R01HG010730

NIH – National Human Genome Research Institute

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X.-J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., … Gharavi, A. G. (2023). Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nature Genetics, 55(7), 1091–1105. https://doi.org/10.1038/s41588-023-01422-x

Authors:

Krzysztof Kiryluk

Elena Sanchez-Rodriguez

Xu-Jie Zhou

Francesca Zanoni

Lili Liu

Nikol Mladkova

Atlas Khan

Maddalena Marasa

Jun Y Zhang

Olivia Balderes

Simone Sanna-Cherchi

Andrew S Bomback

Pietro A Canetta

Gerald B Appel

Jai Radhakrishnan

Hernan Trimarchi

Ben Sprangers

Daniel C Cattran

Heather Reich

York Pei

Pietro Ravani

Kresimir Galesic

Dita Maixnerova

Vladimir Tesar

Benedicte Stengel

Marie Metzger

Guillaume Canaud

Nicolas Maillard

Francois Berthoux

Laureline Berthelot

Evangeline Pillebout

Renato Monteiro

Raoul Nelson

Robert J Wyatt

William Smoyer

John Mahan

Al-Akash Samhar

Guillermo Hidalgo

Alejandro Quiroga

Patricia Weng

Raji Sreedharan

David Selewski

Keefe Davis

Mahmoud Kallash

Tetyana L Vasylyeva

Michelle Rheault

Aftab Chishti

Daniel Ranch

Scott E Wenderfer

Dmitry Samsonov

Donna J Claes

Oleh Akchurin

Dimitrios Goumenos

Maria Stangou

Judit Nagy

Tibor Kovacs

Enrico Fiaccadori

Antonio Amoroso

Cristina Barlassina

Daniele Cusi

Lucia Del Vecchio

Giovanni Giorgio Battaglia

Monica Bodria

Emanuela Boer

Luisa Bono

Giuliano Boscutti

Gianluca Caridi

Francesca Lugani

GianMarco Ghiggeri

Rosanna Coppo

Licia Peruzzi

Vittoria Esposito

Ciro Esposito

Sandro Feriozzi

Rosaria Polci

Giovanni Frasca

Marco Galliani

Maurizio Garozzo

Adele Mitrotti

Loreto Gesualdo

Simona Granata

Gianluigi Zaza

Francesco Londrino

Riccardo Magistroni

Isabella Pisani

Andrea Magnano

Carmelita Marcantoni

Piergiorgio Messa

Renzo Mignani

Antonello Pani

Claudio Ponticelli

Dario Roccatello

Maurizio Salvadori

Erica Salvi

Domenico Santoro

Guido Gembillo

Silvana Savoldi

Donatella Spotti

Pasquale Zamboli

Claudia Izzi

Federico Alberici

Elisa Delbarba

Michał Florczak

Natalia Krata

Krzysztof Mucha

Leszek Pączek

Stanisław Niemczyk

Barbara Moszczuk

Malgorzata Pańczyk-Tomaszewska

Malgorzata Mizerska-Wasiak

Agnieszka Perkowska-Ptasińska

Teresa Bączkowska

Magdalena Durlik

Krzysztof Pawlaczyk

Przemyslaw Sikora

Marcin Zaniew

Dorota Kaminska

Magdalena Krajewska

Izabella Kuzmiuk-Glembin

Zbigniew Heleniak

Barbara Bullo-Piontecka

Tomasz Liberek

Alicja Dębska-Slizien

Tomasz Hryszko

Anna Materna-Kiryluk

Monika Miklaszewska

Maria Szczepańska

Katarzyna Dyga

Edyta Machura

Katarzyna Siniewicz-Luzeńczyk

Monika Pawlak-Bratkowska

Marcin Tkaczyk

Dariusz Runowski

Norbert Kwella

Dorota Drożdż

Ireneusz Habura

Florian Kronenberg

Larisa Prikhodina

David van Heel

Bertrand Fontaine

Chris Cotsapas

Cisca Wijmenga

Andre Franke

Vito Annese

Peter K Gregersen

Sreeja Parameswaran

Matthew Weirauch

Leah Kottyan

John B Harley

Hitoshi Suzuki

Ichiei Narita

Shin Goto

Hajeong Lee

Dong Ki Kim

Yon Su Kim

Jin-Ho Park

BeLong Cho

Murim Choi

Ans Van Wijk

Ana Huerta

Elisabet Ars

