U01CA261822

NIH – National Cancer Institute

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

De Felice, D., Alaimo, A., Bressan, D., Genovesi, S., Marmocchi, E., Annesi, N., Beccaceci, G., Dalfovo, D., Cutrupi, F., Medaglia, S., Foletto, V., Lorenzoni, M., Gandolfi, F., Kannan, S., Verma, C. S., Vasciaveo, A., Shen, M. M., Romanel, A., Chiacchiera, F., … Lunardi, A. (2024). Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer. EMBO Reports. https://doi.org/10.1038/s44319-024-00335-y

Authors:

Dario De Felice

Alessandro Alaimo

Davide Bressan

Sacha Genovesi

Elisa Marmocchi

Nicole Annesi

Giulia Beccaceci

Davide Dalfovo

Federico Cutrupi

Stefano Medaglia

Veronica Foletto

Marco Lorenzoni

Francesco Gandolfi

Srinivasaraghavan Kannan

Chandra Verma

Alessandro Vasciaveo

Michael M. Shen

Alessandro Romanel

Fulvio Chiacchiera

Francesco Cambuli

Andrea Lunardi

Affiliated Authors:

Alessandro Vasciaveo

Michael M. Shen

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Hepatocyte Nuclear Factor 3-alpha (MeSH)

Prostatic Neoplasms (MeSH)

Signal Transduction (MeSH)

Prostate (MeSH)

Retinoic Acid Receptor gamma (MeSH)

Stem Cells (MeSH)

Advancements in Prostate Cancer Research (OpenAlex Topic)

Regulation and Functions of FoxO Transcription Factors (OpenAlex Topic)

Fertility Preservation in Cancer Patients (OpenAlex Topic)

Author Keywords:

foxa1

organoids

prostate

retinoic acid

foxa1 protein, human

foxa1 protein, mouse

hepatocyte nuclear factor 3-alpha

receptors, retinoic acid

retinoic acid receptor gamma

tretinoin

androgen

hepatocyte nuclear factor 3alpha

retinoic acid receptor

anatomical axis

animal experiment

animal model

animal tissue

article

breast cancer

cell dedifferentiation

chromatin

controlled study

cytoarchitecture

dna binding

gene mutation

genital system

human

human tissue

loss of function mutation

male

molecular model

mouse

nonhuman

promoter region

prostate cancer

signal transduction

stem cell

tubulogenesis

vertebrate

animal

cell differentiation

genetics

metabolism

pathology

prostate tumor

animals

humans

mice

prostatic neoplasms

stem cells

Grants:

U01CA261822 (NIH – National Cancer Institute)

R01CA238005 (NIH – National Cancer Institute)

Publication Type:

Article

Unique ID:

10.1038/s44319-024-00335-y

PMID:

39633177

DOI:

10.1038/s44319-024-00335-y

Journal:

EMBO Reports

Publication Date:

2024-12-04

Data Source:

OpenAlex

Source Link:

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Record Created:

Wednesday, January 8, 2025 - 09:52

Inverse agonists of retinoic acid receptor/retinoid X receptor signaling as lineage-specific antitumor agents against human adenoid cystic carcinoma

Viragova, S., Aparicio, L., Palmerini, P., Zhao, J., Valencia Salazar, L. E., Schurer, A., Dhuri, A., Sahoo, D., Moskaluk, C. A., Rabadan, R., & Dalerba, P. (2023). Inverse agonists of retinoic acid receptor/retinoid X receptor signaling as lineage-specific antitumor agents against human adenoid cystic carcinoma. JNCI: Journal of the National Cancer Institute, 115(7), 838–852. https://doi.org/10.1093/jnci/djad062

Authors:

Sara Viragova

Luis Aparicio

Pierangela Palmerini

Junfei Zhao

Luis E Valencia Salazar

Alexandra Schurer

Anika Dhuri

Debashis Sahoo

Christopher A Moskaluk

Raul Rabadan

Piero Dalerba

Affiliated Authors:

Sara Viragova

Luis Aparicio

Pierangela Palmerini

Junfei Zhao

Luis E Valencia Salazar

Alexandra Schurer

Anika Dhuri

Raul Rabadan

Piero Dalerba

Columbia Affiliation:

Subjects:

Antineoplastic Agents (MeSH)

Carcinoma, Adenoid Cystic (MeSH)

Receptors, Retinoic Acid (MeSH)

Grants:

P30CA013696 (NIH – National Cancer Institute)

R35CA253126 (NIH – National Cancer Institute)

U01CA261822 (NIH – National Cancer Institute)

UG3TR003355 (NIH – National Center for Advancing Translational Sciences)

TL1TR001875 (NIH – National Center for Advancing Translational Sciences)

UL1TR001873 (NIH – National Center for Advancing Translational Sciences)

R01AI155696 (NIH – National Institute of Allergy and Infectious Diseases)

R01DE028961 (NIH – National Institute of Dental & Craniofacial Research)

RC1DE020687 (NIH – National Institute of Dental & Craniofacial Research)

R01GM138385 (NIH – National Institute of General Medical Sciences)

T32GM008224 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1093/jnci/djad062

PMID:

37040084

DOI:

10.1093/jnci/djad062

Journal:

Journal of the National Cancer Institute

Publication Date:

2023-07-06

Data Source:

PubMed

Source Link:

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Record Created:

Friday, August 9, 2024 - 14:05

Immune mechanisms shape the clonal landscape during early progression of prostate cancer

Tshering, L. F., Luo, F., Russ, S., Szenk, M., Rubel, D., Tutuska, K., Rail, J. G., Balázsi, G., Shen, M. M., & Talos, F. (2023). Immune mechanisms shape the clonal landscape during early progression of prostate cancer. Developmental Cell, 58(12), 1071-1086.e8. https://doi.org/10.1016/j.devcel.2023.04.010

Authors:

Lara F. Tshering

Fu Luo

Savanah Russ

Mariola Szenk

Diana Rubel

Karis Tutuska

James G. Rail

Gábor Balázsi

Michael M. Shen

Flaminia Talos

Affiliated Authors:

Michael M. Shen

Flaminia Talos

Columbia Affiliation:

Subjects:

Prostatic Neoplasms (MeSH)

Immunobiology of Dendritic Cells (OpenAlex Topic)

Cancer Immunotherapy (OpenAlex Topic)

Genomic Landscape of Cancer and Mutational Signatures (OpenAlex Topic)

Author Keywords:

clonal competition

immunoediting

prostate cancer

single-cell transcriptomics

Grants:

K22CA188169 (NIH – National Cancer Institute)

R01CA238005 (NIH – National Cancer Institute)

R21CA270610 (NIH – National Cancer Institute)

U01CA261822 (NIH – National Cancer Institute)

F99DK131481 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R35GM122561 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1016/j.devcel.2023.04.010

PMID:

37148881

DOI:

10.1016/j.devcel.2023.04.010

Journal:

Developmental Cell

Publication Date:

2023-06-01

Data Source:

OpenAlex

Source Link:

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Record Created:

Monday, August 12, 2024 - 10:48

OncoLoop: A Network-Based Precision Cancer Medicine Framework

Vasciaveo, A., Arriaga, J. M., de Almeida, F. N., Zou, M., Douglass, E. F., Picech, F., Shibata, M., Rodriguez-Calero, A., de Brot, S., Mitrofanova, A., Chua, C. W., Karan, C., Realubit, R., Pampou, S., Kim, J. Y., Afari, S. N., Mukhammadov, T., Zanella, L., Corey, E., … Abate-Shen, C. (2022). OncoLoop: A Network-Based Precision Cancer Medicine Framework. Cancer Discovery, 13(2), 386–409. https://doi.org/10.1158/2159-8290.cd-22-0342

Authors:

Alessandro Vasciaveo

Juan Martín Arriaga

Francisca Nunes de Almeida

Min Zou

Eugene F Douglass

Florencia Picech

Maho Shibata

Antonio Rodriguez-Calero

Simone de Brot

Antonina Mitrofanova

Chee Wai Chua

Charles Karan

Ronald Realubit

Sergey Pampou

Jaime Y Kim

Stephanie N Afari

Timur Mukhammadov

Luca Zanella

Eva Corey

Mariano J Alvarez

Mark A Rubin

Michael M Shen

Andrea Califano

Cory Abate-Shen

Affiliated Authors:

Alessandro Vasciaveo

Juan Martín Arriaga

Francisca Nunes de Almeida

Min Zou

Eugene F Douglass

Florencia Picech

Maho Shibata

Antonina Mitrofanova

Chee Wai Chua

Charles Karan

Ronald Realubit

Sergey Pampou

Jaime Y Kim

Stephanie N Afari

Timur Mukhammadov

Luca Zanella

Mariano J Alvarez

Michael M Shen

Andrea Califano

Cory Abate-Shen

Columbia Affiliation:

Subjects:

Advancements in Prostate Cancer Research (OpenAlex Topic)

Targeted Protein Degradation in Biomedical Research (OpenAlex Topic)

Genomic Landscape of Cancer and Mutational Signatures (OpenAlex Topic)

Prostatic Neoplasms, Castration-Resistant (MeSH)

Grants:

U01CA217858 (NIH – National Cancer Institute)

P01CA221757 (NIH – National Cancer Institute)

P01CA265768 (NIH – National Cancer Institute)

R01CA238005 (NIH – National Cancer Institute)

R01CA173481 (NIH – National Cancer Institute)

R01CA183929 (NIH – National Cancer Institute)

U01CA272610 (NIH – National Cancer Institute)

U01CA261822 (NIH – National Cancer Institute)

U54CA209997 (NIH – National Cancer Institute)

P01CA163227 (NIH – National Cancer Institute)

P50CA097186 (NIH – National Cancer Institute)

R00CA194287 (NIH – National Cancer Institute)

P30CA013696 (NIH – National Cancer Institute)

UL1TR001873 (NIH – National Center for Advancing Translational Sciences)

S10OD012351 (NIH – Office of the Director, National Institutes of Health)

S10OD021764 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1158/2159-8290.cd-22-0342

PMID:

36374194

DOI:

10.1158/2159-8290.cd-22-0342

Journal:

Cancer Discovery

Publication Date:

2023-02-06

Data Source:

PubMed

Source Link:

View PubMed Record

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Record Created:

Friday, August 16, 2024 - 12:25