R01AG070194

NIH – National Institute On Aging

Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

Dridi, H., Liu, Y., Reiken, S., Liu, X., Argyrousi, E. K., Yuan, Q., Miotto, M. C., Sittenfeld, L., Meddar, A., Soni, R. K., Arancio, O., Lacampagne, A., & Marks, A. R. (2023). Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nature Neuroscience, 26(8), 1365–1378. https://doi.org/10.1038/s41593-023-01377-6

Authors:

Haikel Dridi

Yang Liu

Steven Reiken

Xiaoping Liu

Elentina K Argyrousi

Qi Yuan

Marco C Miotto

Leah Sittenfeld

Andrei Meddar

Rajesh Kumar Soni

Ottavio Arancio

Alain Lacampagne

Andrew R Marks

Affiliated Authors:

Haikel Dridi

Yang Liu

Steven Reiken

Xiaoping Liu

Elentina K Argyrousi

Qi Yuan

Marco C Miotto

Ottavio Arancio

Andrew R Marks

Columbia Affiliation:

Subjects:

Cognitive Dysfunction (MeSH)

Heart Failure (MeSH)

Ryanodine Receptor Calcium Release Channel (MeSH)

Grants:

R01HL142903 (NIH – National Heart, Lung, and Blood Institute)

R25HL156002 (NIH – National Heart, Lung, and Blood Institute)

T32HL120826 (NIH – National Heart, Lung, and Blood Institute)

R01HL145473 (NIH – National Heart, Lung, and Blood Institute)

R01HL140934 (NIH – National Heart, Lung, and Blood Institute)

R01DK118240 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01AG070194 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41593-023-01377-6

PMID:

37429912

DOI:

10.1038/s41593-023-01377-6

Journal:

Nature Neuroscience

Publication Date:

2023-08-01

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

Record Created:

Wednesday, August 7, 2024 - 16:29

Targeting ryanodine receptors to treat human diseases

Marks, A. R. (2023). Targeting ryanodine receptors to treat human diseases. Journal of Clinical Investigation, 133(2). https://doi.org/10.1172/jci162891

Authors:

Andrew R. Marks

Affiliated Authors:

Andrew R. Marks

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Physiology and Cellular Biophysics

Grants:

R25HL156002 (NIH – National Heart, Lung, and Blood Institute)

R01HL140934 (NIH – National Heart, Lung, and Blood Institute)

R01HL145473 (NIH – National Heart, Lung, and Blood Institute)

R01HL142903 (NIH – National Heart, Lung, and Blood Institute)

T32HL120826 (NIH – National Heart, Lung, and Blood Institute)

R01DK118240 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R25NS076445 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG070194 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1172/JCI162891

PMID:

36647824

DOI:

10.1172/JCI162891

Journal:

Journal of Clinical Investigation

Publication Date:

2023-01-17

Data Source:

Scopus

Source Link:

View Scopus Record

Record Created:

Friday, August 16, 2024 - 13:13

A drug and ATP binding site in type 1 ryanodine receptor

Melville, Z., Dridi, H., Yuan, Q., Reiken, S., Wronska, A., Liu, Y., Clarke, O. B., & Marks, A. R. (2022). A drug and ATP binding site in type 1 ryanodine receptor. Structure, 30(7), 1025-1034.e4. https://doi.org/10.1016/j.str.2022.04.010

Authors:

Zephan Melville

Haikel Dridi

Qi Yuan

Steven Reiken

Anetta Wronska

Yang Liu

Oliver B. Clarke

Andrew R. Marks

Affiliated Authors:

Zephan Melville

Haikel Dridi

Qi Yuan

Steven Reiken

Anetta Wronska

Yang Liu

Oliver B. Clarke

Andrew R. Marks

Columbia Affiliation:

Subjects:

Calcium (MeSH)

Ryanodine Receptor Calcium Release Channel (MeSH)

