR002369 (NIH – National Center for Advancing Translational Sciences)
KL2RR024151 (NIH – National Center for Research Resources)
U01HG004610 (NIH – National Human Genome Research Institute)
P50AG005142 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
P30AG066508 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
P30AG062715 (NIH – National Institute On Aging)
P30AG035982 (NIH – National Institute On Aging)
P30AG066507 (NIH – National Institute On Aging)
P30AG066468 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
U01AG052410 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
P30AG066515 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
RF1AG054080 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P50AG047366 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
P30AG066512 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
RF1AG054023 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
K25AG055620 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
U01AG058635 (NIH – National Institute On Aging)
P50AG047270 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
P30AG049638 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
P30AG062428 (NIH – National Institute On Aging)
RF1AG066107 (NIH – National Institute On Aging)
P30AG053760 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG062421 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
RF1AG051504 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
P30AG062429 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
R01AG061796 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
P50AG047266 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1001/jamaneurol.2020.3536
PMID:
33074286
DOI:
10.1001/jamaneurol.2020.3536
Journal:
JAMA Neurology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View PubMed Record

Record Created:

CSV