Jose Ballarin

Sigrid Lundberg

Bruno Vogt

Laila-Yasmin Mani

Yasar Caliskan

Jonathan Barratt

Thilini Abeygunaratne

Philip A Kalra

Daniel P Gale

Ulf Panzer

Thomas Rauen

Jürgen Floege

Pascal Schlosser

Arif B Ekici

Kai-Uwe Eckardt

Nan Chen

Jingyuan Xie

Richard P Lifton

Ruth J F Loos

Eimear E Kenny

Iuliana Ionita-Laza

Anna Köttgen

Bruce A Julian

Jan Novak

Francesco Scolari

Hong Zhang

Ali G Gharavi

Affiliated Authors:

Krzysztof Kiryluk

Elena Sanchez-Rodriguez

Francesca Zanoni

Lili Liu

Nikol Mladkova

Atlas Khan

Maddalena Marasa

Jun Y Zhang

Olivia Balderes

Simone Sanna-Cherchi

Andrew S Bomback

Pietro A Canetta

Gerald B Appel

Jai Radhakrishnan

Iuliana Ionita-Laza

Ali G Gharavi

Columbia Affiliation:

Subjects:

Glomerulonephritis, IGA (MeSH)

Grants:

U01HG008680 (NIH – National Human Genome Research Institute)

R01HG010730 (NIH – National Human Genome Research Institute)

U01AI130830 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI148276 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI149431 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI024717 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI150748 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI150585 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI152960 (NIH – National Institute of Allergy and Infectious Diseases)

R01AR073228 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)

R01DK082753 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK078244 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK105124 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

RC2DK116690 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

P41GM103311 (NIH – National Institute of General Medical Sciences)

R01NS099068 (NIH – National Institute of Neurological Disorders and Stroke)

R01LM013061 (NIH – National Library of Medicine)

Publication Type:

Article

Unique ID:

10.1038/s41588-023-01422-x

PMID:

37337107

DOI:

10.1038/s41588-023-01422-x

Journal:

Nature Genetics

Publication Date:

2023-07-01

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

Record Created:

Friday, August 9, 2024 - 13:59

Multiancestral polygenic risk score for pediatric asthma

Namjou, B., Lape, M., Malolepsza, E., DeVore, S. B., Weirauch, M. T., Dikilitas, O., Jarvik, G. P., Kiryluk, K., Kullo, I. J., Liu, C., Luo, Y., Satterfield, B. A., Smoller, J. W., Walunas, T. L., Connolly, J., Sleiman, P., Mersha, T. B., Mentch, F. D., Hakonarson, H., … Kottyan, L. (2022). Multiancestral polygenic risk score for pediatric asthma. Journal of Allergy and Clinical Immunology, 150(5), 1086–1096. https://doi.org/10.1016/j.jaci.2022.03.035

Authors:

Bahram Namjou

Michael Lape

Edyta Malolepsza

Stanley B DeVore

Matthew T Weirauch

Ozan Dikilitas

Gail P Jarvik

Krzysztof Kiryluk

Iftikhar J Kullo

Cong Liu

Yuan Luo

Benjamin A Satterfield

Jordan W Smoller

Theresa L Walunas

John Connolly

Patrick Sleiman

Tesfaye B Mersha

Frank D Mentch

Hakon Hakonarson

Cynthia A Prows

Jocelyn M Biagini

Gurjit K Khurana Hershey

Lisa J Martin

Leah Kottyan

Affiliated Authors:

