R01AG069750

NIH – National Institute On Aging

Ligand-specific regulation of a binary enhancer code dictating cellular senescence

Suter, T., Friedman, M. J., Tazearslan, C., Merkurjev, D., Ohgi, K., Meluzzi, D., Rosenfeld, M. G., & Suh, Y. (2025). Ligand-specific regulation of a binary enhancer code dictating cellular senescence. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2506321122

Authors:

Thomas Suter

Meyer J Friedman

Cagdas Tazearslan

Daria Merkurjev

Kenny Ohgi

Dario Meluzzi

Michael G Rosenfeld

Yousin Suh

Affiliated Authors:

Yousin Suh

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Obstetrics and Gynecology
- Department of Genetics and Development

Subjects:

DNA Nanotechnology and Bioanalytical Applications (OpenAlex Topic)

Regulation of Chromatin Structure and Function (OpenAlex Topic)

Mechanisms and Applications of RNA Interference (OpenAlex Topic)

Cellular Senescence (MeSH)

Enhancer Elements, Genetic (MeSH)

Senescence-Associated Secretory Phenotype (MeSH)

Author Keywords:

cellular senescence

enhancers

nfi

p65

smad2/3

activin a

dimethyl sulfoxide

activin

smad2 protein

smad3 protein

activins

ligands

transforming growth factor beta2

hiseq 4000

biological factor

ribosome rna

senescence associated secretory phenotype

short hairpin rna

transcription factor

transforming growth factor beta

unclassified drug

ligand

acute myeloid leukemia

article

body mass

brain artery aneurysm

c reactive protein level

carcinogenesis

cell cycle

chromatin

chromatin immunoprecipitation

chromatin immunoprecipitation sequencing

chronic lymphatic leukemia

controlled study

data analysis

fibroblast

gene expression

gene knockout

gene set enrichment analysis

genetic transcription

human

human cell

lung fibroblast

microscopy

mrna expression level

nonhuman

population size

protein blood level

real time reverse transcription polymerase chain reaction

rna sequence

rna sequencing

senescence

senescence associated beta galactosidase signallling

single nucleotide polymorphism

staining

tissue culture

wilcoxon signed ranks test

cell aging

enhancer region

genetics

metabolism

senescence-associated secretory phenotype

enhancer elements, genetic

humans

Grants:

R01AG057706 (NIH – National Institute On Aging)

R01AG061521 (NIH – National Institute On Aging)

R01AG069750 (NIH – National Institute On Aging)

R01DK018477 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK039949 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK127778 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R37DK039949 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1073/pnas.2506321122

PMID:

40493192

DOI:

10.1073/pnas.2506321122

Journal:

Proceedings of the National Academy of Sciences of the United States of America

Publication Date:

2025-06-10

Data Source:

PubMed

Source Link:

View PubMed Record

View Web of Science Record

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View OpenAlex Record

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Record Created:

Tuesday, July 1, 2025 - 12:18

Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction

Wei, S., Kohl, E., Djandji, A., Morgan, S., Whittier, S., Mansukhani, M., Hod, E., D’Alton, M., Suh, Y., & Williams, Z. (2021). Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-81487-y

Authors:

Shan Wei

Esther Kohl

Alexandre Djandji

Stephanie Morgan

Susan Whittier

Mahesh Mansukhani

Eldad Hod

Mary D’Alton

Yousin Suh

Zev Williams

Affiliated Authors:

Shan Wei

Esther Kohl

Alexandre Djandji

Stephanie Morgan

Susan Whittier

Mahesh Mansukhani

Eldad Hod

Mary D’Alton

Yousin Suh

Zev Williams

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Diagnostic Methods for COVID-19 Detection (OpenAlex Topic)

Paper-Based Diagnostic Devices (OpenAlex Topic)

Coronavirus Disease 2019 Research (OpenAlex Topic)

COVID-19 (MeSH)

COVID-19 Testing (MeSH)

Molecular Diagnostic Techniques (MeSH)

Nucleic Acid Amplification Techniques (MeSH)

RNA, Viral (MeSH)

SARS-CoV-2 (MeSH)

Grants:

R01HD086327 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

R01HD100013 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

RF1AG057341 (NIH – National Institute On Aging)

R01AG069750 (NIH – National Institute On Aging)

R01AG057433 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41598-021-81487-y

PMID:

33510181

DOI:

10.1038/s41598-021-81487-y

Journal:

Scientific Reports

Publication Date:

2021-12-01

Data Source:

Scopus

Source Link:

View Scopus Record

View PubMed Record

View Web of Science Record

View OpenAlex Record

Record Created:

Monday, April 28, 2025 - 12:36

A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation

Kim, S.-S., Hudgins, A. D., Yang, J., Zhu, Y., Tu, Z., Rosenfeld, M. G., DiLorenzo, T. P., & Suh, Y. (2021). A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation. PLOS ONE, 16(9), e0257265. https://doi.org/10.1371/journal.pone.0257265

Authors:

Seung-Soo Kim

Adam D Hudgins

Jiping Yang

Yizhou Zhu

Zhidong Tu

Michael G Rosenfeld

Teresa P DiLorenzo

Yousin Suh

Affiliated Authors:

Seung-Soo Kim

Adam D Hudgins