T32EY007157

NIH – National Eye Institute

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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., … Lambert, J.-C. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436. https://doi.org/10.1038/s41588-022-01024-z
Authors:
Celine Bellenguez
Benjamin Grenier-Boley
Vincent Damotte
Marcos R. Costa
Julien Chapuis
Philippe Amouyel
Jean-Charles Lambert
Fahri Kucukali
Christine Van Broeckhoven
Jasper Van Dongen
Kristel Sleegers
Iris E. Jansen
Sven J. van der Lee
Henne Holstege
Marc Hulsman
Yolande A. L. Pijnenburg
Philip Scheltens
Niccolo Tesi
Wiesje M. van der Flier
Danielle Posthuma
Luca Kleineidam
Victor Andrade
Michael T. Heneka
Wolfgang Maier
Anja Schneider
Michael Wagner
Frank Jessen
Alfredo Ramirez
Rafael Campos-Martin
Maria Carolina Dalmasso
Klaus Fliessbach
Matthias Schmid
Annika Spottke
Sonia Moreno-Grau
Itziar De Rojas
Pablo Garcia-Gonzalez
Carla Abdelnour
Emilio Alarcon-Martin
Montserrat Alegret
Merce Boada
Miguel Calero
Ana Espinosa
Isabel Hernandez
Marta Marquie
Laura Montrreal
Adelina Orellana
Gemma Ortega
Alba Perez-Cordon
Raquel Puerta
Natalia Roberto
Maitee Rosende-Roca
Oscar Sotolongo-Grau
Juan Pablo Tartan
Lluis Tarraga
Sergi Valero
Agustin Ruiz
Daniel Alcolea
Rafael Blesa
Dolores Buiza-Rueda
Laura Cervera-Carles
Juan Fortea
Maria J. Bullido
Ana Frank-Garcia
Jose Maria Garcia-Alberca
Carmen Lage
Alberto Lleo
Adolfo Lopez de Munain
Angel Martin Montes
Miguel Medina
Pablo Mir
Fermin Moreno
Jordi Perez-Tur
Alberto Rabano
Eloy Rodriguez-Rodriguez
Ingvild Saltvedt
Pascual Sanchez Juan
Miren Zulaica
Jordi Clarimon
Najaf Amin
Amber Yaqub
Ivana Prokic
Shahzad Ahmad
Mohsen Ghanbari
M. Arfan Ikram
Cornelia M. van Duijn
Adam C. Naj
Jin Sha
Valentina Escott-Price
Pavel P. Kuksa
Chien-Yueh Lee
Otto Valladares
Li-San Wang
Yi Zhao
Gerard D. Schellenberg
Peter A. Holmans
Catherine Bresner
Janet Harwood
Lauren Luckcuck
Rachel Marshall
Julie Williams
Rebecca Sims
Anne Boland
Celine Besse
Delphine Daian
Bertrand Fin
Robert Olaso
Jean-Francois Deleuze
Yiyi Ma
Mikko Hiltunen
Teemu Kuulasmaa
Alexa Beiser
Anita Destefano
Kathryn L. Lunetta
Gina Peloso
Ruiqi Wang
Lindsay A. Farrer
Qiong Yang
Lena Kilander
Malin Lowemark
Claudia L. Satizabal
Sudha Seshadri
Oscar Lopez
Bruce M. Psaty
Joshua C. Bis
Vilmantas Giedraitis
Martin Ingelsson
Dag Aarsland
Ignacio Alvarez
Monica Diez-Fairen
Pau Pastor
Victoria Alvarez
Irene Rosas Allende
Carmen Martinez Rodriguez
Manuel Menendez-Gonzalez
Nicola J. Armstrong
Henry Brodaty
Anbupalam Thalamuthu
Perminder Sachdev
Karen Mather
Anthoula Tsolaki
Tegos Thomas
Magda Tsolaki
Carmen Antunez
Ildebrando Appollonio
Elisa Conti
Lucio Tremolizzo
Marina Arcaro
Daniela Galimberti
Elio Scarpini
Silvana Archetti
Alfonso Arias Pastor
Raquel Huerto Vilas
Gerard Pinol-Ripoll
Beatrice Arosio
Simona Ciccone
Paolo Dionigi Rossi
Evelyn Ferri
Lavinia Athanasiu
Srdjan Djurovic
Alexey A. Shadrin
Ole A. Andreassen
Henri Bailly
Emmanuelle Duron
Olivier Hanon
Jean-Sebastien Vidal
Nerisa Banaj
Gianfranco Spalletta
Miquel Baquero
Sandra Barral
Richard Mayeux
Nikolaos Scarmeas
Giuseppe Tosto
Badri N. Vardarajan
Marco Spallazzi
Shima Mehrabian
Latchezar Traykov
Ana Belen Pastor
Teodoro del Ser
Jennifer E. Below
Penelope Benchek
William S. Bush
Michelle Grunin
Jonathan L. Haines
Yeunjoo Song
Luisa Benussi
Giuliano Binetti
Silvia Fostinelli
Roberta Ghidoni
Claudine Berr
Valentina Bessi
Benedetta Nacmias
Sandro Sorbi
Alessandra Bizarro
Alessandra Lauria
Eric Boerwinkle
Jan Bressler
Chloe Sarnowski
Alessandro Padovani
Barbara Borroni
Innocenzo Rainero
Silvia Boschi
Paola Bossu
Sigrid B. Sando
Geir Brathen
Myriam Fornage
Keeley J. Brookes
Luis Ignacio Brusco
Carolina Muchnik