Author Keywords:

rycals

calcium channels

calmodulin

calstabin

cryoem

electrophysiology

ion channels

muscular dystrophy

ryanodine receptor

sarcoplasmic reticulum

Grants:

R01HL145473 (NIH – National Heart, Lung, and Blood Institute)

R01HL142903 (NIH – National Heart, Lung, and Blood Institute)

T32HL120826 (NIH – National Heart, Lung, and Blood Institute)

R01HL140934 (NIH – National Heart, Lung, and Blood Institute)

R01DK118240 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01GM129325 (NIH – National Institute of General Medical Sciences)

P41GM103311 (NIH – National Institute of General Medical Sciences)

R01AG070194 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/j.str.2022.04.010

PMID:

35580609

DOI:

10.1016/j.str.2022.04.010

Journal:

Structure

Publication Date:

2022-07-07

Data Source:

Web of Science

Source Link:

View Web of Science Record

View PubMed Record

Record Created:

Thursday, December 19, 2024 - 08:48

IP3 receptor orchestrates maladaptive vascular responses in heart failure

Dridi, H., Santulli, G., Gambardella, J., Jankauskas, S. S., Yuan, Q., Yang, J., Reiken, S., Wang, X., Wronska, A., Liu, X., Lacampagne, A., & Marks, A. R. (2022). IP3 receptor orchestrates maladaptive vascular responses in heart failure. Journal of Clinical Investigation, 132(4). https://doi.org/10.1172/jci152859

Authors:

Haikel Dridi

Gaetano Santulli

Jessica Gambardella

Stanislovas S Jankauskas

Qi Yuan

Jingyi Yang

Steven Reiken

Xujun Wang

Anetta Wronska

Xiaoping Liu

Alain Lacampagne

Andrew R Marks

Affiliated Authors:

Haikel Dridi

Gaetano Santulli

Jessica Gambardella

Qi Yuan

Jingyi Yang

Steven Reiken

Anetta Wronska

Xiaoping Liu

Andrew R Marks

Columbia Affiliation:

Subjects:

Calcium Signaling (MeSH)

Heart Failure (MeSH)

Inositol 1,4,5-Trisphosphate Receptors (MeSH)

Muscle, Smooth, Vascular (MeSH)

Myocytes, Smooth Muscle (MeSH)

Vasoconstriction (MeSH)

Author Keywords:

calcium channels

calcium signaling

cardiology

cardiovascular disease

cell biology

Grants:

R01HL142903 (NIH – National Heart, Lung, and Blood Institute)

R01HL146691 (NIH – National Heart, Lung, and Blood Institute)

R01HL159062 (NIH – National Heart, Lung, and Blood Institute)

R01HL145473 (NIH – National Heart, Lung, and Blood Institute)

T32HL120826 (NIH – National Heart, Lung, and Blood Institute)

R01HL140934 (NIH – National Heart, Lung, and Blood Institute)

T32HL144456 (NIH – National Heart, Lung, and Blood Institute)

R25HL156002 (NIH – National Heart, Lung, and Blood Institute)

R01DK118240 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK033823 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R00DK107895 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK123259 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01AG070194 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1172/jci152859

PMID:

35166236

DOI:

10.1172/jci152859

Journal:

Journal of Clinical Investigation

Publication Date:

2022-02-16

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

View Web of Science Record

Record Created:

Tuesday, February 18, 2025 - 11:21

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Zanou, N., Dridi, H., Reiken, S., Imamura de Lima, T., Donnelly, C., De Marchi, U., Ferrini, M., Vidal, J., Sittenfeld, L., Feige, J. N., Garcia-Roves, P. M., Lopez-Mejia, I. C., Marks, A. R., Auwerx, J., Kayser, B., & Place, N. (2021). Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27422-1

Authors:

Nadège Zanou

Haikel Dridi

Steven Reiken

Tanes Imamura de Lima

Chris Donnelly

Umberto De Marchi

Manuele Ferrini

Jeremy Vidal

Leah Sittenfeld

Jerome N Feige

Pablo M Garcia-Roves