Krzysztof Kiryluk

Cong Liu

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Nephrology
- Department of Biomedical Informatics

Subjects:

Genome-Wide Association Study (MeSH)

Asthma (MeSH)

Author Keywords:

genetics

asthma

gwas

polygenic risk score

prs

phewas

Grants:

R01HD089458 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

R01HD099775 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

R01HL135114 (NIH – National Heart, Lung, and Blood Institute)

R01HL132344 (NIH – National Heart, Lung, and Blood Institute)

R01HL132153 (NIH – National Heart, Lung, and Blood Institute)

R21HL145422 (NIH – National Heart, Lung, and Blood Institute)

U01HG006380 (NIH – National Human Genome Research Institute)

U01HG006378 (NIH – National Human Genome Research Institute)

U01HG011181 (NIH – National Human Genome Research Institute)

U01HG011176 (NIH – National Human Genome Research Institute)

R01HG011411 (NIH – National Human Genome Research Institute)

U01HG006382 (NIH – National Human Genome Research Institute)

U01HG008666 (NIH – National Human Genome Research Institute)

U01HG008680 (NIH – National Human Genome Research Institute)

U01HG011169 (NIH – National Human Genome Research Institute)

U01HG008672 (NIH – National Human Genome Research Institute)

U01HG006830 (NIH – National Human Genome Research Institute)

U01HG011172 (NIH – National Human Genome Research Institute)

R01HG010730 (NIH – National Human Genome Research Institute)

U01HG011167 (NIH – National Human Genome Research Institute)

U01HG008679 (NIH – National Human Genome Research Institute)

U01HG006388 (NIH – National Human Genome Research Institute)

U01HG006379 (NIH – National Human Genome Research Institute)

U01HG011166 (NIH – National Human Genome Research Institute)

U01HG008684 (NIH – National Human Genome Research Institute)

U01HG008676 (NIH – National Human Genome Research Institute)

U01HG008673 (NIH – National Human Genome Research Institute)

U01HG008685 (NIH – National Human Genome Research Institute)

U01HG006389 (NIH – National Human Genome Research Institute)

U01HG011175 (NIH – National Human Genome Research Institute)

U01HG008664 (NIH – National Human Genome Research Institute)

R01HG010166 (NIH – National Human Genome Research Institute)

U01HG008701 (NIH – National Human Genome Research Institute)

U01HG006385 (NIH – National Human Genome Research Institute)

U01HG008657 (NIH – National Human Genome Research Institute)

U01HG004603 (NIH – National Human Genome Research Institute)

U01HG006375 (NIH – National Human Genome Research Institute)

U01HG006828 (NIH – National Human Genome Research Institute)

U01HG004609 (NIH – National Human Genome Research Institute)

U01HG004438 (NIH – National Human Genome Research Institute)

U01HG004424 (NIH – National Human Genome Research Institute)

U01HG004599 (NIH – National Human Genome Research Institute)

U01HG004608 (NIH – National Human Genome Research Institute)

U01HG004610 (NIH – National Human Genome Research Institute)

U19AI070235 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI127392 (NIH – National Institute of Allergy and Infectious Diseases)

U54AI117804 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI130830 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI150748 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI148276 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI139126 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI024717 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI141569 (NIH – National Institute of Allergy and Infectious Diseases)

R01AR073228 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)

P30AR070549 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)

R01DK107502 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01GM055479 (NIH – National Institute of General Medical Sciences)

R25GM129808 (NIH – National Institute of General Medical Sciences)

R01NS099068 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS096053 (NIH – National Institute of Neurological Disorders and Stroke)

UG3OD023282 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/j.jaci.2022.03.035

PMID:

35595084

DOI:

10.1016/j.jaci.2022.03.035

Journal:

Journal of Allergy and Clinical Immunology

Publication Date:

2022-11-01

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

View Web of Science Record

Record Created:

Tuesday, September 24, 2024 - 15:34