Merel Mol
Jeroen van Rooij
John van Swieten
Katharina Burger
Martin Dichgans
Michael Ewers
Vanessa Burholt
Laura B. Cantwell
Amanda B. Kuzma
Genevieve Chene
Carole Dufouil
Jaeyoon Chung
Gyungah R. Jun
Michael L. Cuccaro
Jeffery Vance
Ines Quintela
Roberta Cecchetti
Patrizia Mecocci
Michela Scamosci
Camille Charbonnier
Gael Nicolas
Olivier Quenez
Hung-Hsin Chen
Caterina Chillotti
Jurgen A. H. R. Claassen
Christopher Clark
Anais Corma-Gomez
Marta Fernandez-Fuertes
Juan Macias
Juan A. Pineda
Luis M. Real
Emanuele Costantini
Antonio Daniele
Michela Orsini
Carlo Custodero
Vincenzo Solfrizzi
Efthimios Dardiotis
Jean-Francois Dartigues
Stephanie Debette
Peter Paul de Deyn
Katia de Paiva Lopes
Jack Humphrey
Towfique Raj
Lot D. De Witte
Gijsje J. L. Snijders
Jurgen Deckert
Martin J. Herrmann
Thomas Polak
Nicola Denning
Alun Meggy
Janine Diehl-Schmid
Oliver Goldhardt
Timo Grimmer
Emrah Duzel
Gudny Eiriksdottir
Sebastiaan Engelborghs
Kelley M. Faber
Tatiana M. Foroud
Tagliavini Fabrizio
Giaccone Giorgio
Giacomina Rossi
Sune Fallgaard Nielsen
Borge G. Nordestgaard
David W. Fardo
Lucia Farotti
Lucilla Parnetti
Chiara Fenoglio
Raffaele Ferrari
John Hardy
Catarina B. Ferreira
Alexandre de Mendonca
Peter Fischer
Tormod Fladby
Geir Selbaek
Bernard Fongang
Xueqiu Jian
Habil Zare
Nick C. Fox
Jonathan M. Schott
Emlio Franco-Macias
Maria Bernal Sanchez-Arjona
Lutz Froelich
Lucrezia Hausner
Brian Fulton-Howard
Alison M. Goate
Silvia Mendoza
Sebastian Garcia-Madrona
Guillermo Garcia-Ribas
Ina Giegling
Annette M. Hartmann
Dan Rujescu
Duber Gomez-Fonseca
Antonio Gonzalez-Perez
Maria Eugenia Saez
Caroline Graff
Charlotte Johansson
Anne Kinhult Stahlbom
Abbe Ullgren
Giulia Grande
Erika J. Laukka
Goran Papenberg
Emma Green
Edna Grunblatt
Vilmundur Gudnason
Tamar Guetta-Baranes
Kevin Morgan
Annakaisa Haapasalo
Margaret A. Pericak-Vance
Georgios Hadjigeorgiou
Brian W. Kunkle
Kara L. Hamilton-Nelson
Eden R. Martin
Farid Rajabli
Susan Slifer
Harald Hampel
Stefanie Heilmann-Heimbach
Per Hoffmann
Markus M. Nothen
Seppo Helisalmi
Anne Koivisto
Jenni Lehtisalo
Hilkka Soininen
Alina Solomon
Clive Holmes
Geert Jan Biessels
Yuriko Kastumata
John Kauwe
Patrick G. Kehoe
Seth Love
Olivia Skrobot
Miia Kivipelto
Francesca Mangialasche
Johannes Kornhuber
Mary H. Kosmidis
Walter A. Kukull
William Longstreth
Lenore Launer
Jakub Hort
Tiia Ngandu
Ondrej Lerch
Martin Vyhnalek
Dolly Reyes-Dumeyer
Catherine A. Macleod
Gill Windle
Bob Woods
Carlo Masullo
Christiane Reitz
Simon Mead
Susanne Moebus
Laura Molina-Porcel
Laura Morelli
Thomas Mosley
Shubhabrata Mukherjee
Anne Tybjaerg-Hansen
Ruth Frikke-Schmidt
Caffarra Paolo
Florence Pasquier
Pierre Pericard
Oliver Peters
Josef Priller
Laudia Pisanu
Julius Popp
Jesper Qvist Thomassen
Inez Ramakers
Frans Verhey
Marcel J. T. Reinders
Perry Ridge
Steffi Riedel-Heller
Peter Riederer
Arvid Rongve
Jose Luis Royo
Elisa Rubino
Paraskevi Sakka
Florentino Sanchez-Garcia
Raquel Sanchez-Valle
Norbert Scherbaum
Martin Scherer
Leonie Weinhold
Ingun Ulstein
Davide Seripa
Manuel Serrano
Alessio Squassina
Eystein Stordal
Andre Uitterlinden
Aad van der Lugt
Rik Vandenberghe
Jonathan Vogelgsang
Jens Wiltfang
David Wallon
Mary Yannakoulia
Xiaoling Zhang
Congcong Zhu
Affiliated Authors:
Yiyi Ma
Sandra Barral
Richard Mayeux
Nikolaos Scarmeas
Giuseppe Tosto
Badri N. Vardarajan
Dolly Reyes-Dumeyer
Christiane Reitz
Columbia Affiliation:
Grants:
R01CA129769 (NIH – National Cancer Institute)
UL1TR001445 (NIH – National Center for Advancing Translational Sciences)
UL1RR029893 (NIH – National Center for Research Resources)
KL2RR024151 (NIH – National Center for Research Resources)
T32EY007157 (NIH – National Eye Institute)
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
U01HL130114 (NIH – National Heart, Lung, and Blood Institute)
R01HL085083 (NIH – National Heart, Lung, and Blood Institute)
R01HL120393 (NIH – National Heart, Lung, and Blood Institute)
R01HL103612 (NIH – National Heart, Lung, and Blood Institute)
R01HL087652 (NIH – National Heart, Lung, and Blood Institute)
U01HG006375 (NIH – National Human Genome Research Institute)
U01HG008657 (NIH – National Human Genome Research Institute)
U01HG004610 (NIH – National Human Genome Research Institute)
P30DK063491 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01MH080295 (NIH – National Institute of Mental Health)
UH2NS100605 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS017950 (NIH – National Institute of Neurological Disorders and Stroke)
U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS059873 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS118146 (NIH – National Institute of Neurological Disorders and Stroke)
P50NS039764 (NIH – National Institute of Neurological Disorders and Stroke)
U01AG046161 (NIH – National Institute On Aging)
P01AG003991 (NIH – National Institute On Aging)
P01AG003949 (NIH – National Institute On Aging)
U01AG052409 (NIH – National Institute On Aging)
RF1AG059421 (NIH – National Institute On Aging)
R01AG033040 (NIH – National Institute On Aging)
U01AG046152 (NIH – National Institute On Aging)
U01AG049505 (NIH – National Institute On Aging)
P50AG005138 (NIH – National Institute On Aging)
R01AG030653 (NIH – National Institute On Aging)
P30AG066530 (NIH – National Institute On Aging)
R01AG022018 (NIH – National Institute On Aging)
R01AG023651 (NIH – National Institute On Aging)
R01AG023629 (NIH – National Institute On Aging)
F99AG073565 (NIH – National Institute On Aging)
P50AG016573 (NIH – National Institute On Aging)
R37AG015473 (NIH – National Institute On Aging)
R01AG041718 (NIH – National Institute On Aging)
P30AG072976 (NIH – National Institute On Aging)
P30AG013846 (NIH – National Institute On Aging)
U24AG041689 (NIH – National Institute On Aging)
R01AG041232 (NIH – National Institute On Aging)
P01AG026276 (NIH – National Institute On Aging)
U01AG006786 (NIH – National Institute On Aging)
P50AG025688 (NIH – National Institute On Aging)
U01AG068880 (NIH – National Institute On Aging)
R01AG031581 (NIH – National Institute On Aging)
R01AG037212 (NIH – National Institute On Aging)
ZIAAG007270 (NIH – National Institute On Aging)
R01AG033193 (NIH – National Institute On Aging)
R01AG032990 (NIH – National Institute On Aging)
P30AG053760 (NIH – National Institute On Aging)
R56AG055824 (NIH – National Institute On Aging)
P50AG005136 (NIH – National Institute On Aging)
P30AG012300 (NIH – National Institute On Aging)
R01AG020098 (NIH – National Institute On Aging)
U01AG024904 (NIH – National Institute On Aging)
U19AG068753 (NIH – National Institute On Aging)
R01AG036836 (NIH – National Institute On Aging)
P30AG013854 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
P50AG033514 (NIH – National Institute On Aging)
P50AG016570 (NIH – National Institute On Aging)
P30AG019610 (NIH – National Institute On Aging)
P50AG023501 (NIH – National Institute On Aging)
R01AG036042 (NIH – National Institute On Aging)
P50AG005134 (NIH – National Institute On Aging)
P30AG010124 (NIH – National Institute On Aging)
R01AG054005 (NIH – National Institute On Aging)
P30AG010133 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
U19AG062418 (NIH – National Institute On Aging)
K08AG065463 (NIH – National Institute On Aging)
P30AG066512 (NIH – National Institute On Aging)
P30AG066511 (NIH – National Institute On Aging)
P30AG062715 (NIH – National Institute On Aging)
P50AG005146 (NIH – National Institute On Aging)
P01AG066597 (NIH – National Institute On Aging)
P50AG005142 (NIH – National Institute On Aging)
P50AG008702 (NIH – National Institute On Aging)
R01AG030146 (NIH – National Institute On Aging)
R01AG048927 (NIH – National Institute On Aging)
U19AG024904 (NIH – National Institute On Aging)
U01AG006781 (NIH – National Institute On Aging)
P50AG005133 (NIH – National Institute On Aging)
P50AG005131 (NIH – National Institute On Aging)
P30AG072977 (NIH – National Institute On Aging)
P30AG028383 (NIH – National Institute On Aging)
P30AG010129 (NIH – National Institute On Aging)
R01AG013616 (NIH – National Institute On Aging)
U01AG046139 (NIH – National Institute On Aging)
R01AG037985 (NIH – National Institute On Aging)
R01AG018023 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
RF1AG057473 (NIH – National Institute On Aging)
R01AG062622 (NIH – National Institute On Aging)
P30AG072980 (NIH – National Institute On Aging)
U01AG016976 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
P01AG017586 (NIH – National Institute On Aging)
R21AG063130 (NIH – National Institute On Aging)
R01AG048015 (NIH – National Institute On Aging)
K99AG066849 (NIH – National Institute On Aging)
R01AG042437 (NIH – National Institute On Aging)
RF1AG061872 (NIH – National Institute On Aging)
P30AG028377 (NIH – National Institute On Aging)
P30AG066514 (NIH – National Institute On Aging)
R01AG049607 (NIH – National Institute On Aging)
R01AG041797 (NIH – National Institute On Aging)
U01AG058654 (NIH – National Institute On Aging)
U24AG072122 (NIH – National Institute On Aging)
U24AG056270 (NIH – National Institute On Aging)
R01AG019085 (NIH – National Institute On Aging)
R01AG012101 (NIH – National Institute On Aging)
P50AG005681 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
R01AG022374 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
P30AG066462 (NIH – National Institute On Aging)
P30AG072979 (NIH – National Institute On Aging)
P30AG008017 (NIH – National Institute On Aging)
P30AG066509 (NIH – National Institute On Aging)
R01AG027944 (NIH – National Institute On Aging)
R01AG035137 (NIH – National Institute On Aging)
P30AG072972 (NIH – National Institute On Aging)
R56AG057191 (NIH – National Institute On Aging)
U01AG032984 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
RF1AG057519 (NIH – National Institute On Aging)
P30AG066444 (NIH – National Institute On Aging)
P30AG008051 (NIH – National Institute On Aging)
R01AG028786 (NIH – National Institute On Aging)
P01AG017216 (NIH – National Institute On Aging)
U24AG021886 (NIH – National Institute On Aging)
P50AG016574 (NIH – National Institute On Aging)
RF1AG061351 (NIH – National Institute On Aging)
R01AG017173 (NIH – National Institute On Aging)
U24AG026395 (NIH – National Institute On Aging)
P50AG025711 (NIH – National Institute On Aging)
R01AG011101 (NIH – National Institute On Aging)
RC2AG036547 (NIH – National Institute On Aging)
RC2AG036502 (NIH – National Institute On Aging)
P50AG016582 (NIH – National Institute On Aging)
R01AG009956 (NIH – National Institute On Aging)
P01AG002219 (NIH – National Institute On Aging)
RC2AG036650 (NIH – National Institute On Aging)
R01AG025259 (NIH – National Institute On Aging)
P01AG010491 (NIH – National Institute On Aging)
RC2AG036528 (NIH – National Institute On Aging)
P20MD000546 (NIH – National Institute On Minority Health and Health Disparities)
Publication Type:
Article
Unique ID:
10.1038/s41588-022-01024-z
PMID:
35379992
DOI:
10.1038/s41588-022-01024-z
Journal:
Nature Genetics
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record

Record Created:

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